COPD

ASTHMA CHRONIC BRONCHITIS EMPHYSEMA

Allergens H. influenza Cigarette Anti alpha antitrypsin D.

(dust, pollens, molds Diplococcus Pneumoniae Smoking
Cigarettes, smoke,etc.)

Inflammation of the Bronchi Breakdowns of elastin

Activates Ige
Bradykinin, Histamine, destruction of
Prostaglandin alveolar wall septa

Mast cells & Basophils Inc. capillary Permeability

Inc. Dead space

Dec.pulmonary bed
Release Histamine, Leukotrienes, Fluid/ Cell Exudation
Prostaglandin, Cytokines, Serotonin
Inc. CO2 Inc.blood flow
Edema of mucous membrane

Inflammation of bronchial airway hypercapnea Inc. RBC

Inc. activity of Goblet Cells

Vasodilation Hypersecretion of mucous additional expansion of

the thorax

Bronchoconstriction Plugged airway pinkish

Dec. intrathoracic
Barrel
pressure chest
wheeze Persiste
s d Cough
Dec. O2 lungs

hypoxia

Decreased Oxygen Blood circulation

cyanosis