LOA LOA FILARIASIS

26, 2016
: . -
: . 1196


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Loa loa filariasis
.
Chrysops spp(Deer Fly Mango Fly) Loa loa.
Loa loa ,
.
Loa loa ,
.
,
. diethylcarbamazine (DEC)
,
.

(filariasis such as loiasiasis)
.
.
,
. (Calabar) 3 10 cm,
. ,

, .
1 3 ,
( ) ().
.

Loa loa .
, 15 .
,
.
.
,
.

-, Loa loa
,

 4 . ,
. ,
- 17 .

Loa loa (L3) (deer-fly),

Chrysops silica C. Dimidiata. , ,
, .
( L3 ) ( L5 ) . -
.
mango deer
-

Chrysops spp.

Loa loa.
.
: ,
( . ), .
,
cross-over .
Chrysops Langi.

Loa loa -(
Diptera : Tabanidae) .
Tabanus Loa,
Chrysops- C. silacea C. dimidiata.
deer
mango .

Chrysops spp (5-20 )

. -.
, ,
.
. ,
5 7 .
,
. 1- 6 cm 1-3
.
e
Tabanidae.
mango ,
,
.
( mango deer fly).


, .
, Chrysops silacea C. dimidiata ,
. ,
.
,
, .
of Chrysops spp C. silacea C.
dimidiata 90% , 10%
, , .

Loa . Loa
( 30-34 0.35-0.42) ( 4070 0.5). ,
.
250-300m , 6-8m

.

Loa loa filariasis Chrysops,

C. silacea C. Dimidiata. , (
Chrysops, )
- .
.
40-70 0.5 , 30-34
0.35-0.43 . ,

 . ,
, (noncirculation phase),
.
.. ,

.
.

.

.
Loa loa.
( 10h
14h ). , Giemsa
.
.
2% ( Knott), .
(immunoassay)

,
. ,
.

-
,

-
Loa loa 2008.
-
.
, .
luciferase immunoprecipitation assay (LIPS) QLIPS
( ). LISXP-1 ELISA
(55%), QLIPS , 15
(97%,

diethylcarbamazine
.)

, ( Calabar - )
.
a .

,
.
,
Dirofilaria iminitis .
,
, ,
.
,
,

. ,
,
.

Diethylcarbamazine Loa
loa. Loa , , : 6 20
, 0 16
DEC- . IgG
-.
300 mg DEC .

. .
-
,
, , ,
, Loa loa
.
- ,
.

.
.


, ,
.
, diethylcarbamazine (DEC),
. DEC 6
mg/kg/d, , 12 . . DEC

( ).
, , DEC
,
. ,
,

.
Loa loa ,

.
( ). 2007

- , 0.5 ml 2%
1:100,000, . 2mm
.
(
DEC- -
- ).

2009, 11 ,
, 12-13 .
, ,
, , ,
. Loa loa ,
, , .
, , ,
.
Loa loa- , 9 70%
.
( )
>20% ,
( 2007).

, Chrysops dimidiata C. silicea.

 ,
Loa loa
, .
,
(
Onchocerciasis) , . ,
,
.
, ,
.
:
(SAEs).
SAEs,

.
,
onchocerciasis
loiasis.
,
. ,
- L.loa O.volvulus,
(SAE).
, .
L.loa .

SAE , ,
.

, ,

.

L.loa 3.000 ml .
12-24 - (D1),
, , ,
. .
(D2), , ,
, .
. ,
, SAE
L.loa D2
D5 . 5

,
. ,
-. ,
SAE 6-7 ;
,
, ,
.
SAE . ,
.


.
, SAE.


,
.
,
- ,
L.loa SAE.
Wolbachia O.volvulus.
-

.
onchocerciasis .
O.volvulus na
Wolbachia,
,
L.loa. 5 - .
, 12.000
.

Wolbachia
. , 97%
,

onchocerciasis, L.loa .

,
.
. 10
Loa loa.
-
,

(SAEs=serious adverse effects)
Loa loa .
Loa loa

. , ,
diethylcarbamazine,
Loa loa .

Loa loa ( )
1770 .
. ,
1778, ,
;
.
1890
. ,
, 1895
, , .
-, Loa loa
1910 ( . ).
- Chrysops spp.- 1912
.

: ,
loaiasis, loaina, loa loa filiaris, filarial loa, filarial lacrimalis,filarial subconjuctivalis,
, microfilaria diurnal. Loa loa,

 ,
.

1. http://web.stanford.edu/group/parasites/ParaSites2006/Loiasis/Index.html
2. http://www.parasitesinhumans.org/loa-loa-eye-worm.html
3. http://web.stanford.edu/group/parasites/ParaSites2009/JosephCartwright_Loiasis
/CartwrightJoeParasite.htm
4. http://www.cdc.gov/parasites/loiasis/
5. https://en.wikipedia.org/wiki/Loa_loa_filariasis