REPORT OF THE SIX-MONTH INDUSTRIAL TRAINING

OF
STUDENTS’INDUSTRIAL WORK EXPERINCE SCHEME
(SIWES)

UNDERTAKEN AT

GAUZE PHARMACEUTICALS AND LABORATORIES ENU-

IFITE VILLAGE AWKA

PRESENTED BY:

IKEH ,PRINCE CHKWUEMEKA

2019204168
DECEMBER, 2022
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OUTLINE

 INTRODUCTION TO SIWES
 OVERVIEW OF GAUZE PHARMACEUTICAL AND LABORATORIES
 WORKDONE AT GAUZE PHARMACEUTICALS AND LABORATORIES
 PHARMACEUTICAL PRODUCTION
 MIST MAGNESIUM TRISILLICATE SUSPENSION
 SOME OF THE EQUIPMENTS USED IN CHEMICAL ANALYSIS
 RELEVANCE OF BIOCHEMISTRY TO PHARMACEUTICAL INDUSTRY
 CONCLUSION

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HISTORY OF SIWES

 SIWES is an acronym for students industrial work experience scheme.

 It was established in the year 1973 with the aim of improving the
standard of education geared towards technological advancement.

 It is funded by the Federal Government and managed by the industrial

training fund(ITF).

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BRIEF HISTORY OF THE COMPANY
 Gauze Pharmaceuticals and Laboratories, a production company
producing varieties of drugs, potable water and bar soap was
established in 1992.

 There was no immediate commencement of productions that same year

because it took the company time to affirm its quality and standard
operating procedures. Production commenced in full measure in the
year 2000, with about eight products receiving consent from NAFDAC.

 In the year 2003, more products were registered, and today, the
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company has over 40 registered products with NAFDAC.

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PHARMACEUTICAL PRODUCTION
Mist Magnesium Trisilicate Suspension
It is an antacid used for relief
of hyperacidity,
heart burns, flatulence
and discomfort of indigestion.
Ingredients for production;
• Magnesium trisilicate
• Sodium bicarbonate
• Light magnesium carbonate
• Purified water (as bulking agent)
• Peppermint oil
• Methyl paraben (Preservative) 6

• Propyl paraben (Preservative)

Procedure for production
 The ingredients were weighed accordingly, and the first 3 ingredients
which were the Active pharmaceutical Ingredients (API’s) Magnesium
trisilicate, Sodium bicarbonate, Light magnesium carbonate were
poured in a tank with water and then mixed for about 10 minutes.

 After mixing, the white suspension was sieved to remove any debris
from the raw material and then poured into the production tank, and
about 2/3 of water was then added into the production tank.

 Then the preservatives; Methyl Paraben(MPB) and Propyl

Paraben(PPB) were dissolved in ethanol and poured into the tank 7

containing the API’s.

Procedure for production Cont’d
 Dilute the peppermint oil in ethanol and add gently, keep stirring and
after a while the suspension was filled up to the required volume with
water.

 Then the sample was taken from the base tap of the production tank to
the quality assurance unit for examination to confirm satisfactory
product formation, when satisfied stop the stirring and call for quality
test on the sample.

 On the receipt of satisfaction of quality assurance result, transfer the

product for filling according to required dispensing volume. 8
ANALYSIS OF SAMPLE
 Physical Appearance: A white suspension
 Taste: Potash-like with peppermint flavour
Specific Gravity at 30C
Weight of pycnometer - 53.443g
Weight of pycnometer + water - 104.431g
Weight of pycnometer + sample - 108.442g
Weight of water - 50.988g
Weight of sample - 54.999g
S.G = 54.999g * 0.99462g|mol/50.988g
=1.07g|mol
pH=8.42 9

Filling volume=200ml
Mist Mag Trisilicate Cont’d
MECHANISM OF ACTIONS OF THE ACTIVE
PHARMACEUTICAL INGREDIENTS (API)
• Mechanism of Action of Magnesium Trisilicate
The gelatinous silicon dioxide, formed by the reaction of
magnesium trisilicate with gastric contents is said to protect the
ulcerated mucosal surfaces and favor healing.
• Mechanism of Action of Light Magnesium Carbonate
It reacts with hydrochloric acid in the stomach to form
carbon(iv)oxide and magnesium chloride thus neutralizing
excess acid in the stomach.
• Mechanism of Action of Sodium bicarbonate
Sodium bicarbonate acts as an antacid and reacts chemically to
neutralize or buffer existing quantities of stomach acid but has
no direct effect on its output. This action result in increased PH
value of stomach contents, thus providing relief of hyperacidity 10

symptoms.
SOME OF THE EQUIPMENT USED IN CHEMICAL ANALYSIS

• Electronic Weighing Balance: This is an electronic digital device used to

measure weight or mass of a sample specifically in grams or milligrams.

• Moisture Analyzer: This is used to determine the moisture content of a

sample.

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SOME OF THE INSTRUMENTS USED IN CHEMICAL ANALYSIS

• Conductivity Meter: This is used to check the total dissolve solute

(TDS) and the conductivity of a solution.

• UV-spectrophotometer :For reading the absorbance of wavelength

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Relevance of biochemistry to pharmaceutical industry
• Drug Constitution: Biochemistry gives an idea of the constitution
of the drug, its chances of degradation with varying temperature
etc. How modification in the medicinal chemistry helps improve
efficiency, minimize side effects etc.
• The half life and Drug storage: This is a test done on biochemical
drugs to know how long a drug is stable when kept at so and so
temperature. For example many enzymes, hormones are stored for
dispensing. These get deteriorated over time due to temperature or
oxidation, contamination and also due to improper storage.
• Drug metabolism: It also gives an idea of how drug molecules are
metabolized by many biochemical reactions in presence of
enzymes. This helps to avoid drugs which have poor metabolism or
those with excessive side effects from being prescribed or
dispensed to the patient. 13
CONCLUSION

 My experience at Gauze Pharmaceuticals opened my eyes to the struggle in

the work field. It really made me to see what life outside school looks like.

 My six Months of industrial training attachment at Gauze Pharmaceutical &

Laboratory has been one of most productive and instructive experience in
my life. Through this training programme, I gained a whole lot of
comprehensive knowledge on industrial skills and practices in a
pharmaceutical company.

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THANKS FOR YOUR AUDIENCE

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