100.04.

22



First Generation Antipsychotic Medications
Second Generation Antipsychotic Medications


dopamine2 (D2)
High Potency : haloperidol

Haldol D2

Low Potency :

chlorpromazine Morefine


H1

M1
D2

Four Dopamine Pathways

Mesolimbic pathway

Positive symptoms
Mesocortical pathway

Negative symtoms
Nigrostriatal pathway

EPS
Tuberoinfundibular pathways

Prolactin


Extrapyramidal Symptoms
Anticholinergic Effects
Antiadrenergic Effects
Antihistamine Effects
Neuroleptic

Malignant Syndrome


Acute dystonia

Akathisia

Parkinsonism

Tardive dyskinesia


Dry mouth
Blurred vision
Constipation
Urinary retention


Postural

hypotension


Neuroleptic Malignant Syndrome
39-41 WBC
12000

CK,CPK,K,GOT,GPT

 Haldol ( Binin-U ):
5mg, 50mg

Flanxol depot : 20mg

Clopixol depot : 50mg

5HT2A

SDA
D2

MARTA

Serotonin-Dopamine Antagonism
Risperidone (Risperdal)

Consta 25 37.5

Ziprasidone (Geodon)
Abilify
Solian

Multi-Acting Receptor Targeted Agents

(MARTAs)

Clozapine (Clozaril)
Olanzapine (Zyprexa)
,10mg

Quetiapine (Seroquel)
Zotepine (Lodopin)


EPS Risperdial
:Olanzapine, Seroquel
Solian
QTc prolongation

Cloazpine
Cloazpine, Olanzapine
Cloazpine
Cloazpine,Lodpine
Geoden, Cloazpine,
Olanzapine, Seroquel,


Clozapine olanzapine risperidone

Seroquel Solian Gendon

XR,ER
: 40


First Generation Antipsychotic Medications
Second Generation Antipsychotic Medications



Carbamazepine Tegretal
Valproate Depakine, Convulex
Benzodiazepine BZD, Rivtoril
Inderal

3050
0.6-1.2meq/dl


1.5-2.0meq/dl

2.0-4.0meq/dl
EKG
4.0meq/dl

Carbamazepine
Tegretal

Steven-

Johsons syndrom

Lamictal

Stevens - Johnson

Steven-Johsons syndrom

macrolide or

doxycycline .

Valproate
Depakine, Convulex
Carbamazepine


First Generation Antipsychotic Medications
Second Generation Antipsychotic Medications


Benzodiapine BZD
Xanax Gendergine , Rivotril, Ative, Lexoten,
Librium, Erispam, Valium, serenal ,
Alpraline

Buspirone Buspar


BZD

 hypnotics
BZD:

Dalmadorm * cap 15 mg
Stilnox:


Eszo:

Imovan, Genclone:


First Generation Antipsychotic Medications
Second Generation Antipsychotic Medications

 -CPY450
TCA
MAOI
SSRI
2A SARI)
SNRI
NRI
(NDRI)
SDRI
NaSSA

 TCA
Tofranil

MAOI
tryamine

SARI
Trazodone, Cirzodone Mesyrel ,


150-400 150-600

SSRI
Prozac Zactin Fluoxetine , Cipram

Citalopram , Luvox Fluvxamine ,

Zoloft Sertraline ,
Seroxate Paroxetine
TCA
2-4 6-12

SNRI
Effexor
75-225
20-30mmHg
2-3

Ixel
MAOI digoxin clonidin

NRI
Reboxetine( Edronax, Vestra):
Atomoxetine ( Strattera):

NDRI
Bupropion

100mg,bid.
2-4

Wellbutrin SR

Bupropion

NaSSA
Remeron ( Mirtazapine )
30mg
SSRI Effexor

SGPT


First Generation Antipsychotic Medications
Second Generation Antipsychotic Medications


Artane
Bipiden
Akenton
Inderal
PK-merz FC