142

fect f odrnalne on Bloo prr u

Laline
Sadne
Sobne ep2

AcrenaliN ach o -x,, P, G, and reptuc

blad leluele-Cau Valolontnton

exundibnal x- preent in

Achbn oAdreaalin
tontenhahin odtnalbre acb n all rephor.
At ipLs
he Conten hrhbn of
adrnalin gh
adrnaline inhavenously inihaly
en Ae
Soi ll oct oh
adhons d F(Masodiahn)
Rut octn of lvasbtonthnthtr) predorninale
e hl i 8ledd pe ure
So -Hher

illprdominale
ak t
ncennt) bnly ackon of ,
o only fall inoo prelur i Seen
uu and odvenc e Yleh of adenolir
Therapeuh
hok
cheite n anaplylaehl
Dug of durahn d- anasttesia and o decrease ha
lal anast elklg ho pviong
Alona Loth
áblosphit
ylona adver
cfkeh by decrtmihy
Aduse elkeh
algrahbn
Aimiey
 EPeco pinepine, nlorepirephrire and ILoprcnalire on 8p
143
60

120

aline isp calme

Sore no&
Saline p

ruluy biphasl ycipn Bp on

E pinephrne
is b t n o f achur
N A ach
n da hut dvesnbt lauuLA \laoduahtn
u it an

lasoconshhaHtn, herte rreu 8p

t produtes
acho
nod achon
SoptnaUre od
on
P, P2,Pz but
cauk
al in Gp
tprouces volodilnhurn, hente
Noradenain uSeg -ULig
rale o
infusitn at ale
infusin 22-uLu
b tahate sla
bta1hale flao iv
iv
lorodrenaline
aiechon

NoradCnaline ADRS
dfulh
palpitahm reApirahy
Anxiehy,
headathe
nîe of 8p,
A auk
Nec hoki, unngkne
Valahbn
x ha
ulemua

ch gravid pnin, pm llor a nol

Contra
hut0erlantn Vblent haodache. phoopobid , anginal
Evere
Jcocakng m yertyoia

Auet.
sopenoi
angl fbr
tmeat of ehok, ghskec adn
am
8mthudilator

UMd as doun )
(not uke ouo
Snelom
a man kdoventnuular ralè HIl
pacemaker
oCCabrally u d fo i impbnlid
 Dale AtanomoloY eenal phenomend)
144

otamin
T Adrenale

Adtrole n glen allei adminishehin ot an d blot

Lohen Acrenae ker lit egonme
oa metode
ot d blotker I an
adminishrehtr

1 eutiled (dueo
blre
LOhen of
odrtnalirt

n ochbn
Scen, a^ only
ony tall 8p is
maphor) Reerial as it wa, fint blenved h
T h phenamenon Colld Dale' Vaiomolor

Dale

of
ok emh
ih e ah
uM of rgotamir attack
mwgraire
dk ugraine
ok be oux
be
aculi
a cui
ukd ho hco
htot
was
gotaumin Phects
cide e utnne
ok ulanne
abtorphn, frquent ancd
and lo ha t nn
hatl procst
hemohoge
potparhum
hatment of
4UXd
w d in
in

Conshichon
eatene etkch due lo Corbnany
lEhcirn, tmgial pain
pochu ral ky po Numbnese, gangre,
paracthutiK igling
lana,Vomihirg,

a c t m i n R h a h n
produu
pholong d
 on 8p
Effec on proponalol
145

60

Epi NA iso
Na iso

nea 8locker
Alphablotker

p-bloken)
Cand other Nay klecHve
propanolol
Adrenale
enhance c nle in 8p ausd b ioprenaline,
talodilahn ad l lin 8h
etoked hy
BlocL
revertel hat a
Lesn allad-btottode
otasNolo
Therr ic rerevenral

Dnditatns o -blotkes
NLon Cardat
Cardia
Anteny
erlensi Miqraire
fngina pechri
AoCardial i n f e r h i n
thyrotokito

Cardic ahythymias

Advene eFkeh

8onckolpas
VauoCposhl Angina
Worening o
iplodee m diabeh paionte
Hypocilceln
Alfered Uid profile,
CanraSndiahbry
4Binchia athma

Paxhal Complelë hat bltk.

 SPFect ot poPamine on BP
146
t8o

D, rephorn h renal, mhknt

IMall doet (2-Syllglmin). tt shimulal
Vaiodibhdn ((t) in (AMp level)
Cononony velielt lodn_ ho
ncrtaxs renal Hbol flos , GFR and Caulec natriuresik
Mart pmduca
+In moderalë doxL Cy-louglemn), t thNlal rrepön in
oih Ve notwpil and Chtonotrpd ochond
Relca hor odrenaUne rom nernet by Pi timulatHn
DDeno Chang2 TPRand HR
shotk act CCE
r t a t clinilal bene it in CUC
i n hia do tet Clo-2oMgllglmin), th'muulalës Vatulor odrthegil o rtephve
VouDConthizhbn CaNA releau) Ond decrakd rrnal blood lo

Dopamirt u
Cordsmena thock

Sephic sot
h l heart faiure

ADRS
Axr thmias
Anxichy
Headache
Ahortnes oF brath.
 Ath ond hRtanine on 8p
147

ud

12D

Lo
30

ahs
20

endothela tellg
endothelia ellg
\atular
receptovs prexnE on oxide
H EDRF hith i nitn
though inho
dikhus inko
VauodilaHbn i Ach dith
Ach
Lsue dikan,
isue dikam,
Cndothelium i damaged by Via rephts
M rephs
Via M
'Lohen tatotonshthd

Smooth Musc
le and auws
Nascelar
ontheir lama membrane ponent )
indirect
indirec
preenlid is Hh Cooponent)
Paryl H
arRyC
Vasodilahtn
i Cauxd by Hhamine endothelial Cells
oCaled on
EDRE N raploí beng nunck
Medialed thrDugh lolalzd on \latcular Smooth
that ar
ach on HReCeplor
Hitamine acHpn.
acfDn,
dirct

Cuu Vasodilatbn by
ekch
and side Mena euer' dneale
s dneaie
4tamine Uses in Menaeuer's
hcatment ook Vithgo
htahment
Vith9o
il ued in
+p-hisHne
 on 8
SPRc o atelytcholie ond akopre
148
801

loO
ath

60 atMaoo
achs
uo
20

+Ah Cau all in 8p at loto dosec. tohith is blotlad by atmineloutaind a

animal phoducec raise in 8p due o imulahan et
Highdore ACh in awpinised relcam of alzcholomine e
ADRENAL MEDULLA t h
Snpathehil gangia ad

u o Atropine
4Speia anhdole in OP poraonig
to deceale hronchal keeton
u k in prronathehl mediahn
recluu pnin by relaxing ilay ard alto ody
u d in rit, indtyctihs as it
ad heubnt bh int and lênc.
al teinatly along ith nidhh hv brak

Adven elleeh al rope

DNJ MOth dny etin decreavd twecating, blumig of uliDn, diluled Pupi. phaelaphda,

Cyelopgia