Professional Documents
Culture Documents
AND
TOXICOLOGY
Presented by:
Prof. Orland B. Badiango
Forensic Chemist
is a specialist who practice forensic chemistry
Evidence
refers to a proof of allegation. A mean suctioned
by law to ascertain in a judicial proceedings
respecting a matter of fact.
Three Major Classification of Evidence
1. Direct Evidence
A kind of evidence that directly establishes
the main fact of issue, it may simply refer to what
the senses perceive. Any fact to which the
witness testifies based on what he saw, heared,
smelled, touched or tasted.
2. Circumstantial Evidence
A kind of evidence that seeks to establish
a conclusion by inferences from proven facts.
It establishes a fact or circumstances from which
the court may infer, another fact at issue.
3. Hearsay Evidence
Proceeds not from personal knowledge of
the witness but from the mere repetition of what
the witness heared from other people. A statement
made by a witness on the authority of another and
not from his own personal knowledge or observation.
3. Experimental Evidence
An expert witness may be required to perform
experiments to prove a certain fact.
4. Documentary Evidence
Any written evidence presented by an expert
in court that is relevant to the subject matter
in dispute and not excluded by the rules of court.
WITNESS
A person, other than the suspect, who is
requested to give information concerning an
incident or person. He testifies in court, may be
a victim, complainant, accuser, source of
information, or an observer of an occurrence.
SUSPECT
- is a person whose guilt is considered a reasonable
grounds to be a practical possibility.
1. Ordinary Witness
States facts and may not express his/her opinion
or conclusion and may testify to impression of common
experienced.
2. Expert Witness
One who possessed a special skill.
3. Eye Witness
The person who saw the fatal act.
BLOOD AND BLOOD STAINS
Blood is called the circulating tissue of the
body. It refers to a highly complex mixtures
of cells, enzymes, protein, and inorganic substances.
Composition of blood
1. Solid portion (45%) consist of red blood cells,
white blood cells, and blood platelets.
2. Liquid portion (55%) plasma.
PLASMA
yellowish fluid of blood in which several blood
corpuscles are suspended
SERUM
straw-yellow liquid formed when blood clott
are allowed to stand for some time and the
blood contracts.
PROBLEMS IN THE STUDY OF BLOOD
1. Where blood has to be search
2. Collection, Preservation, packing and transportation
of specimen suspected to contain blood.
Genes
- complex chemical units in the chromosomes
by which hereditary characters are transmitted. They
are responsible for the transmission
of hereditary characteristics,
they occur in pairs. There are two genes or
factors called gene A and gene B, these are found in
the chromosomes.
Phenotypes
-used to denote the expression in the
inherited characteristics as found in the individual,
these are actually the blood groups.
Genotype
- paired genes
Steps in the Inheritance of Blood Groups
1. Write the blood group or the phenotypes of the
parents
2. Bring the group of the parents down. Say A, this
contains agglutinogen A and this can be inherited
as established by Dungern and Hirszfeld, and this
one of the genes in the pair of genes called genotype
3. Match the pair of genes of the parents by employing
the criss-cross method to arrive the genotype of the
children.
4. Determine the dominant to determine the blood
group of the children
SEMEN AND SEMINAL STAINS
Characteristics Pattern
gaping hole, smudging, singeing, tattooing, burning
tattooing and smudging
evidence of powder tattooing is seldom present
Chemical Test for Gun Powder Residues
1. Method pattern after diphenylamine paraffin test
2. Walker’s Test - this method is used if the powder particles are
deeply embedded
Determination of Probable Time when the Gun has been fired
1. Rust - if a gun has not been fired at all, no rust can be
detected inside the barrel of the gun. If it has been fired, iron
salts are formed and are found inside the barrel. These iron salts
are soon oxidized, thus resulting in the formation of rust.
2. Nitrite - determined by addition of DPA reagent blue in color.
3. Nitrate - determined by addition of diphenylamine yellow green
in color.
4. Metallic Fragment
5. Soot - black substance that is formed by combustion .
Explosives - any substance that may cause an
explosion by its sudden decomposition or combustion.
CLASSIFICATION OF EXPLOSIVES
A. Inorganic Compound
example: lead azide
B. Organic Compound
examples:
TNT, picric acid, nitrocellulose, and mercury fulminate)
2. With respect to functioning characteristics
Parts of Hair
1. Root - portion embedded in the skin
1. Scalp Hair - they are more mature than any kind of human hair
2. Beard Hair - coarse, curved, very stiff, and often in triangular in cross section
3. Hair from eyebrows, eyelid, nose, and ear - short, stubby and have wide
medulla, eyebrow and eyelashes are usually very short and has a sharp tip
4. Trunk hair - vary in thickness along the shaft and are immature but are
somewhat similar to head hairs, they have fine, and long tip ends.
5. Limb Hair - similar o trunk hair but usually are not so long or so coarse and
usually contains less pigment.
6. Auxiliary Hair - is fairly long with unevenly distributed pigment. They
vary considerably in diameter along the shaft and have frequently a
bleached appearance. It has an irregular shape and structure. Looks like
pubic hair but the ends are sharper and the hair is not so curly.
7. Pubic Hair - similar to axillary hair but are coarse, and do not appear
bleach; more wiry, have more constriction and twist and usually have
continuous broad medulla, has many broken ends because the clothing rubs.
Approximate Age of an Individual through Hair
Examination
1. Cotton - unicellular filament, flat, ribbon like twisted spirally to right or left on
its axes, central canal is uniform in diameter.
2. Mercerized Cotton - straight, cylindrical with occasional twist; unevenly
lustrous, smooth except for occasional transverse folds or wrinkles and cuticle
are mostly lacking.
3. Linen - multicellular filament, straight and cylindrical not twisted and flattened,
tapering to a sharp point. The cell wall are thick, the lumen appearing is narrow
and dark line in the center of the fibers to appear jointed resembling bamboo.
4. Cultivated silk - smooth cylindrical lustrous thread, usually single but often
double, the twin filament held together by an envelope of gum. They are more or
less transparent, and without definite structure.
5. Wild silk - similar to cultivated silk but broader and less regular in outline.
Mark by very fine longitudinal striation with infrequent diagonal cross
markings.
6. Artificial silk - cylindrical, lustrous, appearing like a glass rod.
7.Wool - easily distinguished by the presence of flattened,
overlapping epidermal scales not found in silk or any of the vegetables fibers.
Chemical Test for Fibers
Egyptian Papyrus
one of the earliest substance used for
writing, derived from the name papyrus from which
the paper word derived
Composition of Paper
1. Preliminary Examination
deals with the appearance of the document
as observed the folds and creases, odor,
impression caused by transmitted
light and presence of
discoloration in daylight and under ultra violet light.
Water Marks - distinctive marks or designs placed in the paper
at a time of its manufacture by a roll usually a dandy roll.
Wire Marks- marks produced on paper by a flexible
wire soldered on the surface of the dandy roll that carries the
water marks.
2. Physical Test Causing No Perceptible Change
It is easy to determine the direction from which the shot was fired
1.On one side of the hole numerous small flakes of glass will be
found to have been blown away giving the hole appearance of
volcano creater.
2.If the shot was fired perpendicular to the window pane the flake
marks are evenly distributed around the hole
3.If the shot was fired at an angle from the right, the left side will
suffer more flaking than the right
4.Excessive flaking’s on the right side of the window pane
indicate the shot fired at an angle from the left.
BROKEN WINDOWS CAUSED BY STONE
The direction of the blow in case the window was smashed
by fist or stone is quite difficult but the principle of radial crack
and concentric crack or fracture will apply.
THE PRINCIPLE OF 3R’s RULE FOR RADIAL CRACK AND
RFC RULE FOR CONCENTRIC
3R’s Rule - states that the “stress lines on radial cracks will be at
the right angle to the rear side of the glass”.
RFC Rule - states that the “stress lines on concentric cracks
will be at the right angle to the front side of the glass”.
FOOT IMPRESSION AND TOOL IMPRESSION
Impression - is a strong mark produced by a pressure
that goes below the surface. This can refer to a stamp
form or figure resulting from a physical contact and it
caused damage to an object.
Types of soil
Grime (heavy dirt) - this is formed when dust is mixed with sweat
and grease with human body
COMPOSITION OF DUST
Whatever is the origin of dust and wherever it is found, it
always contain substances derived from substances of plant and
animal origin and substances of mineral origin.
CLASSIFICATION OF DUST
1.Dust deposited from the air
2.Road and footpath dust
3.Industrial dust
4.Occupational dust
1.Origin of fire
2.Motive
3.Identification of prime suspect
4.Identification of fire setter.
Origin of the Fire - the first step in recognizing arson is
the exclusion if all accidental and natural causes of fire.
CAUSES OF FIRE
Fire may belong to anyone of the following,
1. Natural causes without human intervention
q Lightning
q Explosion
q Spontaneous combustion
q Miscellaneous causes, examples: damage to
electric cables due to earthquake or storm,
breaking of gas, pipes, etc.
2. Accidental causes with or without human intervention
a.Faulty wiring
b.Careless handling of inflammables
c.Children playing with match
d.Careless smokers
e.Careless handling of electric stoves, candle cigarette butts,
mosquito coils
f.Arson or touch off fires (a set of fire) – when all natural and
accidental cause have been eliminated then the fire is
classified as suspicious and it is then the task of the
investigation
to determine if it is in fact a “touch off” fire.
TELL TALES SIGNS – signs that may be obvious
for the firemen to suspect arson. These are to
be observed to determine if it is really arson.
SOME TELL TALE SIGNS OF ARSON:
TOXICOLOGY:
KINDS OF DOSE
1. Safe dose – one that does not cause any harmful effect.
2. Toxic or Poisonous dose – one that is harmful to both the healthy and
sick
3. Lethal dose – one that kills
4. Minimum dose – is the smallest amount that will produce the
therapeutic effect without causing harm.
5. Maximum dose – is the largest amount that will cause no harm and at
the same time produces the desired therapeutic effect
ENTRANCE OF POISON
POISON MAY ENTER THE BODY THROUGH:
1. Mouth are absorbed into the circulation after passing
through the stomach and intestinal wall.
2. The noses and enter the blood from the upper
respiratory passages or lungs.
3. Eyes
4. Rectum, vagina, urethra, bladder and ureter by
injection.
5. Hypodermic injection
6. Intravenous injection
ELIMINATION OF POISONS
Poisons may be eliminated by:
1.Emesis
2.Respiration
3.Feces
4.Urine
5.Milk
6.Saliva
7.Sweat
8.Tears
DIAGNOSIS OF POISONING BEFORE DEATH –
Diagnosis of poisoning before death is very difficult
because of:
1. The large number of poison and the factors
modifying them
2. Some of the symptoms observed in cases of
poisoning are also seen in certain diseases.
DISTINGUISHING POISON FROM DISEASE
1. Symptoms of poisoning come suddenly in a person who
previously has been in good health, while diseases are usually
preceded by a number of hours, days, or even weeks of local or
general disposition.
2. In case of poisoning, the symptoms commonly make their
appearances after taking of food and medicines.
3. If several persons take the same food and drinks, they should
all show similar symptoms.
4. Diseases are generally much slower in their progress and are
preceded by circumstances such as exposure, recognized
symptoms and general or local indisposition of longer duration.
SYMPTOMS CAUSED BY POISONING AND DISEASE
1. Vomiting (frequently associated with purging and abdominal pain)
POSIONS: arsenic, antimony, corrosive acid and alkali, barium,
cantharides, digitalis, copper, iodine, mercury, phosphorous, phenols,
wood, alcohol
DISEASE: gastritis, gastro-enteritis, choler, acidosis, early stage of
pregnancy, brain tumor.
2. Convulsion
POISON: cyanide, strychnine
DISEASE: tetanus, epilepsy, uremia
3. Coma
POISON: opium, and most of its derivatives, chloral hydrate, paraldehyde,
CO2, chloroform, atropine, various alcohols and phenols
DISEASE: uremia, acidosis, cerebral thrombosis
4. Dilation of pupils
POISON: belladonna, cocaine, nicotine
DISEASE: certain nervous diseases cause optic atrophy
5. Contraction of pupils
POISON: opium and its derivatives, physostigmine and
its derivatives
DISEASE: certain diseases of the nervous system
6. General and partial paralysis
POISON: cyanides, CO and CO2, botulism
DISEASE: brain tumor, meningitis.
7. Slow respiration
POISON: opium and its derivatives, CO
DISEASE: uremia, compression of the brain as from
hemorrhage
8. Rapid respiration
POISON: atropine group, cocaine, C02
DISEASE: acute respiratory disease
9. Delirium
POISON: atropine group, cannabis, cocaine
DISEASE: epilepsy, insanity, meningitis
10. Cyanosis
POISON: nitrobenzene, aniline, acetanilide, opium
DISEASE: disease of cardiac and respiratory system
GENERALL TREATMENT OF POISONING
After the physician has recognized that he is dealing
with poisoning cases, his chief effort should be directed
towards treatment of the patient.
The plan of the procedure as it follows:
1.Removal of poison from the stomach
2.Administration of antidotes
3.Elimination of poison by excretion
4.Stimulation and other symptomatic treatment
5.Special treatment
REMOVAL OF POISON FROM THE STOMACH
If the poison is taken orally, the removal of the poison
is brought about by:
1. Inducing vomiting using emetics
EMETIC- substance or agent that produces vomiting
2. Use of stomach pump of stomach tube
If the poison is applied or instilled – wash
If the poison is injected – ligatures and bleeding
ANTIDOTES – are any agents which neutralize a poison or otherwise
counteract of oppose it or its effects.
ADMINISTRATION OF ANTIDOTES
KINDS OF ANTIDOTES
A. Mechanical antidote – an agent that removes the poison without
changing it or coats the surface of the organ so that absorption is
prevented.
Examples of mechanical antidote:
1. Stomach or tubes of pumps
2. Emetics
3. Cathartics
4.
Demulcents
5.
Precipitants
EMETIC – is a substance the produces vomiting.
CLASSES OF EMETICS
a. Local Emetics – produce their effects by their irritation of the
terminal nerve filaments of the pharynx, esophagus or stomach.
b. System or general emetics – produce their effects through the
medium of circulation.
CATHARTICS – agents which produce intestinal evacuation.
DEMULCENTS – substance which soothe and protect the part which
they are applied.
PERCIPTANTS – these are substances which prevent absorption of
poisons by precipitating them and rendering them soluble.
A. Chemical Antidotes – is a substance that makes the
poison harmless by chemically altering it.
B. Physiological Antidotes – sometimes called
antagonist. An agent that acts upon the system so as
to counteract the effect of the poison. It merely mask
the symptoms produced.
ELIMINATION OF POISON BY EXCRETION
Poison are eliminated through the excretory
organs. This is done by the intravenous infusion of
saline solution, diluted alkali solution or diluted
solution of glucose. The poison is generally
excreted through the urine, feces, vomitus or
saliva.
STIMULATION OF OTHER SYMPTOMATIC TREATMENTS
1. Fore excessive pain – morphine or analgesic
2. For convulsion – chloroform
3. For shock – oxygen inhalation
SPECIAL TREATMENT
a. If the poison is a gas – there is an immediate need for fresh air
and artificial respiration.
b. If the poison is external, like burn on the hand by concentrated
acid – wash with plenty of water or with alcohol, sodium
bicarbonate, lime water, or milk of magnesia.
c. If alkali burn – wash with lemon or other citrus fruits.
d. If the poison came from a bite or injection – the poison can
be checked from spreading through the body by
applying tourniquet or a restricting band tightly above the
wound. This retards the absorption of the poison by the
blood. The poison may then be removed by sucking.
INVESTIGATION OF FATAL CASES
In the investigation of fatal cases, it is not necessary that an investigator
should be an expert in poisons since he will be assisted in his investigation by
a medico legal officer and a toxicologist. Then again, it is important and will be
of great help to him if he knows the following:
1. Symptoms of various kinds of poisoning
2. The lethal dose of poisoning
3. The length of time that may elapse after the poison has been taken before
death occurs
4. Where the poison was obtained
5. The chemical formula of the poison
6. Other names it is known in the market
7. Use of poison
8. Antidote of the poison
EVIDENCE OF POISONING IN THE LIVING BODY
The evidence of poisoning will depend upon whether
the poisoning is acute or chronic. In acute poisoning,
the symptoms appear suddenly while the individual is in
good health. The person is usually affected with a
group of symptoms of definite characteristics out of
consonance with his precious state of health. In chronic
poisoning, the onset of symptoms is more gradual and
insidious due to the small quantity of poisons which has
been administered on such occasion since the intention
of the prisoned is to kills the victim slowly in order to
advert suspicion.
EVIDENCE OF POISONING IN THE DEAD
In all cases of poisoning whether homicidal or suicidal, fatal
or not, the presence of poison must be proven and proofs
of poisoning in the dead may be obtained from:
1. The post - mortem examination or autopsy – an examinations of
a dead body especially to determine the cause of death.
2. Evidence from chemical analysis of the organs taken from the
body – the most important proof of poisoning is the detection of
the poison within the body. In some cases, however, on account
of the decomposition of the tissue, the lapse of time between
death and examination, and the instability of some poisons,
negative results may be obtained even if the time of death
certain poisons are present.
SPECIMEN/ ORGANS TO BE SUBMITTED FOR CHEMICO-TOXICOLOGICAL ANA YSIS
SPECIMEN/ORGANS MINIMUM AMOUNT POISONS FOR WHICH BEST
SUITED
1. Stomach content all available in case of poisoning in which it is suspected that the
poison was taken by mouth within a few hours.
2. Stomach the whole stomach for all types of poisoning taken by mouth
3. Intestinal contents all available for cases in in which poison was taken by mouth
within one or two days.
4. Liver 300 grams metals, barbiturates, fluorides, oxalate, sulfonals and many other
poisons.
5. Kidney one kidney metals, especially Hg, sulfonamides Blood at least 10 cc all gas
poisons, sulfonamides, bromides alcoholism, drowning for chloride contents.
6. Brain 500 grams volatile poisons, barbiturates, alkaloids, alcoholism
7. Urine all available in nearly all types of poisoning
8. Bone 200 grams lead, arsenic, radium
9. Muscles 200 grams in most acute poisoning and internal organs are badly putrefied
10.Hairs 5 grams chronic arsenic poisoning
REASONS FOR NEGATIVE RESULTS OF THE TOXICOL GI AL
EXAMINATION
1. Some poisons may be rapidly altered in the body to a form
which is not detectable by the methods of analysis employed.
2. Some poisons with or without previous chemical change may
be rapidly excreted although its toxic effect remains, and may
only be detectable in the urine but not in the body tissues or
organs.
3. Sometimes symptoms of poisoning may appear, which may be
fatal fallowing the administration of even small and ordinarily
harmless quantity of a substance classed as a poison.
FORENSIC QUESTIONS FOR THE TOXICOLOGIST TO EXPLAIN/ANSWER:
In every case of poisoning, the expert is often confronted with forensic questions
which he should explain in order to help the investigator in assessing the evidence.
1. Was the death or illness of the subject cause by poison?
2. What poison produced the illness or death?
3. When and how was the poison administered?
4. Could the substance that was administered cause illness or death?
5. Was the poison found by the toxicologist in the body the poison which caused the
death?
6. Is the substance given in minute quantity a poison?
7. Was the poison taken in sufficient quantity to produce death?
8. May poisoning have occurred and the poison either be or become detectable?
9. May the poison extracted from the body have an origin other than that of
poisoning?
10.May the poisoning be stimulated?
PRESERVATION OF SPECIMENS FOR TOXICO OGICAL
EXAMINATION
1. Blood – place in a tube test with sodium oxalate or
anticoagulant.
2. Refrigerate with solid carbon dioxide (dry ice) good for 72 hours
3. Chemical preservative – 100 cc ethyl alcohol (95%) for each
100
grams of sample and extra 250 cc for analysis.
4. Do not use denatured alcohol, rubbing alcohol, or similar
preservative since denaturant will give false and misleading
results in the analysis.
5. Formalin – extremely undesirable as preservative of specimen
for toxicological examination since it will seriously interfere
with the test for most organic poisons.
LABORATORY METHODS USED IN TOXICOLIGICAL
ANALYSIS
1. Physical test
2. Crystalline test
3. Chemical test
4. Spectrophotometric test
5. Chromatographic test
LAWS REGARDING THE SALE AND STORAGE OF ONS
– The laws controlling the sale and storage of poison are
found under Section 755 to 757 of the Administrative Code.
1. Section 755 – provisions relative to dispensing of violent
poisons like arsenic, cyanide, atropine, cocaine, morphine,
strychnine
2. Section 756 – provisions relative to dispensing of less
violent poisons like aconite, belladonna, cantharides,
digitalis, ergot, carbolic acid, chloroform
3. Section 767 – receptacle for poisonous drugs
THREE STAGES IN CHLOROFORM POISONING
1. Stage of excitement
2. Stage of surgical anesthesia
3. Stage of paralysis
COMMON VOLATILE, NON-VOLATILE AND METALLIC POISONS:
1. Benzene – also called Benzol. A solvent for rubber, gums resins and fats.
2. Carbon disulfide – a solvent for sulfur. Burns with bluish flame giving carbon
dioxide and carbon disulfide.
3. Nitrobenzene – a pale yellow, oily liquid with sweet odor. Resembles oil of bitter
almond.
4. Acetone – used as solvent for cellulose acetate and nitrocellulose. Colorless liquid
of characteristic odor.
5. Ether – highly volatile and inflammable liquid. Transparent, colorless, mobile
liquid. Used as general anesthesia. Safer than chloroform
6. Caffeine – found in coffee
7. Salicylic acid – found in “ap-ap” solution.
8. Formalin – an embalming fluid
9. Cocaine – found in coca leaf
10. Picrotoxin – derived from fish berries (the fruit of pictroxin.) Locally known as
“lagtang”.
11. Ethyl alcohol or ethanol – alcohol found in wine. Also called grain
alcohol.
12. Ergot – develops in rye plants. A fungus that grows in kernels of rye
and other cereal grains.
13. Barbiturates – sleeping pills. A derivative of malonyl urea or barbituric
acid. Example: secobarbital, Phenobarbital, amobarbital
14. Strychnine – an alkaloid found in dried ripe fruits of nux vomica.
15. Nicotine – found in leaves of tobacco plants.
16. Morphine – found in poppy plants (papaver somniferum). An alkaloid
present in opium by about 9%; white crystals.
17. Physostigmine – also called serine. Found in calabar beans.
18. Chloral hydrate – used as “knock out” drops.
19. Carbolic acid or phenol – obtained from coal tar. A very violent poison.
20. Arsenic – a rat poison. Brittle, steel gray.
21. Lysol – a disinfectant. A brown liquid from cresol and soap emulsion.
22. Methyl alcohol or methanol – causes blindness. A solvent for varnish. An
anti-freeze in automobiles. Also called wood alcohol.
23. Chloroform – colorless liquid with sweet taste and suffocating odor. An
anesthesia.
24. Carbon tetrachloride – a dry cleaning agent. Found in “pyrene” fire
extinguisher.
25. Formic acid – acid found in ants and spiders.
26. Hydrogen cyanide – found in kamoteng kahoy. Also called hydrocyanic
acid of prussic acid.
27. Acetic acid – acid found in vinegar. In pure form, it is called glacial acetic
acid.
28. Aspirin – an analgesic. Its chemical name is acetosalicylic acid.
29. Atropine – obtained from the plant group “SOLANACEAE”
30. Phosphorous – glows in the dark.
ADDITIONAL NOTES IN TOXICOLOGY
3. LIVER- part of the body where the oxidation of alcohol takes place almost
entirely.
5. CO2 and H2O- 95% to 98% ethanol (C2H5OH) is oxidized in the body.
6. BOTULISM - poisoning from eating foods in which certain bacillus has developed
because of improper canning and preserving.
8. DROSS - the product that remains in the pipe after opium has been smoked.
9. TOXIC - poison produced by microorganism. Poison formed by certain plants and secreted
by certain animals.
10. MESCALINE - the principal alkaloid of the cactus which grows in northern region of
Mexico.
12. INHALANTS - substance such as glue, gasoline, paints, solvents and the l likes that
are sniffed to obtain intoxication.
13. URINE- the sample of choice for the detection of doping in athletes. The
concentration of a drug in urine maybe about 100 times that in the blood
and it is free from protein with a consequent
low background of interference. The disadvantage of urine is that some
drugs/poisons are excreted almost entirely by this route.
14. SODIUM FLOURIDE - A preservative for blood. It prevents the degradation of blood to
proceed further.
16. STOMACH CONTENTS- where drugs or poisons when taken orally can be
found in its highest concentration.
17. LIVER - the most useful and best sample for toxicological examination. 18. Saline
Solution – 0.09% NaCl dissolved in Water.
18. STOMACH CONTENTS, BLOOD, URINE, LIVER, BILE,
BRAIN, AND KIDNEYS - Visceral organs often used and best sample
for toxicological examination.
19. BRAIN - the specimen best suited for solvent and cyanide
poisoning.
3. NARCOTIC DRUGS - drug that dull the senses, induces sleep, and with
prolong use becomes addictive.
• Philippus Aurelus Paracelsus – determined that the Specific Chemicals were actually
responsible for the Toxicity of a Plant or Animal Poison.
• Mathieu Orfila – The first to describe a systematic correlation between the Chemical and
Biological properties of poisons of the time. He was considred as the Father of
Toxicology.
EFFECTS OF BLOOD ALCOHOL (ETHANOL) N
CONCENTRATIO
STAGE OF PRESENCE CLINICAL
INTOXICATIO OF MANIFESTATION
N ETHANOL IN
Stimulation BLOOD
0.01 – 0. 10 normal by ordinary
observation
Apparent Stimulation 0.05 – 0.20 decreased inhibition
emotional instability
in coordination
slowing of reaction to stimuli
Confusion 0.10 – 0.30 disturbance of sensation
decrease pain sense
staggering gait
slurred speech
Stupor 0.25 – 0.40 marked decreased to stimuli
approaching paralysis
Coma or Death 0.35 – 0.50 complete unconsciousness
subnormal temperature
anesthesia
impairment of circulation
stertorous breathing
END!!!
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