Ludiomil

Md. Muzahidul Islam

Portfolio Manager

ITC /Sero / MI / 2009

 Antidepressants

1. Tricyclic Antidepressants (most common)

Imipramine

Amitryptylin

Nortryptylin

Clomipramine

2. Second generation Antidepressants: Maprotiline

3. SSRIs

4. SSNRIS

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 Antidepressants

Tricyclic Antidepressants (most common)

 Imipramine: Tofranil

 Amitryptylin : Amilin, Amitryptylin,Tryptin

 Nortryptylin: Nortrieilin

 Clomipramine: Anafranil

Second generation Antidepressants: Maprotiline (Ludiomil)

SSRIs: Serolux, Chear, Setra

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 Ludiomil
Tetracyclic Antidepressant

ITC /Sero / MI / 2009

 Composition , Forms, Strength

Active ingredient:
Maprotiline Hydrochloride

Forms & Strengths:

Coated tablets : 25 mg

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 Mechanism of action
It strongly inhibits the reuptake of nor-adrenaline in the
brain and peripheral tissues.

Maprotiline also exerts a sedative effect on the anxiety

component of depressive illness.

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 Pharmacodynamics

1. Shares a number of basic therapeutic properties with the

tricyclics

2. Displays a well-balanced spectrum of action

3. Has a potent and selective inhibitory effect on the reuptake of

noradrenaline into the presynaptic neurones

4. Brightens the patient’s mood and alleviates anxiety, agitation,

and psychomotor retardation

ITC /Sero / MI / 2009

 Pharmacokinetics

Peak Plasma Concentrations : Within 8 hrs.

Protein Binding : 88-89 %

Plasma Elimination Half Life : 43 hr.

Excretion : Within 21 days. Through

urine and faces

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 Indications

Depression:
 All forms of depression
 Endogenous: involutional form
 Psychogenic: reactive, neurotic, exhaustion
 Somatogenic : organic and symptomatic
 Masked depression
 Menopausal depression
 Other depressive mood disorders characterized by anxiety,
dysphoria, or irritability

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 Masked depression

When no organic cause is found & patients do not respond

well to specific therapy

Patients complaints are like:

 Sleep disturbance

 Loss of interest

 Headache

 GI disturbance

 Poor concentration

Ludiomil –the best alternative because of its

anxiety-relieving property
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 Why Ludiomil?
Anxilolytic cannot improve the underlying depressive mood
and do not posses any depression relieving effect.
 Ludiomil the only single drug having anxiety-relieving
antidepressant with a bipolar effect
They tend to induce dependence from which is it is extremely
difficult to free the patients
 Ludiomil does not
Since depressive states are often associated with a risk of
suicide, its necessary above all to brighten the patients mood.
Tranquillizers have no influence on suicidal tendencies
 Ludiomil brightens the patients mood
SSRIs cause sexual Dysfunction
 Ludiomil does not have this.
Up to 90% of depressed patients experience symptoms of
ITC /Sero / MI / 2009
anxiety!!!
 Why Ludiomil?

Safety with optimal effectiveness, the first tetracyclic

antidepressant
 Ludiomil is safe for long term use ie. Ensures Patients
Compliance
A new generation antidepressant that goes beyond the tricyclics
 Better/wider therapeutic option
Cardiovascular safety profile better than older molecules
Fewer, less severe anticholinergic side effects
 Ensures better safety profile
Symptomatic relief within the first week in some patients
 Rapid onset of action

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 Dosages:
Dosage Guidelines:
• Always individualized

• Start with low dosage

• Gradually be increased cautiously

• Usually one daily dose

• A daily dose of 150 mg. should not be exceeded

• Patients must be kept under close surveillance

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 Dosage: ..Continued

Mild to moderate depression

25 mg. 1-3 times daily or 25-75 mg. once a day

Severe cases : 25 mg. t.i.d. or 75 mg. once a day. If necessary

raise upto 150 mg. maximum

Other depressive mood disorders

Children and adolescents

Start with 10 mg. t.i.d. or 25 mg. once a day

Can be raised stepwise to upto 25 mg. t.i.d.

Elderly

Same as children and adolescents

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 Pack and presentation

Brand Presentation Pack size MRP TP Inv MRP /

(Tk) (Tk) price Tab
(Tk) (Tk)

Ludiomil Tab 25mg 50’s 250 188.679 219.811 5.00

(5X10’s)

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 Contraindications

Known hyper-sensitivity to maprotiline

Should not be employed in epileptics

In patients with freshly sustained myocardial infarction

In patients with defects in narrow angle glaucoma, or

retention of urine

ITC /Sero / MI / 2009

 Ludiomil
Feature & Benefits

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 Feature & benefits

Feature Benefit

Indicated in all forms of All symptoms of

depression depression can be
treated effectively
Relieves anxiety with
Possesses anxiolytic/
depression.
sleep inducing
properties Restores normal sleep
pattern.

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 Feature & benefits

Feature
2-3 tabs. In the evening in
a single dose is effective.
Benefit
Better patient compliance.
Less chance of dosage
error.
Reduction of side effects,
like day time drowsiness.

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 Feature & benefits

FEATURE BENEFIT
More than 975 Well Documented, Safe
publications have made
Doctor can prescribe
Ludiomil one of the best
confidently
studied antidepressant

Confirms patient compliance

Good tolerability

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 Thank you
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