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  • Colibacillosis and STa-induced secretory diarrhea

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    Ahmad
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    Colibacillosis is caused by enterotoxigenic Escherichia coli (ETEC) that produce heat-stable enterotoxins (STa) which induce secretory diarrhea. STa binds to guanylate cyclase C receptors in the intestine, increasing cyclic GMP levels and stimulating the coupled secretion of chloride and sodium ions into the intestinal lumen. This disrupts the normal absorption of fluids and electrolytes, resulting in watery diarrhea that helps ETEC colonize and infect the intestines.

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    Pathogenesis of colibacillosis

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    Colibacillosis is caused by enterotoxigenic Escherichia coli (ETEC) that produce heat-stable enterotoxins (STa) which induce secretory diarrhea. STa binds to guanylate cyclase C receptors in the intestine, increasing cyclic GMP levels and stimulating the coupled secretion of chloride and sodium ions into the intestinal lumen. This disrupts the normal absorption of fluids and electrolytes, resulting in watery diarrhea that helps ETEC colonize and infect the intestines.

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    © All Rights Reserved
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    15 views7 pages

    Colibacillosis and STa-induced secretory diarrhea

    Uploaded by

    Ahmad
    Colibacillosis is caused by enterotoxigenic Escherichia coli (ETEC) that produce heat-stable enterotoxins (STa) which induce secretory diarrhea. STa binds to guanylate cyclase C receptors in the intestine, increasing cyclic GMP levels and stimulating the coupled secretion of chloride and sodium ions into the intestinal lumen. This disrupts the normal absorption of fluids and electrolytes, resulting in watery diarrhea that helps ETEC colonize and infect the intestines.

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    © All Rights Reserved
    Download as PPT, PDF, TXT or read online from Scribd
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    of 7

    Colibacillosis

    BBM

    Saeed et al., 1987


    Na/Cl coupling

    Na Glucose Na Cl

    H+
    HCO3-
    H+ HCO3-

    CO2 + H2O

    Na

    K ATP
    K Na
    2Cl ADP + Pi
    Pathogenesis of STa-induced diarrhea

    Secretory Diarrhea
    ETEC attachment and
    colonization
    Cl and Na
    NaGlucose Na Cl

    H+ STa
    Cl HCO3
    -

    Na Na
    cGMP
    STa
    Na

    K Na K ATP
    2Cl ADP + Pi

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