Low-grade inflammation,

Dietary composition and

health
FABRIKAM RESIDENCES

D r. H n i n Ya d a n a r Ky a w
 Acute immunosurvillence and host defense
I n fl a m m a ti o n
(friend and foe)
Chronic metabolic syndrome(MetS),
NAFLD, T2DM and CVD
 Low-grade inflammation in cardiometabolic
disease
• At h e r o s c l e r o s i s , N A F L D
• A d i p o s e ti s s u e h y p e r t r o p h y - i m m u n e c e l l i n fi l t r a ti o n T h i s
impedes insulin signaling cascade to induce insulin
r e s i s t a n c e - d y s r e g u l a ti o n o f g l u c o s e a n d l i p i d m e t a b o l i s m i n
a d i p o s e ti s s u e , s ke l e t a l m u s c l e a n d l i v e r.
• M H O a n d i n fl a m m a t o r y m a r ke r s
• S t r o n g t h e r a p e u ti c t a r g e t t o r e d u c e t h e r i s k o f T 2 D M , C V D
and NAFLD in obese.

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Gut-systemic infl ammatory associati on
• Promotes development and maintenance of the mucosal
immune system.
• Bacterial lipopolysaccharides(LPS)- an important trigger in
t h e d e v e l o p m e n t o f i n fl a m m a ti o n a n d m e t a b o l i c d i s e a s e s .
• I t c a n a l s o i n fl u e n c e t h e r i s k o f h i g h - g r a d e a u t o i m m u n e
i n fl a m m a t o r y c o n d i ti o n s . ( T 1 D M , I B D , R A , C o e l i a c d i s e a s e s )
• D e n d r i ti c c e l l m a t u r a ti o n
• M i c r o b i o t a a n d b i l e a c i d r e l a ti o n
Low-grade systemic infl ammati on and
neuroinfl ammati on
• Sickness behavior
• M i c r o g l i a h a v e a v e r y l o w t u r n o v e r , r e s u l ti n g i n a p r o l o n g e d
and heightened response.
• C l i n i c a l s t u d y o f A l z h e i m e r ’s d i s e a s e p a ti e n t s
• I n fl a m m a t o r y p a t h w a y s a s i m p o r t a n t t a r g e t s f o r s t r a t e g i e s
p r o m o ti n g h e a l t h y b r a i n a g i n g a n d r e d u c i n g t h e r i s k o f a g e -
r e l a t e d c o g n i ti v e d e c l i n e .
Dietary modulati on of low-grade
infl ammati on
• Reduced postprandial glycaemia and lipaemia are
a s s o c i a t e d w i t h r e d u c e d c o n c e n t r a ti o n s o f m a r ke r s o f l o w -
g r a d e i n fl a m m a ti o n .
• I m p r o v e d c o g n i ti v e f u n c ti o n a n d a r e d u c e d r i s k o f a g e -
r e l a t e d n e u r o d e g e n e r a ti v e d i s e a s e s a r e a s s o c i a t e d w i t h
i n c r e a s e d f r u i t a n d v e g e t a b l e i n t a ke .
• D i e t a r y fl a v o n o i d s – n e u r o p r o t e c ti v e e ff e c t s
Early life nutriti on and infl ammati on
• Dutch Hunger Winter
• Obese pregnant women give birth to babies with a high risk of
SGA, LGA and developing MetS.
• ‘ F e t a l p r o g r a m m i n g ’ o r ‘d e v e l o p m e n t a l p r o g r a m m i n g ’
• N u t r i ti o n a l d e fi c i e n c y d u r i n g a c r i ti c a l p h a s e o f d e v e l o p m e n t c a n
inhibit organ growth.
• ( I L - 6 f r o m a d i p o s e ti s s u e i n t o p o r t a l b l o o d c o u l d s t r o n g l y
s ti m u l a t e h e p a ti c s y n t h e s i s o f h e p c i d i n , a n e g a ti v e r e g u l a t o r o f
F e a b s o r p ti o n a n d l o w e r F e s t a t u s a s s o c i a t e d w i t h a n i n c r e a s e d
risk of wheezing in children.)
Thank you for
your attention !
• Diet
Ve g e t a b l e - f r u i t c o n s u m p ti o n w i t h p h y s i c a l a c ti v i t y
• E x e r c i s e & P h y s i c a l a c ti v i t y
At least 150 mins of moderate intensity/75 mins of vigorous
intensity
S u p e r v i s e d e xe r c i s e p r e v e n t i n j u r y, f a l l , p h y s i c a l d y s f u n c ti o n

• Sleep
C o g n i ti v e b e h a v i o r a l t h e r a p y ( C B T ) ( G o l d S t a n d a r d )

• Stress management
C B T, M i n d f u l n e s s , Yo g a