Code No: BP604T PCI SET - 1

III B. Pharmacy II Semester Regular Examinations, Oct/Nov - 2020

BIOPHARMACEUTICS AND PHARMACOKINETICS
Time: 3 hours Max. Marks: 75
Note: 1. Question paper consists of three parts (Part-I, Part-II & Part-III)
2. Answer ALL (Multiple Choice) Questions from Part-I
3. Answer any TWO Questions from Part-II
4. Answer any SEVEN Questions from Part-III
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PART –I
1. (i) Which of the following is not a rate limiting step in absorption (1M)
a) Dissolution b) Disintegration
c) Permeation d) First pass metabolism
(ii) Passive diffusion of drugs can often be described mathematically---law (1M)
a) Noys whitney b) Ficks first law of diffusion
c) Mixed order equation d) Zero order equation
(iii) ------------is the process of engulfing liquid particles by the cell (1M)
a) Pinocytosis b) Phagocytosis c) Passive diffusion d) All above
(iv) Protein bound drug is (1M)
a) Inactive b) metabolized fast
c) excreted in urine d) easily cross BBB
(v) The high pressure at the end of the arterial capillary is called-------- (1M)
a) Low blood pressure b) Hydrostatic Pressure
c) High blood pressure d) Plasma Pressure
(vi) In BBB, The capillary endothelial cells are surrounded by a layer of ---- (1M)
a) Glial cells b) Capillary membrane
c) Basement membrane d) Epithelial cells
(vii) ----------is the volume of blood flowing through the renal vasculature per (1M)
unit time
a) Renal clearence b) organ clearence
c) Renal Blood Flow d) None of the above
(viii) --------is the volume of fluid filtered from the renal glomerular capillaries (1M)
a) Drug clearance b) Glomerular Filtration rate
c) Organ clearance rate d) All above
(xi) The rapid metabolism of an orally administered drug prior to reach general (1M)
circulation is----------------
a) Entero hepatic circulation b) Biliary Excretion
c) First pass metabolism d) PulmonaryExcretion
(x) The cycle in which a drug is absorbed , excreted in to the bile and reabsorbed (1M)
is known as--------------
a) Presystemic circulation b) Entero hepatic circulation
c) Extrahepatic circulation d) All above
(xi) -----------is defined as the blood level of a drug beyond which side effects (1M)
will result
a) Minimum effective concentration b) Peak plasma concentration
c) Maximum safe Concentration d) Therapeutic level concentration

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 Code No: BP604T PCI SET - 1

(xii) -------------is defined as the total integrated area under the plasma level time (1M)
curve, expresses the total drug that comes in to the systemic circulation
a) AUC b) C max c) Tmax d) Therapeutic range
(xiii) Kidney, heart, lungs are -------------perfused (1M)
a) High b) low c) Medium d) moderate
(xiv) --------of a drug in drug product may be measured by comparing the (1M)
respective bio availabilities after an oral and intravenous bolus injection
a) Relative Bioavailability b) Bioequivalence
c) Pharmaceutical Equivalence d) Absolute Bio availability
(xv) Approximately how many half lifes it require to eliminate more than 99% of (1M)
drug ----------
a) 7 b) 6 c) 5 d) 8
(xvi) Absorption rate constant (Ka) can be determined by (1M)
a) Feathering technique b) Wagner Nelson method
c) flipflop technique d) both a&b
(xvii) To reach 99% of steady state plasma drug concentration requires approx ---- (1M)
------- half lifes
a) 3-4 b) 4-5 c) 5-6 d) 6-7
(xviii) ------------ drug will not show nonlinear pharamcokinetics (1M)
a) Griseofulvin b) Phenytoin c) Riboflavin d) Metformin
(xix) ----------------Pharmacokinetics describes the changes in drug ADME due to (1M)
normal physiologiocal circardian rhythams
a) Chrono b) Mixed order c) Nonlinear d) two compartment
(xx) A hypothetical drug is observed to follow Nonlinear P, Km is 0.1mcg/ml and (1M)
Vmax 0.5mcg/ml.h calculate Ke when plasma conc. is 3.2mcg/ml
a) 0.44 b) 0.485 c) 0.501 d) 0.556
PART –II
2. a) Write about active transport, carrier mediated transport in drug absorption. (5M)
b) Write about clinical significance of protein binding of drugs. (5M)

3. a) Give note on glucuronide conjugation with examples. (5M)

b) Discuss non-renal clearance of drugs. (5M)

4. a) Write about parallel design and crossover design. (5M)

b) Write the difference between Sigma minus method and Rate excretion method. (5M)

PART -III

5. Write a short note on BBB. (5M)

6. Discuss about diffusion layer model for mechanism of dissolution. (5M)

7. Discuss about Passive diffusion and Facilitated diffusion. (5M)

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8. Write short note on Vd and T1/2. (5M)

9. Write a short note on MRT and MAT. (5M)

10. Discuss factors effecting percutaneous absorption. (5M)

11. Write about mechanism of oxidation of drugs. (5M)

12. Describe the methods used to determine AUC. (5M)

13. Discuss about reasons for Non linear Pharmacokinetics. (5M)

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