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MULTIPLE CHOICE
1. Participants in a clinical trial might report different symptoms when they know they are part of
the intervention group instead of the control group. To avoid that, researchers use the following:
a. Confounding
b. Randomization
c. Concealment of random allocation
d. Masking
e. Effect modifiers
ANS: D
Masking is used to prevent participants from knowing whether they are receiving an intervention
(most times a drug) or a control (placebo).
2. In a clinical trial, researchers might influence the selection of participants into a group
(intervention or control), hence introducing bias into the study. What can be done to prevent
from this threat to the validity of the study?
a. Confounding
b. Randomization
c. Concealment of random allocation
d. Masking
e. Effect modifiers
ANS: B
The main purpose of randomization is to prevent the potential bias on the part of the
investigators from assigning participants into the groups of the trial.
3. In a clinical trial, sometimes patients agree to receive an intervention but later decide to stop
taking the medication. Moreover, some patients who were assigned to placebo decide to stop
taking the placebo pill and buy the drug on their own (even when they do not know that they are
taking a placebo pill). When this happens, researchers typically do the analysis according to the
original assignment of the treatment regardless of the actual treatment received. What is the
name of this procedure to analyze the data?
a. Randomization
b. Intention-to-treat analysis
c. Concealment of random allocation
d. Analysis as treated
e. Mediation analysis
ANS: B
Regardless of the actual treatment that patients receive, researchers typically analyze the data
respecting the original assignment of patients to the study arms. For example, a patient is
assigned to receive treatment A (taking a pill daily), but he decides to stop taking such pill.
When the analysis is done, this patient will be categorized into the treatment A group. This
analysis is called intention-to-treat.
4. Two similar drugs (drug A and drug B) to alleviate back pain were released simultaneously.
An investigator decides to test which of the drugs works better. He decides to conduct a trial in
which randomly, half of the participants receive drug A for a month while the other half received
drug B. After 2 weeks without any medication, participants switch the drug they were receiving
(those who received A start taking B, and those who received B start taking A). What type of
study design was illustrated in this example?
a. Cross-sectional study
b. Factorial randomized clinical trial
c. Crossover randomized clinical trial
d. Crossover cohort study
e. Phase II clinical trial
ANS: C
In a crossover clinical trial, participants receive one drug and later switch to another one. The
effect of these drugs is compared within the same population.
Just before entering the town, we passed the Bir el Hamia, one of
the chief wells of the district, and the one from which most of the
drinking water of Qasr Dakhl is drawn. The water from the well,
effervescing strongly, rushed from beneath a stone platform that had
been built over its mouth into a large clear pool, in which a number of
the inhabitants were bathing as we passed, the water from this well
being hot, is considered to have medicinal properties. It is said to
have formerly been much hotter than at present; it is even stated that
eggs could be boiled in it.
The ’omda invited the whole party to lunch with him, and an
excellent lunch it proved to be. The sheykhs of this village claim to
be descended from the Qoreish tribe of Arabia, to which the prophet,
Mohammed, belonged, and state that they settled in the oasis about
A.D. 1500. They give themselves no small airs in consequence.
For a long time nothing happened. Then loud cries for help,
followed by the most piercing and blood-curdling shrieks were heard
coming from the temple, and they knew that the talisman must be
working, and guessed that the afrit was getting the worst of it.
Nothing more happened for some time. Then they heard a
crackling sound, followed by dense clouds of black smoke arising
from the temple. The crackling sound and the smoke continued for
some time, and then Rohlfs emerged from the temple, looking very
pleased and smiling, announced that he had found the treasure at
last, and invited them all to come and see it.
They all trooped in and found that he had discovered the opening
to the treasure chamber, which was a trap-door covering a flight of
steps that led down into a vault that was filled with gold and silver
and diamonds and treasure of all kinds, and Rohlfs was very
pleased.
Then they looked for the black man, but could not see him. At last,
in another part of the temple, one of them discovered the glowing
embers of an enormous fire, and in it were the charred skull and
some bones—the black man had been sacrificed by Rohlfs to
propitiate the afrit!
Several of the men present concurred in this story. None of them,
though they were living in Qasr Dakhl, had been present on the
occasion; but they had heard of it, and everybody in the oasis knew
about it.
They did not quite know what had happened to the treasure, but
Rohlfs had a very large caravan with him, and all the camels were
loaded when he left, so they supposed he took it all away with him.
All this was told with the utmost gravity, and with considerable
detail, and they all unquestionably believed the story themselves. Yet
it was all supposed to have happened close to their own village, and
many of them were not only living at the time, but must have been
young men and not children. They, none of them, thought any the
worse of Rohlfs for this sacrifice—in fact they seemed to think all the
better of him for having overcome the afrit.
CHAPTER V