Professional Documents
Culture Documents
2023)_(0323796834)_(Elsevier).pdf 14th
Edition John L. Cameron
Visit to download the full and correct content document:
https://ebookmass.com/product/current-surgical-therapy-14e-jan-23-2023_032379683
4_elsevier-pdf-14th-edition-john-l-cameron/
tSURGICAL
THERAPY
FOURTEENTH EDITION
u
Any screen.
Any time.
Anywhere.
Activate the eBook version
of this title at no additional charge.
Elsevier eBooks+ gives you the power to browse, search, and customize your content,
make notes and highlights, and have content read aloud.
John L. Cameron
MD, FACS, FRCS(Eng)(Hon), FRCS(Ed)(Hon), FRCSI (Hon)
The Alfred Blalock Distinguished Service Professor
Department of Surgery
Johns Hopkins University School of Medicine
Baltimore, Maryland
Andrew M. Cameron
MD, PhD, FACS
Professor
Director, Department of Surgery
Chief, Division of Transplantation
Johns Hopkins University School of Medicine
Baltimore, Maryland
ELSEVIER
1600 John F. Kennedy Blvd.
Ste. 1600
Philadelphia, PA 19103-2899
No part of this publication may be reproduced or transmitted in any form or by any means, electronic or
mechanical, including photocopying, recording, or any information storage and retrieval system, without
permission in writing from the publisher. Details on how to seek permission, further information about the
Publisher's permissions policies, and our arrangements with organizations such as the Copyright Clearance
Center and the Copyright Licensing Agency can be found at our website: www.elsevier.com/permissions.
This book and the individual contributions contained in it are protected under copyright by the Publisher (other
than as may be noted herein).
Notices
Knowledge and best practice in this field are constantly changing. As new research and experience broaden
our understanding, changes in research methods, professional practices, or medical treatment may become
necessary. Practitioners and researchers must always rely on their own experience and knowledge in
evaluating and using any information, methods, compounds, or experiments described herein. In using such
information or methods they should be mindful of their own safety and the safety of others, including parties
for whom they have a professional responsibility. With respect to any drug or pharmaceutical products
identified, readers are advised to check the most current information provided (i) on procedures featured or
(ii) by the manufacturer of each product to be administered, to verify the recommended dose or formula, the
method and duration of administration, and contraindications. It is the responsibility of practitioners, relying
on their own experience and knowledge of their patients, to make diagnoses, to determine dosages and the
best treatment for each individual patient, and to take all appropriate safety precautions. To the fullest extent
of the law, neither the Publisher nor the authors, contributors, or editors, assume any liability for any injury
and/or damage to persons or property as a matter of products liability, negligence or otherwise, or from any
use or operation of any methods, products, instructions, or ideas contained in the material herein.
Previous editions copyrighted 2020, 2017 by Elsevier Inc.; 2014, 2011, 2008, 2004, 2001, 1998, 1995, 1992, 1989,
1986, 1984 by Saunders Inc, an affiliate of Elsevier Inc.
Printed in Canada
Errol L. Bush, MD, FACS Melissa S. Camp, MD, MPH Timothy D. Chilton, DO
Surgical Director Assistant Professor Resident Physician
Advanced Lung Disease and Transplant Department of Surgery Vascular and Endovascular Surgery
Program Johns Hopkins Hospital St. Louis University
Associate Professor Baltimore, Maryland St. Louis, Missouri
Division of Thoracic Surgery Breast Implant-Associated Anaplastic Large Cell Management of Infected Grafts
Johns Hopkins University Lymphoma
Baltimore, Maryland Walter Cholewczynski, MD
Extracorporeal Membrane Oxygenation for Yilin (Linda) Cao, MD Associate Chairman of Surgery
Respiratory Failure Resident Physician Director of Surgical Critical Care
Department of Radiation Oncology and Department of Surgery
Ronald W. Busuttil, MD, PhD Molecular Radiation Sciences Bridgeport Hospital
Distinguished Professor Emeritus and Johns Hopkins University School of Bridgeport, Connecticut;
Executive Chair Medicine Clinical Assistant Professor
Department of Surgery Baltimore, Maryland Department of Surgery
Founding Chief Neoadjuvant and Adjuvant Therapy for Yale School of Medicine
Division of Liver and Pancreas Colorectal Cancer New Haven, Connecticut
Transplantation Antibiotics in Surgical Critical Care
David Geffen School of Medicine at Ned Z. Carp, MD
University of California Los Angeles Michael A. Choti, MD, MBA
Barbara Brodsky Chief of Surgery and Chair
Los Angeles, California Chief, Department of Surgery
Department of Surgery
Management of Budd-Chiari Syndrome Banner MD Anderson Medical Center
Lankenau Medical Center
Phoenix, Arizona
Wynnewood, Pennsylvania
Surgical Management of Colon Cancer
Jo Buyske, MD Management of Male Breast Cancer
CEO and President Joani Christensen, MD
American Board of Surgery Fabio Casciani, MD Assistant Professor
Adjunct Professor Department of Surgery Department of Surgery
Department of Surgery University of Pennsylvania Perelman School Washington University in St. Louis School
University of Pennsylvania Perelman School of Medicine of Medicine
of Medicine Philadelphia, Pennsylvania St. Louis, Missouri
Philadelphia, Pennsylvania Management of Complications After the Lymphedema
The American Board of Surgery Certifying (Oral) Whipple Procedure
Examination Adrienne N. Christopher, MD
Elliot L. Chaikof, MD, PhD Resident Physician
Kristine E. Calhoun, MD Johnson and Johnson Professor of Thomas Jefferson University Hospital
Professor Surgery Clinical Research Fellow
Director of Medical Student Surgical Department of Surgery Division of Plastic Surgery
Education Harvard Medical School University of Pennsylvania Hospital
University of Washington School of Chair, Roberta and Stephen R. Weiner Philadelphia, Pennsylvania
Medicine Department of Surgery Use of Various Meshes in Hernia Repair
Seattle, Washington Beth Israel Deaconess Medical Center
Ductal and Lobular Carcinoma in situ of the Boston, Massachusetts Anna Chudnovets, MD
Breast Popliteal and Femoral Artery Aneurysm General Surgery Specialist
Department of Surgery
Nicholas A. Calotta, MD Ahmed Chatila, MD Johns Hopkins Medical Institutions
Resident Physician Fellow Baltimore, Maryland
Plastic and Reconstructive Surgery Department of Gastroenterology and Preoperative Bowel Preparation: Is It Necessary?
Johns Hopkins School of Medicine Hepatology
Baltimore, Maryland University of Maryland Jose R. Cintron, MD
Nonmelanoma Skin Cancers Baltimore, Maryland Chairman, Division of Colon and Rectal
Management of Cutaneous Melanoma Pneumatosis Intestinalis and the Importance Surgery (Retired)
for the Surgeon John H. Stroger Hospital of Cook County
Richard P. Cambria, MD Associate Professor (Retired)
Robert R. Linton Professor of Vascular and University of Illinois College of Medicine at
Sophia Y. Chen, MD, MPH
End-Vascular Surgery Chicago
Resident Physician
Harvard Medical School Chicago, Illinois
Johns Hopkins University School of
Division of Vascular and Endovascular Surgical Management of Constipation
Medicine
Surgery Baltimore, Maryland
St. Elizabeth Medical Center Management of Radiation-Induced Injury Bryan M. Clary, MD, MBA
Boston, Massachusetts to the Small and Large Bowel Professor and Chair
Open Repair of Abdominal Aortic Aneurysms Department of Surgery
Endovascular Treatment of Abdominal Aortic UC San Diego
Albert Chi, MSE, MD
Aneurysms San Diego, California
Associate Professor
Management of Acute Cholecystitis
Division of Trauma, Critical Care, and Acute
Care Surgery
Oregon Health & Science University
Portland, Oregon
Fluid and Electrolyte Therapy
C ontributors ix
Danielle K. DePeralta, MD Joy Zhou Done, MD, MHS Anne P. Ehlers, MD, MPH
Assistant Professor Resident Senior Fellow
Surgical Oncology Johns Hopkins University of Washington
Northwell Health Baltimore, Maryland Seattle, Washington
New York, New York PET Scanning in the Management of Colorectal Endoscopic Treatment of Barrett’s Esophagus
Management of Malignant Liver Tumors Cancer
Treatment Trends in Locally Recurrent and Daniel L. Eisenson, MD
Niraj M. Desai, MD Metastatic Breast Cancer Resident
Assistant Professor Johns Hopkins University School of
Department of Surgery Jay J. Doucet, MD, MSc, FACS, Medicine
Johns Hopkins University School of FRCSC Baltimore, Maryland
Medicine Professor Management of Hepatic Abscess
Baltimore, Maryland Department of Surgery
Transplantation of the Pancreas UC San Diego S. James El Haddi, MD, MS
San Diego, California General Surgery Resident
Melissa Louise DeSouza, MD Endocrine Changes with Critical Illness
Surgeon Oregon Health & Science University
Foregut and Bariatric Surgery Portland, Oregon
Quan-Yang Duh, MD Fluid and Electrolyte Therapy
The Oregon Clinic
Professor and Chief
Portland, Oregon
Section of Endocrine Surgery
Management of Disorders of Esophageal Mohamad El Moheb, MD
UC San Francisco
Motility General Surgery Resident
Attending Surgeon
University of Virginia
VA Medical Center
Lauren M. DeStefano, MD Charlottesville, Virginia;
San Francisco, California
Breast Surgical Oncologist Postdoctoral Research Fellow
Management of Thyroid Nodules
Department of Surgery Massachusetts General Hospital
Cedars-Sinai Medical Center Boston, Massachusetts
Mark D. Duncan, MD, FACS Use of Opioids in the Postoperative Period
Los Angeles, California
Associate Professor
Ductal and Lobular Carcinoma in situ of the
Division of Surgical Oncology
Breast Ramy El-Diwany, MD, PhD
Johns Hopkins Medical Institutions
Resident
Associate Professor
Laurence P. Diggs, MD Johns Hopkins University School of
Department of Oncology
Chief Resident Medicine
Miller Coulson Academy of Clinical
Rutgers Robert Wood Johnson University Baltimore, Maryland
Excellence
School of Medicine Management of Small Bowel Tumors
Baltimore, Maryland
New Brunswick, New Jersey Management of Gastric Adenocarcinoma
Management of Gastrointestinal Stromal James K. Elsey, MD, FACS
Tumors Professor
Mark A. Eckardt, MD
Department of Surgery
Surgical Resident
Conor Dillon, DO Medical University of South Carolina
Yale School of Medicine
Instructor, General Surgery Charleston, South Carolina
New Haven, Connecticut
Homer Stryker School of Medicine Management of Abdominal Aortic Aneurysm
Management of Adrenal Cortical Tumors
Western Michigan University with Concomitant Nonvascular Abdominal
Kalamazoo, Michigan Pathology
Barish H. Edil, MD
Surgical Site Infections
Professor and Chair
Joel Elterman, MD, FACS
Department of Surgery
Associate Clinical Professor
Joseph DiNorcia, MD University of Oklahoma
Department of Surgery
Associate Professor Oklahoma City, Oklahoma
University of Colorado School of Medicine
Recanati/Miller Transplantation Institute Management of Gallstone Ileus
Anschutz Medical Campus
Icahn School of Medicine at Mt. Sinai
Fort Collins, Colorado;
New York, New York David T. Efron, MD Trauma and Acute Care Surgery
Management of Budd-Chiari Syndrome Professor Medical Center of the Rockies
Department of Surgery Loveland, Colorado
Gerard M. Doherty, MD University of Maryland Shock Trauma Septic Response and Management
Moseley Professor and Chair of Surgery Center
Harvard Medical School Medical Director and Chief of Trauma
Zachary Obinna Enumah, MD, MA
Surgeon-in-Chief and Crowley Family RA Cowley Shock Trauma Center
General Surgeon
Chair University of Maryland School of Medicine
Johns Hopkins Hospital
Brigham and Women’s Hospital Baltimore, Maryland
Baltimore, Maryland
Boston, Massachusetts Emergency Department Resuscitative
Tenets of Damage Control
Nontoxic Goiter Thoracotomy
Acid-Base Disorders
James M. Donahue, MD Jonathan E. Efron, MD
David M. Euhus, MD
Associate Professor Professor of Surgery and Urology
Professor
Department of Surgery Johns Hopkins University
Department of Surgery
University of Alabama at Birmingham Baltimore, Maryland
Johns Hopkins University
Birmingham, Alabama Management of Toxic Megacolon
Baltimore, Maryland
Management of Esophageal Perforation
Pregnancy and Breast Cancer Management
C ontributors xi
Douglas B. Evans, MD David V. Feliciano, MD, FACS, MAMSE James W. Fleshman Jr., MD, FACS,
Donald C Ausman Family Foundation Clinical Professor FASCRS
Professor and Chair Department of Surgery Chairman, Department of Surgery
Department of Surgery University of Maryland School of Baylor University Medical Center
Medical College of Wisconsin Medicine Clinical Professor
Milwaukee, Wisconsin Attending Surgeon Emeritus Texas A&M College of Medicine
Palliative Interventions for Patients with Shock Trauma Center Dallas, Texas
Operable and Advanced Pancreatic and University of Maryland Medical Center Surgical Management of Crohn’s Colitis
Periampullary Cancer Baltimore, Maryland
Penetrating Abdominal Trauma Katherine L. Florecki, MD
Mikael A. Fadoul, MD Assistant Professor
Resident Physician David J. Feller-Kopman, MD, FACP Department of Surgery
Department of Vascular and Endovascular Professor Division of Acute Care Surgery
Surgery Department of Medicine Johns Hopkins University School of
Cooper University Hospital Geisel School of Medicine at Dartmouth Medicine
Camden, New Jersey Hanover, New Hampshire; Baltimore, Maryland
Endovascular Management of Vascular Injuries Chief, Pulmonary and Critical Care Ventilator-Associated Pneumonia
Medicine Post–Intensive Care Syndrome
Peter J. Fagenholz, MD Dartmouth-Hitchcock Medical Center
Associate Professor Lebanon, New Hampshire
Division of Trauma, Emergency Surgery, Yuman Fong, MD
Tracheostomy The Sangiacomo Family Chair in Surgical
and Critical Care
Massachusetts General Hospital Oncology
Associate Professor
Kirkpatrick Beekman Fergus, MD, MAS City of Hope National Medical Center
Resident Physician Duarte, California
Harvard Medical School
UC San Francisco Cystic Disease of The Liver
Boston, Massachusetts
San Francisco, California
Current Management of Rectal Injury
Management of Chronic Ulcerative Colitis Zhi Ven Fong, MD, MPH
Marissa Famularo, DO Complex General Surgical Oncology Fellow
Integrated Vascular Resident Carlos Fernandez-del Castillo, MD Department of Surgery
Vascular Surgery Professor Massachusetts General Hospital
Cooper University Hospital Department of Surgery Boston, Massachusetts
Camden, New Jersey Massachusetts General Hospital Ablation of Colorectal Carcinoma Liver
Endovascular Management of Vascular Injuries Boston, Massachusetts Metastases
Rare and Unusual Pancreatic Tumors Diagnosis and Management of Autoimmune
Sandy Hwang Fang, MD
Pancreatitis
Associate Professor
Department of Surgery Alessandro Fichera, MD, FACS,
Oregon Health & Sciences University FASCRS Ryan B. Fransman, MD
Portland, Oregon Surgery Safety and Quality Officer Trauma Surgery
Preoperative Bowel Preparation: Is It Necessary? Division Chief, Colorectal Surgery University of Maryland Shock Trauma Center
PET Scanning in the Management of Colorectal Baylor University Medical Center Baltimore, Maryland
Cancer Dallas, Texas Emergency Department Resuscitative
Surgical Management of Crohn’s Colitis Thoracotomy
Alik Farber, MD, MBA Surgical Management of Fecal Incontinence
Chief Julie A. Freischlag, MD, FACS,
Division of Vascular and Endovascular John P. Fischer, MD, MPH FRCSEd(Hon), DFSVS
Surgery Assistant Professor Professor, Vascular and Endovascular
Associate Chair for Clinical Operations Division of Plastic Surgery Surgery
Department of Surgery University of Pennsylvania Wake Forest University School of Medicine
Boston Medical Center Pennsylvania, Philadelphia Chief Executive Officer
Professor of Surgery and Radiology Use of Various Meshes in Hernia Repair Atrium Health Wake Forest Baptist
Boston University School of Medicine Dean, Wake Forest University School of
Boston, Massachusetts Adam Fish, MD Medicine
Management of Peripheral Arterial Resident Physician Winston-Salem, North Carolina;
Thromboembolism Department of Interventional Radiology Chief Academic Officer
Yale School of Medicine Atrium Health Enterprise
Genevieve Fasano, MD, MS
New Haven, Connecticut Charlotte, North Carolina
Resident
Vena Cava Filters Thoracic Outlet Syndrome
NewYork-Presbyterian/Weill Cornell
Medicine P. Marco Fisichella, MD, MBA, FACS
New York, New York Christopher Frost, MD
Associate Professor Resident Physician
Surgical Management of the Axilla Department of Surgery Plastic and Reconstructive Surgery
Harvard Medical School Johns Hopkins Hospital
Associate Chief of Surgery Baltimore, Maryland
Department of Surgery Nerve Injury and Repair
West Roxbury VA
Boston, Massachusetts
Management of Cysts, Tumors, and Abscesses of
the Spleen
xii CONTRIBUTORS
Alodia Gabre-Kidan, MD, MPH Danon E. Garrido, MD Armando E. Giuliano, MD, FACS,
Assistant Professor Assistant Professor FRCSEd
Department of Surgery Vascular and Endovascular Surgery Chief, Surgical Oncology
Johns Hopkins School of Medicine University of Mississippi Medical Center Department of Surgery
Baltimore, Maryland Jackson, Mississippi Cedars-Sinai Medical Center
Management of Rectal Prolapse Balloon Angioplasty and Stents in Carotid Artery Clinical Professor
Occlusive Disease Department of Surgery
Vivian Gahtan, MD UCLA School of Medicine
Chair, Department of Surgery Susan L. Gearhart, MD, MEHP Los Angeles, California
Stritch School of Medicine Associate Professor of Colorectal Surgery Molecular Targets in Breast Cancer
Loyola University Director, Colorectal Surgery Fellowship Ablative Techniques in the Treatment of Benign
Staff Physician Program and Malignant Breast Disease
Department of Surgery Johns Hopkins University School of
Edward Hines Jr. VA Hospital Medicine Natalia O. Glebova, MD, PhD
Maywood, Illinois Baltimore, Maryland Vascular Surgeon
Buerger’s Disease (Thromboangiitis Obliterans) Gastrointestinal Tubes for Feeding and Mid-Atlantic Permanente Medical Group
Decompression Rockville, Maryland
Susan Galandiuk, MD Tibioperoneal Arterial Occlusive Disease
Price Endowed Professor of Surgery Mary L. Gemignani, MD, MPH
Director, Price Institute of Surgical Attending Surgeon Ana Gleisner, MD, PhD
Research Program Director, Breast Surgery Fellowship Associate Professor
Director, Division of Colon and Rectal Breast Service Department of Surgery
Surgery Department of Surgery University of Colorado
Program Director, Division of Colon and Memorial Sloan Kettering Cancer Center Aurora, Colorado
Rectal Surgery New York, New York Management of Benign Liver Tumors
Hiram C. Polk Jr, MD, Department of Breast Cancer: Surgical Therapy
Surgery Lee A. Goeddel, MD, MPH
University of Louisville Christos Georgiades, MD, PhD Assistant Professor
Louisville, Kentucky Professor Department of Anesthesiology and Critical
Management of Diverticular Disease of the Radiology and Radiological Sciences Care Medicine
Colon Director, Interventional Oncology Johns Hopkins University School of
Johns Hopkins University Medicine
Samuel M. Galvagno Jr., DO, PhD, MS, Baltimore, Maryland Assistant Professor
FCCM Transjugular Intrahepatic Portosystemic Shunt Biomedical Engineering
Professor of Anesthesiology Transhepatic Interventions for Obstructive Johns Hopkins Whiting School of
R. Adams Cowley Shock Trauma Center Jaundice Engineering
Executive Vice Chair, Anesthesiology Baltimore, Maryland
University of Maryland School of Zachary German, MD Perioperative Optimization
Medicine Medical Student
Baltimore, Maryland; Wake Forest School of Medicine Eric M. Goldberg, MD
Colonel, Air Force Reserve Winston-Salem, North Carolina Associate Professor
USAF Pentagon Thoracic Outlet Syndrome Department of Medicine and
Arlington, Virginia Gastroenterology
Management of Diverticular Disease of the University of Maryland School of Medicine
Colon Bruce L. Gewertz, MD
Chair and Surgeon in Chief Baltimore, Maryland
Airway Management in the Trauma Patient Pneumatosis Intestinalis and the Importance
Department of Surgery
Cedars-Sinai Medical Center for the Surgeon
Raisa Gao, DO Los Angeles, California
Instructor, General Surgery Takayasu’s Arteritis Reyna Gonzalez, MD, MS
Homer Stryker MD School of Medicine Emergency General Surgery Medical
Western Michigan University Director
Kalamazoo, Michigan Omar M. Ghanem, MD, FACS
Assistant Professor Riverside University Health Systems
Surgical Site Infections Moreno Valley, California
Department of Surgery
Mayo Clinic Glucose Control in the Postoperative Period
Brian T. Garibaldi, MD Rochester, Minnesota
Associate Professor Diagnosis and Management of Motility Amy V. Gore, MD
Pulmonary and Critical Care Medicine Disorders of the Stomach and Small Bowel in Assistant Professor
Johns Hopkins University School of the Current Era Department of Surgery
Medicine Rutgers New Jersey Medical School
Baltimore, Maryland Newark, New Jersey
COVID-19 and Health Care Delivery in a Joseph S. Giglia, MD
Professor Management of Intraabdominal Infections
Pandemic
Interim Chief of Vascular Surgery
Department of Surgery
University of Cincinnati College of Medicine
Cincinnati, Ohio
Atherosclerotic Renal Artery Stenosis
C ontributors xiii
Brenda S. Nettles, DNP, MS, Wasay Nizam, MBBS Tawakalitu O. Oseni, MD, MPH
ACNP-BC, CNE Research Associate Assistant Professor
Assistant Professor Department of Surgery Department of Surgery
School of Nursing Johns Hopkins Medical Institutions Massachusetts General Hospital
Acute Care Nurse Practitioner Baltimore, Maryland Boston, Massachusetts
Division of Surgical Oncology Esophageal Function Tests Benign Breast Disease
Johns Hopkins Hospital Mediastinal Masses
Baltimore, Maryland Greg M. Osgood, MD
Surgical Palliative Care Yuri W. Novitsky, MD
Associate Professor
Director, Columbia Comprehensive Hernia
Chief, Orthopedic Trauma
Lisa Ann Newman, MD, MPH Center
Department of Orthopedic Surgery
Professor, Department of Surgery Columbia University Medical Center
Johns Hopkins University School of
NewYork-Presbyterian Hospital/Weill Professor, Department of Surgery
Medicine
Cornell Medical Center Columbia College of Physicians and
Baltimore, Maryland
Chief, Division of Breast Surgery Surgeons
Early Management of Pelvic Ring Disruption
Director, NewYork-Presbyterian Hospital Chief, Division of Abdominal Wall Surgery
Network Interdisciplinary Breast Columbia University School of Medicine
Program New York, New York Luis Ostrosky-Zeichner, MD, FACP,
Medical Director and Founder Abdominal Wall Reconstruction FIDSA, FSHEA, FECMM
International Center for the Study of Breast Professor and Division Chief
Cancer Subtypes Brant K. Oelschlager, MD Division of Infectious Diseases
Weill Cornell Medicine Professor, Byers Endowed Chair in University of Texas Health Science Center at
New York, New York Esophageal Research Houston
Surgical Management of the Axilla Department of Surgery Medical Director for Epidemiology
University of Washington Memorial Hermann Texas Medical Center
Division of General Surgery Houston, Texas
Nariman Nezami, MD
University of Washington Medical Center Antifungal Therapy in the Surgical Patient
Associate Professor
Seattle, Washington
Division of Vascular and Interventional
Surgical Management of Gastroesophageal Shane Ottmann, MD
Radiology
Reflux Disease Transplant Surgeon
Department of Diagnostic Radiology and
Endoscopic Treatment of Barrett’s Esophagus Department of Surgery
Nuclear Medicine
University of Maryland School of Medicine Johns Hopkins Hospital
Jennifer B. Ogilvie, MD Baltimore, Maryland
Associate Professor Section Chief, Endocrine Surgery
Experimental Therapeutics Program Hepatic Malignancy: Resection Versus
Yale School of Medicine Transplantation
University of Maryland Marlene and Stewart New Haven, Connecticut
Greenebaum Comprehensive Cancer Management of Adrenal Cortical Tumors
Center Theodore N. Pappas, MD
Baltimore, Maryland Professor
John A. Olson Jr., MD, PhD
Transarterial Therapies for Primary and Department of Surgery
William K. Bixby Professor and Chair
Metastatic Liver Tumors Duke University
Department of Surgery
Durham, North Carolina
Washington University School of Medicine
Dennis C. Nguyen, MD Management of Asymptomatic (Silent)
Surgeon-in-Chief
Assistant Professor Gallstones
Barnes-Jewish Hospital
Plastic and Reconstructive Surgery St. Louis, Missouri
Washington University School of Medicine Surgical Management of Thyroid Cancer Charudutt Paranjape, MD, FACS
St. Louis, Missouri Assistant Professor
Evaluation and Management of the Patient Kristofor A. Olson, MD, PhD Department of Surgery
with Craniomaxillofacial Trauma Administrative Chief Resident Harvard Medical School
Surgery and Perioperative Care Trauma Emergency and Critical Care
Hien T. Nguyen, MD, MBA The University of Texas at Austin Surgeon
Director of the Comprehensive Hernia Dell Medical School Massachusetts General Hospital
Center Austin, Texas Boston, Massachusetts;
Associate Professor Acute Mesenteric Ischemia Chief, General Surgery and Acute Care
Department of Surgery Surgery
Johns Hopkins Medical Institutions Charles S. O’Mara, MD, MBA Mass General Brigham Newton-Wellesley
Baltimore, Maryland Professor Emeritus Hospital
Incisional, Epigastric, and Umbilical Hernias Department of Surgery Newton, Massachusetts
University of Mississippi Medical Center Management of Small Bowel Obstruction
Jake A. Nicholson, DO Jackson, Mississippi
Resident Physician Balloon Angioplasty and Stents in Carotid Artery
Vascular Surgery Occlusive Disease
Spectrum Health
Michigan State University
Grand Rapids, Michigan
Gangrene of the Foot
C ontributors xxi
Adrian E. Park, MD, FRCSC Walter Pegoli Jr., MD Elisa Port, MD, FACS
Chair and Surgeon in Chief Professor of Surgery and Pediatrics Chief, Breast Surgery
Department of Surgery University of Rochester Mount Sinai Health System
Luninis Health Rochester, New York Professor
Annapolis, Maryland; Appendicitis: Diagnosis and Management Icahn School of Medicine at Mount Sinai
Professor New York, New York
Department of Surgery Bruce A. Perler, MD, MBA Genetic Counseling and Testing
Johns Hopkins University School of Medicine Julius H. Jacobson II Professor
Baltimore, Maryland Vice Chair for Clinical Operations Carolyn R. Postol, DO
Splenectomy for Hematologic Disorders Chief Emeritus, Division of Vascular Resident Physician
Surgery and Endovascular Therapy Vascular Surgery
Pauline K. Park, MD Johns Hopkins University School of Spectrum Health
Professor Medicine Michigan State University
Division of Acute Care Surgery Baltimore, Maryland; Grand Rapids, Michigan
University of Michigan Vice President Lower Extremity Amputation
Ann Arbor, Michigan American Board of Surgery
Postoperative Respiratory Failure Philadelphia, Pennsylvania Ajita S. Prabhu, MD
Carotid Endarterectomy Associate Professor
Jessica M. Pastoriza, MD Department of Surgery
Breast Surgical Oncology Fellow Nancy D. Perrier, MD, FACS Cleveland Clinic
Department of Surgery Walter and Ruth Sterling Endowed Professor Cleveland, Ohio
Johns Hopkins Hospital of Surgery Management of Spigelian, Obturator, and
Baltimore, Maryland Surgical Oncology Lumbar Hernias
Role of Stereotactic Biopsy in Management of MD Anderson Cancer Center
Breast Disease Houston, Texas Joshua E. Preiss, MD
Pregnancy and Breast Cancer Management Persistent and Recurrent Hyperparathyroidism Fellow
Cardiothoracic Surgery
Purvi P. Patel, MD Benjamin Philosophe, MD, PhD University of Washington
Assistant Professor Surgical Director Seattle, Washington
Department of Surgery Comprehensive Transplant Center Primary Tumors of the Thymus
Loyola University Medical Center Johns Hopkins Medical Institutions
Chicago, Illinois Baltimore, Maryland Jason D. Prescott, MD, PhD
Management of Traumatic Brain Injury Liver Transplantation Associate Professor
Department of Surgery
Shirali T. Patel, MD, FACS Henry A. Pitt, MD NYU Grossman School of Medicine
Chief of General Surgery Distinguished Professor New York, New York
St. Agnes Department of Surgery Primary Hyperparathyroidism
Baltimore, Maryland Rutgers Robert Wood Johnson Medical
Management of Common Bile Duct Stones School Leigh Ann Price, MD
Chief of Oncologic Quality Director, Department of Surgery
Marco G. Patti, MD Rutgers Cancer Institute of New Jersey National Burn Reconstruction Center
Professor New Brunswick, New Jersey Assistant Professor
Department of Surgery Management of Echinococcal Cyst Disease of Plastic and Reconstructive Surgery
University of Virginia the Liver Johns Hopkins University School of
Charlottesville, Virginia Medicine
Management of Zenker’s Diverticulum Jennifer K. Plichta, MD, MS Baltimore, Maryland
Associate Professor Electrical and Lightning Injury
Timothy M. Pawlik, MD, PhD, MPH, Department of Surgery
MTS, MBA, FACS Duke University Medical Center Matthew D. Price, MD
Professor and Chair Durham, North Carolina General Surgery Fellow
Department of Surgery Inflammatory Breast Cancer Johns Hopkins University School of
Ohio State University Medical Center Medicine
Urban Meyer III and Shelley Meyer Chair Dina Podolsky, MD Baltimore, Maryland
for Cancer Research Assistant Professor Management of Pruritus Ani
Wexner Medical Center at Ohio State University Department of Surgery Management of Chronic Pancreatitis
Columbus, Ohio Columbia University Medical Center
Management of Colorectal Liver Metastases New York, New York Scott G. Prushik, MD
Abdominal Wall Reconstruction Vascular Surgeon
Gregory J. Pearl, MD, FACS Division of Vascular and Endovascular
Chair, Department of Vascular Surgery Amani D. Politano, MD, MS Surgery
Baylor Scott & White Heart and Vascular Assistant Professor St. Elizabeth’s Medical Center
Hospital Vascular Surgery Brighton, Massachusetts
Chief, Division of Vascular Surgery Oregon Health & Science University Endovascular Treatment of Abdominal Aortic
Baylor University Medical Center Portland, Oregon Aneurysm
Clinical Professor Pseudoaneurysms and Arteriovenous Fistulas
Texas A&M Health Sciences Center
Dallas, Texas
Brachiocephalic Reconstruction
xxii CONTRIBUTORS
Carla M. Pugh, MD, PhD Christina Maria Yesenia Rojas-Khalil, MD, FACS
Thomas Krummel Professor Regelsberger-Alvarez, DO Assistant Professor
Department of Surgery Clinical Assistant Professor Department of Surgery
Stanford University School of Medicine Trauma and Surgical Critical Care Baylor College of Medicine
Stanford, California Brody School of Medicine Houston, Texas
Loss of Domain in Abdominal Wall Reconstruction East Carolina University Management of Large Bowel Obstruction
Greenville, North Carolina
T. Robert Qaqish, MD Postoperative Respiratory Failure Rae S. Rokosh, MD
Clinical Assistant Professor General Surgery Resident
Thoracic Surgery Thomas Reifsnyder, MD NYU Langone Health
University at Buffalo Johns Hopkins Bayview Medical Center New York, New York
Buffalo, New York Department of Surgery Popliteal and Femoral Artery Aneurysm
Achalasia of the Esophagus Johns Hopkins University
Baltimore, Maryland Riccardo Rosati, MD, FACS
Zaffer Qasim, MBBS, FRCEM, EDIC Hemodialysis Access Surgery Professor
Assistant Professor of Emergency Medicine Gastrointestinal Surgery
and Critical Care Linda M. Reilly, MD San Raffaele Hospital
University of Pennsylvania Perelman School Professor Milan, Italy
of Medicine Vascular Surgery Management of Zenker’s Diverticulum
Philadelphia, Pennsylvania UC San Francisco
Prehospital Management of the Trauma Patient San Francisco, California J. Bart Rose, MD, MAS, FACS
Chronic Mesenteric Ischemia Assistant Professor
Jacob A. Quick, MD Department of Surgery
Associate Professor Taylor S. Riall, MD, PhD University of Alabama Birmingham
Department of Surgery Professor Birmingham, Alabama
University of Missouri Department of Surgery Management of Biliary Dyskinesia
Columbia, Missouri Associate Director, Oncology Services
University of Arizona Cancer Center Laura H. Rosenberger, MD, MS
Abdomen That Will Not Close
University of Arizona Associate Professor
Tucson, Arizona Department of Surgery
Amanda Radisic, MD Duke University
General Surgery Resident Pancreatic Neuroendocrine Tumors of the
Pancreas Excluding Gastrinoma Durham, North Carolina
Robert Wood Johnson University Inflammatory Breast Cancer
Hospital
New Brunswick, New Jersey John Peter Ricci, MD, FACS Robert C. Ross, MD
Injuries to Small and Large Bowel Assistant Professor Fellow in Surgical Metabolism and
Department of Surgery Metabolic Surgery
Shannon N. Radomski, MD Zucker School of Medicine at Hofstra/ Department of Metabolic Surgery
Resident Northwell Pennington Biomedical Research Center
Department of Surgery Hempstead, New York; Baton Rouge, Louisiana
Johns Hopkins School of Medicine Chief, Colon and Rectal Surgery Cardiovascular Disease Risk Reduction After
Baltimore, Maryland Long Island Jewish Medical Center Bariatric Surgery
Management of Rectal Prolapse New Hyde Park, New York
Management of Crohn’s Disease of the Small Gedge D. Rosson, MD
Bowel Associate Professor
Todd E. Rasmussen, MD Department of Plastic and Reconstructive
Professor and Vice-Chair for Education Anamaria J. Robles, MD Surgery
Department of Surgery Assistant Professor Johns Hopkins University School of
Vascular Surgeon Department of Surgery Medicine
Mayo Clinic UC Davis Baltimore, Maryland
Rochester, Minnesota Sacramento, California Nerve Injury and Repair
Management of Vascular Injuries Catheter Sepsis in the Intensive Care Unit Breast Reconstruction Following Mastectomy:
Considerations, Techniques, and Outcomes,
Abhinav V. Reddy, MD Douglas Rodgers, MD Part I
Resident Physician Resident
Radiation Oncology Rishi A. Roy, MD
Vascular Surgery Partner and Founder
Johns Hopkins University School of University of Cincinnati Medical Center
Medicine Advanced Vascular and Vein Associates
Cincinnati, Ohio Jackson, Mississippi
Baltimore, Maryland Atherosclerotic Renal Artery Stenosis
Intraoperative Radiation for Pancreatic Cancer Balloon Angioplasty and Stents in Carotid Artery
Occlusive Disease
Alexandra B. Roginsky, MD, FACS
Christopher R. Reed, MD Assistant Professor
Resident Physician Grace S. Rozycki, MD, MBA
Department of Surgery Professor
Department of Surgery Johns Hopkins University School of
Duke University Medical Center Department of Surgery
Medicine Johns Hopkins School of Medicine
Durham, North Carolina Baltimore, Maryland
Management of Asymptomatic Baltimore, Maryland
Multiple Organ Dysfunction and Failure Surgeon’s Use of Ultrasound in the Trauma and
(Silent) Gallstones
Critical Care Settings
C ontributors xxiii
Adil A. Shah, MD Jason K. Sicklick, MD, FACS Thomas J. Smith, MD, FACP
Fellow Professor Director of Palliative Medicine
Department of General and Thoracic Surgery Departments of Surgery and Pharmacology Johns Hopkins University Medical Institutions
Children’s National Medical Center Division of Surgical Oncology Professor of Oncology and Palliative
Washington, DC University of California San Diego Moores Medicine
Injured Spleen Cancer Center Sidney Kimmel Comprehensive Cancer
University of California San Diego Health Center
Brian D. Shames, MD San Diego, California Johns Hopkins
Chief, Division of General Surgery Proper Use of Cholecystostomy Tubes Baltimore, Maryland
General Surgery Residency Program Surgical Palliative Care
Director Frederick Sieber, MD
University of Connecticut Health Center Professor Thomas W. Smith Jr., MD, MS
Program Director Anesthesiology and Critical Care Medicine Professor
General Surgery Residency Johns Hopkins Medical Institutions Department of Pathology
University of Connecticut School of Medicine Baltimore, Maryland UMass Chan Medical School
Farmington, Connecticut Management of Postoperative Delirium Worcester, Massachusetts
Management of Zollinger-Ellison Syndrome Contralateral Prophylactic Mastectomy
Justin M. Simmons, DO, RPVI Anthony Sorrentino, MD
Ashwyn K. Sharma, MD Vascular Surgeon General Surgery Resident
Resident Physician Division of Vascular Surgery NYU Langone
Department of Surgery Spectrum Health Medical Group New York, New York
UC San Diego Clinical Instructor Surgical Management of Gallbladder Cancer
San Diego, California Department of Surgery
Proper Use of Cholecystostomy Tubes Michigan State University Julie Ann Sosa, MD, MA
College of Human Medicine Leon Goldman MD Distinguished Professor
Robert Sheridan, MD Grand Rapids, Michigan and Chair
Medical Director, Burn Service Lower Extremity Amputation Department of Surgery
Shriners Hospital for Children Affiliated Faculty
Professor, Department of Surgery Sarah S. Sims, MD Philip R. Lee Institute for Health Policy
Harvard Medical School Endocrine Surgeon Studies
Boston, Massachusetts Department of Surgery UC San Francisco
Medical Management of the Burn Patient Caremount Medical San Francisco, California
Poughkeepsie, New York Management of Hyperthyroidism
Aditya S. Shirali, MD Management of Thyroid Nodules
Surgical Endocrinology Fellow Konstantinos Spaniolas, MD, FACS,
University of Texas MD Anderson Cancer Vikesh K. Singh, MD, MSc FASMBS
Center Professor of Medicine Professor
Houston, Texas Division of Gastroenterology Department of Surgery
Persistent and Recurrent Hyperparathyroidism Director of Pancreatology Stony Brook University
Johns Hopkins University School of Stony Brook, New York
Artem Shmelev, MD Medicine Athletic Pubalgia
Clinical Fellow Director of Endoscopy
Department of Surgery Johns Hopkins Hospital Jason Sperry, MD, MPH
Columbia University Medical Center Baltimore, Maryland Andrew B. Peitzman Professor of Surgery
New York, New York Management of Hepatic Encephalopathy Section Chief, Trauma and General Surgery
Management of Common Bile Duct Stones Obstructive Jaundice: The Role of Endoscopic University of Pittsburgh
Intervention Pittsburgh, Pennsylvania
Shmuel Shoham, MD Nutrition Therapy in the Critically Ill Surgical
Matthew R. Smeds, MD
Professor Patient
Professor
Department of Medicine
Department of Surgery
Johns Hopkins University School of Scott R. Steele, MD, MBA
Division of Vascular and Endovascular
Medicine Chairman, Department of Colorectal Surgery
Surgery
Baltimore, Maryland Cleveland Clinic
Saint Louis University
Epidemiology, Prevention, and Management Professor
St. Louis, Missouri
of Occupational Exposure to Bloodborne Cleveland Clinic Lerner College of Medicine
Management of Infected Grafts
Infections of Case Western Reserve University
John Nikolhaus Smith, MD Cleveland, Ohio
Jaimie T. Shores, MD Chief Fellow Management of Pilonidal Disease
Clinical Director of Hand and Upper Department of Cardiology
Extremity Transplantation Johns Hopkins Hospital Jonathan M. Stem, MD
Assistant Professor Baltimore, Maryland Assistant Professor
Plastic and Reconstructive Surgery Cardiovascular Pharmacology Department of Surgery
Johns Hopkins University School of University of North Carolina School of
Medicine Medicine
Baltimore, Maryland Chapel Hill, North Carolina
Surgical Infections of The Hand Management of Colonic Volvulus
C ontributors xxv
Crisanto M.Torres, MD Brooks V. Udelsman, MD, MHS Andrew L. Warshaw, MD, FACS,
Assistant Professor of Surgery Cardiothoracic Fellow FRCSEd (Hon), MAMSE
BU School of Medicine Department of Surgery Emeritus Surgeon-in-Chief
Trauma and Acute Care Surgeon Intensivist Yale–New Haven Hospital Massachusetts General Hospital
Boston Medical Center New Haven, Connecticut W. Gerald Austen Distinguished Professor
Boston, Massachusetts Multimodality Therapy in Esophageal Cancer of Surgery
Injuries to Small and Large Bowel Harvard Medical School
Abdominal Compartment Syndrome and Marissa Vane, MD, MSc Physician Director
Management of the Open Abdomen Department of Surgery Network Development and Integration
Maastricht UMC+ Mass General Brigham
Susan Tsai, MD, MHS Maastricht, Limburg, Netherlands Boston, Massachusetts
Professor of Surgical Oncology Ablative Techniques in the Treatment of Benign Diagnosis and Management of Autoimmune
Department of Surgery and Malignant Breast Disease Pancreatitis
Medical College of Wisconsin
Milwaukee, Wisconsin George Velmahos, MD, PhD Philip J. Wasicek, MD
Management of Periampullary Cancers John F. Burke Professor of Surgery Resident
Palliative Interventions for Patients with Harvard Medical School Department of Plastic Surgery
Operable and Advanced Pancreatic and Division Chief of Trauma, Emergency University of Pittsburgh
Periampullary Cancer Surgery, and Surgical Critical Care Pittsburgh, Pennsylvania
Massachusetts General Hospital Necrotizing Skin and Soft Tissue Infections
Yvonne Tsitsiou, MBBS, BSc (Hon) Boston, Massachusetts
Department of Radiology Management of Small Bowel Obstruction Sharon R. Weeks, MD
Division of Vascular and Interventional Abdominal Transplant Surgeon
Radiology Jack P. Vernamonti, MD Department of Surgery
Johns Hopkins University School of Medicine Surgical Research Fellow Johns Hopkins School of Medicine
Baltimore, Maryland Pediatric Surgery Baltimore, Maryland
Charing Cross Hospital University of Michigan Hepatic Malignancy: Resection Versus
Imperial NHS Healthcare Trust Ann Arbor, Michigan Transplantation
Imperial College London Postoperative Respiratory Failure
London, United Kingdom Roi Weiser, MD
Transjugular Intrahepatic Portosystemic Shunt Charles M.Vollmer Jr., MD Breast Surgical Oncology Fellow
Transhepatic Interventions for Obstructive Professor, Chief of Gastrointestinal Surgery Department of Surgery
Jaundice Department of Surgery University of Texas Medical Branch
University of Pennsylvania Galveston, Texas
Eric Tsung, MD Philadelphia, Pennsylvania International Surgical Oncology Fellow
Acute Care Surgeon Management of Complications after the Department of Surgical Oncology
Trauma, Critical Care Whipple Procedure University of Texas MD Anderson Cancer
Acute Care Surgery, Burns Center
Yale–New Haven Health Houston, Texas
Bridgeport Hospital Halley Vora, MD Lymphatic Mapping and Sentinel
Bridgeport, Connecticut Department of Surgical Oncology Lymphadenectomy
Antibiotics in Surgical Critical Care Loma Linda University
Loma Linda, California
Clifford R. Weiss, MD
Benign Breast Disease
Anthony Tufaro, MD, DDS, FACS Professor of Radiology
Professor and Interim Chief Radiologic Science and Biomedical
Department of Surgery Peter S.Vosler, MD, PhD, FACS Engineering
Division of Plastic Surgery and Surgical Assistant Professor Department of Radiology/Division of
Oncology Department of Otolaryngology-Head and Interventional Radiology
Case Western Reserve University Neck Surgery Johns Hopkins University School of
Cleveland, Ohio Johns Hopkins University Medicine
Nonmelanoma Skin Cancers Baltimore, Maryland Medical Director of Johns Hopkins Center
Management of Cutaneous Melanoma Management of Solitary Neck Mass for Bioengineering Innovation and Design
Department of Biomedical Engineering
Kiara A.Tulla, MD Christi M. Walsh, MSN, CRNP Johns Hopkins University School of
Abdominal Transplant Fellow Department of Surgery Medicine and the Whiting School of
Department of Surgery Johns Hopkins Hospital Medicine
Johns Hopkins Medicine Management of Chronic Pancreatitis Baltimore, Maryland
Baltimore, Maryland Total Pancreatectomy and Islet Transarterial Therapies for Primary and
Liver Transplantation Autotransplantation for Chronic Pancreatitis Metastatic Liver Tumors
Matthew J. Weiss, MD, MBA David R. Whittaker, MD, FACS, RPVI Daniel J. Wong, MD, MHS
Deputy Physician-in-Chief Associate Professor General Surgery Resident
Director of Surgical Oncology Vascular and Endovascular Surgery Beth Israel Deaconess Medical Center
Northwell Health Cancer Institute Johns Hopkins University School of Boston, Massachusetts
Lake Success, New York Medicine Popliteal and Femoral Artery Aneurysm
Management of Malignant Liver Tumors Bethesda, Maryland
Treatment of Varicose Veins Virginia L. Wong, MD, FACS
Ethel D. Weld, MD, PhD Associate Professor
Assistant Professor of Medicine Elizabeth C. Wick, MD Vascular Surgery
Infectious Diseases Professor University Hospitals Cleveland Medical Center
Clinical Pharmacology Division of General Surgery Case Western Reserve University
Johns Hopkins University School of Medicine UC San Francisco Cleveland, Ohio
Baltimore, Maryland San Francisco, California Management of Aneurysms of the Extracranial
Epidemiology, Prevention, and Management Management of Chronic Ulcerative Colitis Carotid and Vertebral Arteries
of Occupational Exposure to Bloodborne Upper Extremity Arterial Occlusive Disease
Infections Fatima G. Wilder, MD, MS
Cardiothoracic Surgery Fellow Douglas E. Wood, MD, FACS, FRCSEd
Jennine H. Weller, MD, PhD General Surgeon The Henry N. Harkins Professor and Chair
General Surgery Resident Johns Hopkins University School of Department of Surgery
Johns Hopkins Hospital Medicine University of Washington
Baltimore, Maryland Baltimore, Maryland Seattle, Washington
Repair of Pectus Excavatum Management of Esophageal Cancer Primary Tumors of the Thymus
Extracorporeal Membrane Oxygenation for
Respiratory Failure Cameron D. Wright, MD
Adam S. Weltz, MD, FACS
Attending Surgeon Professor
Associate Professor Austin D. Williams, MD, MSEd Department of Surgery
Department of Surgery Assistant Professor Massachusetts General Hospital
Anne Arundel Medical Center Department of Surgical Oncology Harvard Medical School
Annapolis, Maryland Fox Chase Cancer Center Boston, Massachusetts
Splenectomy for Hematologic Disorders Philadelphia, Pennsylvania Management of Spontaneous and Secondary
Management of Male Breast Cancer Pneumothorax
Russel N. Wesson, MBChB
Assistant Professor Timothy K. Williams, MD Clement Wu, MBBS, MRCP, MMed,
Division of Transplantation Associate Professor MCI
Johns Hopkins Hospital Vascular and Endovascular Surgery Consultant Gastroenterologist
Baltimore, Maryland Wake Forest Baptist Health Department of Gastroenterology and
Portal Hypertension: Role of Shunting Procedures Winston-Salem, North Carolina Hepatology
Thoracic Outlet Syndrome Singapore General Hospital
Singapore
Steven D. Wexner, MD, PhD (Hon),
James E. Wiseman, MD, MBA Enteral Stents in the Treatment of Colonic
FACS, FRCS(Eng), FRCS(Ed),
Department of Surgery Obstruction
FRCSI(Hon), Hon FRCS(Glasg)
Director, Digestive Disease Center University of Arizona College of Medicine
Chair, Department of Colorectal Surgery Tucson, Arizona Lawrence W. Wu, MD
Cleveland Clinic Florida Management of Inguinal Hernia Resident
Weston, Florida; Department of Medicine
Clinical Affiliate Professor Michael W. Witthaus, MD Johns Hopkins Hospital
Division of Surgery Reconstructive Urology Fellow Baltimore, Maryland
Charles E. Schmidt College of Medicine UC San Diego Neoadjuvant and Adjuvant Therapy for
Florida Atlantic University San Diego, California Pancreatic Cancer
Boca Raton, Florida; Renal and Ureteral Traumatic Injuries
Clinical Professor Stephen C.Yang, MD
Herbert Wertheim College of Medicine Aric Wogsland, MD Professor of Surgery and Oncology
Florida International University Fellow The Arthur B. and Patricia B. Modell
Miami, Florida Vascular Surgery and Endovascular Therapy Endowed Chair in Thoracic Surgery
Management of Clostridioides Difficile Colitis University Hospitals Cleveland Medical Department of Surgery
Center Division of Thoracic Surgery
Glenn J.R. Whitman, MD Case Wester Reserve University Johns Hopkins Medical Institutions
Professor Cleveland, Ohio Baltimore, Maryland
Division of Cardiac Surgery Upper Extremity Arterial Occlusive Disease Management of Esophageal Cancer
Johns Hopkins School of Medicine
Co-Director, CVSICU Christopher L. Wolfgang, MD, PhD Linda Ye, MD
Johns Hopkins Hospital Chief, Hepatobiliary and Pancreatic Surgery Resident Physician
Director, Cardiac Surgery Quality and Safety NYU Grossman School of Medicine Department of Surgery
Johns Hopkins Health System NYU Langone Health System David Geffen School of Medicine at
Baltimore, Maryland New York, New York University of California Los Angeles
Cardiovascular Pharmacology Surgical Management of Gallbladder Cancer Los Angeles, California
Management of Pancreatic Necrosis
xxviii CONTRIBUTORS
The first edition of Current Surgical Therapy was published in 1984. boards or recertifying. Medical students have also given us feedback
The textbook has thus been in existence for almost 40 years, and that they believe the text is of value to them. However, Current
this is the fourteenth edition. In each edition, we have updated the Surgical Therapy is not written principally for medical students. We
material to reflect the continuing evolution of the field of general believe a more classic surgical textbook with substantial sections on
surgery. The textbook continues to be perhaps the most popular disease presentation, diagnosis, and pathophysiology is more appro-
surgical book in the field, and as long as it fulfills a need, we plan to priate for medical students.
continue the publication every 3 years. It has been a special privilege We remain grateful to the many surgeons throughout the
and honor for the two editors to be able to review contributions from country, as well as to the international surgeons, who participated
surgeons around the country and, indeed, from around the world, in creating this textbook. Most of the potential authors whom we
on what they believe is the current surgical therapy for essentially solicit respond enthusiastically to the opportunity to present their
all common general surgical topics. It is an enjoyable task and keeps expert views. Their efforts obviously are what make this textbook
two surgeons who care for surgical patients current on all general a success. In addition, we could not have compiled this textbook
surgical topics. without the herculean efforts of Ms. Irma Silkworth, who has been
As with prior editions, nearly every chapter has been written by a involved with virtually all of these editions. Ms. Katie DeFrancesco
new author. All authors have contributed their specific and personal at Elsevier has also has been a terrific help and stands out in the
thoughts on the current surgical therapy of the disease about which publishing industry.
they are experts. Therefore, to obtain a broad view of the topic, the Both editors continue to enjoy and thrive in our chosen profes-
reader may want to review the contributions of the other experts in sion of general surgery. In recruiting medical students into our spe-
the past two or three editions of Current Surgical Therapy. cialty over the past 40 years, we have used the statement, “If you pick
As with the past editions, disease presentation, pathophysiology, a profession you love, you never have to work the rest of your life.” In
and diagnosis are discussed only briefly, with the emphasis on cur- our view, that profession is surgery.
rent surgical therapy. When an operative procedure is discussed, an Finally, we would like to dedicate this edition, as with the others,
effort has been made to include brief and concise descriptions with to the surgical house staff and fellows at Johns Hopkins Hospital,
figures and diagrams when possible. Current Surgical Therapy is who are “the best of best.”
written for surgical residents, fellows, and fully trained surgeons in
private practice or in an academic setting. Many have told us that it Andrew M. Cameron, MD
is an excellent textbook to review before taking the general surgical John L. Cameron, MD
xxix
Contents
Management of Disorders of Esophageal Motility 45 Management of Crohn’s Disease of the Small Bowel 134
Melissa Louise DeSouza, MD, and Lee L. Swanstrom, MD John Peter Ricci, MD, and Mark A. Talamini, MD
xxxi
xxxii CONTENTS
Management of Short Bowel Syndrome 161 Neoadjuvant and Adjuvant Therapy for Colorectal Cancer 259
Jon S. Thompson, MD Yilin (Linda) Cao, MD, and Nilofer Azad, MD
Management of Radiation-Induced Injury to the Small Management of Peritoneal Surface Malignancies 267
and Large Bowel 171 Fabian M. Johnston, MD, and Juliet Siena Lumati, MD
Sophia Y. Chen, MD, MPH, and Chady Atallah, MD
Management of Lower Gastrointestinal Bleeding 274
Anna Liveris, MD, and Peter Muscarella II, MD
Management of Liver Hemangioma 363 Management of Common Bile Duct Stones 476
Victor M. Zaydfudim, MD, MPH, and Reid B. Adams, MD Artem Shmelev, MD, Shirali T. Patel, MD, and Steven C. Cunningham, MD
Management of Malignant Liver Tumors 375 Management of Benign Biliary Strictures 486
Danielle K. DePeralta, MD, and Matthew J. Weiss, MD, MBA Heather A. Lillemoe, MD, and Keith D. Lillemoe, MD
Hepatic Malignancy: Resection Versus Transplantation 380 Management of Cystic Disorders of the Bile Ducts 491
Sharon R. Weeks, MD, and Shane E. Ottmann, MD Sean P. McGuire, MD, and Nicholas J. Zyromski, MD
Management of Colorectal Liver Metastases 384 Management of Primary Sclerosing Cholangitis 497
Jordan M. Cloyd, MD, and Timothy M. Pawlik, MD, MPH, PhD Gillian M. Ahrendt, MD, and Steven A. Ahrendt, MD
Ablation of Colorectal Carcinoma Liver Metastases 391 Management of Intrahepatic, Perihilar, and Distal
Naomi M. Sell, MD, MHS, Zhi Ven Fong, MD, PhD, Extrahepatic Cholangiocarcinoma 501
and Kenneth K. Tanabe, MD Mohammad Al Efishat, MD, and William Reece Burns, MD
Genetic Testing and High-Risk Pancreatic Cancer Incisional, Epigastric, and Umbilical Hernias 671
Screening 587 Hien T. Nguyen, MD, MBA, and Katherine McDermott, MD
Daniel J. Delitto, MD, PhD, and Kevin E. Behrns, MD
Management of Spigelian, Obturator, and Lumbar Hernias 678
Management of Periampullary Cancers 589 Ajita S. Prabhu, MD
Stephanie Young, MD, MPH, and Susan Tsai, MD, MHS
Athletic Pubalgia 686
Management of Complications after the Whipple Samer Sbayi, MD, MBA, and Konstantinos Spaniolas, MD
Procedure 599
Abdominal Wall Reconstruction 693
Fabio Casciani, MD, and Charles M. Vollmer Jr., MD
Dina Podolsky, MD, Kelly H. Tunder, DO, and Yuri W. Novitsky, MD
Vascular Reconstruction During the Whipple
Loss of Domain in Abdominal Wall Reconstruction 702
Operation 606
Yewande Alimi, MD, David Hindin, MD, and Carla M. Pugh, MD, PhD
Benedict Kinny-Köster, MD, and Jin He, MD, PhD
Use of Various Meshes in Hernia Repair 708
Palliative Interventions for Patients with Operable and
Adrienne N. Christopher, MD, and John P. Fischer, MD, MPH
Advanced Pancreatic and Periampullary Cancer 609
Ashley Krepline, MD, Susan Tsai, MD, MHS, and Douglas B. Evans, MD
Transplantation of the Pancreas 641 Pregnancy and Breast Cancer Management 740
Niraj M. Desai, MD, and James F. Markmann, MD, PhD Jessica M. Pastoriza, MD, Ranim Alsaad, MD, and David M. Euhus, MD
Total Pancreatectomy and Islet Autotransplantation for Ablative Techniques in the Treatment of Benign and
Chronic Pancreatitis 646 Malignant Breast Disease 746
Isabel S. Dennahy, MD, Christi Walsh, MSN, CRNP, Marissa Vane, MD, MSc, and Armando E. Giuliano, MD, FACS, FRCSEd
and Martin A. Makary, MD, MPH Lymphatic Mapping and Sentinel Lymphadenectomy 749
Roi Weiser, MD, and V. Suzanne Klimberg, MD, PhD, MSHCT
Management of Male Breast Cancer 779 Cardiovascular Disease Risk Reduction After Bariatric
Austin D. Williams, MD, MSEd, Kaitlyn Kennard, MD, Surgery 884
and Ned Z. Carp, MD Robert C. Ross, MD, Vance L. Albaugh, MD, PhD, and Philip R. Schauer, MD
Breast Implant-Associated Anaplastic Large Cell Lymphoma 805 Nerve Injury and Repair 937
Melissa S. Camp, MD, and Michele Ann Manahan, MD, MBA Christopher Frost, MD, and Gedge D. Rosson, MD
Surgeon’s Use of Ultrasound in the Trauma and Critical Care Abdominal Compartment Syndrome and Management
Settings 1243 of the Open Abdomen 1374
Alisa Cross, MD, and Grace F. Rozycki, MD, MBA Crisanto M. Torres, MD, and Alistair J. Kent, MD, MPH
Emergency Department Resuscitative Thoracotomy 1252 Abdomen That Will Not Close 1387
Ryan B. Fransman, MD, and David T. Efron, MD Stephen L. Barnes, MD, and Jacob A. Quick, MD
Chest Wall Trauma, Hemothorax, and Pneumothorax 1264 Endovascular Management of Vascular Injuries 1405
Raul Coimbra, MD, PhD, and David B. Hoyt, MD Joseph V. Lombardi, MD, Mikael A. Fadoul, MD,
and Marissa Famularo, DO
Management of Pulmonary Parenchymal Injury 1270
Alison M. Bales, MD, and Mary C. McCarthy, MD Extremity Compartment Syndrome 1411
Charles E. Lucas, MD, and Anna M. Ledgerwood, MD
Blunt Abdominal Trauma 1275
L.D. Britt, MD, MPH, and Michael Martyak, MD Burn Wound Management 1418
Christina Lee, MD, Philip S. Barie, MD, MBA,
Penetrating Abdominal Trauma 1288
and Abraham P. Houng, MD, MSE
David V. Feliciano
Medical Management of the Burn Patient 1422
Management of Diaphragmatic Injuries 1293
Robert Sheridan, MD, and Jeremy Goverman, MD
Kazuhide Matsushima, MD, and Kenji Inaba, MD
Cold-Induced Injuries and Hypothermia 1428
Management of Traumatic Liver Injury 1299
Sean Hickey, MD, and Colleen M. Ryan, MD
Elizabeth R. Benjamin, MD, PhD, and Deepika Koganti, MD
Electrical and Lightning Injury 1433
Pancreatic and Duodenal Injuries 1305
Leigh Ann Price, MD, and Laurie Anne Loiacono, MD
Madhu Subramanian, MD, and Elliott R. Haut, MD, PhD
Management of Postoperative Delirium 1507 Acute Kidney Injury in the Injured and Critically Ill 1554
Amballur David John, MD, and Frederick Sieber, MD Gary A. Bass, MD, MSc, MBA, PhD, Niels D. Martin, MD,
and Lewis J. Kaplan, MD
Acid-Base Disorders 1564
Surgical Critical Care Zachary Obinna Enumah, MD, PhD, MA, and James E. Harris Jr., MD
COVID-19 and Health Care Delivery Catheter Sepsis in the Intensive Care Unit 1568
in a Pandemic 1513 Anamaria J. Robles, MD, and Christine S. Cocanour, MD
Michael S. Burnim, MD, and Brian T. Garibaldi, MD
Septic Response and Management 1572
Surgical Palliative Care 1517 Chris Cribari, MD, and Joel Elterman, MD
Avani Amin, MD, Brenda S. Nettles, DNP, ACNP-BC,
Multiple Organ Dysfunction and Failure 1576
and Thomas J. Smith, MD
Alexandra B. Roginsky, MD
Cardiovascular Pharmacology 1522
Antibiotics in Surgical Critical Care 1582
John Nikolhaus Smith, MD, Thomas S. Metkus Jr., MD, PhD,
Walter Cholewczynski, MD, and Eric Tsung, MD
and Glenn J.R. Whitman, MD
Endocrine Changes with Critical Illness 1592
Glucose Control in the Postoperative Period 1528
Laura M. Adams, MD, and Jay J. Doucet, MD, MSc, FRCSC
Reyna Gonzalez, MD, and Krista L. Kaups, MD
Nutrition Therapy in the Critically Ill Surgical
Postoperative Respiratory Failure 1531
Patient 1597
Christina Maria Regelsberger-Alvarez, DO, Jack P. Vernamonti, MD,
Jason Sperry, MD
and Pauline K. Park, MD
Coagulation Issues and the Trauma Patient 1604
Ventilator-Associated Pneumonia 1537
Nadia Ijaz, MD, and Michael B. Streiff, MD
Katherine L. Florecki, MD, MPH, Li Ting Tan, MBBS, Traci M. Grucz,
PharmD, BCCP, and Mariuxi C. Manukyan, MD Post–Intensive Care Syndrome 1615
Pamela A. Lipsett, MD, MHPE, and Katherine L. Florecki, MD
Extracorporeal Membrane Oxygenation for Respiratory
Failure 1541 Index 1621
Fatima G. Wilder, MD, MS, and Errol L. Bush, MD
Video Contents
Enteral Stents in the Treatment of Colonic Obstruction Management of Spontaneous and Secondary Pneumothorax
Uncovered self-expandable metal stent (USEMS) in malignant colonic Normal lung sliding
stricture process Absence of lung sliding with no shimmering appearance of bright
pleural line
Management of Spigelian, Obturator, and Lumbar Hernias
Laparoscopic obturator repair Acute Mesenteric Ischemia
Laparoscopic lumbar hernia repair Acute embolic mesenteric ischemia in the setting of chronic SMA
Reverse transversus abdominis release (reverse TAR) atherosclerosis and IMA occlusion following open exploration,
Mesh fixation utilizing bone anchors resection, and SMA endarterectomy
xxxix
The American Board of Surgery
Certifying (Oral) Examination
of Surgery Certifying The content of the Certifying Examination is generally aligned with
the ABS SCORE Curriculum Outline. The majority of the exam will
(Oral) Examination focus on topics that are listed among the core content of the curric-
ulum. The remainder of the exam will be on complications of these
basic scenarios or may be taken from the advanced portion of the
Jo Buyske, MD, and Daniel L. Dent, MD curriculum.4 While each exam roster contains 12 cases, the content
for the exam comes from 13 question-writing committees. There
PRINCIPLE is some overlap of the content between committees. For example,
a case of septic shock secondary to a colonic perforation from an
The American Board of Surgery (ABS) was founded in 1937, with a incarcerated hernia could have been put forward as content from
mission to protect the public and enhance the profession. At the time, the colorectal, hernia, or critical care committees. Each roster of
the standards for becoming a surgeon were vague and inconsistent. cases is reviewed for breadth of content and consistency of difficulty
Some people did a Halstedian residency. Some apprenticed them- relative to historical performance of the individual questions so exam
selves to surgeons. Others did internships and then were self-taught, difficulty is consistent across all rosters. Because the candidate will
or they skipped formal training altogether. The public had no way to also be tested as to baseline surgical knowledge on the qualifying
distinguish the training or skill of these practitioners. The ABS and the (written) exam, it is not generally expected that the candidate will
certification process was a way to set standards for the profession and be asked to regurgitate basic surgical facts. With that said, the candi-
to provide a testimonial to patients that their surgeon was qualified. date can expect that some questions may include a list of questions
Certification by the ABS is the culmination of surgical training. It asking how the candidate’s management plan might change in the
is a testimonial to quality, knowledge, and judgment based on several face of variations of patient presentation or pathologic findings, or
distinct components. First, training in an Accreditation Council for in the setting of intraoperative or postoperative complications. This
Graduate Medical Education (ACGME)-accredited training pro- should not necessarily be interpreted as meaning that the candidate
gram is a prerequisite for certification in nearly all cases. Second, is off track, but rather is a way of probing the candidate’s skill and
candidates must meet the standards of training as set by the ABS, judgment in managing a variety of situations.
including things like passing knowledge and skills tests in laparos-
copy (FLS), endoscopy (FES), trauma (ATLS), and cardiovascular PROCESS
events (ACLS). Candidates must meet case minimums both in the
early years of training to “prepare the soil” and also during the chief The Certifying Examination consists of three exam sessions that
year to demonstrate maturation. There are time requirements, and each last 30 minutes. In each session, the candidate will be presented
required observations of both clinical and operative skills. Third is with four case scenarios. Two examiners are used in each session
a knowledge exam, the Qualifying Examination. The Qualifying or to help ensure the validity of the exam. All examiners are in active
written examination is a 300-plus question, computer-based multiple practice, currently certified by the ABS, and participating in the
choice exam designed to test foundational knowledge.1 Finally, after ABS Continuous Certification Program. All of the examiners have
all of these other qualifications have been met, the Certifying, or oral taken the certifying exam themselves, some of them more than once.
examination, is a test of judgment and applied knowledge. The two Examiners are all volunteers, and they do not receive any financial
tests measure different assets, and candidates’ performance is not compensation for their service.5–7
predictable across the two exams. That is to say, doing well on one The examiners will typically alternate in presenting the case
exam does not predict doing well on the other exam. They measure information to the candidate. In presenting the case scenarios, the
different attributes, and each one is important to fulfill the ABS mis- goal of the examiners is to provide a clear description of each case.
sion of serving the public and the profession.2 It is the intent of the examiners to provide sufficient information at
The Certifying Examination consists of a series of carefully cre- each step in the case so the candidate may make pertinent decisions
ated scenarios. The scenarios are the tool that supports the examiners on how to progress in the workup and treatment of the patient.
in their charge, which is to “evaluate a candidate’s clinical skills in The COVID-19 pandemic presented a new challenge for the
organizing the diagnostic evaluation of common surgical problems administration of the Certifying Examination. The inability to
and determining appropriate therapy. Emphasis is placed on candi- administer the exam in person created a need to administer the exam
dates’ ability to use their knowledge and training to “safely, effectively in a virtual format. In the 2020–2021 academic year, the exam was
and promptly manage a broad range of clinical problems.” Addition- administered with all candidates and examiners participating virtu-
ally, “Technical details of operations may also be evaluated, as well ally. This necessitated some modifications to the timing of the exam,
as issues related to a candidate’s ethical and humanistic qualities.”3 specifically that each room was given an extra 5 minutes in case of
1
2 The American Board of Surgery Certifying (Oral) Examination
technical difficulties. The time allotted to answering questions did information to give a passing grade, such as when the candidate
not change; if the extra time was not needed, then there was simply spends more time asking questions than answering them, or
a short break between sessions. The candidates found the experience when the candidate makes multiple noncritical errors while also
to be fair and the vast majority support keeping the exam in a virtual making a number of correct management choices. The examiners
format going forward.8 are charged with assessing the following characteristics of the
candidate’s performance:
PREPARATION
■ Demonstrates an organized approach and solid rationale for
The ideal preparation for the Certifying Examination is to have suc- planned actions.
cessfully provided evidence-based care for each condition that will be ■ Rapidly determines and interprets key findings in a clinical
covered during the exam. Surgical residency, as currently structured presentation.
by the parameters of the ACGME, Residency Review Committee ■ Effectively and efficiently uses clinical knowledge to solve clinical
(RRC), and ABS, provides strong foundation for the exam. Given the problems; effectively addresses key management points.
breadth of general surgery, however, it is likely that candidates will ■ Avoids errors and critical fails (omission and commission) asso-
encounter scenarios they have not seen in training. Before taking the ciated with the case.
exam, candidates are encouraged to practice taking oral exams with ■ Recognizes personal limitations in knowledge and expertise
colleagues who have successfully completed the examination process when diagnosing and treating clinical problems.
as the concise oral presentation of decision making benefits from ■ Reacts in a prompt but flexible manner to alterations in the
repetition and practice. In doing so, the candidate should practice patient’s course (e.g., disease or treatment complications).
case scenarios over a wide range of pathologic conditions. Specific ■ Overall, demonstrates appropriate surgical judgment, clinical
recommendations for preparing for the exam include the following: reasoning skills, and problem-solving ability.2,3
■ Practice clarity of communication with regard to explaining the In answering the examiners’ questions, candidates should be able
decision-making process. to not only state what they would do, but also concisely explain how
■ Practice anatomic descriptions of common procedures (e.g., and why they would provide the stated care.5
inguinal herniorrhaphy) as verbalizing operative anatomy can be
challenging in a high-stakes setting. SUMMARY
■ Recognize that the goal of the exam is to convey how one would
actually safely manage a patient, not to try to guess what the The ABS Certifying Examination is an assessment of a surgeon’s
examiners want to hear. thought processes in managing surgical conditions. Board certifica-
■ Plan for management of complications and consequences of treat- tion is the culmination of targeted training in accredited programs,
ment decisions. For example, in appropriately selected patients meeting specific training requirements in order to be eligible for the
with colon pathology, it may be appropriate to perform primary exam process, and then passing a written foundational knowledge
anastomosis. However, the candidate should also know how to exam and an oral exam of judgment delivered by trained surgical
handle the potential consequence of an anastomotic leak. Con- examiners. The process serves as a testimonial that board-certified
versely, if the candidate initially chooses to manage the patient surgeons have met the standards established by the profession.
with a colostomy, it is reasonable to expect that the candidate can
also manage ostomy ischemia and parastomal hernia.
■ Recognize that the exam is not a multiple-choice exam and that Suggested Readings
each case discussion is an ongoing conversation. As the case
1. The American Board of Surgery. Training and Certification. General
evolves, the optimal management evolves with it. For example, Surgery Qualifying Examination (QE) https://www.absurgery.org/default.
it may be appropriate to initially manage a patient nonopera- jsp?certgsqe.
tively but then convert to operative management if the patient’s 2. Kopp J, Ibanez B, Jones A, et al. Association between American Board
condition changes. of Surgery General Surgery Initial Certification and risk of receiv-
ing severe disciplinary actions against medical licenses. JAMA Surg.
2020;155(5):e200093.
ASSESSMENT 3. The American Board of Surgery. Training and Certification. General
Examiners receive standardized training before giving an exam. This Surgery Qualifying Examination (QE). https://www.absurgery.org/
includes practice scoring, implicit bias training, and team review default.jsp?certcehome.
4. The American Board of Surgery. Training and Certification. SCORE
of the scenarios. In addition, examiners routinely get formative Curriculum Outline for General Surgery. https://www.absurgery.org/
feedback from observers and their co-examiners. Finally, examiner default.jsp?scre_booklet.
scoring patterns are evaluated from a psychometric perspective, 5. The American Board of Surgery. Training and Certification. Taking
looking at patterns of consistency and severity as well as any evidence the CE—What to Expect. https://www.absurgery.org/default.jsp?certce_
of bias.9 whattoexpect.
6. The American Board of Surgery. Training and Certification, CE Candidate
■ Each examiner records a score for each case to maximize the Video. https://www.absurgery.org/default.jsp?certce_video.
number of independent observations that contribute to the can- 7. The American Board of Surgery. Training and Certification. FAQs.
didate’s total score. A total score that reflects the ability to safely htttp://www.absurgery.org/default.jsp?faq_gsce.
8. Chen H, Tseng JF, Chaer R, et al. Outcomes of the First Virtual General
care for the broad array of cases that are presented over the course Surgery Certifying Exam of the American Board of Surgery. Ann Surg.
of the exam is considered a passing grade. There is no preset pass 2021;274(3):467–472.
or fail rate for the exam. On each scenario, candidates may be 9. Ong TQ, Kopp JP, Jones AT, Malangoni MA. Is there gender bias on the
given a passing grade, a failing grade, or an equivocal grade. The American Board of Surgery General Surgery Certifying Examination?
equivocal grade is given when the examiners do not have enough J Surg Res. 2019;237:131–135.
Esophagus
Esophageal Function tip in the stomach. Characteristics of the pressure waveform after a
swallowing event allow for the recognition of the UES, the esoph-
Tests ageal body, the LES, and the gastric cardia (Fig. 1). However, con-
ventional manometry has several limitations including: (1) widely
spaced sensors that preclude information on motor activity less than
Wasay Nizam, MBBS, Hamza Khan, MD, and 5 cm apart, (2) unidirectional sensors unable to record pressures
Malcolm V. Brock, MD accurately in an asymmetrical lumen, and (3) false pressure readings
during swallowing because of the tendency of the sphincters to move
cephalad, dislodging the catheter.
3
4 Esophageal Function Tests
30 6
Esophageal body
50 11
Length
Fifth channel 70 16
with 4 sensors
at the same
level
90 21
Resp.
FIG. 1 Esophageal manometry 100
showing a transnasally placed cathe- Lower esophageal sphincter
18
ter that records a normal waveform Time
progression. Newer solid-state cathe-
ters have sensors placed 1 cm apart.
FIG. 2 Clouse plot showing a peristaltic wave after swallowing in a healthy individual. (From Baldwin D, Puckett Y. Esophageal manometry. Updated Sep 28,
2021. In: StatPearls. Treasure Island, FL: StatPearls Publishing; 2021. https://www.ncbi.nlm.nih.gov/books/NBK559237/.)
it helped accelerate esophageal HRM’s current position as the state- the supine position for 10 wet (5-mL) swallows spaced 30 seconds
of-the-art diagnostic tool that has thoroughly replaced conventional apart. This is followed by a single multiple rapid swallow sequence
line tracing. Before the procedure, patients are obliged to fast for a (five 2-mL swallows, 2–3 seconds apart) that can be repeated up to
minimum of 4 hours, and then the procedure begins with patients in three times. Following this, the patient is placed upright and given
E so p h ag us 5
five additional wet swallows and one rapid drink challenge (200 mL anesthesia is used. It is an outpatient procedure requiring no seda-
of water ingested as fast as possible). More provocative testing may tion, and patients can drive home afterward. It is important, however,
include the utilization of a solid swallow test, a solid test meal, or that patients stop H2-blockers, proton pump inhibitors, opioids,
even pharmacologic provocation. Pressure sensors within the body nitrates, and calcium channel blockers before the study to avoid any
of the catheter then record intraluminal pressure that is transmitted interference with testing. Furthermore, it must be remembered that
to an external recording device. Clouse plots generated from HRM patients with a history of esophageal surgery, peptic stricture, or
are interpreted with consideration of the following five metrics: those with a current hiatal hernia are prone to false readings.
1. Integrated relaxation pressure (IRP): the average deglutitive relax- ESOPHAGEAL pH MONITORING
ation pressure in a 4-second window beginning at UES relaxation
2. Distal contractile integral: the product of amplitude, duration, Acid reflux into the esophagus may be assessed with intraluminal pH
and length of the distal esophageal contraction monitoring. This can be performed with catheter-based devices or a
3. Distal latency: the interval between UES relaxation and the con- wireless device (Bravo probe, Medtronic, Minneapolis, MN). Cathe-
tractile deceleration point ter-based devices are inserted transnasally, with the distal pH probe
4. Peristaltic breaks located approximately 5 cm above the LES. This device is then left in
5. Pressurization patterns situ for 24 hours with patients instructed to record meals, symptoms,
and periods of sleep by pressing buttons on a recorder. A wireless
Information from these indices may be applied toward the diag- device is placed endoscopically in the distal esophagus and attached to
noses of esophageal motility disorders. The Chicago Classification the esophageal mucosa with a clip. This device then transmits informa-
broadly divides these disorders into disorders of esophagogastric tion to a recorder. As there is no external component to this method,
junction (EGJ) outflow or of peristalsis. A useful algorithm presented patient activities, dietary patterns, and comfort levels are more natural.
in the classification then allows for the delineation of specific disor- Furthermore, because this is a single device, pH levels are only assessed
ders, based on manometry findings (Fig. 3). at a single level, rather than across the length of the esophagus.
HRM is the preferred diagnostic tool when evaluating esophageal pH monitoring is used to determine whether or not acid expo-
motor function, especially when radiologic or endoscopic studies are sure to the esophagus is physiologic. Data gathered from the probe
unable to explain the patient’s symptoms. It is safe, with a low-risk are correlated with symptoms, patient positioning, and relation to
profile of complications that is similar to those of nasogastric tube meals. The information from the device is then used to calculate a
placement, namely, gagging, oropharyngeal discomfort, epistaxis, composite pH or DeMeester score. Scores of 14.72 (95th percentile
and rarely aspiration or perforation. Diet can be resumed immedi- of normal) or greater are considered abnormal. The components of
ately following removal of the catheter because only topical nasal the DeMeester score include the following:
FIG. 3 Esophageal motility disorders on high-resolution manometry: Chicago classification version 4.0 Hierarchical Classification Scheme. EGJOO,
Esophagogastric junction outflow obstruction; FLIP, functional lumen imaging probe; IBP, intrabolus pressurization; IRP, integrated relaxation pressure; LES,
lower esophageal sphincter; MRS, multiple rapid swallows; PEP, pan-esophageal pressurization; RDC, rapid drink challenge; TBE, timed barium esophagram.
(From Yadlapati R, Kahrilas PJ, Fox MR, et al. Esophageal motility disorders on high-resolution manometry: Chicago classification version 4.0. Neurogastroenterol Motil.
2021;33:e14058.)
6 Esophageal Function Tests
Bolus entry
1. Percent total time pH <4 probe, and within the balloon, electrodes are present, enabling the
2. Percent upright time pH <4 detection of impedance. The balloon may be inflated with saline in
3. Percent supine time pH <4 10-mL increments up to 70 mL. The data from the sensors are then
4. Number of reflux episodes converted in real time to allow for assessment of the various metrics
5. Number of reflux episodes ≥5 minutes such as wall stiffness, pressure changes, diameter, volume, and EGJ
6. Longest reflux episode (in minutes) dynamics. FLIP panometry may be used as a complementary tool in
diagnosing esophageal motility disorders as well as intraoperatively
IMPEDANCE TESTING during antireflux procedures to assess the adequacy of esophageal
wraps.
Impedance testing utilizes the principles of current resistance. A
long flexible catheter with 6 to 8 sensors is placed transnasally for CONCLUSION
24 hours, with patients instructed to proceed with normal activity.
The tube is connected to a small receiver for data recording. A small Esophageal function testing can provide valuable information regard-
voltage is applied between two electrodes. In principle, at resting ing the biomechanics of esophageal motility. The practicing surgeon
state, an electrical charge within the esophageal mucosa carries must be well aware of the utility of these tests and be able to interpret
current between the catheter sensors. Because liquids permit faster them in light of the patient’s symptoms. Optimal outcomes require
ion conductivity, a liquid bolus will be sensed as a rapid decrease in close collaboration between the radiologist, gastroenterologist, and
impedance (resistance) between the sensors. In contrast, air is a poor surgeon within the clinical realm to treat these complex patients.
conductor, and swallowed air boluses will be detected as increased As technology evolves, newer testing techniques may improve our
impedance. Based on the direction of change, this can assess both understanding of complicated esophageal disease and assist with
antegrade and retrograde movement (normal peristalsis or gastro- intervention.
esophageal reflux). Data on change in impedance gathered from
multiple electrodes along the catheter is then used to determine the
position of a bolus after swallowing and whether there is reflux back Suggested Readings
into the esophagus after it has entered the stomach (Fig. 4). Special
impedance catheters are also available that combine impedance Gyawali CP, Bredenoord AJ, Conklin JL, et al. Evaluation of esophageal motor
testing with assessment of esophageal pH sensors and manometry function in clinical practice. Neurogastroenterol Motil. 2013;25(2):99–133.
testing (high-resolution impedance manometry [HRIM]), allowing Hamer PW, Holloway RH, Crosthwaite G, et al. Update in achalasia: what the
surgeon needs to know. ANZ J Surg. 2016;86(7-8):555–559.
for improved diagnosis. Pandolfino JE, Kahrilas PJ; American Gastroenterological Association.
AGA technical review on the clinical use of esophageal manometry.
FUNCTIONAL LUMINAL IMAGING PROBE Gastroenterology. 2005;128(1):209–224.
PANOMETRY van Hoeij FB, Bredenoord AJ. Clinical application of esophageal high-res-
olution manometry in the diagnosis of esophageal motility disorders. J
Functional luminal imaging probe (FLIP) panometry is an emerg- Neurogastroenterol Motil. 2016;22(1):6–13.
ing technology in esophageal function testing used in concert Yadlapati R, Kahrilas PJ, Fox MR, et al. Esophageal motility disorders
with endoscopy. It is performed with a catheter possessing a distal on high-resolution manometry: Chicago classification version 4.0©.
overlying balloon. The tip of the catheter functions as an imaging Neurogastroenterol Motil. 2021;33(1):e14058.
Another random document with
no related content on Scribd:
science, has not been able to distract me from it? Let not your
Excellency think it self-praise in me, if I am bold to present to you my
defence.
When I was studying in the School of the Redeemer, I was
surrounded on all sides with powerful obstacles that made against
science, and in those years the influence of these tendencies was
almost insurmountable. On the one hand, my father, who had never
had any other children but me, said that in leaving him I, being his
only son, had left all his possessions (such as they were in those
parts), which he had acquired for me in the sweat of his brow, and
which strangers would carry away after his death. On the other hand,
I was confronted with unspeakable poverty: as I received but three
kopeks a day, all I dared spend a day for food was half a kopek for
bread and half a kopek for kvas, while the rest went for paper, shoes
and other necessities. In this way I passed five years, and did not
abandon study. On the one hand, they wrote to me that, knowing the
well-being of my father, well-to-do people of my village would give
me their daughters in marriage, and in fact they proposed them to
me, when I was there; on the other hand, the small schoolboys
pointed their fingers at me, and cried: “Look at the clodhopper who
has come to study Latin at the age of twenty!” Soon after that I was
taken to St. Petersburg, and was sent abroad, receiving an
allowance forty times as large as before. But that did not divert my
attention from study, but proportionately increased my eagerness,
though there is a limit to my strength. I most humbly beg your
Excellency to feel sure that I will do all in my power to cause all
those who ask me to be wary in my zeal to have no anxiety about
me, and that those who judge me with malicious envy should be put
to shame in their unjust opinion, and should learn that they must not
measure others with their yardstick, and should also remember that
the Muses love whom they list.
If there is anyone who persists in the opinion that a learned man
must be poor, I shall quote on his side Diogenes, who lived in a
barrel with dogs, and left his countrymen a few witticisms for the
increase of their pride; on the other side I shall mention Newton, the
rich Lord Boyle, who had acquired all his glory in the sciences
through the use of a large sum of money; Wolff, who with his lectures
and presents had accumulated more than five hundred thousand,
and had earned, besides, a baronetcy; Sloane, in England, who had
left such a library that no private individual was able to purchase it,
and for which Parliament gave twenty thousand pounds. I shall not
fail to carry out your commands, and remain with deep respect your
Excellency’s most humble servant, Mikháylo Lomonósov. St.
Petersburg, May 10, 1753.
II
MORNING MEDITATIONS
EVENING MEDITATIONS
ON SEEING THE AURORA BOREALIS
[134] To his patron, upon his having expressed his fear that
Lomonósov would lose his zeal for the sciences when he
received the gift of an estate from the Empress.
[135] Kalchák-pasha was the commander of Khotín.
Alexander Petróvich Sumarókov. (1718-1777.)
Sumarókov is the first litterateur of Russia, that is, the first
man to regard literature as a profession, independently of an
official position. After graduating from the military school, in
1740, he served for a while under some military commanders,
but devoted all his leisure time to writing poetry according to
the rules laid down by Tredyakóvski. There was no species of
poetical literature in which he did not try himself and did not
produce prolifically. He has left odes, eulogies, fables, satires
and dramas. In many of these he broke virgin soil in Russia,
and in his unexampled conceit he was not slow to proclaim
his highest deserts: “What Athens has seen and Paris now
sees, after a long period of transition, that you, O Russia,
have perceived at once by my efforts.” In spite of his
mediocrity and acquaintance with only the pseudo-classic
French style (for he disdained all serious study of antiquity),
Sumarókov was highly valued in his day, and his example has
done much to advance Russian literature. In 1756 the
Russian Theatre was created by a decree of the Senate, and
Sumarókov was chosen as its first director. To fill his
repertoire, he was compelled to write plays himself, and he
produced them with astounding facility. His best drama is
probably The False Demetrius, though there is little historical
truth in it. In 1761 he issued the first independent journal, The
Industrious Bee, which, however, was filled mainly with his
own writings. Sumarókov’s influence on Russian letters lasted
up to the time of Púshkin, though Karamzín was the first to
doubt his greatness.
Sumarókov’s The False Demetrius has been translated into
English: Demetrius the Impostor; a tragedy [in five acts and in
prose], translated from the Russian, London, 1806.
Act II., Scene 7, is also given in C. E. Turner’s Studies in
Russian Literature, and, the same, in Fraser’s Magazine,
1877.
THE FALSE DEMETRIUS
SCENE 7
Demetrius (alone). My crown lies not firmly upon my head, and the
end of my greatness is at hand. Each moment I expect a sudden
change. O Kremlin’s walls that frighten me! Meseems each hour you
announce to me: “Villain, you are a foe, a foe to us and the whole
land!” The citizens proclaim: “You have ruined us!” And the temples
weep: “We are stained with blood!” The fair places about Moscow
are deserted, and Hell from its abyss has oped its jaws at me; I see
the sombre steps that lead to the infernal regions, and the tormented
shades of Tartarus: I am already in Gehenna, and burn in the flame; I
cast my glance to heaven, and see the celestial regions: there are
good kings in all the beauty of their natures, and angels besprinkle
them with dew of paradise; but what hope have I to-day in my
despair? I shall be tormented in eternity even as I suffer now. I am
not a crowned potentate in a magnificent city, but an evil malefactor,
in hell tormented. I perish, dragging a multitude of the people to
destruction. Flee, tyrant, flee! From whom?—From myself, for I see
no one else before me. Run! But whither? Your hell is ever with you!
The assassin is here, run! But I am that assassin! I tremble before
myself, and before my shade. I shall avenge myself! On whom?
Myself. Do I hate myself? I love myself! For what? I see it not. All cry
against me: rapine, unfair justice, all terrible things,—they cry
together against me. I live to the misfortune, shall die to the fortune
of my nearest. The fate of men, the lowliest, I envy: even the
mendicant is sometimes happy in his poverty. But I rule here,—and
am always tormented. Endure and perish, having ascended the
throne by deceit! Drive, and be driven! Live and die a tyrant!
INSTRUCTION TO A SON
Perceiving his tearful end near at hand, a father thus instructed his
beloved, only begotten son:
“My son, beloved son! I am old to-day; my mind grows dull, my
fervour is all gone; I am preparing to go before the Judge, and shall
soon pass to eternity, the immeasurable abode of mortals. So I wish
to tell you how you may live, and to show you the road to happiness.
You will travel over a slippery path: though all in the world is vanity,
yet why should one disdain happiness in life? Our whole mind ought
to be bent upon obtaining it, and our endeavour should be to get all
we need.
“Give up that chimera which men call honour; of what good is it
when you have nothing to eat? It is impossible to get along in
commerce without cheating, and in poverty without dishonesty and
theft. By hook and by crook I have scraped together a fortune for
you; now, if you should squander it all, I shall have sold my soul in
vain. Whenever I think of that, my rest is gone.
“Increase your income, keep indolence from your heart, and keep
your money against an evil day. Steal, if you can steal, but do it
secretly,—by all means increase your income every year! The eye is
not satisfied with mere looking on. If you can cheat, cheat artfully, for
’tis a shame to be caught in the act, and it often leads to the gallows.
Make no acquaintances for the mere sake of knowing them, but put
your spoon there where the jam is thickest! Revere the rich, to get
your tribute from them. Never tire praising them with condescension;
but if they be distinguished people, subdue them by creeping!
“Be humble with all men, and simulate! If a mighty person chides
anyone, together with the mighty chide him! Praise those whom the
powerful praise, and belittle those they belittle! Keep your eyes wide
open and watch whom great boyárs are angry with.
“If you walk upon the straight road, you will find no fortune. Swim
there where favourable winds carry you! Against men whom the
people honour speak not a word; and let your soul be ever ready to
thank them, though you receive nothing from them! Endeavour to
speak like them. Whatever the puissant man says are sacred words;
never contradict him, for you are a small man! If he say red of that
which is black, say too: ‘’Tis rather red!’ Before low-born men rave
like a devil; for if you do not, they will forget who you are, and will not
respect you: the common people honour those who are haughty. But
before the high-born leap like a frog, and remember that a farthing is
as nothing in comparison with a rouble. Big souls have they, but we,
my beloved son, have only little souls! Be profuse in thanks, if you
expect some favour from your benefactor; spare your thanks where
you have nothing to gain, for your grateful spirit will be lost.
“Do yourself no injury, and remain honest to yourself, loving
yourself most sincerely! Do no injury to yourself, but for others have
only appearances, and remember how little wisdom there is in the
world, and how many fools. Satisfy them with empty words: honour
yourself with your heart, but others with your lips, for you will have to
pay no toll for fondling them. Let others think that you place yourself
much lower than them, and that you have little regard for yourself;
but do not forget that your shirt is nearer to your body than your
caftan!
“I will allow you to play cards, provided you know how to handle
them. A game without cunning has no interest, and playing you must
not sacrifice yourself to others. Whatever game you play, my son,
remember not to be always honest!—Have contempt for peasants,
seeing them below your feet, but let your lips proclaim the puissant
as gods, and speak no surly word to them. But love none of them, no
matter what their worth, though their deeds be trumpeted through the
subsolar world! Give bribes, and yourself accept them! When there
are no witnesses, steal and cheat as much as you please, but be
wary with your misdoings in presence of witnesses! Change the
good that there is in people into evil, and never say a good word of
another! For what are you to gain from praising them? Indeed, their
virtues put you only in a bad light. Go not out of the way to serve
another, where there is no gain for you.
“Hate the learned, and despise the ignorant, and ever keep your
thoughts fresh for your own advantage! Above all, beware of getting
into the satire of impudent scribblers! Disturb and break the ties of
families, friendship and marriage, for ’tis more convenient to fish in
muddy waters. Know no love, family nor friends, for ever holding
yourself alone in mind! Deceive your friends, and let them suffer
through you sorrow and misfortune, if you are the winner thereby!
Garner your fruits wherever you can! There are some who foolishly
call it dishonest to bring woes to your friends, but they do not see
that duty teaches me only to love myself, and that it is not at all
dishonourable when necessity demands that others perish: it is
contrary to nature not to love yourself best. Let misfortune befall my
country, let it go to the nethermost regions; let everything that is not
mine be ruined,—provided I have peace.
“Forget not my rules! I have left you my fortune and my wisdom.
Live, my son, live as your father has lived!”
He had barely uttered these words, when he was struck by
lightning, and he departed from his child and home; and the soul that
had for so long been disseminating poison flew out of the body and
took its flight to hell.
FOUR ANSWERS
You ask me, my friend, what I would do: (1) if I were a small man
and a small gentleman; (2) if I were a great man and a small
gentleman; (3) if I were a great man and a great gentleman; (4) if I
were a small man and a great gentleman. To the first question I
answer: I should use all my endeavour to become acquainted in the
houses of distinguished people and men of power; I would not allow
a single holiday to pass, without making the round of the city, in
order to give the compliments of the season; I would walk on tiptoes
in the antechambers of the mighty, and would treat their valets to
tobacco; I would learn to play all kinds of games, for when you play
cards you can sit down shoulder to shoulder with the most
distinguished people, and then bend over to them and say in a low