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UNIT-T
* CHE07HERAY
a
nthabaculag agen
ubeeulosiis is
rm
Chrbvonicgranulomaty s eas and ror
halhi oblen indevelopingiCount 78
ndia hanon Dhe
lls motadultin
ejechous distast In2ol2 hiavt
ha
ndla \hos dedareo TR tbee a_bolale
Jatstiunvey h Znda 3
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a
ist bnt dogs Setoodine ongs
rm
sonia ziq
FRidanopip
Pyra inamide 1 luoroguinofonu ofhes oxa Lnjedable
EAhambu oloxadno o
Levefoxacin_Eonamide Ekanamycso
ha
Shepbomydo
Moxloxacn_ loserin Aikacin
GhofhxacinTvizidooe Capxtanyn
EParaamino-
lP
Saliyi
hentne
el
M0.t
Soniazid i= anvhbeular
anexcellept
is anhuber cus
ew
primarily
pidly lld but9uieceat a oly
Vabibikd O
chanism ation
C
lhe pirnary
ntheus myceecacidk
TNH Jnnbikon Companen
oich oxtunigut atty atid
mycobacesja cell ll 7he bid Cortnt
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aluced Z
cobotua
ene
expased
wkich contis
Sensibive
Catalasc
tbackio
buoidase enym nte q
a
metakoCe The Halbive VzNHmaboik
The
rm
addutwh NADP ay wellohich rlwbibs
mytobackia DH fRase ulhr nntomphin
hDNA synthesis
ha
Phaorecoelig Conplt absbd al pnd
all bocy JissuTi
issug blacnia neninqs Exkingie
medaboedn iv Extdn rne
lP
nieattons Alorniniu) ydrowde aki6: INH
absphon
el
Adyesse edisturbanceshumbnes
well folesatdby ma badiente.
Menta et dishrbm
ew
a
Jofeups RNA Syn/heais by bincing to
myebacksial DMAdeheodedt RNA
rm
subvr'
podnease ondbocking sormei'g unttien
oapiun bactaiida.
honaceeoties lell_abscdsed_exall widelu
ha
Coyihll
obstiburlesl in he bro pentktg
lacenta and mtaioge Medaboized iniea
lxcretolmainy la bile ne in Uin ao
lP
Ihe 25 ks
Avessej Hepdiis r advuse
a
hvega direase
e
n
el
ni- leproticDagr
ar
clormage
ausingskio esio andbdm/e
hase
aialy ffeuksheSkin
bhezaD- nes
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Claaifatond Atlepeli d
a
Sulone Phenazin Ant T ah ant:boh
rm
FDapaont desivative duss
Ryncopain
eocin
Moiloxacin
laciine FEHionamide Mineocint
ha
Fclaithycin
Dapcont dbhenylsuon
Tidiacnind
lP
mos aclve
Thesioplest oldestcheahtstbih
and mog
ommnly eg merober ih
Class
el
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a
diskibutcd jn the bocly pentlatien i csSA
pops bound to plasaaprotein
rm
Metabe-tteg aeexoteo in bile andtabobed
nlubine evretion otus nordy in uine
Plasrna isvaiable 24 tas. Elirnatin
Z
takes -2 weels o lrnge-
Aduesse
0omg/day lac ha I
less
is welltolesaded a da
ildhernrydic antria
lP
is ConMo20 s
jototuance-nauyeaand
dase elatel toxiihy
anovexiah&dachte,
4astic
eve
el
and
deeloprmeot istance
Leprosyis chrmic.
q,ahulornabu Uinechian caucabM Lepra
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pirnasil oecodia
sEin mernbrang 4
rukou Nbional Leprg
Jodiahe
launche n195s
a
Cenbst ogramroC
Changed o Nationa epro
rm
adicat'm Proammein1492
lep
he ohsatenal siopich lHodivided.
2Pauutbacilay resyP&
bail:ahi
tubeuloid
ha
andborelin
L) Patieak
infechious Tinuole
ubesculod
has
lP
MulbibacilayJepa (MAL )
baillasy-
baillassy load and i
htenthasli
lnfecinus
el
ncude, laprematougborcdeslinesebts.culoi
borduline p
y =
ew
MDTMulidng
Mulhbaily abacilas
Raoin 6o0rag once a
ar
onhSupeuired tnahthsupesvistd-
Dase aoiaistod
omgolai sel
C
admiaid
Closozimine 3og onceanonh-
subedistd t50 q daila
R adwnisu
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a
Chilo das
-
rm
kiampin ohc mmtbly
Closazininc lose
ha
onte nothly
Dapsone dg olaiy
lP
Atfugal
el
mostly assoiaed
Shechdo anbiotieg Cobicostereiok nCcones
d
at tepica onuguggl hayebecn
ar
antseptieCsa Twa
lwo
ovailable Since the
imprtant antbiodia Onphoteivin -dea!
wihgctecni mycosis aadgaiseulin o
to
C
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Clacakon Anigaldrga
a
Ally adre
rm
Antbiotic ornelabe-ltsAzols.
Tes bingint
oidazoles Triazols
ha
Polyencs Hettroecle Efluconqzel
1Benzofuran Thatonazole
Anphoti Voi Conazole
8.Fieg esoin
FNyslabin Flosa tonazote
lP
EcinoCanclig Topical Sysleric
-clotómode Ekeatonazoe
Cashourgin
LEconazole
el
MiConazde
FAntdutaungn0xiconazole
ew
Tobreaagnts
Tdraate
ar
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a
rm
Anphoteidn B I is ohfaincd
Sttbtomyces hodogus
ha
ainh o ugestralpesst inngal_cel
mebra ne h onbine h iGetjnkesded int
themntmbroneond irevsap_ boyene modeculeso
lP
'(vopore 7he wroport Stabibizec
ushich L up he Apaces b)o
b/o
membrone Slards
heAM3motcules n the Lipophib'eide bemcabsioh
Consthtng ou Sudarei hepove el
el
-Bgbuce
Synthast
C
AraphotesicHudzople
opehobre
side
noltadg
side
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hamnatodenetic
AM3ishot
bot-absorhed oall,
but Lon
a
widely
htbs bul il
m
inhboy peneration nCsA\P,
rm
9 binds slesels inissuesond to poprolg
n plasma L is 15 dags Abo
60
dng mdabolized wn lives ExLakmot
slo bolhin uxnn.c4 bile bul upna
ha
Conaaion aivedr
Adveselect Coist ckills
aths
lP
ond Voiha
U
Nephxotxick ishe potantwhtn
AnemiaCN S foxiit.
el
Andicdg
ew
Vises ax
heutmalexptgsion
obliaate
inracclLular. pasasilsm The n0 Only take
nutmio roohe ththosceu bul ako eirto o
ar
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a
hepatihs ving
rm
Ardi herbs ot-influenza Ati-
vis dngs
TdoKuicoc Amantadine
Tunoline
ha
Rimapladin
Audlei seltocmivic
Valacydoyvi Zanamivi
famiuyclavi Peramic
lP
Ganciclavi
osCAek
torHehactiks torHepabihsC
ELamivdine Ribavin
el
Entetavi ntefecn
Tenovi EDaclatasi
ew
Tbivuoine HLhdpasvic
hegeAxe he deugs
ar
Bas Vinu.
Tdoxuidine iocdo- deoxyuidineith
I isS-
c as a thymicine analogue Is Hhe
s
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Pymicbinontmetabolteto be dd a atvia
dng L Lomplela ith thypraione
a
intvira! DNAs thadaulh Dw
Tdoxuricbng
rm
beaksdon eAsily
is cdive nly4ais DN insesand
clinia
hoses
O utita, 0iilee
milel ohopia trinmt
kuaihis
-&icoplex
ha
analoguue
ii AHulovi- -lhik deyguanosine
uirs a vins sbeci enoe o onvso
that
Spcefi tazrat metabotin
Theactve
lP
inkisiEDnASynthtais and isalepkahon
Aylavi
cdioednage
herpsing speaiHei
el
Mono-phosFhalz
Ayel
ew
Callula kinase
salibit hapes |
FoyrnuE
tebhosphofe vis DNA
Aclavix el
ar
Cornbet
D
CTetr morpovatdin ti
C
DA ARbi DMA-poly me
Jrevessbly
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Pcokinciis-On
ayclovir
obout o
bsorhco
an ora dos e
lasma
potun brnd cand widely distibute a Haining
50
is50
a
Caetethaton SE Conc. ha lask
Plasm
Conc OE
exfd undhanged in unne
rm
2-3 hou
is
Acluese eltet- Topica sknging t uing
n te eachabhiaiom
Oral
nauxea
ed ha iswll tola.ated
ore CNS tc
headlache
lP
Tnkavtnous Kh Sueairg mesisandl
oCC
nB
el
been_daibed to
Hallucinatons feno d,_hae
ih oloses
ew
t and
keyalhs ed Jh rupefiia)
3 diapler Comea_uu end _bette
slendtichonal nfechord becausee
C
dep
2o g00d
Conu!_penchaben
ckenpor
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a
hal
B ts mono tiphosphate olcrivalvig
rm
inacellulasly by hosk kinass i
GTP Snthais and via RA Synhesis.
RNA
islance le_ibayiio A ra
Oval bio avallabibih,
ha
ibavmn is v 50 meJabolized
9 Pasll Cl"
eininade ainly. Jeidneys Th iso c
lP
Antirekovi dnigs
FNeviapine Tndinavir
ormiuoine
Stavuc ne Eavisen2 Nuinavi
Abacav Delovrdne
Cobinavir
ar
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hcs
hesae dugs ative oginst urnan )omuno
a
avalable dor use in 187.
rm
Zidovdne -
obe phasphopylabion
n he hogf
ha
vial vesse ranspaseun ernce t culalac
DNA rtymuase
lP
Single kronded vhal knA
vins dicehd xtvease tanstiftase
inibik by zidonobine tiphosfhate
el
drug
oss roSse placenta ound oundJn milk
Advease
C
Advess
elaled
lut:
advesne
Anoemia.Nauopenianp. doce
deck Alasea, anorexia
headarhe obd onna paun Jndornrua.
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Andhelninths
deg Antheoohies e
a
cding helminthM
reva lent globa
rm
Jelmintlhiasis i
but is_moy Cornmonin devtlopingCounti
wib ox casona andCnvirdnrnenlal hysicre
abode
In the wman body iE isako Lve
ha
m
Many htlminths But _som N
in tissues or uthcu lava mi9zate ato H
lP
Clasifiationg
Mebtndaza
-Pipesazine Abrdrzse
Levamisele
ar
to threaduwom) tosflouaiis
Diemylcarba mazie
yumcctin
C
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a
Ve
onthelmintiacbvih but nof the
rm
Jts pmdecessa Mebendazate ha
produc ound curtat
wo
reducbim
hookLDOmM.
in
2
Caetdheuss tapeuwemg
15 has beun buted in
ha
but H. nang iselatively insendtive txbel
Tidinellaspixabis
Lasuo that have
intstioespbu
migraled
abo
lP
muscles is unatainR
he ejox sit ed_atic)
mebendazole appeass to behemitntubulag
atio B-Atbulin h batasit
el
Mebendaze
ew
lepltes grgensa
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inibids
ucegen
mhoch on cdra
enzns4dlekes
Hatebing henctode
Sts tors
a
and theis lavae ae asoinibiled
rm
Pokinetiu Absebtion nisintsine onai.
75-90/: gn raolose basse in he
aeesThe aebon isexek2o
cbsobed sexCrekomain
os inacdivemetabrtitg i acce
Advese Jes E
ha
willtolsatd
huseaandaldonina.haio Expulsioa
Diachou
Asw
lP
mouthmoitb o nose bobably
have i ocuued
olue e Stayationhe pasasit
Slosdealh
el
endazele iSubsegusot V
Jnhoduced
ohgene- mebenda2oe
Rains he broad
speskiaacti 0ntdosearaeat bu
ew
hetessagf
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aken
takenlth atincalbrain J Gnd idedy ishrbubed
Johe booly nles xedin uinc
a
T is 5 hou Thus alhen dazede ablc fo
exut ontiheimintic aelvip n Aisrues ag well.
rm
Side fecks Well oleu.aled Ony 9 it. side
tects hae been noleo gat aut
Patícns ave
izineS heaolache-
nuuophtnia
Suiient
pr 4 Sstaloldesyorng tuite daily
el
lapew0ms
3 Con&ecutiveday
(3) iconosis 4 ubencoud aiat igan
ew
hese 4 elapse
_aatnenba evenbon
malaiq
Malayna Cus by- speer
C
arasitt Plasnod
Plasmodiem
Zhe tozoa A
endunic d mout ats ndia and
otht piLa Counms 9 Continuex tobe
rmainlyeueto
a ros ubli hthpeblen.its Covn
plicakr.
P dacu ubon Cuno
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uicle
sclizopto
Tissve
Mosqi
a
Precythic
rm
xoeyo
. hi
Mozork
ha
Relapse
lP
iizatucids
sizo omchodde
el
s
ew
Clasiication Andmalaaia
-aminogcint-binest
ar
Cinthona Diomoicint
alkalolok
Lchlorogurn irmethanin
Ouinine FSulfacdoie
Aoecingulnt
C
FOuini b Juameh
P:haguio Pane
(uindne -Ornguipoind
tmethanot biauende Dap
EMlogune _Fouan megin
Taemoyuine
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a
Artemelh
Cndamy cin EAhethes
rm
Frtuelsn
Antirnalavia osug.
Arnino alohots
Halofanint
ha Naphoguin Naphyicboe
lP
FAte Fonattoting
untgantene
Methanis Aciogyi-
s arabia
el
acling esythroy
Schizentoide against_all pecie
liical a ttocks_inpuibhtiaJ
2day tith
ew
Centrols mast
pakasits blod in
disapptasancc
-3 day
ar
rlasiabasasik)
C
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a
Larjaomount toxi Cto_he
hem ih
paasik. To Otdna
na.
rm
prold hl hepaasi
rroizes the hotoxi emozoin,
Seguestoroin he_pasasttes ood Vau
Chlovaguine nt he polymci zaton hemste
he aceumulation herne ls in lyis
bath the pasasit
Advse
uncontrolla ble
= Alasa voruhng
khing hiqatta c
anoreei
pain 1htada!
Can be used knent Malardaa
ar
clusin9 ho abojacdant
tetaogenie e hou been kot
C
ky- ea intestnaV
amotbiosi
Kheuoatoid rthii
Lepm eacbon
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Sulfonanides
Sulfonaoide ime hamint
dapione qr hoE bar-Laulasly e
a
have
antimadarial dngs in hi wnihiL
SomeJnkibitory Jnfluen on he rythxoykc
rm
phase espcial PJaleiharun
Conbinat'on
Supsa -a
ddibve
iskeStyutntia
p4dmethâvnc clu blockThough
Th (mpoment are slou the Cormbinaten
ac as
ha aa
So it_l0nbe mplae
linia Cusabe
lP
I5oom pyrimetha-
As tiniaD uative -Suljadonioc
dore
=Mine rBtob)Sirg
inportanie o ulfa-pimethamioe oro
el
Ihemajoc
binaico is olue to Jica gainst, (a
-sistonce Jakihonu Slladonine ond
ew
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pacs
utosaa
muossa ag Commcnrak
ove
orm cyss ha Pas. mt
rt
Thetols ond to pgaleheuciceicnce
mobiculku
a
mnds Th mucasa
0
rm
lassifiation ogniamotbic olugs
ha
HssuC omcebicGde uminal amoebicide
IrnidazoleAfkatord 8-aroaive
ew
eonidazole_Fbnein C9uiniodochlog
Tnidazde Dehyoactin w Droelomodon
Oshida2ele
ar
ehonidazole
dazeke nteclueeo
s
i he protorybehito-
ini H59 o ichomamiais
C
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CainoetebicondoiDatoplilic ri vooyonism
a
Metkanism
aion
rm
Mehonidazee
fwedorin
Mchonidazale Batternum
>tduced)D
ha
ferdoxin DNA
DRdizzd
DNAngrnenkeol
lP
Pharrnacokintius i amostCorndy
ahrobed samfhe srnalU ntstnt
el
ives by byOxiclatioo
ivs and9lueusaniole Lonfgabon
olloed
ollDed na exoion Plasmq 2_
8 hous dyoess
ar
ihhking
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