Lymphatic System

Vessels, Organs and Tissues

Lymphatic System
 Vessels: Connect to CV
 Lymphatics
 Capillaries
 Collecting vessels
 Trunks
 Transport fluid => lymph
 Organs: house immune cells
 LN
 Spleen
 Thymus
 Tissues
 Tonsils
 GALT
 MALT
Fluid Compartments
 Capillary Dynamics
 Hydrostatic/Hydraulic
 Osmotic
 Fluid Compartments
 ICF
 ECF
 ISCF
 Plasma
 Lymph
Lymphatic Capillary
Lymph Flow
Lymphatic Valve
Lymphatic Vessels and Ducts
Thoracic Duct
Lymph Return
Problem Lymph Return : Lymphedema
Lymphatic Vessel Circuits
Lymph Node: Location
L.N. : Specimen
Lymph Node: Gross Anatomy
 1. Afferent Lymphatics
 2. Cortex
 3. Germinal Center
 4. Capsule
 5. Medullary cord
 6. Valve
 7. Efferent Lymphatics
LN Structure: CT and vessels
 Capsule
 Subcapsular sinus
 Trabecula
 Reticular CT stroma
 Vessels
 Types
 Afferent
 Efferent
 Valves
Lymph Node
Lymph Node: Histology

B cells
T cells
MO
Lymph Node: Capsule Region
Lymph Node: Cortex

Lymphatic Nodule
Germinal Center
Lymph Node: Medulla
Lymph Node: Medullary Cords

Macrophages Medullary Cords

Sinusoids
L.N. Medullary Cells

 P = Plasma cells (daughter cells of Activated B cells

 M = Macrophages (mature monocytes in tissues)
LN Histology Summary
Diagnostics for Lymphatics and LN

Lymphangiogram
Lymphatic Problem: Lymphoma
Lymphatic Nodule:
Basic structure for All Lymphatic tissue
Spleen: Location
Spleen: Gross Anatomy
Spleen: Histology

Splenic
Sinusoid
Spleen Problems
 Rupture
 Cancer
 Infection

Hydatid cyst
Thymus: Location
Thymus: Gross
Thymus Embryological
Development  1. Mandibular arch

 2. Hyoid arch
 3. Cervical sinus entry
 4. 3rd pharyngeal pouch
 5. 4th pharyngeal pouch
 6. Foramen cecum
 7. Thyroid
 8. Cervical sinus
 9. Thymus (3rd pouch)
 10. Thymus (4th pouch)
Thymic Cell Development
 1. Thymic capsule
 2. Thymic nurse cells
 3. CT septa and BV
 4. Subcapsular epithelium
(for the blood thymus barrier)
 5. Cortical Epithelial cells
 6. Medullary epithelial cells
 7. Dendritic cells
 8. Hassall’s Corpuscle
 9. Macrophages
 10. Cortex
 11. Medulla
Thymic Organization
Thymic Capsule, Septa and Lobules
Thymus: Cortex
Thymic Medulla
Thymic Age Degeneration
Thymic Problem

Thymic Aplasia
Tonsil: Location
 Pharyngeal [Adenoids]
 Palantine
 Lingual
 Tubal
Palatine Tonsil
Tonsil: Epithelial Histology
Tonsil Lymphatic Nodules
Tonsilar Crypt
Tonsil Problem: Tonsillitis
Gut Associated Lymphatic Tissue
(GALT) Location
GALT
Peyer’s Patches
Ileum Problems

Inflammation Necrosis
Appendix: Gross
Appendix
Appendix Problems

Appendicitis

Appendix rupture and necrosis

MALT

epiglottis
bronchus
Summary Overview
Questions?