2022 IEEE International Conference on Current Development in Engineering and Technology

SAGE University
Bhopal, India, December 24, 2022

Paper Title : Computing Model for Alzheimer Prediction Using Support Vector Machine Classifier

 
Authors: Dr. R. Kishore Kanna*1
Assistant Professor,
Department of Biomedical Engineering,
Vels Institute of Science Technology and Advanced Studies [VISTAS], Chennai, India

1
Plan of Presentation
Introduction
Related work
Methodology
Block Diagram
Results & Discussion
Conclusion
References

2
Introduction
 The first stage of Alzheimer's disease is known as Mild Cognitive Impairment.

 Identification of MCI subjects who are at high risk of developing frame over time is crucial for
successful therapy.

 In order to track the progress of numerous Alzheimer's forecasts over time, automated modelling was
used in this work.

 Three separate longitudinal data systems are used to train models. Then, for each experimental
investigation, these models are used to assess biomarker data. Finally, MCI patients at risk of acquiring
in the future are identified using a typical support vector machine categorization.

 Both cognitive points and magnetic resonance image-based measurements are used to thoroughly
assess the proposed models' prediction ability.

 Important findings of this research include: Clinical changes in magnetic resonance image- based
therapies may be predicted more accurately than cognitive points in two ways: 1. Multiple predictive
models are more accurate in predicting change than single biomarker models. 2. Neuropsychology
3
programme by themselves may provide superior long-term change prediction.
Related work

 Astronomically speaking, there are two categories of MCI instances. In the next era, delicate those who
announce (MCI p) and those who maintain MCI (mcis). As a result, predicting the MCI- to- Announcement
conversion comes within the same category as predicting the MCI group's twofold partition into MCIP
and MCI. There is still disagreement around the biomarker or emulsion biomarker that is connected to
the most precise bracket system for predicting the transition from MCI to Announcement.

 Even yet, there aren't many studies that track how complaints develop over time. Prognostications are
established using magnetic resonance image and psychiatric data as independent variables, and
retrospective and direct retrogression are often utilized to model MCI-to-Announcement changes. Even
yet, the model's delicateness is still under 70.

4
Methodology
• Information was acquired from the Alzheimer's Disease Neuroimaging Initiative website and utilized in this
investigation.
•Approximately 300 adults who are cognitively normal(CN) will be followed fort two years, 350 people with MCI will be
followed for two years, and 150 adults with frame will be followed for two years and three years as part of the
methodology, a Six-year social collaboration that included 750 adults, aged 45 to 75.

• A 5-fold verification approach with 80% of cases is used to split the MCI population into training and test groups.
Utilized for testing, whilst the other circumstances are used for training.

•The generation and validation of auto regressive(AR) parameters involve training data, which is also characterized as
Leave-one-out(LOO)opposite validation set up

5
Block Diagram

6
Results & Discussion

• • When training causes substantial test losses, the model performance is calculated by deducting the final
metric points. To obtain reasonable performance, this procedure is repeated (n = 5 iterations) with various
components of the train/test database.

• • Scheduled classification was utilised for the split of the test and the integration of the training sets to
guarantee that there is no variation in scores owing to class disparity.

• •The database has a total of 61.1% MCI converts (n = 155) and a total of 37.2% MCI converters (n = 211).
65.4% (n = 134) of the MCI converters were high-risk, compared to 33.8% (n =67) of the less vulnerable.

7
Conclusion
• It is interesting that combining many projections yields more precise forecasts for upcoming clinical changes.
• The support vector machine section was then given the indicated trajectories in order to distinguish between
mcip and mcis.
• The best AUC estimates in the suggested framework were higher than previous recently presented techniques
at 89.93% and 88.13% across 2 and 3 consecutive years, respectively.
• By picking features and developing algorithms, this framework's functionality will eventually be improved.
• In order to build a strong model and forecast more accurate conversions, other non-existent valuation
methodologies will also be added.

8
References
1) Mirzaei G, Adeli H. Machine learning techniques for diagnosis of alzheimer disease, mild cognitive disorder, and other types of dementia. Biomedical Signal Processing and Control.
2022 Feb 1; 72:103293.
2) Sharma S, Mandal PK. A Comprehensive Report on Machine Learning-based Early Detection of Alzheimer's Disease using Multi-modal Neuroimaging Data. ACM Computing
Surveys (CSUR). 2022 Mar 14;55(2):1-44.
3) Alatrany AS, Hussain AJ, Mustafina J, Al-Jumeily D. Machine learning approaches and applications in genome wide association study for Alzheimer’s Disease: A systematic review.
IEEE Access. 2022 Jun 13.
4) Kanna RK, Vasuki R. Advanced Study of ICA in EEG and Signal Acquisition using Mydaq and Lab view Application. International Journal of Innovative Technology and Exploring
Engineering (IJITEE) ISSN. 2019 May:2278-3075.
5) Binder J, Ursu O, Bologa C, Jiang S, Maphis N, Dadras S, Chisholm D, Weick J, Myers O, Kumar P, Yang JJ. Machine learning prediction and tau-based screening identifies potential
Alzheimer’s disease genes relevant to immunity. Communications Biology. 2022 Feb 11;5(1):1-5.
6) Khan A, Zubair S. Development of a three-tiered cognitive hybrid machine learning algorithm for effective diagnosis of alzheimer’s disease. Journal of King Saud University-Computer
and Information Sciences. 2022 Jul 25.
7) Kumhar SH, Kapula PR, Kaur H, Krishna RR, Kirmani MM, Athavale VA, Ahmad MW. Machine Learning Model-Based Applications for Food Management in Alzheimer’s Using
Regression Analysis Approach. Journal of Food Quality. 2022 May 19;2022.
8) Agarwal M, Rajak A, Shrivastava AK. Alzheimer Disease Prediction Using Learning Algorithms. InInternational Conference on Computing in Engineering & Technology 2022 (pp.
331-339). Springer, Singapore.
9) Harish MV, Dinesh C, Sasikala S, Kumar A. Alzheimer's Disease Prediction Using Machine Learning Methodologies. In2022 International Conference on Computer Communication
and Informatics (ICCCI) 2022 Jan 25 (pp. 1-6). IEEE.
10) Kanna RK, Subhalakhsmi N, Gomathy V, Vasuki R. Monitoring and analysis of coma patients using variable motion sensor system. Drug Invention Today. 2019 Jul 1;11(7).

9
Thank you

10