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UNIT-T
* CHE07HERAY

a
nthabaculag agen
ubeeulosiis is

rm
Chrbvonicgranulomaty s eas and ror
halhi oblen indevelopingiCount 78
ndia hanon Dhe
lls motadultin
ejechous distast In2ol2 hiavt
ha
ndla \hos dedareo TR tbee a_bolale
Jatstiunvey h Znda 3

Lasg ang -17


lP
eatd batient hau MDR- 18
Rornasablepa
has benmad oveiahelast10auioch
introduch'on Zn /970 Cicay hort tcawe
el

irmonhx la domiciliae im as bcen


cu atment 9uideli
clermonkatd andcleas
ew

ave been orroulata.


udo noe on9s bedaguik
and delamanid hae bero enty obreed
ar

Accdb the lorayut:b he ani-TR ds


nto i
Canb ides
n
C

T5 dssha igh ahthbescla


ag ow
aLwell oniuh
econod Une Thge otnuga a esthes louw
igh
an'-T8iay tomiuty
bo both

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Classifiabon o7 ori-T8 okrs .

a
ist bnt dogs Setoodine ongs

rm
sonia ziq
FRidanopip
Pyra inamide 1 luoroguinofonu ofhes oxa Lnjedable
EAhambu oloxadno o
Levefoxacin_Eonamide Ekanamycso

ha
Shepbomydo
Moxloxacn_ loserin Aikacin
GhofhxacinTvizidooe Capxtanyn
EParaamino-
lP
Saliyi

hentne
el

M0.t
Soniazid i= anvhbeular
anexcellept
is anhuber cus
ew

drg anoan egental Corobonet g all


din4 hof able o
airoens unles fthe badient
olg ale or bacli istont
hby culocida! au ouli'pingogankms
ar

primarily
pidly lld but9uieceat a oly
Vabibikd O
chanism ation
C

lhe pirnary
ntheus myceecacidk
TNH Jnnbikon Companen
oich oxtunigut atty atid
mycobacesja cell ll 7he bid Cortnt

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aluced Z
cobotua
ene
expased
wkich contis
Sensibive
Catalasc
tbackio
buoidase enym nte q

a
metakoCe The Halbive VzNHmaboik
The

rm
addutwh NADP ay wellohich rlwbibs
mytobackia DH fRase ulhr nntomphin
hDNA synthesis

ha
Phaorecoelig Conplt absbd al pnd
all bocy JissuTi
issug blacnia neninqs Exkingie
medaboedn iv Extdn rne
lP
nieattons Alorniniu) ydrowde aki6: INH
absphon
el

Adyesse edisturbanceshumbnes
well folesatdby ma badiente.
Menta et dishrbm
ew

ae the most mporkánt de debendeat tonic


Aeek Hebehis a noK aderscletfect
ZNH are inChilden bu mor Cmm
em
ar

in dol people in alcohois


C

Sernisynmebie deivative qam bicn


epore mcoNksanei
AgaistTR bacill
othesflicacos
LNHand bettes than all
a
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M0.A /owpicn inlibito DNA dependeal RnA


nthesis Mytoba and othe jonisras
elo
dtveloh sitance foifonpio athe

a
Jofeups RNA Syn/heais by bincing to
myebacksial DMAdeheodedt RNA

rm
subvr'
podnease ondbocking sormei'g unttien
oapiun bactaiida.
honaceeoties lell_abscdsed_exall widelu

ha
Coyihll
obstiburlesl in he bro pentktg
lacenta and mtaioge Medaboized iniea
lxcretolmainy la bile ne in Uin ao
lP
Ihe 25 ks
Avessej Hepdiis r advuse
a
hvega direase
e
n
el

padients ih_ twkig


oltu n n

Ghack and 3na


bahlessr heemysis
vomibing
Naussa abdaninal rarnpr
ew

ni- leproticDagr
ar

Lep tol b4 Mylobacfegivm pracA


as Jndechio sisease aink4
Chrenid Cuable
C

clormage
ausingskio esio andbdm/e
hase
aialy ffeuksheSkin
bhezaD- nes

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Claaifatond Atlepeli d

a
Sulone Phenazin Ant T ah ant:boh

rm
FDapaont desivative duss
Ryncopain
eocin
Moiloxacin
laciine FEHionamide Mineocint

ha
Fclaithycin

Dapcont dbhenylsuon
Tidiacnind
lP
mos aclve
Thesioplest oldestcheahtstbih
and mog
ommnly eg merober ih
Class
el

Mechoniso ioq Ischernica lyelaTtd


ocien
to sulfnaraids 4Same0chanim
ew

nkibikeo PARAincoporaton intogolic


acid by olade
nthase hel ardhacdeia
achin dopsoack antagenissoby PAaA
aprssarteatvy aco Concenkraien
Tis
ar

wkile oth many othe


hacteranshe
osulgenawds aret at aishe
Contenrabon-
C

DapsneS ati ainch (uain.


botozaa as e Combint.o
th dmhartine
Palcihaur 4 Tonoplaa gndii
Sodck on
t-ilinayspuk has_been
detecko

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haatokinebi Daornt is (ornpldelyabsobed


Qes oraladmiiskration bnd wicdely

a
diskibutcd jn the bocly pentlatien i csSA
pops bound to plasaaprotein

rm
Metabe-tteg aeexoteo in bile andtabobed
nlubine evretion otus nordy in uine
Plasrna isvaiable 24 tas. Elirnatin
Z
takes -2 weels o lrnge-
Aduesse
0omg/day lac ha I
less
is welltolesaded a da
ildhernrydic antria
lP
is ConMo20 s
jototuance-nauyeaand
dase elatel toxiihy
anovexiah&dachte,
4astic
eve
el

i Tootant hbesculoddal ang


ew

aso the Jmporant- nstbottnt_cil


a
o
kileel in3-l
M
lepra upo 9929 MLprae
olaysbyb0o L/day dlore
lortouekeit A hot sadifackos
ar

alone Rifonpinhas beeninuded Jo he


Deprosy whe-
snca
horoshe
_pomat
olsaten
C

and
deeloprmeot istance

Leprosyis chrmic.
q,ahulornabu Uinechian caucabM Lepra

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pirnasil oecodia
sEin mernbrang 4
rukou Nbional Leprg
Jodiahe
launche n195s

a
Cenbst ogramroC
Changed o Nationa epro

rm
adicat'm Proammein1492
lep
he ohsatenal siopich lHodivided.
2Pauutbacilay resyP&
bail:ahi
tubeuloid
ha
andborelin
L) Patieak
infechious Tinuole
ubesculod
has
lP
MulbibacilayJepa (MAL )
baillasy-
baillassy load and i
htenthasli
lnfecinus
el

ncude, laprematougborcdeslinesebts.culoi
borduline p
y =
ew

MDTMulidng
Mulhbaily abacilas
Raoin 6o0rag once a
ar

onhSupeuired tnahthsupesvistd-

Dase aoiaistod
omgolai sel
C

admiaid
Closozimine 3og onceanonh-
subedistd t50 q daila
R adwnisu

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Duration months 6 )'hs.

a
Chilo das

-
rm
kiampin ohc mmtbly

Closazininc lose

ha
onte nothly
Dapsone dg olaiy
lP
Atfugal
el

Ihse e dgs se oxsuperliia


deep ungal iqechonc gal Joections ae
oih the St brnad
ew

mostly assoiaed
Shechdo anbiotieg Cobicostereiok nCcones
d
at tepica onuguggl hayebecn
ar

antseptieCsa Twa
lwo
ovailable Since the
imprtant antbiodia Onphoteivin -dea!
wihgctecni mycosis aadgaiseulin o
to
C

Supplement atak cn demaophyles Les


iotmoucad ardund 6o-

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Clacakon Anigaldrga

a
Ally adre

rm
Antbiotic ornelabe-ltsAzols.
Tes bingint

oidazoles Triazols

ha
Polyencs Hettroecle Efluconqzel
1Benzofuran Thatonazole
Anphoti Voi Conazole
8.Fieg esoin
FNyslabin Flosa tonazote
lP
EcinoCanclig Topical Sysleric
-clotómode Ekeatonazoe
Cashourgin
LEconazole
el

MiConazde
FAntdutaungn0xiconazole
ew

Tobreaagnts
Tdraate
ar

Ben zoic acd


Brctho
FUndeakntC add.
C

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Poly ecAnbbiotieg i e nome oyene


derived om #htu deuble bonded
Stnuchrt

a
rm
Anphoteidn B I is ohfaincd
Sttbtomyces hodogus

Mechanisno_ Adion Polyentantibiota have

ha
ainh o ugestralpesst inngal_cel
mebra ne h onbine h iGetjnkesded int
themntmbroneond irevsap_ boyene modeculeso
lP
'(vopore 7he wroport Stabibizec
ushich L up he Apaces b)o
b/o
membrone Slards
heAM3motcules n the Lipophib'eide bemcabsioh
Consthtng ou Sudarei hepove el
el

Jntaßed, Chofeztexo reacntun kast cell


menbrane xhauttctet- Sglucon
olein
ew
ar

-Bgbuce
Synthast
C

AraphotesicHudzople
opehobre
side
noltadg
side
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hamnatodenetic
AM3ishot
bot-absorhed oall,
but Lon

d Caspension rmarle i thehelp o


deoychetal(Doc)

a
widely
htbs bul il
m
inhboy peneration nCsA\P,

rm
9 binds slesels inissuesond to poprolg
n plasma L is 15 dags Abo
60
dng mdabolized wn lives ExLakmot
slo bolhin uxnn.c4 bile bul upna

ha
Conaaion aivedr
Adveselect Coist ckills
aths
lP
ond Voiha
U
Nephxotxick ishe potantwhtn
AnemiaCN S foxiit.
el

Andicdg
ew

Vises ax
heutmalexptgsion
obliaate
inracclLular. pasasilsm The n0 Only take
nutmio roohe ththosceu bul ako eirto o
ar

i goefaboticnathina yniheize nuouiss


pastile
Dresave be develobed
chasa
C

vins pesi lepsike penekah


uncoatnN7rtvease ransCphom Vinu Ostmbl
txaion oad eleose
pmhos cell el

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Claaiations cnlivica! das

a
hepatihs ving

rm
Ardi herbs ot-influenza Ati-
vis dngs

TdoKuicoc Amantadine
Tunoline

ha
Rimapladin
Audlei seltocmivic
Valacydoyvi Zanamivi
famiuyclavi Peramic
lP
Ganciclavi
osCAek
torHehactiks torHepabihsC
ELamivdine Ribavin
el

Entetavi ntefecn
Tenovi EDaclatasi
ew

Tbivuoine HLhdpasvic

hegeAxe he deugs
ar

acbre g ainst he hops goup DN viu


whichinclade htvpes iroplexvi 1Hopes
Epskein_
sinbltxvinu2 Vasicella- Zostor vins
C

Bas Vinu.
Tdoxuidine iocdo- deoxyuidineith
I isS-
c as a thymicine analogue Is Hhe
s

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Pymicbinontmetabolteto be dd a atvia
dng L Lomplela ith thypraione

a
intvira! DNAs thadaulh Dw
Tdoxuricbng

rm
beaksdon eAsily
is cdive nly4ais DN insesand
clinia
hoses
O utita, 0iilee
milel ohopia trinmt
kuaihis
-&icoplex

ha
analoguue
ii AHulovi- -lhik deyguanosine
uirs a vins sbeci enoe o onvso
that
Spcefi tazrat metabotin
Theactve
lP
inkisiEDnASynthtais and isalepkahon

Aylavi
cdioednage
herpsing speaiHei
el

Mono-phosFhalz
Ayel
ew

Callula kinase
salibit hapes |
FoyrnuE
tebhosphofe vis DNA
Aclavix el
ar

Cornbet

D
CTetr morpovatdin ti
C

ard tapseng thuri

DA ARbi DMA-poly me
Jrevessbly

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Pcokinciis-On
ayclovir
obout o
bsorhco
an ora dos e
lasma
potun brnd cand widely distibute a Haining

50
is50

a
Caetethaton SE Conc. ha lask
Plasm
Conc OE
exfd undhanged in unne

rm
2-3 hou
is
Acluese eltet- Topica sknging t uing
n te eachabhiaiom
Oral
nauxea
ed ha iswll tola.ated
ore CNS tc
headlache
lP
Tnkavtnous Kh Sueairg mesisandl
oCC
nB
el

been_daibed to
Hallucinatons feno d,_hae
ih oloses
ew

Genita Hacpes diroper


les OMuCocutone0us H.cimplex mis loabsea
loabsu
gurms
ps
ar

t and
keyalhs ed Jh rupefiia)
3 diapler Comea_uu end _bette
slendtichonal nfechord becausee
C

dep
2o g00d
Conu!_penchaben
ckenpor

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i ibaviin ks purint nuclcosid analnue


has b 0adspeckwm antvira
unluding gcuns induenza

a
hal
B ts mono tiphosphate olcrivalvig

rm
inacellulasly by hosk kinass i
GTP Snthais and via RA Synhesis.
RNA
islance le_ibayiio A ra
Oval bio avallabibih,

ha
ibavmn is v 50 meJabolized
9 Pasll Cl"
eininade ainly. Jeidneys Th iso c
lP
Antirekovi dnigs

Nutlepside Reveta Non-Nualcos tde Poteas


is
el

ropstiblage inkibito Reunse onsoiplase


Ritonaviv
Jbibil
Zidovuol ne Atazonavir
ew

FNeviapine Tndinavir
ormiuoine
Stavuc ne Eavisen2 Nuinavi
Abacav Delovrdne
Cobinavir
ar

Didano Sine Etavnin DaWnav


Tengovi
C

bohy inkibita CCR-s Receptor ogrose nwbit


Jnwbito
Cnfuwrhde Maravio Ralteov
Dalstegravi vir.

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hcs
hesae dugs ative oginst urnan )omuno

diency Vnus Hiv) evins The


ant thoviny
d ovuine ta mad

a
avalable dor use in 187.

rm
Zidovdne -

thyrnidire analoque the


the

obe phasphopylabion
n he hogf

Cell idovusasne ithouphatSelctie inibit

ha
vial vesse ranspaseun ernce t culalac
DNA rtymuase
lP
Single kronded vhal knA
vins dicehd xtvease tanstiftase
inibik by zidonobine tiphosfhate
el

Double standed rovirnl DNA


.
ew

Lokincbis The oal bio avail abiliy 65/


abs ors orally uickly cleared hepatic
uconidat ty ). 15-26/ he vndegud
along fh etabrti'te exCETdio uvire
ar

drug
oss roSse placenta ound oundJn milk
Advease
C

Advess
elaled
lut:
advesne
Anoemia.Nauopenianp. doce
deck Alasea, anorexia
headarhe obd onna paun Jndornrua.

Uses- s eain HIV Jofeted padents Combihati


Lith atleast ofhes ARV dhugs,

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Andhelninths
deg Antheoohies e

tha cihes. Jil vemmicide


or epuEe

a
cding helminthM
reva lent globa

rm
Jelmintlhiasis i
but is_moy Cornmonin devtlopingCounti
wib ox casona andCnvirdnrnenlal hysicre
abode
In the wman body iE isako Lve

ha
m
Many htlminths But _som N
in tissues or uthcu lava mi9zate ato H
lP
Clasifiationg

or Round uorr tos wkih wom fos tape


el

hookor inuwrrh0 AJbendezole azguanic


EAlbendaze?
Mebendazote Aitlosamide
ew

Mebtndaza
-Pipesazine Abrdrzse
Levamisele
ar

to threaduwom) tosflouaiis
Diemylcarba mazie
yumcctin
C

Albendatote- Tvemecbn torhydati


ALbendaz0 dislne.
Abendsz
Mebendaz

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Mchendozote- I is benzimidazole inroouced


Jn 1972 ThsCenjunca hahtndazele hecame
bopulas becasse it elaincel the bread

a
Ve
onthelmintiacbvih but nof the

rm
Jts pmdecessa Mebendazate ha
produc ound curtat
wo
reducbim
hookLDOmM.
in
2
Caetdheuss tapeuwemg
15 has beun buted in

ha
but H. nang iselatively insendtive txbel
Tidinellaspixabis
Lasuo that have
intstioespbu
migraled
abo
lP
muscles is unatainR
he ejox sit ed_atic)
mebendazole appeass to behemitntubulag
atio B-Atbulin h batasit
el

Mebendaze
ew

inibitng miaotubtule Snthtais


ar

bndoith ebulin tntibit brne


-zatm
C

block aueose uphke in aiaike

lepltes grgensa

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inibids
ucegen
mhoch on cdra
enzns4dlekes
Hatebing henctode
Sts tors

a
and theis lavae ae asoinibiled

rm
Pokinetiu Absebtion nisintsine onai.
75-90/: gn raolose basse in he
aeesThe aebon isexek2o
cbsobed sexCrekomain
os inacdivemetabrtitg i acce
Advese Jes E
ha
willtolsatd
huseaandaldonina.haio Expulsioa
Diachou
Asw
lP
mouthmoitb o nose bobably
have i ocuued
olue e Stayationhe pasasit
Slosdealh
el

endazele iSubsegusot V
Jnhoduced
ohgene- mebenda2oe
Rains he broad
speskiaacti 0ntdosearaeat bu
ew

prodeuced ades in ascasiasishook Lom


ahih ae Cenparable
wih mebendazole.
sA
3 dayseatmeat
3days CDukse
h
ar

ackievedntasdey CuLe 10nd


seCmoCous
2epoated aftt3week aciall all
pates 3 day
be Tnd
C

hetessagf

Plokines i Absopto lbendazale a oal


administered niiadtbd
Centanced
inConsistaat
Ahsophon shendhedng

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aken
takenlth atincalbrain J Gnd idedy ishrbubed
Johe booly nles xedin uinc

a
T is 5 hou Thus alhen dazede ablc fo
exut ontiheimintic aelvip n Aisrues ag well.

rm
Side fecks Well oleu.aled Ony 9 it. side
tects hae been noleo gat aut
Patícns ave
izineS heaolache-
nuuophtnia

Uses Oxatesbna ha wO itshould be jien


lP
onLrnpt sonoch
Astasi hoðkuoo a single dose _4oomg

Suiient
pr 4 Sstaloldesyorng tuite daily
el

lapew0ms
3 Con&ecutiveday
(3) iconosis 4 ubencoud aiat igan
ew

alirna lasia ong


dnis ued rephylasis
ar

hese 4 elapse
_aatnenba evenbon
malaiq
Malayna Cus by- speer
C

arasitt Plasnod
Plasmodiem
Zhe tozoa A
endunic d mout ats ndia and
otht piLa Counms 9 Continuex tobe
rmainlyeueto
a ros ubli hthpeblen.its Covn
plicakr.
P dacu ubon Cuno

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uicle
sclizopto
Tissve

Mosqi

a
Precythic

rm
xoeyo
. hi

Mozork

ha
Relapse
lP
iizatucids
sizo omchodde
el

s
ew

Clasiication Andmalaaia

-aminogcint-binest
ar

Cinthona Diomoicint
alkalolok
Lchlorogurn irmethanin
Ouinine FSulfacdoie
Aoecingulnt
C

FOuini b Juameh
P:haguio Pane
(uindne -Ornguipoind
tmethanot biauende Dap
EMlogune _Fouan megin
Taemoyuine

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Ant biobis Sgulbentaclong


Do atylye line EArtaaat

a
Artemelh
Cndamy cin EAhethes

rm
Frtuelsn
Antirnalavia osug.

Arnino alohots
Halofanint
ha Naphoguin Naphyicboe
lP
FAte Fonattoting
untgantene
Methanis Aciogyi-
s arabia
el

acling esythroy
Schizentoide against_all pecie
liical a ttocks_inpuibhtiaJ
2day tith
ew

Centrols mast
pakasits blod in
disapptasancc
-3 day
ar

Heaogdabin- Globin utbasasike


lzed
malaia

rlasiabasasik)
C

HenLhzhl toe for


Chloroun rtymease
Quinvnee Hene
Moou HemozomnNon toxie to plhsmodiun

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heba%asile ueligsts h hos Cels henolebin ko


obtain Csseotia amino adcs The brotcss ta,

a
Larjaomount toxi Cto_he
hem ih
paasik. To Otdna
na.

rm
prold hl hepaasi
rroizes the hotoxi emozoin,
Seguestoroin he_pasasttes ood Vau
Chlovaguine nt he polymci zaton hemste
he aceumulation herne ls in lyis
bath the pasasit

P'colsintis ha and h_KBC

Oralobs pion_ is exrellen


lP
About50 et bavnd in he plasrna
ar
Selcctiveacpoulabion Jn etina iS sonsible
he
the oculas, toxiuh Sen wh_ologed e
Vastyntdabrdized bylei and lo crckd
el

i Uine he plasng raies


dlayg
K-l0
ew

Advse
uncontrolla ble
= Alasa voruhng
khing hiqatta c
anoreei
pain 1htada!
Can be used knent Malardaa
ar

clusin9 ho abojacdant
tetaogenie e hou been kot
C

ky- ea intestnaV
amotbiosi
Kheuoatoid rthii
Lepm eacbon

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Page 24 of 26
Carewell Pharma - A Family of Learning
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Sulfonanides
Sulfonaoide ime hamint
dapione qr hoE bar-Laulasly e

a
have
antimadarial dngs in hi wnihiL
SomeJnkibitory Jnfluen on he rythxoykc

rm
phase espcial PJaleiharun
Conbinat'on
Supsa -a
ddibve
iskeStyutntia
p4dmethâvnc clu blockThough
Th (mpoment are slou the Cormbinaten

ac as
ha aa
So it_l0nbe mplae
linia Cusabe
lP
I5oom pyrimetha-
As tiniaD uative -Suljadonioc
dore
=Mine rBtob)Sirg
inportanie o ulfa-pimethamioe oro
el

Ihemajoc
binaico is olue to Jica gainst, (a
-sistonce Jakihonu Slladonine ond
ew

a ultra aching suenamids


Sulfomehaz
Ania gbiccga
ar

Ihege dras ax uul n


prihozoa
cienscaused
batarmoeb aistolatica
y
by he anatsobic
Aroocbaasighas asaword ide
diskibution. 9
C

endervic ostpa of he rda.


Aroebics
tphozoiker
aching hentutineransfouLinto clond
ohichuthuuiveonth Sfate

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Carewell Pharma - A Family of Learning
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pacs
utosaa
muossa ag Commcnrak
ove
orm cyss ha Pas. mt
rt
Thetols ond to pgaleheuciceicnce
mobiculku

a
mnds Th mucasa
0

Gnd Ase acde olysen

rm
lassifiation ogniamotbic olugs

ha
HssuC omcebicGde uminal amoebicide

r intstina tvr cuka-iateina


lP
Cxtraintstina amoebiasis only Anides Antlbioha
amotbisis chlopuine Di0Naade TCkacyclie
usoate Porornonyúnt
Ntazoxanicle
el

IrnidazoleAfkatord 8-aroaive
ew

eonidazole_Fbnein C9uiniodochlog
Tnidazde Dehyoactin w Droelomodon
Oshida2ele
ar

ehonidazole
dazeke nteclueeo
s
i he protorybehito-
ini H59 o ichomamiais
C

jelodeed ia_and Jate


ighly activeamocbicde
be undfo a
SpeekumCiolalacbinh
dt haybad
againkt
antsbic
proozoaMeomidlszeslee nse t

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CainoetebicondoiDatoplilic ri vooyonism

a
Metkanism
aion

rm
Mehonidazee

fwedorin
Mchonidazale Batternum
>tduced)D

ha
ferdoxin DNA
DRdizzd

DNAngrnenkeol
lP
Pharrnacokintius i amostCorndy
ahrobed samfhe srnalU ntstnt
el

unabsobed ug eacheg the ddon. J widel,


distibudtd n Vhe bocly Metabokm ouss in
ew

ives by byOxiclatioo
ivs and9lueusaniole Lonfgabon
olloed
ollDed na exoion Plasmq 2_
8 hous dyoess
ar

Advese cfeetr mortxiahauiea mouth.


entallie faste uiphtralkneuopethy
luskg htat
C

ihhking

Usy O_ArnoebiasisMetonidazete a fat


dive dbus oY all jormg oamocbic-
inuin
Giasdiasis (3 ihomonas vaginiti ()Anaeoic
() backya
incukios

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