SUKUMARA GHRITA

PROLACTIN

Dr. DHARITRI PUROHIT

DR. DHARITRI PUROHIT
I Md ptsr I MD
DEPTOF PTSR

SUKUMARA GHRITA
PROLACTIN
 SUKUMARA GHRITA
पचेत्पुनननवंतुल ं तथ दशपल पृथक्।
दशमूल पयस्य श्वगन्धॆरण्ड शत वरी॥
व्दददर्नशर क शेक्षुमूल पोटगल व्ित ।
वहे अप मष्टर् गस्ये तत्र त्रत्रशत्पलंगुड त्॥
प्रस्थमेरण्ड् तॆलस्य ददॊ घृत त्पयसस्तथ ।
आवपेद्व्ददपल ं शश्च कृष्ण तन्मूलसॆन्धवम् ।
यष्टीमधुकमृद्वीक यव नीन गर त्रि च।
तव्िधं सुकुम र ख्यं सुकुम रं रस यनम् ॥
INGREDIENTS-
 Kwatha dravya- each drug in 1 pala quantity with 1
drona of jala
Punarnava Moola Darbha
Dashamoola Naala
Ksheeravidari Shara
Ashwagandha Kaasha
Eranda Ikshumoola
Shatavari Patolagola
CONTII..
 Drava dravya –
goksheera – ardha adhaka
 Sneha dravya –
goghrita – ardh adhaka
eranda taila – 1 prastha
 aavapa dravya – each in dvipala matra
pippali draksha
pippalimoola yavaani
saindhava shunthi
yashtimadhu guda - trimshad pala
METHOD OF PREPARATION

 According to sahasrayoga-
prepare kwatha of all the kwatha dravyas in
1drona of jala by reducing it to 1/4th
 Then add all the other ingredients like kalka,
sneha and aavapa dravyas and boil till
snehavashesha.
 Then strain the ghrita and let it to cool.
CONTII,…
 While chakradatta exlained to prepare punarnava
kwatha and rest of the kwatha dravyas into two
separate kashayas.
 Then mix all the other ingredients including
moorchita eranda taila, moorchita ghrita, kalka
and aavapa dravyas with punarnava kwatha and
boil.
 Now add the second kashaya (dashamooladi) to
this boiling ghrita.
 Boil the ghrita till snehavashesha.
 Strain it and let it to cool.
INDICATIONS

 …… सुकुमरं रस यनम्।
व त तप ध्वर् ष्य स्त्रीपररह येष्वयंत्रिम्॥
प्रयोज्यं सुकुम र ि मीश्वर ि ं सुख त्मन म् ।
नृि ं स्त्रीवृन्दर्तनि मलक्ष्मीकलीन शनम् ।
सवनक लोपयोगेन क व्िल वण्यपुत्रष्टदम्॥
वर्ध्नत्रवद्रत्रधगुल्म शोयोत्रनशोल त्रनल त्रतनषु।
शोफोदरखुडप्लीहत्रवड् त्रवबंधेषु त्रचत्तमम॥
 सहस्रयोग घृत प्रकरि १४८
INDICATIONS
 The ghrita has to be used in people who are more
exposed to vaata, aatapa, adhva, atistri gamana. And in
sukumara vyakti who are dhanaadhya (eshwaraputra),
raja etc sukhsatmya jana.
 Indication- vrudhhi, vidradhi, gulma, pliha, arsha,
yonishoola, vatavyadhi, shopha, udara, vatarakta,
vidvibandha.
 Action- it acts as alakshmi- kalinashana
 on consuming for a long duration it acts as kaantikara,
lavanyakara, pushtikara, and rasayana.
DOSE AND ANUPANA

 Dose- 1 tola
 Aushadhasevana kala – (as mentioned by
chakradatta) before food
 Anupana - godugdha
RESEARCH WORKS ON SUKUMARA GHRITA

 A comparitive clinical study on efficacy of sukumara

ghrita in sukhaprasava-
 20 primigravidas were given 10ml sukumara ghrita
before food at night with warm milk from 36 weeks of
gestation and 20 were given plian goghrita 10ml. It wa
sobserved that there was significant reduction in
duration on 1st stage of labour in 1st group, better
cervical ripening and dilatation was seen. The 2nd stage
of labour wa suneventful in most the cases in 1st group
as compared to more cases with cervical, perneal,
vaginal tears seen in 2nd group.
CONTII…
 Assessment of significance of samskara in the preparation of
sukumara ghrita by physiochemical analysis.
 Result showed that -
 There was an increase in Specific Gravity,Saponification Value, Iodine
Value, Refractive Index, Loss on Drying value and Ester value of
Sukumara Ghrita prepared with Murchita Ghrita.
 There was a decrease in Acid Value, Density, Viscosity, Total fatty
acid value and Free Fatty Acids of Sukumara Ghrita prepared with
Murchita Ghrita.
 From the analytical reports, it was concluded that Murchita Ghrita
when used in the preparation of Sukumara Ghrita, certainly
attributes better quality of absorption, distribution, bioavailability,
metabolism and therapeutic action.
PROLACTIN
INTRODUCTION
It is a 199 amino acid, single chain peptide of
molecular weight 23000.
Structurally it is similar to growth hormone and
placental lactogen. But functionally differs from
both.
Originally prolactin was discovered as the hormone
which cause secretion of milk from crop glands of
pigeon, later it was found (in1970) to have role in
humans as well.
Synonyms- luteotropic hormone, luteotropin
FUNCTIONS..

 Prolactin is primarily responsible for stimulating

breast development during pregnancy
 Initiating and sustaining lactation postpartum

 Inhibition of ovulation as it reduces secretion of

LH and FSH
 Regulation of immunity by stimulating T
lymphocytes
REGULATION OF SECRETION...
PROLACTIN SECRETION

 Prolactin is under consistent inhibition in the

control of hypothalamus through PRIH(
prolactin inhibiting hormone) untill puberty.
 It increases in girls during puberty and gets
higher in adults. It is higher in females than
males.
 There is progressive increase in prolactin seen
during pregnancy and reaches its peak at term.
 It is secreted in a pulsatile fashion.
 Apart from pituitary, prolactin is also secreted by
decidua throughout the gestation. Placenta
produces prolactin like placental lactogen
throughout gestation.
 In males, prolactin increases LH receptors in leydig
cells resulting in increased testosterone
production
 In fetus, it contributes in pulmonary surfactant
synthesis of lungs at term and also enhances
immune tolerance of the fetus by mother
organism.
PHYSIOLOGY OF PROLACTIN
 It is secreted from the alpha cells of anterior pituitary
gland along with thyrotrophin releasing hormone(TRH).
 Its role in the human reproductive physiology and
maintainance of corpus luteum in humans Is not well
known, but there is fact that there high incidence of
anovulation in women with increased prolactin levels in
plasma.
 Prolactin is normally inhibited by PIH, but secretion
starts from 5th month of pregnancy and acts on
mammary glands to brings about alveolar hyperplasia by
proliferation of epithelial cells of alveoli.
EFFECT ON BREAST AND LACTATION..
 It is the primary stimulus which along with estrogen and
progesterone causes growth and development of breast
during pregnancy.
 It promotes proliferation of ductal and acenar cells,
 it induces production of milk proteins and lactose,
 after parturation it induces lactation as the inhibitory
hormones i.e.. progesterone is abruptly cut off.
 High amounts of prolactin during breastfeeding is
responsible for amenorrhoea and inhibition of ovulation
due to its suprressant action on HPO axis by inhibiting
GnRH release.
NORMAL PLASMA VALUES
 IN FEMALES-
In non pregnant women- 10-25microg/L
In pregnant women- 10-209ng/ml
 IN MALES-
10-20microg/L
 In a day peak of Sr prolactin levels is seen during REM sleep
between 4:00-6:00 am at a level of 30microg/L.
 During pregnancy –
Prolactin preferentially enters amniotic fluid and is
highest in concentration by 20-24 weeks of gestation i.e..
10,000ng/ml in comparison with maternal serum levels of
150-200ng/ml and fetal levels of 350ng/ml.
HYPOPROLACTINEMIA
 Decreased prolactin secretion from ant pituitary
can be caused in
 Sheehan’s syndrome
 Hypopituitarism
 Excessive dopamine
 Growth hormone deficiencies
 Head injury
 Pituitary tumors
It causes – delayed puberty, infertility, impotency
and abnormal spermatogenesis.
HYPERPROLACTINEMIA
 Prolactin secretion increases physiologically during
pregnancy and lactation, it can increase at any
stage causing hyperprolactinemia.
 In women, Hyperprolactinemia is responsible for
galactorrhoea, anovulation, amenorrhoea,
infertility.
 In males, it causes gynaecomastea, loss of libido
and depressed fertility.
 It can be caused due to tumors in the pituitary,
hypothyroidism, diseases of hypothalamus and
pituitary etc.
PLACENTAL LACTOGEN
 The prolactin like hormone secreted by
synchiotrophoblast of placenta during
pregnancy.
 It mimics the actions of prolactin
 It reduces insulin sensitivity, leading to
increased maternal blood glucose levels
 It reduces maternal glucose utilization and
ensures adequate fetal nutrition.
 It reaches its peak of 5-7mg/L at term.
PROLACTINERGIC FACTORS
 Factors that increase prolactin secretion are-
-Prolactin releasing hormone (PRH)
-Estrogen during pregnancy (stimulates lactotrophes
to secrete PRL)
-Oxytocin during lactation (causes muscle
contraction and release of milk)
-Thyrotrophin releasing hormone (TRH)
-Breast feeding
-Sleep
-Stress
-Dopamine antagonists (eg- antipsychotic drugs)
PROLACTIN INHIBITORS
1) Dopamine also called prolactin inhibiting hormone

2) Dopamine agonists-
Bromocriptine- (dose-1.25-2.5mg)
 It is a synthetic ergot derivative,potent dopamine agonist. It
decreases prolactin release by activating dopaminergic
receptors lactotrope cells.
 It induces contraction of uterus post partum given to control
excessive bleeding.
Cabergoline- (dose- 0.5-1 mg max )
 It is newer D2 agonist, more selctive and long acting than
bromocriptine.
 These are also used to treat hyperprolactinemias,
acromegaly, parkisonism and prolactin secreting tumors
USES

 Clinically there in no indication of prolactin.

 It is widely used in animals to stimulate
lactation