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Dr Nyi Htwe Win IIP International School Biology

7.1 Chromosomes, Genes and DNA

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Dr Nyi Htwe Win IIP International School Biology

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Dr Nyi Htwe Win IIP International School Biology

•control of the genetic


information of the cell and
thus the heredity
characteristics of an organism

•control of the protein and


enzyme synthesis.

•control of cell division and cell


growth.

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Dr Nyi Htwe Win IIP International School Biology

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Dr Nyi Htwe Win IIP International School Biology

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Dr Nyi Htwe Win IIP International School Biology

Chromosomes
• The nucleus of every cell contains threads
called chromosomes.
• Chromosomes were discovered in the
nineteenth century. Walther Flemming
(1843–1905), a German physician and
biologist, is credited with the discovery of
chromosomes (Greek for colored body) in
1882.
• This was when scientists first had
sufficiently powerful microscopes, and were
first able to see very small things, such as
the structure of cells.

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Dr Nyi Htwe Win IIP International School Biology

Chromosomes
• When you looked at cells using a microscope, you almost certainly
did not see any chromosomes. This is because chromosomes only
become visible with a light microscope when a cell is dividing.
• Chromosomes also need to be coloured using special stains, in
order to be able to see them.

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Dr Nyi Htwe Win IIP International School Biology

Different chromosomes in a plant and animal cell


• This photograph shows a plant cell that is
just beginning to divide into two cells. The
cells have been stained with a special dye
that colours the chromosomes dark red.
You cannot really see any of the other
structures in the cell.
• This photograph shows a chromosome
from a fruit fly. Fruit flies have especially
thick chromosomes, called giant
chromosomes, which are much easier to
see than most chromosomes. You can see
that this chromosome is a long, striped
thread.

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Dr Nyi Htwe Win IIP International School Biology

Number of chromosomes in a human cell


• Different species of organism have different numbers of
chromosomes in the nuclei of their cells.
• Human cells have 46 chromosomes.
• Scientists number the chromosomes in a cell according to how long
the chromosomes are.
• In a human cell, the longest chromosome is chromosome 1, the next
longest is chromosome 2, and so on.

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Dr Nyi Htwe Win IIP International School Biology

All 23 pairs of chromosomes in males

Each chromosome looks like a


cross shape, because – just
before a cell divides – each
chromosome makes a copy of
itself.
The two copies stay joined
together part way along their
length.

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Dr Nyi Htwe Win IIP International School Biology

Questions
1. Explain why we cannot usually see the chromosomes in a cell, even
using a microscope.
• Chromosomes do not usually become visible until just before a cell
divides. Also, they need to be coloured with a stain before they are
visible.
2. Red blood cells do not contain a nucleus. Do you think they contain
any chromosomes? Explain your answer.
• Red blood cells do not contain any chromosomes. Chromosomes are
only found in a nucleus. (Red blood cells do have a nucleus when they
are first formed, but they lose it as they become fully functioning red
blood cells, full of haemoglobin.)
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Genes
• Each chromosome is made up of hundreds of different genes.
• The genes are arranged in a particular sequence along the
chromosome.
• Each gene helps to control a particular characteristic in the organism.
• On this diagram of a short chromosome, the stripes represent
different genes.

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Dr Nyi Htwe Win IIP International School Biology

Genetic variation
• Everyone has genes for eye colour in the
same place on their chromosome 15s.
• But there are different versions of these
genes, so one person could have a
chromosome 15 with eye colour genes
that give them blue eyes, and another
could have a chromosome 15 with eye
colour genes that give them brown eyes.
• That is why the two sisters in this
photograph have different eye colours.

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Dr Nyi Htwe Win IIP International School Biology

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Dr Nyi Htwe Win IIP International School Biology

DNA
• Chromosomes are made of a chemical substance called DNA.
• Each chromosome is one enormously long molecule of DNA. This
means that genes are also made of DNA.
• A DNA molecule has a shape like a twisted ladder. This shape is called
a double helix.
• One gene could be a length of DNA with about 2500 of these twists.
• We cannot see these twists when we use microscopes to look at
chromosomes, because DNA molecules are much too small to see.

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Dr Nyi Htwe Win IIP International School Biology

DNA
• DNA was first discovered in the 1950s.
• Since then, scientists have found out a great deal about how the DNA
in genes helps to determine the characteristics of humans and other
organisms.
• The DNA in a cell determines what the
cell does.
• It contains a complete set of
instructions to make a functioning cell,
and a whole organism.

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Dr Nyi Htwe Win IIP International School Biology

Importance of DNA
• When a plant or animal grows, or when it needs to repair damage to
its body, some of its cells divide to form two new cells.
• Before this happens, all the DNA in the original cell is copied.
• Each new cell then gets a complete copy of all the DNA in the
original cell.

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Dr Nyi Htwe Win IIP International School Biology

Discovery of DNA
• Many people believe that American
biologist James Watson and English
physicist Francis Crick discovered DNA in
the 1950s.
• In reality, this is not the case. Rather, DNA
was first identified and isolated in the late
1860s by Swiss chemist Friedrich
Miescher.
• The double helix structure of DNA was first
discovered by James Watson and Francis
Crick.
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Dr Nyi Htwe Win IIP International School Biology

Questions
3. Explain the difference between a chromosome and a gene.

• A chromosome is a long thread of DNA. Chromosomes are found in


the nucleus of every cell. Chromosomes are thread-like structures in
which DNA is tightly packaged within the nucleus.
• A gene is part of a chromosome that helps to control a particular
characteristic. Each chromosome contains many genes. Genes
contain information that is inherited from an organism’s parents.
• DNA is the substance that chromosomes and genes are made of. DNA
in a cell contains instructions for making a cell and a whole organism.

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Dr Nyi Htwe Win IIP International School Biology

Questions
4. All fruit flies have a gene for wing shape, in the same place on their
chromosome 2. But some fruit flies have normal wings, and some
have very tiny wings – so small that they cannot fly. What can explain
this?

• The fruit flies have different versions of the gene for wing shape. The
DNA in the different versions of the genes is slightly different.

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Dr Nyi Htwe Win IIP International School Biology

Exercise 7.1 Chromosomes, genes and DNA


4. The DNA in a cell contains instructions for making a cell and a whole
organism.
• If any of these instructions are missing or damaged then the cell or
the organism cannot be correctly formed.
• So when a cell divides it is essential that each of the new cells gets a
full set of all the DNA in the parent cell.

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Dr Nyi Htwe Win IIP International School Biology

Keywords
chromosomes: long thread-like structures, found in the nuclei of cells,
which are made of DNA and contain genes
genes: lengths of DNA on a chromosome, which contain a code that
determines the proteins that a cell makes; this in turn determines some
of the characteristics of the cell and of the organism
DNA: the chemical from which genes and chromosomes are made; its
structure constitutes a code that determines the proteins made in a cell

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