Cellular Respiration Part III:

Krebs Cycle
Figure 9.6-3

Electrons Electrons carried

carried via NADH and
via NADH FADH2

Glycolysis Citric Oxidative

Pyruvate acid phosphorylation:
oxidation cycle electron transport
Glucose Pyruvate
and
Acetyl CoA chemiosmosis

CYTOSOL MITOCHONDRION

ATP ATP ATP

Substrate-level Substrate-level Oxidative

phosphorylation phosphorylation phosphorylation
Citric Acid Cycle
Krebs Cycle
(Krebs Cycle)
 Big Idea

In the Krebs cycle, carbon dioxide is released from

organic intermediates, ATP is synthesized from ADP
and inorganic phosphate via substrate level
phosphorylation, and electrons are captured by
coenzymes.

Electrons that are extracted in the series of Krebs cycle

reactions are carried by NADH and FADH2 to the
electron transport chain.

4
Figure 9.11
Pyruvate

CO2
NAD 

CoA
NADH
+ H Acetyl CoA
CoA

CoA

Citric
acid
cycle 2 CO2

FADH2 3 NAD

FAD 3 NADH
+ 3 H
ADP + P i

ATP
6
 Krebs Cycle

• Occurs in the
mitochondrial matrix
• Releases the remaining
carbons from the remnant
glucose
• Transfers the energy to
NAD, FAD, and ADP
Coenzyme A
Carbon dioxide
Electron carrier (NADH)
Carbon dioxide
ATP
Electron carrier (FADH2)
 Coenzyme A

Electron carrier (NADH)

Figure 9.12-1

Acetyl CoA
CoA-SH

Oxaloacetate

Citrate

Citric
acid
cycle
Figure 9.12-2

Acetyl CoA
CoA-SH

1 H 2O

Oxaloacetate
2

Citrate
Isocitrate

Citric
acid
cycle
Figure 9.12-3

Acetyl CoA
CoA-SH

1 H 2O

Oxaloacetate
2

Citrate
Isocitrate
NAD
Citric 3
NADH
acid + H

cycle CO2

-Ketoglutarate
Figure 9.12-4

Acetyl CoA
CoA-SH

1 H 2O

Oxaloacetate
2

Citrate
Isocitrate
NAD
Citric 3
NADH
acid + H

cycle CO2

CoA-SH

-Ketoglutarate
4

CO2
NAD

NADH
Succinyl + H
CoA
Figure 9.12-5

Acetyl CoA
CoA-SH

1 H 2O

Oxaloacetate
2

Citrate
Isocitrate
NAD
Citric 3
NADH
acid + H

cycle CO2

CoA-SH

-Ketoglutarate
4
CoA-SH

5
CO2
NAD

Succinate Pi NADH
GTP GDP Succinyl + H
CoA
ADP

ATP
Figure 9.12-6

Acetyl CoA
CoA-SH

1 H 2O

Oxaloacetate
2

Citrate
Isocitrate
NAD
Citric 3
NADH
acid + H

cycle CO2

Fumarate CoA-SH

-Ketoglutarate
6 4
CoA-SH

FADH2 5
CO2
NAD
FAD

Succinate Pi NADH
GTP GDP Succinyl + H
CoA
ADP

ATP
Figure 9.12-7

Acetyl CoA
CoA-SH

1 H 2O

Oxaloacetate
2

Malate Citrate
Isocitrate
NAD
Citric 3
NADH
7 acid + H
H2O
cycle CO2

Fumarate CoA-SH

-Ketoglutarate
6 4
CoA-SH

FADH2 5
CO2
NAD
FAD

Succinate Pi NADH
GTP GDP Succinyl + H
CoA
ADP

ATP
Figure 9.12-8

Acetyl CoA
CoA-SH

NADH
+ H 1 H 2O

NAD
8 Oxaloacetate
2

Malate Citrate
Isocitrate
NAD
Citric 3
NADH
7 acid + H
H2O
cycle CO2

Fumarate CoA-SH

-Ketoglutarate
6 4
CoA-SH

FADH2 5
CO2
NAD
FAD

Succinate Pi NADH
GTP GDP Succinyl + H
CoA
ADP

ATP
Figure 9.12a

Acetyl CoA
CoA-SH

1 H2O

Oxaloacetate
2

Citrate
Isocitrate
Figure 9.12b

Isocitrate
NAD
NADH
3 + H

CO2

CoA-SH

-Ketoglutarate
4

CO2
NAD

NADH
Succinyl + H
CoA
Figure 9.12c

Fumarate

6 CoA-SH

FADH2 5

FAD
Succinate Pi
GTP GDP Succinyl
CoA
ADP

ATP
Figure 9.12d

NADH
+ H
NAD
8 Oxaloacetate

Malate

7
H2 O

Fumarate
Where does each atom end up?

C6H12O6
28
 So what did we get from Krebs?
• Name the energy related end products of Krebs.

• By what process is ATP formed?

• Name the waste products.

• Where do the events of Krebs occur?

• Do cells in all kingdoms go through the Krebs

cycle?
29
So, What Did We Get From Krebs?

30
One Last Look & Listen!

31
Figure 9.6-3

Electrons Electrons carried

carried via NADH and
via NADH FADH2

Glycolysis Citric Oxidative

Pyruvate acid phosphorylation:
oxidation cycle electron transport
Glucose Pyruvate
and
Acetyl CoA chemiosmosis

CYTOSOL MITOCHONDRION

ATP ATP ATP

Substrate-level Substrate-level Oxidative

phosphorylation phosphorylation phosphorylation