1.

Which of the following methods for lipoprotein electrophoresis depends on

charge and molecular size?
A) Paper
B) Polyacrylamide gel
C) Cellulose acetate
D) Agarose

2. Which of the following statements concerning chylomicrons is false?

A) This lipoprotein is produced in the intestinal mucosa
B) Primary function is to carry dietary (exogenous) lipids to the liver
C) The major lipid transported by this lipoprotein is cholesterol
D) Remains at the origin during lipoprotein electrophoresis

3. The lipoprotein that contains the greatest amount of protein is called:

A) Chylomicrons
B) VLDL
C) HDL
D) LDL

4. True or false? The ideal specimen for triglyceride analysis is serum.

A) True
B) False

5. True or false? Pre-beta (VLDL) lipoproteins migrate further toward the anode on
polyacrylamide gel than they do on cellulose acetate or agarose.
A) True
B) False

6. Several enzymatic triglycerides methods measure the production or consumption

of ____________.
A) Fatty acids
B) Glycerol
C) Diacetyl lutidine
D) NADH

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 7. The most likely cause for serum/plasma to appear "milky" is the presence of:
A) VLDL
B) LDL
C) HDL
D) Chylomicrons

8. In the colorimetric determination of cholesterol, using the enzyme cholesterol

oxidase, ____________ is the agent that oxidizes the colorless organic
compound, 4-aminoantipyrine, to a pink complex.
A) Cholest-4-ene-3-one
B) NAD
C) Hydrogen peroxide
D) Phenol

9. Which of the following lipoproteins is the major carrier of cholesterol to

peripheral tissues?
A) Chylomicrons
B) VLDL
C) LDL
D) HDL

10. True or false? Increased levels of apolipoprotein A-I are associated with
increased risk of coronary artery disease.
A) True
B) False

11. A patient is admitted to the hospital with intense chest pains. The patient's
primary care physician requests that the emergency room doctor order
several tests, including a lipid profile with cholesterol fractionation. The patient's
results are as follows:

Total Cholesterol = 400 mg/dL Triglycerides = 300 mg/dL

HDL Cholesterol = 100 mg/dL LP Electrophoresis - pending

The LDL cholesterol for this patient would be ____________ mg/dL.

A) 160
B) 200
C) 240
D) 300

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 12. A patient is admitted to the hospital with intense chest pains. The patient's
primary care physician requests that the emergency room doctor order
several tests, including a lipid profile with cholesterol fractionation. The patient's
results are as follows:

Total Cholesterol = 400 mg/dL Triglycerides = 300 mg/dL

HDL Cholesterol = 100 mg/dL LP Electrophoresis - pending

This patient's LDL cholesterol is:

A) Optimal
B) Desirable
C) Borderline
D) High

13. As part of a lipoprotein phenotyping, it is necessary to perform total cholesterol

and triglyceride determinations, as well as lipoprotein electrophoresis. The test
results obtained from such studies were:

× Triglyceride, 340 mg/dL (reference range, < 150 mg/dL)

× Total cholesterol, 180 mg/dL (reference range, < 200 mg/dL)
× Pre-beta-lipoprotein fraction increased
× Beta-lipoprotein fraction normal
× No chylomicrons present
× Serum appearance turbid
The best explanation for these results would be that the individual exhibits a
phenotype indicative of:
A) Type I hyperlipoproteinemia
B) Type II hyperlipoproteinemia
C) Type III hyperlipoproteinemia
D) Type IV hyperlipoproteinemia
E) Type V hyperlipoproteinemia

14. Which of the following apolipoproteins, when present in an increased

concentration, would be associated with a decreased risk of coronary artery
disease?
A) Apo AI
B) Apo B-48
C) Apo B-100
D) Apo CII
E) Apo EII

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 15. Which of the following results would be the most consistent with high risk for
coronary heart disease?
A) 20 mg/dL HDL cholesterol and 250 mg/dL total cholesterol
B) 35 mg/dL HDL cholesterol and 200 mg/dL total cholesterol
C) 50 mg/dL HDL cholesterol and 190 mg/dL total cholesterol
D) 55 mg/dL HDL cholesterol and 180 mg/dL total cholesterol
E) 60 mg/dL HDL cholesterol and 170 mg/dL total cholesterol

16. What is the presumed defect in most cases of familial type IIa
hyperlipoproteinemia?
A) Deficiency of hydroxymethylglutaryl (HMG)-CoA reductase
B) Deficiency of cholesterol esterase
C) Deficiency of lipoprotein lipase
D) Defective receptors for LDL
E) Defective esterifying enzymes LCAT and ACAT

17. Hyperchylomicronemia (type I) in childhood has been associated with which of

the following?
A) Deficiencies of apolipoprotein CII and lipoprotein lipase
B) Deficiencies of lipoprotein lipase and apolipoprotein AI
C) Deficiencies of apolipoprotein CII, lipoprotein lipase, and apolipoprotein AI
D) Deficiencies of apolipoprotein CII, LCAT, and apolipoprotein A1
E) Deficiency of LCAT only

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Answer Key

1. B
2. C
3. C
4. B
5. B
6. D
7. D
8. C
9. C
10. B
11. C
12. D
13. D
14. A
15. A
16. D
17. A

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