EIIAI-OI-H

ANMHTONTAI THNMHOEIAEXETIKA METIE OYIIKil OEPANEIEE TA OAPMAKA KAI

Enrcxgrrlxa dyLp6uo yLargotig,dJd. xat xoupeig, t6rcxrrpeE),ourgriu, nolupa1eQ )epaneurfg, yuvaixeExat trrd,youExrouaoyo)"orjwavpt rrlv r6gwlqg faorlg.Ilrtya oe a).yr1trtrct6E, povaorrlQra, oe euyeveQ oe xcL o xowotg 0vr1rotig, ot ooEotig24aL ail.otig av9ptbnoug. o IlapdxeToog (U93-b I)

o Brpl,foo,urcje(var ngoi6v Fro,E rrQootrlnr,xrjg cvclrjrqorlg o1eL rm6. ps rIV cflonr,or(a rcov guorzc6vcpcrelroxsuttxril ouorc6v lto,r rrrlv Oego.neutrxc6v pe0d6olv fiou l3croilowcrr, crut6g,u,c6g oe xo,r l.rsu1 6r,agxc6E enlroluvdpevq 6walri rouE orrlv nogaboolaxrj r,crgr,x{.Xe 6},q rr1gdoq rqg ovclrgrrloqExot ouyygaqrjg rou prp},G ou, 0ev dna{c vo, rvrurrool<ilopcr, and rrlv (,w,aoq nou hcppdver out{ q rdoq. H evocll"l<irrooq rolv Oeganeutrxriv ncrpcoxeuooptirtllv nou ngo6glovrar o,nd tr1 grioq orqv rro,Qo,8ooloxrj r.ctqr.xr{ xrecr,yporonoleirq,r noLt tayttega antl 6oo pnoqorjv va cpo,vraororjv or neqloo6teqor,dvOgonor. Kcr e(vor,yeyov69 6rt Ocrdlel 9erw"(,g enrnrc6oer,g 6l,oug pcrg, oe xcOrig xo,rorrlv nor6rqta ?.r,o,r oro x6or,ogqg r,otpr,xrig pog nepi0ol"llrlg. Avclcp6goparonE oqpo,vrrxdg al"l,cry6E orrlv avoOr,opdggrrloq x,or dl"otvrrrlv lo,tgr.nc6v ouorlptirrrlv, and ro, oglcr,drepo drrlgto nro oriylpovo,, rcov onoiolv o rel,rr6g o"r61oE ivcl q oqOrj1p{orl trov cpapptixovyro rq Oepcneia e torv ao0evetc6v. Autd nou pou ngoxdl,soo,vrn peyal.rfuegqdx*},r1[q e(vu,r,: f r 1 1x

. H 6mcoq xo,r q sxrrp,ov{pe qv onoio, or, dv8golnor,avclqrodv oro cogotre(gxat o,notel"eopo,rr,xdg Oepcrne(eg rudgacrndt6 oupoyroydg,ax6pr1xc,l 6tc,v aurd roug cpdpvel $ar,m(4 0epo,neunx6E oe ovri0eoq pe trg xa0reqopdvegntgrx6g pe0d6oug. r H enlOup(cr 6r,o,xexglp6vrov yr,atqc6v ?4o,r rnrorrltrr6vorv or ono(or, egydlowcn oe x6wgu, uye(crg,epeuvqrlxrl rvotr,torjto,xo,r o,xo,6qpor.xd r,6gripcra- vc elertioouv trg 6uvc,r6qreE rtrlv l.rrloupporr,xcilvcpcgpdxcov 0eponer,6v. xo,r, . H 6r,ogxc6g crulcv6pev1 srlrorrll-rovr.xri pcgrug(a nou unooqgG rIV aogdlera trrw cpaqpd?4ov fiou ngodp!er, tqv crfr,onror(c xo,r, Xowcxro:x614 qjo1. . H exterc,trl6vq pel.dq xur,lgrior; rdtorrov cpuolxc6v cpogpdxcrrv xor, 0eqaner,r6v an6 yratqorig nou o,xol.ouOofvtqv ncgu8oolax{ larqlxr{ oe wo}.}"6E zcrr l8lo[teqo oq feppavfcr. XdQsE r To fiou snrxeo,re( mqvotrlo0eoic oyer,m6. q lqryoq rotv pe ltiog pogp<ixcrlvnou nqodglovrc,r o,n6xn q6oq dler og anordl"eoplatq qy g 6qpr,ou fa xl.(pcwo ouyxuoqg orou E xo,roval.cx6g. tou Br.p],iou,yvrigr.(a <jtr, or. fiexfvqoo rTl ouyyQocprl au"co(s Apegrxo,vo( e(yav cg1(oer,vc avc!4roriv vdeg xareu0fvoerE orrlv enil.uoq rotv ngol3hqpdrrrlv uyeiag rrou o,vrrp,rrinr.[av. eot6oo, 6ev pnoqodoc vo, qo,vroorc6 ro pcOp<i otov ono(o cumi q cvalr{tqorl e(1e 6r.ero6foeloe 6l.o ra otgr6pcra rnE xorvovfa,E.'Eror, evOouolriorqxa drav ou(r{rr1oc pe Or,dgoqoug cv0gr6rrouExroueflav colol.q0e( r,6ra(tseops rcr 0dpcra uye(ag.Aurof or <ivOprrlnor, 6r,60eoo,v nol,ri 1gdvo, ngoxelpdvou vo, Bqouv eval.l.uxrrxdg0epcne[eg,6rc,v oloOrivO4t+cv q naqo8ooloxr{ r,ctqr.x{rouE o,fioyorireuoe dn ruap6yovr,6groug o,vo,fiotel,eopo,rr,u6g Oegcneieg{ 0epcneieg nou evei1ov peycl,rlrepo Bo0trldenrxlvbuv6rqrag. AexdEeg dvOpotnorefdgQooov ouvatoO{trraroonoyo{reuorlE xo,rnlxgiag a},}.d xcr, ev0ouoraop6 xar el,n(6a yro tr,E evatrl.axnzdg pe066oug Oepcrne(og. 'Etoq ouyxdvrgrrtoc 8r,dqopegpcprupfeg cnd o6qyorig qoprqyc6v, xc,nettivroug,nll.drouE,ylatgorig, 6r.xqytigoug, ygoppare(g, pr,Bl"r,oOqx<igr.oug, 6rlpoor,oyqdcpoug, epyrirsE, XrQrordgql,exrpovrxrlv unol.oyrotc6v,prolqpr.xorig,q-ru1ol.6youg, exfio,r8eurrxorig, o0l,qr6g, qoepol4orrolorig,Borcvol.dyoug xo,r 6rxo,ordg.Kc06vcg roug e[1e q vc 6r,q^yq0e[ 0r,zr{rou rotoq(o, xan x6g pq{xe a,vo,xorigron xo,t po{Oer,o and ourd nou or{peqcr c,noxo,}.odpe<eva}.}.anrn"^,td>> r1 cprippcza. "oul.unl"r;polpc,trxci>
*12f

'Orav

X1e0dv6l,ol lgqor,ponolofoo,v rov 6qo <0auptcrouqy{0epcne(o,, ovag6govtav orrE spfirrp(eEtoug. Avcxd),upa enfoqg or,rax.6Sn1 x<inolor yr,crtpofXeqorprofiorofocrv oulvci rov 6po <<Ocrdpo,>>, drc,v yeoqov "rte(yeoupl3eioe zd,noloug ao0evefgnou dyrvav lccpvr,xsl"<i drav nriqcrv dvc cpdgpaxoxrourreorQy6ruv an6 q griorl. H ldln <0aripo>oq(erar. o.uo l,ellx6 tllE<[no,nqdEq r{ dva nopd'Erot,6tuv yeyovrignou yivero,r, ncqd roug cpuor.xofg vdpoug".

pe cvcqqc6oer. ni poriOero pnoE quorxriE ouo(cg, yeyov6g ro

mn6 e(val rdoo cloutrrpfBooto1.rc rreoo66rlpo qg ncgo8oowu"rlg xo rcngr,x{g,cirorero, }.<iyt,a nou Xenorponororjvro,r vo, exqgdoouv t4v yr,o fiorlaln xo,rrrlv avandvrep laqd e(val ouvr{0olg:<<Eivo,r. Oa,uprapla (a>. i\}.}.arre, ouvq0(oup vo, touqy{ Oegane ps Xo,eo,?.(rqp(oupe rov 6ro tg6no xcrr1lg ouprl3crr,xdg Oeqo,neutrxdg ayoy6g nou poE eu"nLrlooouv pr ta anorel,6oporri roug. 'Iootg a,norel"eidxrul,qlr1 6wolo, rou 6pou <<OeEro,neio,>>ro,rerq orrlv xri. O 69og 6ev avcgdgrro,r orrlv ntrriqrl xar, p6vr,pqlctpr.xri axoy"cn6(ocrtE v6pr,lcv ol negtoo6regor. orroorl, 6ncog 0a o,n6epdg. <@ego,neia> ofpqrrwa St"zro Dorland's Medical Dictionary oqpaiver: <H Oego,neutxr{ awtpetc6firoq proE co0dveng rj evcig.rqaripo,tog, 6vc orioqpa 0eqc,neurlxc6v oyatyriv r{ 6vc qdqpo,xo c,nore},eopc,tlxdorrlv o,vrr[.rst6nloq trlrcgv6oou>r. Ocpeil,otvo opol.oyriorrl dtl or, yvr6oer,g pou yro rlE eval"l"cxnx6g ^aatd14 8rdqxer,aqg ouyygccprig g Oegcnefe culriOrlxov 6gopatr,x<i aurod tou l3rpl,(ou. Oauparougy6g Or, Oeqcne yro,tr,E ieg ono(eg0a ocg pr.l,r{oot, po}.ovrful 6ev crvccp6povrcr,r Oovarrlcptigeg os v6ooug ri oe ao06veleg aner,).qtlxdg yro rq [orrj, dlouv elalpetr,xrl oq;rco(c ylcr ep6vo.flpr,v und 611o Oer,Lxri 1g6vr.cnepinou e(1c cglioel va no,igvrrt yl"uxo[otrrfvqdneltc an6 ngotgomi rou yr.arqorj Mrir.xh Mdgei, ev6g lvcootori guor,ono0ol,6you,ngoxe lpdvou vo, o,wrLrsrcDx(oa lpc6ro ta oupnrcirpo,rc ooreocp0girt8oE ora 16qr,cpou. )rjprepa eipo,l neneropdvr;rrtllEn Oegcneia outri ouvdBcl.eoqv xa0uo,r6gr1oq e[6],lqg Eng qS v6oou xor ps an<il,l,ale and tov n6vo nou q ouvo8erier. O olrlE ndvog oTougouvbdopouE tcrw bapril.trlv pou xa0c6g%o,r oroug cwileq6g pou efacpavfunlxe (o ndvog en6o,rpeeetrrdvo 6rov otoptiqoo naqobva4.vl lti.l,rl rtlE yl.uxolapfvr1g) xcr .^arcne ]"cBri pou q dyr.ve nol.f nr,oorcOsqrj zol 6uvotr{. )uv6o,rqoc d}.s ra qdpplaxo nou neqlygricpot plBl,io pou orouEgfl.oug pou xo,rorouEo'uyysve(g oro pou. O o6el"q6gpou xo,rq p(o cbeggri pou, or onoior dlouv n<iOel 6ppqaypo,rou puoxop6(ou,nc,(gvouvxaOr1;reprvd mg ouvdvEupo 200 e-10. r13r

pou psr"c60q?{s orlprowtrti tiotego H lolqotegfvq qg d],Irlg aOe],qt1g crnd (vegyxq6mgqout to ono(o un6 14l{tpq rou na,qc,oxeudoproroE oe neplyptiqor l.enropepr6g aut6 to prpl,(o. flol"l"dg qoedE lpetdorqxe q oroug g0.ouE lrou oe?ttr6.ydn"a kava (kava e(var, q(a tou va,6c6oor q q'urorj ndneql tou pe0uotr,tto6, ono(creivor yvtoomjyto rtE qeelrt,ortpou x6S rt)g rbr,6qteg) 6tav e(1av xgfoer.gdyloug. H avr,tlrr"ti ncfpver, ruripe0goyro rqv xatanol,6p4oq rrlE qprxpavfcrg. O xouvr,riOog irou hypericum owitou Prozac.H evevrlwa6udlgovq pqtdga pou ncrfgver" <iplroe va no(pver,ginkgo biloba ytcl 6rjo 1p6vr,o,an6 t6re nou dgltoe nold. vo elao0eve(q puipq qg. Nop(ol 6n autd tq Bor{0qoe cutori xan6.14 6r,rigzelarrlE o'uyyeocprig H 6peuvc ruou6r.elr{ycrya rou BrBl,(ouljtav nqayponn4. eml"r1xr,tw\xat ta eug{parri qg {tcv yto, rng an6 6r,crqoqelnx6. ra, anorel.6oLrcrro dgeuvcgnou 6xc,vc, ro ruof,ri nou dl.l.a 6exo,ew6cr Br"Bl,(c dyrl ygdpel, tc, neqrootitega an6 to, ono(c )to o,vo,avcrgdpowor,oe Odpctc uye(cg xol 6r,otqocptiE. ntrq(or,c'r'4E p6gogqg ntgtxr{g B{3},npeycrl.rltepo <jtr, E{qonS ploubrcrnfotrrroo, to ypap(crgr{rav riroqro. Aur<j nou lperdoqxe vo, xdvo xugftrlEtjtcrv vc ro ul.lx6, va to avalfoto, vo,to br,aorcugcfool o'ul"l.6Eco Br,Bl,r,oygc9r,x6 enrcrqpdvtov?ro,r ro rQorrovo eyzexqlp6vov appdbr,rov l"irqv rinot1rq rou pl$]"(ou. norfoor, c6orevo y[vel xotcrvoqt6 cnd touE cvayvc6otE q crul,l,oy{ n},qgocpoqr,c6v ro guorxri qdgpcza }4o1, yro rrE Qordoo, un<iplouoegOegcnefeg {rcv oqzerd 0rioxotrqun60eor;.Mo}.ovdrr,61er, fiou cr].pctc66qg otlErlo'norov 6yxo taw w].qgogoqr,c6v tpgooqper.or0e[ pleyahitego pdgogqg dgeuv(owor, orc xtiqlc rnglxti negm6lx<i,to 0eganefeg efval vo,Er[ou yet oyi.oq prro, quorlt<i qdqpaxu ,tuL xLE neguo8r.xd 6ev d1er, xar oe 8qpoor,euprdvo lirl cyyl,6grrwo er[lorlpovr]1,ti ora npaxttxti turv ntqtxc6v 6e6opdlcoxoxoQr,ole( lreropeoors( o(sr,e vrrlv.Kcu quolxd,, 6ev undpler, x<iaola truEfa].[0og r.ctglxrigouOew(og xo,r Jrouvo, enr,pepcr,river vo, Er,crcpox(el orouE axc8qprainorlgxrircl.oug qdgyr,' cpuorxd ro, rc, ororle(c nou 61ouvnqoxritl.rer. crutrd, Ocrupratoupyri poxa. A.r,n(Oerc, cruxo( nou gcr[vetcnvc yvop(ouv neqroodteQooxsrrcpopprixrrrv 0eganerc6v xcn e(var, torv cpuor,xc6v xri pe r4v xl.r,vr,xri Xario"n rouE, Jrou (ouv oe 6r,<icpopeg ?ro,r cro0eve(E or ol erbrxo( 0epcrneutdg HIIA 6r,e[dg6geg rou x6opou. To peyotrriregopdqogqg dgeuvagoTr,g yewn xand neq(wroloqcru6 yr,argorigtcu, enr,on{povrE rrou 6gouv and rSnruai np<rnopoul.[cr 6yt"un6qv enonre(cr{ qv xa0o8r{yqoqt<rlv xol qoqdow uye(cg.'Eroq q dgeuvcr enr"xewgc601lr orov twoJrrr4,om,xc6v qli oror,le(rrrvaad nortfl,eg rqydE xcr Baofo"rq?4e nl.qgogop(eg orrE ylctgotig xal oo0evefg. ar6 earo,rlpoveg, nou ouM"610r1xcrv br,riqogoug
J14.

Tel.r,xd,q dgeuvc cumi o6r{yqos orrl ou},},oyrin},qqogoqrc6vpeyo_ l.tiregou 6yxou and s,urdv nou pnoporios vo, no,rc,xogrcre oe crutd to I B$1,(o.Apl.xri, plerr; Bo{Oelo 6rjo efa(getcrtv egeuvqrc6v, dqlloa va efetril<rl ngooexrlx<i zdOe cpnrorxri grigpcxo xo,l Oeganeic y'a ro onoiu, eflc 6rcrBdoer, o,xorloe'an6 <il,l"oug. Enroxdcpqxo,ex06oerg, f q <irucrrg pey<i},4epnogrxr{ 5xOeoqyro xnv uye[crnou npoypatonor,{_ Oqxeoq Baf,trp6qq, xal po(i ps rouE ouvegy<fueg ouvdl.elcr, pou svrl_ pegoxr,x6ul.r,z6yr.o exc,rovrd8egnqoidvrc rTou,[ceouoldfowav olg puotx'6.gOego,neurlxrfE ouo(eE. Ar,apdocpe exarovrdbeg oyeux6. negroorxd xo,r evron(ocpe ourotig nou e[1o,vlgqor,ponor,{or rJlrruquorxri qdgpcxo. Alarp6lcpe ro Ar,a6[muo yrd, xo,ro,yeygcpp6_ 1c6E vo, xrserororntd xOI n1.r;pocpopieg. Egeuv{oclpe 6},e rr.EBrioer.g 6e6o_ E privorv qenxd pe xrs quorzdE 0eqonefeg .16oo oro, enlorqpovr,xri negr,o0rxri 6oo xo,r,ora, exl.o'ixeupdva ovayvc6opatc. Mr.l,{ocrpe pe Er,cxexpr,prf g enron{povsE rlou XQrl vou ol,pofio rodoav xc,r eq euvor.ioa,v pr,cr nolrul,ic Auor,xc6v Oepro,neuflxc6v ouolc6v.Mil,rioctrle pe xopucpaf_ oug Boravol.dyoug, quolo0 epcneurdg, xa0qyqrd g fi o,vsrr rorrll"rirrw xar utprll,6Ba0po orel"61q erarqrc6vnou aolol.orjwor pe q Bropqlcrvrxrj nopaycoyr{ ttut xafiavfl}.oroq guorxriv 0eqaneuflxc6v ouorc6v otlv Euqc6n4xcr, orr,gHIIA. H 61,4epnelgfc rirav ouvcgnaouxrl, evOcqguvrlx{, evqpeqott_ xri, Orcrgottouxrl, al.ld xor, oulvti ano0ogquvrt"xf xat cnoxap8lo_ lnxrl. Qg xu' eloyqv EqpooloygriqoE rou rorqlxori getoqt<il r{plouv nol.d ev0ouor,copdvq rc euEiporo rrlE 6peuvogal.l,<ixul opr,op6_ pe veg qoqdg a,ncu8ropdvq ond roug c,veOagrxotigloluprroporigyr.cr dr,tigopc Auorx<igtigpoxc. )u1vri anoyoqrerlrrlxo,xc' evoll.r{0qxa cntl tqv ongoOupfc xcrr rrl orev6pucrl"r;crvrlprerc6nloq tou rargrxori xantonlp"fvou, fiou a,qvldrcv ux6pq xo,r vo, o,xor.ioe yla xI I Xa{on ev6E on6l.urc aocpal.orig xal r.crqr,xd 6oxr,poop6vou porrivou pe 0ego,neunz6g l6r,6tqteg,6n."g e(vo,r nriqegqo, fiou Xerlorttonore(_ ro ro,t yro rnv o,vrrperc6nlorl IFr?reov(ag.K<irror,eg rns goq6g xo,ro,vo_ odoc rqv enucpul.crxtlx6"crpu undqler, yfgrrr ax6 ta guolxri g<ig_ nou yro Iro?ro,lOlcireqra6rcv or r,olupr,opo( ttE 0egc,neutrxdE r6r,r5qrdE roug r{rcv elcrlngcypcttxg xat ol rr,p6g rouE oro epnrigr,o uneq$o},r,_ xti utpql,6Exar nr0av<iv ncgcrnl.crvq g. "ctx Tel,rz<i, ogori pi),r1ocpe nol"l,otig coOevefg,yr,arporiExan exrcu1_ povsE,ouvdl.e[a rlE cnrStpelE xouExor xord],r;fia oe x<inola oupnepri_ ol.roro,Baor,op6vq oqv xal.rfu gq ouvol.r,xr{ e alr,o},<iyqoq excnow<i6<rw guolxc6v 0epaneurlxt6v ouor,c6v. Boolx6 eqc6qpa To {rcv noleE cn<5 :15 r

floteE 60eryvcrv oto vo 6l.egcut6g 0c dngene oulffrsQt]dp<o pr,l3trio. unooldpeveExo,t e(1cv tr1 peycl"ritegqenr,otqpovr,xr{ nepr,oo6reqo
rexpqg(rrlorl; flor,eg ouvlotorjocv rto,t fioteE XQrlottlofiotodoav ot J[to autotj tou 1t6gou;floleg tto,t enrctripoveE ol auOevt(eg 8lcrxexpr,pdvot x,ot flor,egngoodl.xuav to ev8lccpdqov aocpal.e(g; rjrov neqr.oo6tego flor,s 0a qv ngooofi qg latprx{g tor,v6tqtag yr,c pe}.}.ovtr.zli 1gr{o1; xcrl 11 eyc6 (6ta ttot fioto,0o ouvtotofoo orouEcp0.oug XQrlorpoJlororioo otqv orxoy6verd trrou,paor,opdvqotqv rinoplq oqpovnxc6v otorye(olv t"xor,qt t oug; yro rqv crnotetreopa,t d oqpcro(cg yla Aur6 to tetreuta(o eqc6qpa {tav crrcoqcowr'txt1g pe epdva. Aql,cbf cv eyr6,yvtop(owcrg 6oc r16qfdpat, 0c onocptio'r,lo 6va vo xar. 6(1trlgxav6va ev6or,cropl6 XQnotponor,{ool evOouoraop<l cpuorx6q<igpclxo r{ vc to ouot{oro oe 6ooug a1an6. Aut6g e(vo't o pe cpdgpaxc crvocpdgowar, l"6yoEyto,xov orofo xcinoro cpuolxcr xriprr,og ptBl.(o xc,t xdnotc til'l.a 611. peyal.titegq hentop6per,ooe aur6 ro nou Kcl0c6gpel.erorioc q paxqr,d tr(otc t<rlvquolxc6v cpcrgp<ixow x6'vo o;roQQhpruo o1e6(alo va ewdlol oto l3tpl.(o,cvoyxdotqxo nor,cr crnd cutd,, 6tdtt,6ev pnoporioo vo, Bpo ototleia, nou 0a enlBepc(rovav t6 0egcneurw"6gr,6t6qt6g toug. Ocpe(l'rlva opol"oytlotrl gdgpaxa negr,l.r{cp0qxo,v pr,p[(o pou ]"dyco oro 6u, ogr,opdvocpuotn<l cvdpeoa pou ttQoE titopcr Jlou ro, XQ1otpofiol.oriv, ro rou oeBcropori T[tti Ntroux, 6vog bgcotrigr.ogpotcrvo].6yog, ora ono(cr e[var,o 0q o 6p T[6r,pglx6gvtov, 6vcg yr,atpdEpe nQoronoploxd 6pyo xct o xcl ycQouoto,or{gtcrtvH[IA, nou .yet:r18rivctrrq Top X<ipnrv, tlvcrg pe q pel.l.ovtr,zrief6l.t[q torv guor,vo, to evOrcrpdeov o,o1ol.r10e( 'Ol.a c,utd, tcr <itopcr eivo,t une60uvc,, xc6v cpappdtttrlv ortE H[IA. xo0riE ruqooeyy(ouv to 06pc Bcror,[dpevo xol (orrlgoocp<i, eucpur{ 11 grigpcxcr. OprcpLriveg cpog6g, otr,g rprrtrQ(eEtoug Ft xc cpuotx<i eyxup6tqto xal 11aflontot6c ev6g cpcqpdxou 1yxewat ornv ttttrug,e}.6q, Xnpdvn Xa{orl xan 6yt, os pto, e}'ey16pevq strtornpovtr,tr1 6nolg enloqpo(vel o 0q fxdgvtov. )uvotlr(owo6, crut6 to BlBl.[oavocpdpetatoe aut<i nou nol],o( enlao0eve(gnrtefouv Yto,ro, tpuolxd ptippcxa xal onipoveg, ylctgo( t<,cl nepr,l.cpBrivsrrLE nl,qpoqog(eE rrou pnoporipe vo ptiOoupe crnd opcptpol,(udtr, undqlouv v6eg, ouvcrpnconxdg cnnorig. Aev urudg1er, pr,oQTUQCeg 0a ng6nsr,va zdvouv tov x6opto vc, nou xrn a6r,<ioerortE pe ofveorl trQoEro guolxd gtigpaxcr. H evqpdptrtoqeivar, ouproqe( roi'ri oqpcwtxq,v,t out6 ouppofvel 6r6tl oritrrqcwope ta eug{poro xrlE crutoritou l3rp},(ou: rng pewriE pou xcrd q 6r,dgxer,c ouYYeogr{g x'l6 x

o Ta l3dtavcr,ol Brtop(vrE ror ril.l.o guotxd, griqpoxa cpfqvouv yr'otgorlgttcrt enlottlcrnot6l.eopa,of pptrlvo pe nol,l.origooOeve(g, poveg-egeuvrP6g. o Efvau cloqa]"r{ 6tav lpqor,ponolot'iwat xatdll'q}'cr xcrl doetto crn6 orrlomleril.oYr{. o )uxv<i tcr guolxti cpdqpaxo xal B6tavc e(vor' el(oou' crv 51t tq qd'gplaxo 11 pe nuproo6rugo, crnoreheopcrttxdxclr' aocpal'r1 tcr g' 0egcrre(eg tq g naga8oorrxr{ g r'crtptxrl o )uvri0olE 61ouv notrti ptxpdteqo zdotog' yr'c nol'l'orig clvOegane(eg" . 'Exouv enmilet <Oaupatougydg (6lo xol 0gc6tougxct e(vot nol,r'ilt0av6 vcr gnogoriv vc xrivouv to yro eodg r! yto xrinor,ov6r,x6oaE dv0galno nou 61el crvdyttq' El,nGol cut6 to p$}"(o vo oog napaxwrloet vcl ro' 6oxr'pd'oete'

n17e

Mrs errcxvdoTCIorl

oro x(l)porrls tqrptKrls Korrrls gCIppCIrcotroyios

TI XPEIMETAI TNOPIZETE NA rIA NAEKMETAfu\EYTEITE EYPHMATA TANEA
orS dlere avcprotq0ei crvra 8ldcpopaguolxd q<igpaxo nou Bl.6T I noupe oro l{,crcorripora uyr,elvrig 6r,ctgogriE,ord gcepcr,%e[cr, oro, noluxc,rq,orripoto xo,r,oro, oodneg pdgxer eivcl,r, r,xcrvdvcr cpdpouv x<inoro anor6l.eotrra.Yndqle r n gtiy pou, xdnota enrctr1 r,xtjal lon rplov otfa rdga an6 u,g unool6oerg yt,o,evruntrlolarti anore].6oporo; Kal, xug(<rrg, egc6qpo e(vo,rcrv crut<iro, cpuorrd gdqpaxa p,nopor.lv to vc qnd prxqdg,aorjpo,vteg ocg Boq0rjoouvvo, Oegcneure(re ooOdveteg, dnog to xotv6 xguoldyqpa rcor ro, 1opql,<ien(neOoevdpyer,og tou oqyo,vr,opor5, av pnogoriv oqoyplatr,xd vc Bonl0rioouvttcr os xreer{ ntrioerg ooBaqc6v,exqul,rotr,xc6v o,neil.qtr,xrfvyr,c fll lotrl vdocrlv, xo,r. 6nolg eivor,q xcq6rox{ aventigrela, o xc,qnivog, ag0g(tl6a, o 6lo,q prinlg, 11 n(ggcoorl, xar<i0l.r,{rn 11 xou n tfupxrj 6r,orcpopj; @c pnogorioe xdnolog vcr 06oer,outd ta egcoojpo,ra sxoropo pdqr,oo,v0qr6noug dl,o rov x6opo nou 61ouv XQTlorpofiouioer oe ple enlrul[a ra cpuotxtigtigpo,xa. A6r,opcpr,oprirnro,,on<iwqoq e6vcl q Oetr,t{. H Xpnon aurc6vtov quolxc6v cpcgp<ixrrlv Bordvrrw 0o, xal plnopotioevo, pelc6oel xor vo crno,}.e(r1.relOuopeve enr,ntc6oerg r{ tr,g [g trrrv oupBanxr6v 0epcrnelr6v 6oov cgoqd qv uye(o,rou ov0qc6nou ?4o,1. or.xovoprxdx6orog. @a dngene routr<illorov va efercrotorlv ro or,0uvct6qrtE ?tor0epaneurlxdgr,Er,6tqteg guolxc6vqagpuixcrtv rrrlv nou dlouv 8onrpaoref xor XQrlorponor,q0e( pe eupdrrlg xuBeqvqrr,xrj dyxgroq oe nohl.dgXc6QeE, ono(eg oupnegr.l.appdvovrcn feeorlg n pov6a, 11 fcl.l,(c xct 1 Ayyl,(cr - Xc6geg nol,6 u!-rr1l.ofenr,owlpovr,xor.i ?40,r, rc,Ter?(orj enln66ou.
I19 T

t'
I I
I
EutulrfE, q ordoq crn6vc,vrl orr.g cpuolxdg 0egcne(eg cl,l.dler goy8aic orr.gH[IA. Xe o,ur6outrrptil"l"er.ol"odvc culcrv<ipevqfiror1q povrxr{n}.qpocpdqq oyerw"6lrs ro, cpuorxricp<igpaxo. oq Ar,axexqr.p6vor enrotrjpoveg yratqo[ 8oxrpd(ouv ?.r,cr xal tdrorcrquorXenorponororjv x<i qtigpazo, xot ouyxQivouv rr.1v cnotel.eopcrttxdrqta xcxtrnv oocpdl,eri rouE pe aur6g rtrlv cpo,epoxeutlx(ivouolc6vnou nap<iyov.ro,r c,nd propqlovieg. r,E cpoQpc?{o @uiveror dtl or Aplepr,xovofcno66lowar pe ev0ouolaop<irc cpdppcxo cn6 B6rcvc, r,u cpurtttd gtippaxc xsl 6l.ov rov el6r6v.ra guolx<i grigpoxa nou 6lari0evrc,r onou8rlnoce6i1atgneglopr,op6{ lorprzrj ouwcry{. <<Icrtgrxo( epner,qoyvc6povsE g(ouv 6rt, ru urToor1 tel.eura(a 66xa 1p<ivr,a, ol.o6vcr neqroorfueqol xa,l tlvOpotnolotp6govror or nol"l"6g Foegdg evo,l.l"a,xrtx6v0eganerc6v,oe oldoq ps nal.crdtegeg eno16g>, 6yga!.re rov Iorjvrc rcu 1996q T[ivc Ko].drc, 6lpoor,oyqdcpog unetiOuw] yro rnroxlpovrttti 06pcro mougTimes l;l1E N6og Y6gxqg. OgropldvoL aunj rqv tdoq rog <rdory Xo,Qo,xrqg(ouv enr,orpocprjg g(eg po,E>, enr.Outrrio orr,g avoxd].upqg trov guolxc6v [no, cpapptixrrlv Xelorl.ronororjoc,v np6yovoi pcg. eordoo, 6ev ngdfiou ol rrervo ncrpopl,6tlroupl,yeyov6g6tr curli q rdorl anote).e(ouvdnera ro Tou ouvo,oJTr,opori r,o1ugc6v xor,v(|)vrxri].y olxovopr,xc6v8uvdperrrv xan evdvrn oro buol3riotay.ro x6moE rrlE uyrrovopr,xriEnep(0crl,r.pqg, orrlv xordqeruorl rcovunegBol,lzoivxal a,vdcplxtrtv unooldosov rrlE oriylgovqg lctqr.rrlE, oq ouvelbqrono(r1oqrotv og(crtvtto,rrcovJrrel,oqr,opc6v xo.L xn1= otqv culcvdpevq aqoulia yrc tlg ncrgev6gyer,eE rrrlv ngoidvtrrtv rtrlv cpcxe["ro,1,ol3r,opq1ovr,c6v. nou 0a plnoporioeva yeyov6g rog Xoecxt,t'rnerorei avr(8gcoq evdvrrd oro crruol.uragl,x6 lotpr,xd orjorrlpa,, <inou ol yr,arqof cpa,ivero,r, 8raOgaplct(ouv ro gd],o rou va @eorj.)e rdtor.eE negmtc6oerg und aurg"ttgouvOrjxeg, cpuorxo,l ro, xri cprigpaxcr xcl $6rovc qo(vovtcr, tog l6ovlx6g l.rioer,g,acpori61ouv ouvr{Oolg no},ri pr.xp&eqo xdotog, Oeotporivral neqrcodrego aoga},{ xal bivouv oroug aoOeveigpeyol,rfuepo negr.Orirplo el,euOeq(ag otqv crwrtrrerc6ntoq uyefag roug. qg Oqr,opvor, zaralr,ro;rdvoIyr,urqoi nou o,xol.ouOoriv napc6oqv owxrl rctqrxri avqouloriv yro rnv 6l,o xar crulovdpevq ecpagpoyrl rr,rlv evol,l,atnw"tiv 0ego,nerr6v,al")"ri dl,l,or, nrorefouv 6tl 11trioq cur{ eCvclxor,vrrtvrzti exlrorrll,rovlxri xo,r 6exrr{ xcr,r xo,rclvoqrr{. E(vcr, c,vorxro( otr;v l6do &r, dl,l"or,nol"rrr.opoi xcr dl"l.eg 1c6pege(vcr, 6uvcrr6 va 6r,a06touvoll6tloroug tp6noug Oeqane(cgv6orrlv nou 0a pnoporioo,vvo, eivor,lqrior,lrsExor yLo,rouE un6].omouE.E[vc,r,
K20x

trom6v, rl0av6 vc pnogoripevc pui0ou xdtt" yro,tlg evcl,l.axrr,xdg p"e (ooqg 61, pr6voond Aordreg 0epaneurdg al,l.d xar and pe066oug srrrorrlprovrxdxato,qnopdvoug ylarqorig tqg Arioqg, dtrrlg eival curo( nou l3p(oxovrar, orq fegplavtcrxar orq fcl,l.iu, 6nou ro, quorxri pdqpoxo o,vnpsron(ovrcn pe rov (6r.o tp6no dncogxal rd, oupcpdppaxa. Batr,xti O Tldr,pg fx6pwov, dvag tl.ru1[ctQoE xrou egydlerar oulv Ouriotyxxov xo,r e(var xa0qyqmjg larpr,xrlgoqv Icrplxr{ )1o}"r{ rou flcrvenroqp(ou qg Tloglrdouv, rolug(etal: yn an6 roug ).crycruE rouE onoioug ot dv9qanot rnpiqowaL ovlv eva)J"axrmr1nrExrl eivat rc yeyou6g6n ro mtgm6 ouotrlpa Eaivetat avenapx;. 2tr7v npayptatmdrrlta, \mvtioupt ptn <tn dll1 ia> avenaqxotiE aw Lpteubrcrygr av yqdvLotuna0r1 eatv. p n o E lrlw a ex arc p pti qta Ape pLxavoi nd.oyouu an6 un 6pr aor1,oapdwa sxatopptjpn nd.oyouyand aq1pirda xat eixoot rpia txaroptrttgnunocptqouv an6 rlpuxgavieg. Kd.Oe ygovo 6va exaroptptipnAptpmavoi npooBd))owat an6 xapxivo xat ntp(nou ro 407o and epd.g npooBArl1otiv 0a xd.nom mryptr1 (atr1g u1g rcug and aurq qopteprl xat ouyud.0avarrlE6po tt6oo. H ouyvfurpa pe rrly rryv onoia epEavilowat ro d.o9pa,r7oxAr1quvorl xatd. nAd.xag,ro otv6qopoyqdvtag x6naoqg, o Ldg AIDS, xa1rbE noMiE d.il.eg rou xat exEufuor 6Ena)oToym g xaramd.ot tg au$dueta t. H oupBar mr1 m Brciaqmr1 nou orlpeubvtt ewun@orax( enmuyia ov1 1eqaneia rav ),otprb$tay, ta't) eneryfwav neqtmarmc|v, xa)tig xar ro)y yeuumdtuelamapdrau, 6ev eivat mav( va otryxpat(oetqv nArT06pa aum6vtav y6oay>. 'Evag

OI NIOENTYNO>IAKE> ANAKAAWEI> >TOXOPO TH>IATPIKH>

q flgtiytrrotr., crvtil.qrl-rq or puorx6g ouo(eg 61ouvtr1 OdoqrouE orn 6rr otiylgovq rctqrxri efanl.c6verat 6lcgxc6g xat axoar6"oncEorig enlotripoveg nou pg(oxovror or uQql"6g 06oelg oe axoEqpaixd xo,t xgarlxri rctqr,xd xdvrgc orlg HIIA, dnrogefval ro Xdqpcgvr ?{o,r ro, e0vr,xd rvotrtorito, uyefog. H cr[lonlotio, rrov guorxriv 0eponer,c6v 6rero&jer otcbr,az<ioro 1c6qo g tlg r,atglzrig.flo),1.6g a[r"6],oye pe].6rE rlou zata8elxvrjouv rrlv clicr row cpuolxc6v0epa,neurlxr6v e21x

ouorcbvl{,dvouvrrlv slrqdvroti roug oe dyxqlro sr[rornpovrx<i negr,o6r,xd. Xq4olponorc6wa,gouoqpti rrlrorq l.rovt xgm{pr"cr,no}.},o[ x<i Er.crxexgrpdvor sesuvq#4 oe Jretrtrorroero, exrculSt"ov xdvtga x6. nrd 6oxr,p<ilouv r6r.6rqteE tr,g rcov guourc6vOeqcrneuttxriyouolc6votqv c,vtrperr6nlorloqr,opdvrrlv and r[E rlro ooBag6g vdooug xo,r rleoxogoriv orq oriyxgr,oqrqg crnorel"eopcrlxdtqro,E 1,(,or crocptil.er,cg rr;g a,urcfvtrrw guorxr6v ouorc6v o16oq pe ng outripanxgqoQLrouuoe g rr,xd ouo[eE xrourrcQooxeu <i[owcr, propqlo,vlx6.. 2uyvd"onE quorxdg 0egoneunxig ouo(egpg(oxouv peydl,q gcgpuxol"oyrxrl6paonxdrtyco-. OgropdvegqoQdEol cpuolxdg ouoieg e(val elfoou crnorel.eopanx4g 6oo xo,r, r,olugti <cprippoxo,> nagc6oor,crxriE tc rrlg ro,rerxrig. Xuv{OoE, ro, guolxd cp<ippcxc e(var fio}.d nlo a,opa}.r1 u"ut 61ouv prxQf { xapfc rolmdqrc x,ol e].dpoteg 11 xa06].ou o1po,vmg x6E cvenr,Oripqre evdpyer,e g. To yeyovdg crur6 trragx<iver va ngoBl,qpcrr.ldprcrore ro rroro, yro 0egane(cr np6nel va Oeotgefral evq,l.l.crxnrr{.)q ouvriOq r,orgr,xrj npoxrr,xrj nou o,xol.ou0e(ral oqv Apegr.v"rl,r,a lolupti gtippcxcr c,norel.ofv ndvr,a qv np6tr1 enr,l.oyrj,evc6ra pq oupBarlxd g<igpaxcr 0eorgoriwo,r, n<ivta ory 11 rel,euro,6a..evq,l.l,uxrtxr1>> l,rioq. Ae 0o {rcrv nr,ol.oylx6 vo Eoxr,pdlouLre negroo6reqeg 01r,E neqmrc6oerg rugc6ro ro nlo {nlo cp<igpaxo rr,E},ryrlregeE pe uvenr0riplreEev6gyer.eg orrl r,o,r ouv61er.o rrQoxoQoriple r,olugdrepo xc,r, nr0c,v<iv, vo oto nlo gnl.roxfv6uvo grippcrxo oE <<evo,l.l.o,xrrxd>, nepinroloq fiou ro npc6ro 0e otqv q6qvel ro enlOupqr<i onoref,dopcro; )ripega, 6l,o xcrr neprco6tepor yrcrpo( xcn c,oOeveig ngoBl"qpct(owd,r oxerrxti pe c,ut6, pe ouvdnera tcr quor,xd gdgpcxcl va dqlovrar oto ngoox{vlo. 'Exoqro 1993l6qt10qxs ou,EHIIAqnipo eval.l,cxrlx{E r.mpr,xrlg oro eOvrx<i rvorlrorira uye(cg.To tpr{pa a,ur<l, po}.ovcrr," e},}.r,nri dyet" XQTttoro6ftr1o4, aolol.e[rcu, onox],erorrxri pe q pe].do1row evc,],].s,xrw(w 0epaner,c6v xan'6yetlgqpcrobomjosr rIV dgeuvo oe xoqugcfo, ffu,orqpovlxti lvorurorjrc yro ryl pel,dq qg onorel,eopctx<1n4roE ?ro,rrrlg aocpdl"er,og rrrw qoqpdzcDv xrou nqodqlowar, and Bdtcvc,, trlerafii trov d]"l,orvpq oupBmr,xc6v 0epuner.c6v. Tov lofvr,o rcu 1996,pu,cenwgonr{ rou rpripcwogeval,l.oxtr,xr{g r,atqr,x{g nq6tewe q 0r,6aottc}.(c pa0r{rou poroErnE evo),l,oxtlxrigntqrxrig orr.glotglxdE xcr.vooql,eur,w"6,gcrtrol,6g. O 69 Oudr,vTl6vag, 6rcu0ul'r{g rou rpripatog, 6rj},ore drr, nep(aou ocpriwc r,cwqlrdgololdg oe 6l"egrlE H[IA, pretclri tov onoitrtv ?ro,r or rcprugcfeElorprxdg olol.dg rou XdpBcgw xo(rrou Tlov X6nxw g, youv rproo0doer. o wqdygappdroug paO{pmc eva}'}ysmtx4g oT r"mpr,xrjg. a22*

MIA OAPMAKEYTIKH TPAIQAIA q Ev pdper,, otpogr{ qg 6geuvag rreoE guor,xdqdgpaxo lrrlg(gavero nr0riprlteg evdqyer,eg ocpei),erclot4v o,ulavdpevq ovqoul[o yr,a rouE rov oupBonzr6v qogp<i?ro)v, onoia pnoqef vcr 61ouv xr,vOdvoug ro, ncpevdpye orlpowr,xdg reg.Or,ovenr0dtrrqreg evdqye rolv gcqptlxorv leg ouvrotorjv pro r[eoyprol,xri eOvrxritgcryof(c yr,o, H[IA. ttg AvapqiBol,G, q cpoelroxeunxrl Br,opr11av(o HIIA nopaoxeudrrov ler, ovogiOpqrc agoidvro, rou nagdlouv peydl.c op6l.q orouE aoOeylo 6oo ro 6uvcr6 peycrf,r3rega ve(g. Qordoo, rl rreooJrri0er,a xdq6rl --ro 1995rl cpdel.r,cr?{sutr.xri qyriOqxe6}.olvtrlv d}.},olvx}.<iBropr;lcrvicr 6orv Brcpqlav(crg oe xdpbry o6{yr1oe orqv urrrQrrgori0r;oq no}.}.6v gcrppdxtrlv pe tp6ao nou tov(el rcr nl.eovextit-tstdrouE xo,runoBcl0toug. Kd0e 1q6vo 6ancvc6vrcr,L0 6r,oexatrr(er qv emxr,vEuv6nlt<i exorqcre(a qcrpp<ixrrrv roppriqra 0otr<igr,o Or,ocpqptottxrl oq nou nol.l,69gog6g naqo,nl.o,vofv rouE oo0vsfE. yeyov6Euur6, enrx(vDuvc To pe yn oe ouv8uaotrr6 qv crvencrqz{ezncibeuoq rorv yr,orpc6v rc cptippo,xcx Jlou xuxl,ogoprotjvoto epn6glo, aufdve r rov xiv6uvo trlv ooBaqc6vcvenrOr.iprgtov evegyer,r6v. naqriDerypa,xd0e 1g6vo Jreerofr,a odregol ax6 1,exctoppdgr,o Apeqrxovo( cvoyx<ilowo,r,vo, voorltreutoriv l.6ytrrcvenr,0riprptov evegyerc6v an6 ra cptigpoxo-61.000 dvOgrrlnor naOaivouvJrcQlrroovlop6 nou ogefl,ercl orr,gnopev6QyasE rov qopp<ixrrlvnou xo,rc,v<1l.ooc,v, 16.000tiv0polnor,ouroreo,upo,r(ovrcrl l.6yor mrrvpcprprixrrlvnou 61ouv n<iqet pe ouwcyi yr,otpori, 163.000 rivOgonol no.gouor,<i[ouv anc6tren,pvlipnE nou ogef],ercu, 61er,enr,ri 6elvor0s[sn6 ta g<igpcrxcnou dlouv ndqer xar, 32.000 tivOpconor 61ouv n<iOelxat<iypata lo1(ou l,6yor ntc6orov Jrou ogeil,ovrcr otrg cvenr,0riprpeg evdqyewEralv goQl.uixrovnou 61ouv xorovolc6oer. Ol negloo6reqeg<oul.tiporov ro, 6rio tg6to- ond ng ovenr,Oripqteg evdgyer,eg pruoqoriocrv eilclv ngoBl.ecp0ei. 0o va flol.ri oulvti dvc qdqpcxo pe preychiregq erlxr,v0uvdrrpo ouvrcyoyeoge(tar 6rov dva dl,l.o coqal"doreqo xal el[oou o,nore].eopcnr,x6 pnoporioe vcr 61eI 0o i { loqqyoriwcr, 6rjo qriqpaxa pal( -<c ono(a Ocr r{tcrvo1e1oqqyr1Oe tlxri cogol"r{ crv Xopqyoriwov ro xa06va p6vo tou- ngoxa},r6waE oo BagdEnoqevdgyer,e l,6yrrlrq g crl"l,ql.en i6pcro{g rou g. E H urepBol.wfi xol o'u1v<ia8uixqrq o'uwoyoygriqqorl qcgprix<rrv gaqpui6yatx&vet trg HIIA 6vo dOvogcn<i e0r,opdvoug xcro,vo,l.crn6E xrrrv.Mol.ovdrr,foOerioupeexcroppriero yro va efcl,e(tl.roupe br,ricpopeg noqrivopeE Bl,cpeqdEouo(eg,ru lep6repo aqoBl.ripard pag rreoro,-

r23r

l.orjwcr, o,ndtov eOlopd pcg 61r,orqv 4qotfvq xo,rrrlv xoxci,vrl { d}.[o vc,gxonlxti, al,l"ti ota gdgpcra fiou XoQnyorlwal v6pr,po. xcl nol,l.dE goedE 6(1o4 npol3trqparr.opd and tqv nl,eupd row yrngc6v yrcr nlv nr0crv{ 6rlpr,ouqy(a eOr,opori. Mr.c pe},6q nou e(Oe q(DE Er1poor.6ro qg rlfrcxE 199766er,leor,tro 1995neqoo6reqor arc66 exctoppripr,aApero gr,xc,vo(6xo,vcv xorrilqqoq orrlv xcrcrvdl,ooq rcrlv ou\ruo,yoyeo,cporipevrrlv cpogp<ixrrrv, dnotgsivo,tro, euqeioExorcvdl,ooqE oylol.uu.x<i qdppaxc. O cgl0pdE aur<igeivar notrri peyatrrftepoE on6 aur6v rrou o,wrorolle( oroug 1q{orsE nQrrlfvnE xoratvqE po[f. Ol ouvdner,eg xa,r ev6E rrjrorcu eOtoporipnoge( va s(var rgopo,xnx6g,xc0c6gpnoge( vo, ?roro,orgdtpouvtq Etrlr{ rcovov0gc6novnou fex(vqoav cvalqrriwcg Bo{Oer,c yro rrl 0epa:refa eril.oyrrlvngoBl.qptirolv, 6nolg sivo,r oL xp(oe6 nuvrxo6,xctt nardlqfcv vc, efvc,re0r,opdvol ota cylotrurr.xd gdptrraxo,{ vc, (vcooq naqo.xol.ou0oriv ngoyq<ipporo anotof g. H al,r{0er,cefvor, drl un<iglouv.gvotxd g<igpoxc enrxiv8uvc,, tc, onoio,Xeqorprorrorofwar xoOqpegr,vd d),o tov x6oproyro rq Oegaoe nefa Dr,dcpogorv vtiorov.Anorel,ef o1e66v eyx]"r1potr.xri npd[q q pq 6r,eqefvqoq rnE Xa{orlEquorxc6v ouorc6v 0eganeutrxdE r6r,6qrsgorrE trle HIIA. Qordoo, un<iqlouv o,pxetd epn66r,o.

H KATA>TA>H NOYETIIKPATEI >TI> HIIA

ayopdler xtinorcEquonrd qdqpcxo oe xorccrnipcnc uyr,er,vqg 6r.crreoq{E, gaqpcxe(o xa,l oorinep pdgxer, xo,Oforotal ourop<iro4 0ripa trov crl"l,6xorovxgctz<6v xavovr,opc6v. cguor.xdg Or ouoiegpe Oeqaneur,xdg t6r,6'r4reE e(vcrr 6ev 6uvat6 va,Or,acpqpr.ororiv notl.q0oriv cguorri vc oE xri cprippaxa,oIId xuxl,oqogoriv otgtgdqr,po, rog oupntr4pc6pma Or,c'Erou, reoq{E. 6ev e(var,Euvard va yvroq(er, xti:norcgpe oxpfBer,orrg r,8rdqregtou ngo'r6woE tr co06vewEpnoge(vc Oepcneiioer. lrcr Ancyoqeri eror rl ovoyeaqri 0egcnernlxc6vev6e errrv orrEo'uox,euo,fi oieg tarv npoidwuw xo,r enwgdnercntrrdvoq cvcygcqri a,6glor<ov xa,l enouor,o66vr,olupr,opc6v'yr.c ncpti8er,ypcdrl dvc ngoi6v enr,6g<i euegyenxd os pro,6opt4{ }.enouqy(arou ot6pcrog, dn<rlE npo'i6v eival <to xol,6 yr,oro, pritlo,>> 11<<xdver" o,roxuxl.ocpopr,xd zal.6 crfoqpcn. Euru1c6g, xdnopl noqcyolyoi efvcr apzetd unefOuvor,nogo,oxeu<iouverEqrtinpoona0orjv va evqpreprioouv louv notrrixal.<ingo[riwcr xc,r, ro xcnava,l.ofitx6 xo w 6, trrol.ov6l,6 eoped owcrr xo,rrrr Qroe(owor, cnd ro xgdroE, rrou o,xroyoeer.ier Oqtrloor,ono(qo4 q Oegcneurlrc6vlolupr,a24x 'Orav

opr6v yla ro fiQoi6vrd ouxd. Qor6oo, 6uoruy6E, dvo,pdeoErrlE oevnttxrlg xpnwrig nou 8dlovrcl or,?r,o,rc,oxru aor(.g r"at or dpnoqor aurr6v rorv guor.xc6v npoidwcw d1er, cl.r1Or,vri Ogr,op6vaan6 ra ngo'r,6l3<ton. wo, a(vo,r, Xopntr{Enor,dtqtog. d},},c eivar, xaxo( ouv6ua,opo(Bordvcrlv nou 6ev 61ouv xavdvc, vd4pa, ev6 dl,l.a negrl6louv t6oo pr,xgrinoo6rrfrcr, svsQyr{g Oeganeurnx;lg ouofug, 6ore Oev dlouv ouorc,orrz<i xaprio clia. ?\),1,c rudl.r, 61ouvnol"riupql,6gr,t"ptg or tlreu8e(g ?ro,t enr,oqptivoelg nou o,vaygtiqowo,r o' o,urd, xa0c6gxo,r or naqcnl,avqtlx6g br.crcpqtrrfoe r,gelonctotiv ro xorvd. Enrnl.6ov, 6ev pnoge( xd,nolog vc, yro, vo tov bncportioouv xc,r Bcor,ors(oroug notl,rpdgtotv ngo'r,dwrov vo, rov evqtrreqc6oouv ooto.r<i yro nE r6rdrrp6g toug, xc,0r6g6ev eival 6l.or. xal.d evqpepcop6vor,. f,)ordoo, aur6 nou xugirog euOrjvero,t, rrlv rioxnpll xcrriorcoq yro nou '1el 8r,ctrroqcpolOef ayoq<i o,urc6vrotv cpuorxc6v oqv npo'iriwrtv e(val 6va xo,ro,oleocprx6 vopo0etlx6 o'riorrlpanou ano0agpfver,qv ovdnrulq, 6oxrpr{ ?{,o,r rroQo,oxeurj ugq},r1g nor6qrcg cpuor,xciv tpoidworv p 0epraneutrxdg l6r,dtqreg. negloo6tega o,n6ra utfql"rjgrrorTa, Stqrag cpuor,r,<i g<ippcxc, dncog eivct to ouvdvlupo e-10, ro cputd hypericum perforatum (l3al,oap61oero),q eyw1xta,ro ydl,c rou yc,i8oupriyxc0ou rto,r ro ginkgo, nagcroxeudlowcl xugfog oe ldveg xcl oq feqplcv(cl-xatt4v Icnolv(a x,o,r o,voouox,eudLoX6QE xuqicog wo,r ornv Apeqr,xriyro,ro o,lrserxo,vrx6 xaraval"ror,tx6 xow6.

|IATI NA MH |INETAI EPEYNA: i\l,l,o dvc nqdBl,npc nou ngoxfnrer afid nE vopo0etrx6EguOp(osr.g oyerm6. ps nE cpuolxdg ouo(eg fiou XQlorponorofvto,r, cp<ippaxo crtg efvcnq v"andmaoq pe rlg ncrrdvreg. Opr,opdvolptrtroriv:Av ol cpuorxdg 0egcnelurulx64 ouo(eg efvar r<ioo xaL(.g,yrar( 6e brefdyovror, neproo6repegpel,dteg,nqoxelp6vou vo, u,vabefiouv xal va sno6e(louv qv offc roug; flori 6ev xdvouv "rdrottg pel.dtegor qo,el.r,o,21,rutr,xdEeralpfeg r{ or, eralg(eg nou ncqdyouv btotpocpr,zd oupn}.qqc6poro; H cndwqoq e(var cnl.ri. Yndqle r,nol,ri trir,xpd xovdva or,xo11 voplxd 6cpel,og uE qoQpoxrurlxdg etor,pie risore !o66Eouv yro g vc yro, vo Or,eqeuvr{oouv rbr.drqregev6g cpappcxeur,txof nE 1g{pato pordvou. H griol xanyet ug nutvreE rov fieQroo6repov guolxr6v goelrcxxsurlxc6v ouorc6v,yeyov6g nou oqpafvel 6tl xov6vog 6ev pnogeI vo, o,noxnjoer ta 6lxalc6poro lnog c,nox],erorrxrlg nacvrag x25x

ol.r6v yla ro fiQoi6vrd ouxd. Qor6oo, Euoruy6E, dvo,pdeoErrlE oevnttxrlg xpnwriE nou 8dlovtcl or,u,o,ro,oxru aor(.g r"at ol dpnoqor aurr6v rorv quorxc6vnpoidwcw d1er, cl.r1Or,vri Ogr,op6vaan6 ra ngo'i6l3<ton. wo, a(vo,r, ouv8uaopo( Bordvcrlv Xopntr{Enor,dtqtag. d},},c eivar, xolxo(, nou 6ev 61ouv xavdvo,vd4pa, evri ril,l.a negrl6louv t6oo pr,xgrinoo6rrfrcr, svsQyr{g Oeganeulnxllg ouofug, 6ore Oev dlouv ouorc,orrz<i xcl.rio clia. ?\),1,crudl.r, 61ouv nol"ri upql,6grl"ptg ?ro,t tlreu8e(genr,or oqptivoelg nou cvaypriqowo,r o' o,urd, xa0c6gxo,r or naqcnl,avqtlx6g br.acpqtrrfoeelono,totiv to xorvd. Enrnl.6ov, 6ev pnoge( xd,nolog vc, r,g pcor,ors( oroug notl,rpdgtotv ngo'r,dwrrtv vo tov bncportioouv xc,r yro, vo, rov evqtrreqc6oouv ooto.r<i yro tlE r6rdrrp6g touE, xa,0r6E 6ev eival dl.or. xal.d evqpepcop6vor,. f,)ordoo, aur6 nou xug(rog euOfvsrar yro, rrlv tioxnpll xcrriorcoq nou '1er Er,cpopcprrl0ef oqv ayop<i o,urc6vrotv cpuorxc6v npot6wctv e(val 6va xo,ro,oleocprx6 vopo0etr,x6 o'riotrlpcrnou ano0agpfver, qv ovdnrulq, 6oxr.pri?.r,cr rroQo,oxeurj ugql,rlg nouiqrag cpuorxciv tpoi6wtrlv F 0epraneutrxdg r,6ldrqteg.Ta negloo6tepra o,n6ra utfql"rjg rrordtqrcE cpuor,r,<i g<ippcxc, dnog eivct to ouvdvlupo e-10, ro cputd hypericum perforatum (l3al,oap61oero),q eywi,zta,ro ydl,c rou yc,i8oupriyxc0ou r,tor ro ginkgo, nagcroxeudlowcl xugfog oe l6veg xcl oq feqplcv(cl-xatt4v Icnolv(c x,o,r o,voouox,eudLoX6QE xuqicog wo,r ornv Apeqr,xriyro,ro o,lrserxo,vrx6 xaraval"ror,tx6 xow6.

|IATI NA MH |INETAI EPEYNA: ?\l,l,o dvc nqdBl,npc nou ngoxfnreL and nE vopo0etrx6g guOp(osr.g oyerm6. pr nE quolx6g ouo(eg fiou XQnorponorofvro,r, cp<ippaxo crtg eivcn q zcrdoraoq pe tlE ncrrdvreg. Opr,opdvor ptrtror.iv: ol cpuorAv xdg Oegcnewr,xdg ouo(eE efvar r<ioo xu\,fg, yrar( 6e 6re[dyovror, neptoo6tepeg pel,dteg,nqoxelp6vou vo, u,vabefiouv xa,l va sno6e(louv qv of(cr roug; flori 6ev xdvouv "rrottg pel"dreg qo,epto,x,euor tr,xdEeralpieg r{ or, erarg(egnou ncgdyouv Ototgogr,zdoupn}.qqc6poro; H andwrloq e(var cnl.ri. Yndgle r,nol,ri trir,xp6 xovdva or,xo11 voplxd 6gel,og yro uE qoQpoxsuxlxdgetor,p(s risore lo66rpouv g vc yro, vo Or,eqeuvr{oouv r8r.drqregev6g cpappcxeur,txof nE 1g{paro pordvou. H griol xanyet ug xanvr,eE rov fieQroo6repov guolx6v goelrcxxurlxc6v ouor6v, yeyov6g nou oqpafvel 6tl xcrv6vog 6ev pnogeI va o,noxnjoer ta 6lxalc6poro [noE c,nox],erorrxrlg naclvrag x25x

'Etor, yro rrlv Jroeoolteu{ xo,r rqv sprloQ(cr, rcJV ouorc6vour6v. pro, qcr,Qlro%rurr,xri etcu,g[aEev d1er, olxovopr,xrix(vqrgo yro vo, npoBe( oe 6onovqg6g dpeuvegxc,uxl.rvrxrjg pel,6teEnpoxelpdvou va OLeqeuvr{oerrtg Oepcrneurr.xdg r,6r,r5tqreE cpuor,xori ev6g pcrgpdxou, nou e(vsr dl,l.tltfie 6r,cr0dor,po 6l.eg 1l,go,vro,ytrlvrorrx6g oe etcr.gfeE.Ta qdptrroxcrnou ncgtiyouv or eoepraxoBr.opqlcvieg cno6i0ouv nol.l.d xdg8q, c4r.pc6g ener,Er{ onortrelorr,x6tqta rnE rroQoyoyriEroug q Er,crogal,(ero,l c,n6 xdnolc, nan6wo.'Etoq xavdvog 6ev pnoge( va rl.6t1rer, anorei,.6oporcrrrlE orl1,ovopr,xr{g ta en6vEuonEFrrcrE etcr,g(cE nou eqeuvd tr,E r6t6tqreE aut6v rolv cpoppdxov. Me rr,Eguorxdg Oegcrneutlxdg ouo(eE,6[roE, nou a,v{xouv oq qrioq, o xc06vcg pnoge( va xl,6t1reorr,6rjnore. r Enml.dov, ol etalgfeE 6e 0d].ouv va dqOouvc,vrlp6tcrlnes fll pe yQcr,cpe p loxQor(a rou Atrre lxcrvlxori Oqyav r,oporiTqo g ip<rrv r,Oc gxc prizrrlv (FDA), ngox,er,pdvou n<igouv dyxqr.oqyr,orqv xuxl,ocpogfa vc guor?.r,rig 0egcneutr.xr{Eouo(ag rog vdo q<igpaxo. To x6oroE !.wcrE e(var,nolrj uQql.6 xor, q 6r,o0r,xo,o(a xqardel nol.ld 1p6vro. Enml.dov, rftloto, 6e 6raogc],(er qv dyngr,orlrou vriou gapprixou. A],i,,ti ox<ipq ?rd,r teLm6. ro v6o quolxd qdgplaxo ntiger, 6yxgr,oq,6e 0o o,v pnoge( va noll,q0eforr,g[6leg u{q},69 npdg nou lolriouv yrcr, ouvrcr, 0enx6. qdppaxc. Me i,,fyo l,6yr,o,I opeQr?i,ovr,xr{ oyoq<i yr,o uE quor,xdgOepcaeurlx(.9 ouokg 6ev efval xaOd].oueuvoixr{. Tc xarooniparo el0c6vuyrervrig OlorgocpljE ?ro,r gcgpaxe[cr dlouv xctc,z].uoref cn6 npoidvra ro, pq(Bolq Eno t6tr1rcE,onotef,eopar w6r,qrag xct coqdle lclg.Qor<ioo, a ra xah6. vdq e6var <irr 6ev e(var a,no,qc,frqtova Olcrrorvlorsicutri r1 xv:cdoraoq.Xe tol.l,dg XdQrEro zl,fpo efvcl6nqogetr,xd.'Evc no].rj xcl.6 naqdberypc e(val aurd qE feqpcrv(cg. Aev efval ru1cfo to yeyov6g <fu1 nol,l,6g qruor,xr{g Oeponeutlxdgouofeg uUrlI{E nor.6qrog xolxltwtx6. el"eyp6veg nqodglowor. on6 tq fegpcv(a.

TO KA@E>TO> IIOY ETIIKPATEI:TH |EPMANIA peytil,o pdqogrrlE srrrorlpovr,nr{g yvc6oqE nou dlel ouoooerutt( rov erxoord arc6vcroyetmd ps xrE euepyeax6g lbuiqreg rctv gcrepoxsurr,xciv $ordv<rlvngorfglerc,r.o,rt<i feppcvfo,, dfiou tl rJll,tr; oqpovr,xr{ ttor nQcr,xtli,r{ ordoq crrtdvc,vtr, aurdE rlE ouofeg eivar, oe Oetr,xr'|. cumi rr11c6pra, 0eganeurlxri B6rova e(vcr eyxexglpd)e ro .26. 'Evo

vo, yro, Er,ti0eoq oqv cyoqri, oro qoQpcx,e(a xan oro, xo,ro,omipatc el6c6v uyrervrig 0ratqocprlg,Eilolg tq ouwayri ylorpori, aad 6vc xuBegvqrlxd gogdc nou eivc,l yvrrlor6g rrlg Enltponrl E xar, eivcl crvt(oror.1og rov Apegnovrxd Opycvr.op6Tpog(paw xcr OcrpptiU,s xov. En(o1S, orq feqtrrav[a 6(vovrat npooextlxdg o6qyieg orouE ylcrgorig oyeux6. plerr,g rbl6r1reE rcrrvcpappdxrrtv nou ngodplovtcu, p6rovo,t{,o,r vdooug otr,gonoieg o,neu0rivovrcrr, an6 0egcneurr,x<i tlE r4v anorel.eopcrtr,xdrr;ro, rqv aogril,el<i toug. Or"cpuolxdg lror Oepcneurtx(.g ouofeg naqooxeu<llowcl pe r,Otafregq nqooop{, undzervro,rorov i6r,oauotqg6 norccm6 dl.eylo nou egagp6lerar, oq qcrppaxoBr,opqlc,viazc,r, evbefier,E ol nou avcyqtigovrcr,ror1 ouoxsucl,o[c roug ovoqdpouv uE eyxsxQrpdveg lqrjor{,g xo,r rq 6ooo}"oy(c roug, nr0c,v6g cvenrOripryeg evdgyereE,tqv rofr,x6rnxo, xo,r,tug ovrev8e(ler,E rouE. H Erulrqon{ E, fiou r8qri0rlxe rc 1978, elerdlel 6}"11 ouylgovrl tq srrrorllpovrx{ paqrug(o nou o,vcgdQsrcrroro, cpuor.zdOepaneurr,xd p6tcvc, otqv onoic, oupnegficpprivowal ol pel"dteg nou 61ouv Oleoe ov0qc6noug, ],apBdver. ?4o,r undrl-rq rqv lorogrxri Xa{on rnE [a10ei por<ivalv.H Enlrgorlrj E 61er.ex6c6oslnep[aou 300 rorv 0egc,neul';ixtily povoyqogiegnou 61ouvtrrg06pa ra 0eqa,neutr.zd B6rcva,200 an6 ra ono(a 61er,eyxq(ver otEanotel.eotrro,nxri xol crn6l.ura oocpcl.{. Aur6g o vopo0erlx6g pr11avr,op6g enlrgdfiel oro xaravol.otrrzd xolvri va 61el epnroroodvq xo,r vo, yvr6oe ot 61,t ogopri ro, quorr,E p6ravu nou notl.ofvrcr,r fegtrrav(a.Ol feppcvof xd 0eqcrneurlxd or4 dlouv q Ouvcrdrnxo vo, cyoqtilouv ra cpuor.xri grigpoxcr b(1olg ouvroyri yratgrori, oxo cpoepoxe(u xat oe dl"l,o xvtc.omlp"ancr rrlE toug. Qot6oo, nol.l"6E goQdE yrcrgo( logqyoriv xo,r, fEror or, or XC6QoE Oeqaneunxri B6rcvc orouE aoOeve(groug. Kal o l.dyog e(val drl 6rov o feppavdg yr.orgdgouorjoel erErxd r{ ouvroyoyqacprioer. 6va ouyxexgrp6vo grigtrrcxo, ro yeepo,vr,x6 oriotqplc uyefcg nl.qqc6vel 'Etot, yr' o.ut6. ol aoOeveig61ouv or,zovoprxdxivqrgo va anoxmjoouv ouvro,yr{ ylarqof , ngoxelpdvou vo fieolr10eutodvro, 0eqaneup6r,avc. )tqv ngaypcrr.x6rqto,,otipgrrlvo,pr plc vdo rigeuvcr, "ct^,t6. "ro80Varcovfegpovc6v yro,rg6v ouvroyoyQocporiv cputr,xri gdppraxcOeqaneurrxd B6ravc. Awd ra quor,xri cprigpcxc unol.oy(ero,r <jtr craorel.odvr,o 277o tov gagpdxoJv rrou noll.ofvral oq fepprcv(o. Ta neqr,oodrepo0qpogr.l,{ e(vcr ro ginkgo, 11 ellvrixrc xo,rro o,oro,r,m6 r,lfuoevy,,t. 'Eroq q feppovia Oecoqe(tcr, Xdeo orqv onofa pnope( vo Bper, n x27 x

'Er,oq xo rrordrrFog 0eponeutr,xd B&ava. 6nrli,g ?rdftoroE xotrdxsQqE unoo,rlg(er o Apegrxov6g 6p Bdgo Tdd"eg, ov 06l"oupevo dloupe xol.ti xal aogol,r,j quolxti cpdqpoxc, pe anotel.eopcmx6m1rao,no6epqlavloporig nou va epeuvqmxri, 6er,ypdvq lgeral6poote vopoOetrxorig unooolp(ouv mg 6oxr,p6s,rnvclr,ol"6yqoqqg crocpd),errg rrlE cr,fioxcx,r retreotrrotlxdqro,E, norotrx6 dl,eyXotrrlv npo'idwov, rrl orrlomjenr,xov q tnv xcrdl.l"ql"q 6oool"oyicr, 1gr{o4 oripavon xal evqp6grrrol(l)ErrQog xo,rnE nl0crv6g cvenlOripqreg evdgyeleg. E[d],],ou, o 69 Triil,ep unootqp(er dn, 11dqeuva,n<lvrrloro, Oegaxeuilx4. B6rcvc e(val rSoo npolcrlgqpdvrl orrl fegpavfcr, crxglBc6g ptipEl6tr,to vopo0etr,x6orioqprc u1g1c6gag ev0oppriver cpuor,xri ra ^aan' po,xc, clr,onor,c6vto.,g crut6 tov tgdno ta anotel,doplara qE dgeuvoE yro roug xcro,vo,l,ortdg yro,rouE yro,reorjg,al,l,d zal xa0rotc6xo,r vroE rcr zepEoqdpo yro xrEercrpfegfiou r[ceo,oxeudlouvxc,r x<ivouv 'Eva pe peydl.o pdeog r<rrv 6oxr,pdg npo'idvta and B6tcva. uQql.rig nordt;rpag 6oxrpc6voyenxd pe tc 0eponeu:nx.6pdrcvo ftou XQnorponorofvrar o't6 HIIA l,t,or 6l,o rov xdopo -oto, ono(o,nepll,opptivoos vro,r ro hyperinium perforatum (6va avtlxcta0l.lnnxd B6ravo), rg (dvcray1ol.utlx6 B6rovo) xol q elrv<ixro, (5va p6tavo nou Bal.egr.dvcr -d1ouv y(ver, xaranotrepd toug r.orig) otr1feppav(a. Exr.l r,o sfirorrlpovr%d-votrloOetlxd plo taOeordg anl.r6gd1er, 6lccpoqel,xr{ avtrperc6nloq xcrr ortioq o,n6vo,vrrotr.g Ouvordrlxrg rov guolxr6v qcrqp<lxow. Evc6 otlE HIIA or" enrcr(poveg eorrd(ouv ro evbracpdpov toug o1e66v anottLetor,txtiota lolugd q<ippoxc, or legg,avo(ouvd8el,cpoirouE seeuvoriv nap<il.l.r1l.a quor,xd evatrIsxntcr fr.a xti cprigpcrxa. ncg<i6erypo,, t994, o Oqyovrol.l6g r,o Tgoq(potvxcr, @agpdttrrlvtrov HIIA evdxqlve qv ngc6tq go,elro?.rcurlxrj ouo(a -r1v tclxqivq (tacrine)- yro rrl Oego.neictqg dvolcg lror rrlE v<loou A.l.ro1dr,preq. gdqtrroxo eivq,l cpxer<i anotel.eoparr,xd, ol"l.<i dlel To tolr,x6Eavenr,Oriprlteg ev6qyer.eE rreQrog(ouvrq XQnoq rrou rou. Trlv (6rc lgovrd, 4 Enlrqonr{ E tqg fegpav(og evdxgrveto ginkgo biloba, 6va tunonor,qp6vo exlri),r,opo o,nd ro pril"l"crrou bdvrgou ginkgo, roE Oegone(ayro,rTV tivon xor rq v6oo. Kal e(var.ngdypo,tr" o,norel.e-oglopdvor, xoquqo(ol Apeplrovof eqeuvnlt6g 0errlgoriv opatlt<i ro pr rlsQr,oodmeo unooldpevo ond qv rcxg(vr1- ?ro,r ouolo,orut xcp(cr ri tolrxdqrc { clvenrOripqreg To evdpyer,eg. ginkgo e(vo,reyxexqr,pdvo eniolE oq feppov(a yr.c rrlv (sy?.(,s(pahtxrl cvendgxrrcln, dvav ril,l,o ylo, 6po nou XQqorpoJroreiro,r va uno6ql.r6osrxq voqrlxr{ napcxprl nou o;et(ercr,r Fr rrlv rrQoxtrlQnpdqr1l,r.zfa.
K28X

TOIO>AIIO<DA)IZEI:
Xe nol.l.6E o,v XdeeE, xtinorcg fyer"xi.not"uanogio ayertx1 pe dva quor_ x<i cpdppazo,;-rnogei l.dper pr,acrfr,6nr,o'rq vcr ofidwqo,n an6 ro ylatpd tou ri ro cpoel"ro1<,onold IIo],]"o( edlxd exnar.8eutrr6vol tou. encyye].parieg enlpl,6nouvrq 0eprti xar.l.oyr.xrj xaravril.orq raw q,uor.xc6v cpcpp<izrov. Xq feqpcvio,, ol ynrgo( xol ot goQpo,ltofiolofeival unolpeotp6vorva neq<ioouvefetdoerg yvriroeowoe 06paro nou crlet(owal pe to Oepcxetxtn6. pdtavo. or, enr,or{poveg auro( l0qqyouv raxrtx|cguolxd oepop&cva xcr ro,ur6lqovc trrnogoriv anorrnioouv os epcrrn{oer,g neu1.i[tt6" va xar o,nogfugoyenx6.pe ta nl,eovexujpcrc rto,rrqv aocprfl,er,<i rouE. eJorrioo, orrE HIIA ouvr{Ocr;g l3gfoxer.xave(g x1noro ylarg6 rj 6e cpoeprol{ofiot6 xdnor,ov<i},}.o ri eLOLxd 1c6qo uyeiog fiou vo,yvtrl_ oro qE p(er. nol.l,ri oyeuxd pe our6g t6 ouoieg. <Av x<irr.6evro dlouv 6r,6c_ y9et xu:c6. 6r.<igxe rov onou8c6v q r,o rouE oro no,venlor{pn, vop(ouv d' 6ev eivcr, cl,ri0ero,>>, o Dg Nrdvr,el. Tdxeg, 6vag Apeqr.xcvdg l.6er eyxexqlpdvogol.l,eqyr,ol.6yog eorrneqr.x6g xor, ruc0ol.dyoE. 6q Trixep O a"'rorel,e(XoeourrlQtorr,xdnapdberypto yroreod nou ngoocprp6leral oT percrpal"l,6pevo o xl"ipa o.ro1c6go qg r,argr,xr{g orrlv enegl<ipevrl fl,o,r evoorpdtorq qg evcl.l"ctl:'lmrlgr,arqr,xrig oqv nagc8oonxrj rcrqlx{, cru<i ono(a nqoxrinrer, oupnl,rqg<rtgturl"xq mqv 11 r,crgr,xr{. 6q T<ixep1gq_ O orponore( dl,s rc xctdl,l.ql,o o,upl3mr,xd qdgpcxa, al,l.d 6rcv pu,c aocpal,doreqq, xctrrfuegqxcr firo olzovoplxrl Oeqoneutxrj ouoio, pno_ gef vc 61er. anot6].eopa, 6nr.rrg outrr,poiver, oqr.opdveg ple 0eqcneu'x6g ouoieEoqv nepinttrlol rqE qplxgcrv(cE, r<ite nqoreiver xc,r c,ur6g. flol"_ l.of br.oponxoi yr,atgo( cq1(ouv vcx svoopo,rc6vouv tqv evol,l,*xtr,xrj rngr,zri oqv zoOqpegr,vrj ngcxtlxri rouE.

EINAI BA>IME> OI ANH>YXIE> fIA THN AEIOilDTIA TON OY>IKQN OAPMAKQN: Yrdglel peytil,o noooor6 ncqanl.qqog6eqonE rou xo,rovo,trrrxlxori xorvorj xur, nol.l.dgqoQdEd1er.olpdver. l.ovOaopdvo ouvoyep69 oye_ rw6' p"errr xQlior rolv quoutc6vOepo,neurlxr6v ouorc6v.Kdnor.egavlouykg e[vcr,ptior,prEti,or *[(er" vcr rrg ngoodfer,x<inolog.Oot6oo, xdnow.g til.l.eg e(vcr, anl,rfg anordl,eopo nogav6qoqg ldycrl xaxrlE nl"4gog6pqoqg.Ogr,opdveg cpogdg ev8ora,opo(xan or avqoulfeg ol ngo6glovr*r o,n<i 8r,otaypldFcEvc 8eporipe al,l,oyrj ora xcOrepro_ ro
X29X

pldva rj orrlv rorQtxri 6nolg u1 yvolq(cpe pl61gr'or{plepc' Kdnoleg ae dyvolc 11, ril'l'eg AoedE o 6r,otayp6g ocpefl.etal crnotr,Lelorwd qoedE,oe fieooofitxorig q6BouErj oupgdpovta' fr,o nogd8etypa' oplnou ngoog(dtl qopor3wclr, ta xpatlxd xovbri}'r'o op6vot enrom{ploveg l'crvOaopdva>otq pel'6tt1 lowar, yto rrlv 6geuvc 0c, <<6loleteu0orjv <rpsuroqoeptixulv rtou 6l,or,yv<oq(ouv tttrlg6ev 61ouv xavdva anor('' l.eopcr>,dnolg lolug(etur, dvc utprl),6pcr0poxuBegvltr'x6 otdl'e1og 'EvaE enlorqpovag nou eqyd[etcr' tov HIIA an<jto 1c6poqg uye(og. oro 1c6qoqg Br,opqloviagunooqg(el 6tt xdnotor ytotqoi 9opo6rtllv qg wo,r,rrtrlgpe rov tqdno out6 0s ltioouv tov r5l"ey1o 0eqaneicLE ttlv guot..6ev pnogotiv va el,rdylouvtq 6ooohol6a crcpori cro0evc6v, ouotr6vp6oottr1gouvtayoygdqqonE' Enfoqg, nol'xc6v0epcneu'rrx<6v 8r,otdlouv vcr ouomioouv quout<i gtippcl,o( yratqo( 6r,xcrr,ol.oytlpdva qv aocpdlelo ttrlv ono(ov 0e yvol?4cyr(I trlv crnorel,eopatrxdqto 11 p(ouv nol.l.d. (Bl.dnete, oe crum{ qv negfutttloq, 0ev undqlouv etalptc6v,c6oteva punr{oouv tTv ndqto exngdootnot qclQpoxeuttxc6v iou rou r,o,tge rouE Yto,vo toug Er6oouv8opedv 6e(ypata xo't ovcrluttx6g e!r1yr]oe6, eQtuvrltrxd, crnotel6opcta xcrt pey60r1ncrlltloeow' npoxelpdvouvo, roug ne(oouv vo XQrlotponorofvdqoBa pla guoltr1 ouo(a') E(var, nohj lqovop6qo Yrtr roug ylcrtgotig vc 0eqclneutr,rcrl nagcxohouOoriv tr.Eefel,frer,gota xfqrcr cptigpaxc xo't' ottE r'tyvtx('g nou lpqotponore( 1 ncgoOoor.axq r,ctgr'xr]'n6oo pril'l'ov otr'g elel'('Fllor, bev anote]'ei dxltrqlrlro YsYor,otgr,xlj. [rrg otln eva].].crxfl,xr1 uog 0", nol.l.o( ynrgo( nou elooxoriv tqv nagcr8oorcn( tctgtxr{ Idve 6rl paOcr(vouv ta guotxd,cpdqpazanup(togand toug yove[gtoug' Ytc Mr{arog whtx6" e(vol clr,6lttotcl 6tr flcrp6l.o nou q r,66cr rc 0eqoneuflxd B6tcva 6ev s(vcr,olr,Snr,ota nol"l"o( efcxol'ouOoriv vcrt4v l'co,t, ol,or6vcx, rreQtoodtegod8crcpoE, 1dver. 'Evag l,6yog yt' crut6 efvcl 1 oriyluoq nou entxgote( aondlowol. p6tcrva' yriqor crr6 tr1v notxr,l.(o,rrou ouvc,w<ito,t'otcr Oepaneuttnd cpcrivetat ouo(eg H iatgtxrl nou Bclo(ero,t ot quolx6g Oeqcrneutlxtig xan d,vxtttltorrll-tovt'x{ otoug Apeplxavofg' oulvd eltongoypcltt"xti rrou pe pdtavo ou1vd,6eo'uvd'Eer' q oecop(o xoorig dva 0egoneutr,x6 p(a 06irer, ouyxexgr,privq lqpr,xr{ rivoorl va otoler'iel orqv ?tcxofio}'dtrlt10eolAum{ 11 vdoou r{ o'upntc6pcrtog' oI FfoExol p6vo ouyxezqr.pr{vqg cpcpptixtrtv' p(cr crnotel.e(q prlol Yro rrlv crvdntull ttrtv oriylpovtrtv f)or6oo, q 0eog(c crumixotapg(ntetal 6rav xdnotog eletrioet lgooetntx'r(l r[ro nep(t],oxo xol eugdogcpriopatogoego,neuttxd o,note-

r30r

rE
tE
)i-

ri
rll foE ct tiDV

nfto:oW tc nrv, Nrl to.

s
dovt E.

KI

[v
E(,

u. cr E, ru ql>.
fY.

(>
E-

l.doporc ro,v qurc6v.Efvar,yeyov696rt or eQsuvnrdE ouv{OoEswofi(_ fouv xal l,app<ivouvond ra qurri tr,Eyrltrtr,x(.g evc6oe6nou 6r.a0dtouv evegy6ggoQpoxsunx6g r.6r,drrpreg. Enforlg, eivc,ryvrrtord drl rc cpuor,_ x<i oupnl.qgdpcra 0r,atgocpriE ev6_ l3co(ovtcr oe autdg ag yqgtn+g oerg r6orevc, eivc,r6qaorr,zri.f)or6oo, 6ev elqyeircu,axgr,Bc6g l.6yoE o yro rov ono(o or, guor,xdgoeqc,neufixdE ouofug nou negldlouv rJrr_ d,dov yr11ttxg evr6oe6 an<iro qur6 e[v*r Egaorr.xdE rtywn( dvc,a,r*_ rdqyaoro exltil.rpo an<i dl,o to cput<ie(vsr. enforlE 6pcorut6. fr,a naqd8er,ypc,pr,clqprxrj 6vorq nou ppioxero,r oro p6rcvo hypericum perforatm, r; unegr,xfvr1, 6ga o4 awrxaraO].tmrxd, o],].ri dva oxcrdg_ yooro exlril,ropc tou gurori '6yet, ax6yq peycl.ritegq 6ptioq. O 69 Porlwr Mntioueg, dvag xoguga(og egeuvrpriE nou epydletcr. oro Nrioel,woeq rqE feqpcrv(cg,unoonigr,le rqv rrrrorrlpovrxrjdnotprl, nou pg(oxer, ol.odva xor peyatrrireqqcno8ori,6rr va p6vo ou<narx<i ponivou Oeve(vsr 8uvatd vc elqyrjoer. 0epraneuu,x6g lErdevdg tou "'E qteE' To nlOcvdtego e(val, <inorg e(ne,6tt q pelrirooq ngodglerar an6 ro <<onotdl,eopo ouvepycofognol"l,r6vzcu,Erdgogcrrv rns ouo[crr,xc6v>>. Qor6oo, nol.l,oi nrorefouv ox6pq zcr orjpegc drl crv pr,c ouo[a 0etlpre(rar Oeganerier drr, neqrco6tegeE on6 p6av6ooug,t6re 6ev pnogei napd v* eivc,r, rivc,<<.!eurog<iqpoxo>, cvofdnr,oro xcr, cvaldl,o_ yo.'Etor, un<ig1er, cx6p4 11 0eolq(cr nou 06l,er, pdgpcxo vo,o,firu_ dva 0dvetal oq 0egcne(a pfag xal p6vo co06vercElro,ryro, no],],origo roluglop6g nol.l,cnl.c6vOeqc,neurlxc6v r,Er.omirotv cnotel,ei q preyotrri_ regr; cn66er,lq <ftr aur6 ro g<iqpaxo efvcr tilqqoro. f)or6oo, o,urd crrorel.ef tl,<ivq. yn<iqlouv nol,l,of enlorltrrovlxri snobexrof l.dyor. nou e[rlyoriv nc6gprc cpuor,xri Oegcrneutrxrjouofa proqef vc, xctq,nol.eprioer.nol"ld pdrolnc raut6lqovo, 'u06E enwl Oercl orrl paOrireqq8laEtxoo(c nou anorel.e rqv cr,ria qE v6oou, f dnog e(var,q cpl,eypovri, nou Oqplloupye( olr6a nor,xil,cov qv vdoolv, ortg onoieg negrl.appdvovro,rI cq0g(rr,6a,ro riogtrrcxar.q agtrlqr,cxri v<loog. mlgeOgo, Bdtu,vonou npof,aplBdver, qplxpcvieg, ono_ To to rlg rel,ef dva elcqetr,xd nagd6er.ypo,. AdyrrltrlE o,v'ql,eytrlovr66ouE 6g<i_ oqETou,oe oprr,op6veE xo,r. Xc6esE Xeqorpofiole6to,r yro rl1v avaxodgr_ oq and ro til.yog rrlE ogOg(tlbcg, xa0c6g xo,r yro, rTv o,vrrl.rsr6nr,or.l 0v0,Jrvruorrxc6vngoBl"r;pdrrrlv. Ax6pl firo rvruJroowxg efvc,r ol rOrdqtegrou l10udl.orou, ftou enr,Ogd l.elrouqyfux60e xum<ipou, oq x60e 'ct'o6 xan x60t- oqy<ivourou av0g6nrvou oc6porogxo,r enqged_ (er, plerov rgrdno aurd dvo eugri gtiopo v<ioorv nou nl.frrouv 8.dcpogo Spyava, on<irov eyxdqcl,o xo,rrqv xcg6r,d pd1qr, nd6ra. ra x31 s

tq 2r{pegc, ps rrlv c},parc68qcrilr;oq tqg yvc6oqgoyttt'xd pre bqtloq 11 br,dqoporv v6o<rlv, ouorc6vornv ?4oro,fiol.6pqoq row a,vnoler,Ocorlxriv yr,o vc ro" rou 0eorqfcr <ev6gcpcpprixou xd0e aoOdve cglile r,eppavc6g tou o xarcggder. Ax6pq xor,o (6r,og ogr,op6g awuolel8olttzori unobql.c6vetr1vnolxll(a xclr rTV euEittlto torv Oeqcneutlxr6vl6rct4turv tou l )fpqalvc pe q 0eolq(a totv etrerj0eorrlv xoronol"6pqoq torv v6ocrrv. ynptx,g pcw pr.!r6v,oro oc6pc pclgun<iglouv pq el.eyl6preveg evr6oetg nou zal,ofwcu, el.eriOepeg eGeE,ol onoieg enlt(0evtat Etagxrig oTc npozof,r6wogxd9e e(6oug1p6vr,cvdoo - 6nrrlgotdvtrtonttrlv zrimc,po,, cptqgrc6v, xag8r,cxdg nqooBol.dg,xc,gx(vo, 6lcBr1q, zataqpd,xnl, al.l.ri xor, exquh,otrzdgv6ooug,6nog e(var q v6oog fltigapOpitrbcr, q ?trvoov,q nl.<iyra pumqocprxqoxl.r{guvor1, v6oog Xd,vtlvyxtov }tot n Atrto1dr,peg.Me qv eloubetdgtrrorloutc6v torv el,edOepclv vdoog qr[c6v, or, owr,ofer,6anm6.g ouo(eg epno8(ouv qv epgdvr,orl1{ol rrlv e[6]"r,[naut6v trrlv v6otrrv. 'Onolg oplopdvegcwlolel6rott'x(.gouokg efvat 6uvat6 va, e(val cpuorz6, 6gdoq rtrlv o,wloe(vou 6poo, rx6gdvawl xdnolorv v6oolv, cootdoo11 olo o"r,t ouorc6v oup$<il.l,er, oqv xattippsuorl rIE o\ryftrlqinE pfu fer,6onrxr6v ouo(o gnogei vcr e(vol rxavrj vc owltrreto:nioel Oego,neutmd6vo-xcil" 'Evo pr6vo o6pnrtrlLroT vdoo. nagri8elypa eivaL r1 XcQo?ttr1Qrorr,x6 I C, nepfntcrlorlqg Br,tcrplivqg q ono(o pnoge( vu anotgdtl-retr,gxcrg6lcxot rdg ngoopol.dgxcll tqv epqdvloq 6l.rrlvtov erbriv xaqx(vou, xa0c6g ro, vc Oepcrnerlorr xpuol,oyr{pcro,vo ovo,nougfoel oln6ta oupntc6prma nl0av6v vo oupB<il,erorllv owr,petc6nlorlnoll.c6v rou <io0pcroE ?ro,r yro xcro,ordoeov. To (6r,or,o1riell.r,cr q prtapivq d),l,ow ncr0ol.oyr.xr6v E xol yr,o dva aru6tc ve6tepa Oouparouqyd cpdgpaxa,to ouvdvlupo o'uxvd on6 toug ytcnqoriE Q-10. To ouv6vlupo Q-10 Xp4or,ponors(tcr yro rrl 0epane(ot4g xcrg8loxr{g averdgxtro,End,rqg xopEro,yyenx{g oq 0egcv6oou, ul,l,ri Xprlor,ponoreftcr ol,o6vc xa,r neplooritQo ?to,r yra rov xa,gxivo. flo].],dE cguotx.g Oepaneutlzdgouo(eg, 6ncog nefcr eivcnsxriorlE lopg6g ro eivar to ginkgo xcx,r ydl,o rou yciOougriyxcrOou, ogeil.etal q 6gaotlx6qowroler,8rrnlxdgouofegxo,r o cur6 axqr,l3r6g v6oov. rti rouE orrlv crwrpttc6nrorlDr.dcpogcov 'Ol,ol qg outo( nou eppdvouvorn Oecog(o, <p(ag ouo(ag ylc p(cl p<ivovdoo> (orog0c dnpenevc efetdoouv rrlv nepintcrloqqg conr,q(vrlE,rl ono(a 61er,en(oqg cpucxringodl,euorl.flcl.aldrega XQnorLro11 ovcl.yqrlx6. )rlpegcr e(var, eugdog6tc6e6opdvrq nororjwc,vpdvo rrrg pdoo. @a pnoxo,r trlEcrwrcp}.eypovc6Oeg Xa{oq rng rrlE avr,txr1xr,w6 x32x

q rl o tt

vc Qofos, dtrrotg, GVoQorI0ri y"6T,oLoE o6(.on d1eI q ovoxofcprcrl xL cfid rov fi6vo LrsuE xoQ8rox6EngooBol,6E.eor6oo, undqler, plc l.oyr.xr{ sQpr1vsfo ourliE rrlE 6gdoqg, dnolg oupBcivsr xo,r pe no}"},dg dl.l"eg 0ega neu"r g ouoie E cput g nqo 6l.euoq w, rxrl g. Mra l,ovOoopdv4 ovril,qqrrl: Ol cpuolxdg0egareunxdE ouofeE Ee lgqor.ponororivrot o@ord.xcr rgripouv xrv8rivouE Tr yiveto,r,l.om<iv,oyer,md" r1v ncga8olq 6ttraoupBorr,xd cpdp_ lrs paxc, e[vo,reyxezgr,pdvo, ouyltzgr,trrdveg yrc lqrjoe lg sn6 rov Oeya_ vr,opd Tpocpiprovxol @oprpuixalv ?ro,r enopdvotgeivcrr, uocpal"rixor, c,norel,eo;ro,tr,xci vo, ro, Xerlorponort( x6notog, evr6ro (6r,o6sv yla rc1der yrd, uE guouxdg Oeqaneurlxdgouoieg; Efval eoga]"p6vr1 r.1 cvtil.4pq 6tr or. cpuolxdgOeganeurrx6gouo(eg XQrlorporrororjvtc,r cbr,oxq(rrrlE 6(1og ouor,c,o*x<i xcr, l,6yo, evc6 oupl[3atlxticprippaxc tc XQIorpofi o roriwa r pdvo y r,oouyxexg lp6vouE ?.r,o,r nrorrlpovr?{tiano_ Eexrorigl,dyoug,aqorj e),ey1Ooriv nlotonorqOorivotgcocpal.rj xol xar onorel.eopcrrlxtf. Kar evc6e(va,ryeyov6g 6n eival cncpaftq",; 11 dyxgroq rorv cpcxgg,ti?t,ov ouvroyoyeogorivtal q,n6 rov Opyavr._ fiou op6 Tgog(FCDv?r,o,r @cgprizrrlv ngorori cur<i Ololereuroriv orqv ayoqd, efvcl enioqg yvroot6 6tr, crn6q otr,ypljnou 0a ndgouv uutr{ qv dyzglorl, or ylo,tpo( pnoqouv vo ro yr,a XQrlolponororiv oaor,o6{_ xote oxox5, efue youv el,ey10e(yro,ro oxon6 aur6 e(re 6r.. Aunj r1 taxr,wrl o,noxal.sitar pn ovoyQog6pevq Xarion rou gcppdxou }.(o,r enexre(vetaL, Er,oqxc6E. )rr1v nqcypcmva6ml^ca, ofpcprrlvo rov Apetrre grxcrvrxri Iatgr,x6 )ril,l.oyo, "co 60va tolv qcpptil.r,olv fiou ouvr(I,yoypccporivtcu, cn6 yr.crqorigorqv Apeqr,xr{-fiou o,vfloror,loriv nepfuou oe 6va 8r,oex,otopprlprlo r.arglx6gouvray6g eqoiclg_ npoog(ovrol yro Fn crvoyqccpdpeveg dlouv syxQr_ lqrjoerg. To gdqpoxa su"r6.6ev (o, 0ei yr,a tr1 Oepone r.ov v6ootv yro, ''E ono(eg loplyorivtc'. Autd orlpaiver, drl r.olupri gtippazc xQrlorpofiororivtal ouoro,otrxr1oe neqmrc60erg yrc fls onofeg Eev d1er el"ey1Oei gepaneuflxr] roug 11 anorel.sotrrarw"6nlra, x<irl ov<il"oyo 64l"a6r{ pe o,urd nou rolrier, yla ttg quorx6g 0ego,neu.rlxdE ouo[eg. H <ioxqoqqg rorgr,xriE eivar negroo6tepot61vq nop<i snlomiprl. Ol neploo6regeE on6 rr,g0eqane[rErroulogrlyoriv xo0qpeplvri or yro,_ tgo( Oeve(vo,r nep*oodreqo g> "ano6e6er,ytrrdve un6 6,nor eval,l.c,xrr.xdEOegcnew'mg pd0o6or.,',gonoiegclpcpr.oBqroriv *no6oxrpri( xor louv. <To vc, ono8dlero,rxrinorcg xo,.vcrXQrlorprofiotef Oeqcne(eg prl tt]"wr,x6" cnobe8er,ypdveg xcrr to.'g exw.tv6uveg,evc6nag<il,l.ql.a vo x33x

E o v I'
F

4 v
v

orroQefnrs rrrQrcodxeQo r oocpo].s(E ]"ry6reQo xor 6cnovqg6gguor,x6g evol.l.oxrlxdgOegonefug crnorel.e( 6va ncqdOolo 0r,nl,6pdrpo aflotr6y1onE", 6notE6{}.ooe o ylotgtig ?\}.av fxtipm ?(o,r ovacp6gelo 69 Mdtxl. Mrige'l oro neploblx6 Natural Altematives. 'Onrrlg dloupe ri6q ovcgdgrr, rrrxeo,rrf yevr,xrigq tinoqq 6rr or quotx6EOega,neutlxdg ouoieg e(varoe yevrxdgyQopFdE cocpol.efg, pq xcr cunj qv dnotfl urogero{v xal doot be yvotg(ouv xal 6ev 61ouv ao1ol,qOe(pe rc qutlxti gdqpcxa xo,rro roroplxri qg ooptil.erdg roug. Ouontd, cutd 6e oqpa(vel drt 6l"egor guor.x6E Oego,netnrxdg ouoieg g efval ewel.c6g o.xiv6uve - x60e d],],o, pd],ro,uo. Kd0e quor.xrjouo(a 6e oqpa(ver,6tr efvar xcl aycOri { cp},op{S. )qv npcryportx&4:ua,ta cpurti61ouvno)"1.69 qoQdEruol,rir,o1ugr1 6gco,rr,x6qtc, xar aur6g o,xple(var,o l,6yog yro,rov ono(o to, cpurtie[vor,ruo],].6g qoe6E onote].eBc6g oporlx<i orq 0egonefo Er,ticpoqcov oo0ever6v. Tc Bdrova np6ner vo o,wrperoln(owor !rc oeBootrrdxcr, npooopi, 6rogogeux<i, q XQ{orl roug efvcr 6uvar6 vu o,noBe(enrp],apriE rnv uyeic rrrlv xutava].<rlyro, r6v. Qorrioo, oe yevlxrlE yQoplprdE pdrcvc xo,ror cpuolxdg ra Oeganeur,t"xg ouokE 51ouv ruotrriprxpdtepq enlxr.vbuv6qtcr oe o16oq pe rc grippaxcl rov go,eirc%oBr,opq1cvrr6v, nol"l,o( cnd epdg ouvOetrx<i fiou xaravo,l.c6voupe dlowog l.iyq en(yvrooqolerlxd pr roug nlOavofg xwbrivouE rrE ovenr,Oriprpeg zror evdqyereg nou pnoqe(vc 61ouv. Xr,l"r,d6eg xaro,vcl.ordg oe 6l.o tov n6opo 61ouv unootei Bl,<iBeg otqv uyeia roug { crx6pqxcl 61ouv neOdvetond rq Xa{on rdrolov ouvO etlxc6vqag ptixrrtv.f,lor5oo, 6va oyeuu,6petr pdvo Jr rorcu,lov<rl e zd 6ql"qrr1q(aoqg and pra cpuor.xri 0eganeurlxri ouofc, nou u,gxer6E qoedEnqodgletor.cnd q l,r{rpq uneqBo},rxr{g noodmltag,6yrvecrgogp{ yro vo Oeorqrl0ofv d}.egor guor,xdg 0egcneutrzdg ouo[egfiou Xoenyoriwcrr6i1og ouwayq yrcrpori enr.pl,cBe(g rrlv uye(c. Atio eOvr.yro x6g tgayolD(egnou ouyxl,6vloav mg H|IA ngoxl"rj0qxov q pic crn6tr1 rtr;v ri Xar{onqg eg66gcrS(qur6 qE or,xoydvKrE ecpe6qr,66v) a}.}.u6g pa lourivyx, nou l,cpBdvero,r oE r|uxorednog ouofcr xar q d].],r1 nrcte(stran <ftr. nqozl.r{Oqxeon6 r,aro\wrfi. xa,tdl.omcrqg 0guntog<ivrfE, xtou oe xar<il,l,ql,eg66oer,gXenorponore(ra,lrrlg unvanm6 ydn. Tdroleg tqoyorb(eE6e 0a 6npene vc o,uppc(vouv xo,r 0a npdaer vu l,cpptivowcr, p6tgc c6oreva pqv eaavcl.qqOorlvoro p6l,l"ov.Ol nrOavof xfvOuvolxc0c6grto,ror o6qyfegoqO{SXa{onE 0c ngdner, o,vo,vo, yqdqowar, trre oagrivela xar euxg(vero, orrE er,wfr,egxal0o,npdnel va 6[vowar, clr.6nr,oreEeyyurioer.g ta gurmd napaoxeudopcrta eival 6rt arcl.l.crypdva an6 enrx(vDuveg npoopefierg xcl negldlouv p<ivom1 x34x

69 o-

)a
ot
br ,!

5. ie
0 tc-

(I

rn
,o ,6
t-

E v

guorx4 ouora fiou ovoyQdgero,rornv ExLv"xa. Aur6 0o lrfioQo{or vo Eloogcl,ro,ef pleqv ur,o0dtqorl xo,vovropr6v v6potv nou 0a 6r,ri_ xo,r Jlouvrnv epnoq(c x,o,t, 6rd0eoqngo'r.6wolv rrl uyr,er.vrig 6latpoqr{g. Ilgoxer,pdvouvc, 6l*ogal,r,oref q nol6qto rrov 6n',0dpevolv npo.r._ dvr'v xo,l 4 aoqtil,erc rcov x*tavcrl.orc6v, cno,rre(ro,r 06on'oq ev6g 1 oupncryodg vopo0etxori ouotripcroE rrou 0a l3oqO(oer rouE xo,rovo_ l,crxdgvc 8rcrxprivouv'E o,notel,eopo,tlx6g,oocpo,l. xan e(g latrrql,ori x6oroug cpuorx6gOeqaneutxdg ouoieg cnd tlg xaxrlg nodqrcE ouo(eE nou 6la06rouv orrlv oyoqd oo'uve(6qtotdpnopor.. Tc neqloodregc cnd rc ngol3l.r,jpolo, rrou oler(,owar ps tr,Ecpuot_ x6g Oegonsutt"x6g ouo[eg0a pnoqorioavvo ],uOof oye:;.;xf"ye{yoeo v xpo,tlxori puOprorlxoriopy<ivou, lrs rrlv (6guoq ev6g enrcrqpovr,xori 6nog e(val q Enlotqonri E nou l.er,roupyef o,norel,eopattxti otq feg_ yro rnv ngoc60rloq rnE xQriorE rrrlv guolxriv 0egoneurlx<6v 1.rc'vio'' ououiv. @c pnoqorlor vo, r,6pu0efun6 .*1v enonreia torv xgo,tr,xc6v qoqdrovuye(cE x<iOe 1c6qcgxo,r vo cnogt(ercr. crn6 xuBepvqtxorig unol.l.ri).oug,oveldgmpoug enr,otrj povrE xo,r enr,orripoveg nou epyd_ lowal oq Bropqlov(a. Kal cpuorxd,aurd 0a rircrv xcrl,d vo, yivel doo ro 8uvatd nr,oygr'yyogo.Ae 0c ngdruer, xano,vc,l.or6g avtlpetor_ or va n(ouv nl.6ov tqv nol.l,dg goQdg naqanl.avrqr,txrl xat !_reuE{ ertxlta rcov guor,xcirv xlo,Qo,oxeucoprirrrlv 0larioewo,r, ornv ayopri. Orfte nou xc,r 0a nqdnel vo ayvoofpe qv rinaqlrl xor rrl oqtrraofcrotv cpuorxdrv Oeganeurlxc6v ouorc6v, nou o,norel,oriv6vo 16oo orlpavr'xd pldgog qE lcrcglx{g nqcxtlxr{E oe 6}.o rov x6opo. E(vor.xcrpdg vc cqliooupe dl.or,pag va ouver8rponolodpe tegdorr,eE tlg buvatdqrug .puor_ "ru xc6vOeganeu.*xftv ouordrv,pe q ouvetr{ xa'ior rouE x*r rrlv evoorpritoori roug oro s0vu?a6 o,rio.rrqpa uyeicg x<iOe y6pcg.

I
t

n35x

rKrr^rlKTrKogqpp0Ko

ra22

yrq rrlv qvq(ooy6vr1or1

rns rcop6rdg
(Iuvdv(upo Q-10)
To ouvdvfupo Q-10 eh'u" 6yu qrigpaxo nou XQqotF.onote(ru, yt"u tqv tdvrooq rqg xag8uig oe dl,o tov xriopo. Axriprl xt ov o ylatgrig ocg 6ev to yvrogffer, pnoge(te erjxolva ro ngopq0eutefte privor, vo ocrg.@u paoqorioevo oog o6oer tq 60{.

flp6xe rtcrr, dva r,o1up6 yla tovorrxd xrou<<rfio,vo,cpogti(e rvrer,>xo,r yonole( ra xdrto,go,rqg zogbldg r,t'crps o,ut6 tov rgdno pnogeI vc 6c(roer, v6eg el.ni6eEos exo,roprtrmigr.c cv0pc6nougpe xa,g6lax<inpor,6r,c(repo aurorig nou ndolouv and oulrgoQlrrxq zaeoe Bl,ryplara, 6r,axrjaventiqz,elo,, xct:t6.otooq xord tqv onoic o xog6raz6g pug Sttu obuvorilel orcrblo,xti, ngozcl.c6vtaEtr1 otcbr.cxrj enlEe[vo]oTl rliE rgocpobotr,x{g },er,rouqy(og qg xag6r.dg.H xatdoraorl autq e(var nol.ri ouvr10rop6vr1, r,6la[teqcoroug r1],r,xlotp6voug, no],],6g xcl goQdE 6ev d1e anordl"eopope l,E ouppctlxdg0epone r ieg.Mnogef vu,ocpe(l.eto,r, 1g<ivr,a orrl uqn[{ cgqglazrl n(eoq, oro Or,crpr1n1, Euicpoge g oe royevefgvdooug, orrlv unegpo]"lx{ xatov<i}"oor1a}.xo6}. xat no}"d oulv<i oe xdnola rcgOrcxrl ngool3ol.{ r; on},rig oqv xcOqplegr,vrj gOogri l,6yo m1g 6lo6r.xsofaE rrlE yliQovoqg. 'E1ovto,g unoote[ pl<il3q,ro, prltQooxonw.6" xfrtcrga m1gxag8r,dE6ev pnogorjv nl,dov vc nagdyouv apxetrl evdpyelc yLo,vo, fieoyplorofioloriv.ng Ouvcrtdg ouotol"6gqg xuq8uig, ol ono(eg eivo,tano,gakqr,eg yrc rqv nuxl.ox37x

v (.yere nq<iBl"qpo rnv xcqbrd oo,g, ng6nelvo yvrop(fere pe 0o, tqv rincqfir1prog ouo(cErrou ovopdlercr.ouvdvEupLo e-10.

rou o(poroE oe 6].o to oc6pa.Efor,t(clgqE avendp]rsroE rtllv cpoQfo rl xurrdprrlv qE xag6r.dg, Qoli rou aipotog enrpqa6rivercrxor q l.erq cg1(el vo, g0iver,. <.Ouoro,orrx<i xcg6r,cxr{ roupy[c r"4Exc,g8r,<ig g eve crvendgxerc, e(vc,r plo xu:c6.oraor1 gyer,czrj or6qqoq g rrlE ?.{,oel.6er, 6vaExag6r,ol.6yog. Tunlxri oupntc6pcta trlg v6oou e[vcr, 6r<igr', q 6uoxol.(a orrlv q,vo,rTvor], zdncrlon, I ouoodpeuoq uygori orouE q nvedpoveg,xc0c6g xo,r ro ng{llpo xtrlv oorQoyd}.olv.)rablaxd r1 une rpoon<iOelayro,vo,l,er,tougyrlxap0rd, nou xctcl3dl.l.er, gBol.r,xri xal vo oEqyrjoel otq ota8lcxr{ enr.6eG oer, pnopei vo efcroOevrioel tou A[(er voorf rrfg xu:c6.otuor1g oc6pcrtogxutr,eLwtd oto O<ivcrto. va oqp,elol0e( q ouvnl0qg &r, Oegcne(oyro rn ouircpoeqrrxri xaqbloxr{ avendpxercrnegrlotrrBriver. Xa{orl cpagprixolv tr1 drrrlg o 6amu}.G r;'g, u,a06g xor, brougqrlxritv, oyyero6raotoltt,x6v qappldztov zar cvaotoldorv rou perorpenrlxoti ev[ripou rrlg oyysrorcr,ofvqE(ACE inhibitors). H rehr,xri 0eqone(c e[vor q perapdoleuoq xapbr,rig. 0egarefo rrou XQrlorpofiorelot<5oo, undgler xo,r l.lld,dl"l.q ouvrlOqg e(rcn pe peyril,q txmuy(a os 6l.o tov x6opo. Enavevegyonore(tqv H xaqbri 6(vovtcg otc, xrirrc,gd vl; v6a sno06purcr ev6pyer,ag. (a ourl y(vetcr lrc ro ouvdvlupo Q-10 xol rc Ocuparougyd Oegcne qg yvrrlot<ioe apxerodg xap0r.ol.6youg. crnorel.doplarti e(var.

H @AYMATOYPfH @EPAIIEIA TH> >OYZAN An6 rc xaubglL rou )avdtou orrlv aud.ppaorl Tov Oxtc6perorou 1994rl Xod[cv fldgte q ritclv o1e66v sxor,po<<'Hro,v avtndQ?rsroE. afrcf,tiruqq xor, O<ivotql"6yroxcrpOr,axrlg 16oo oErjvspq, r6ote pe 6uoxol,(o pnoporloe va oqxol0e( aa6 ro m1g>, l"6ern xdQI rIE. <H pqrdgo pou 6ev pnogorioevc xpel3tirr, o,vo,nverjoer,(tcty notrf xougcop6vrl xo.t etye ouoocogeurei uyq6 otoug nveiipov6grr1E. fr,a to l.6yo aut6 eilope a,xugrioer q 6e!(rrrotl Yr0,rIV xewrptoor,rl ycpril,la endtslo trrlv yovlc6v pou. H pqrdqc r]rov 16oo cEdvapq, c6ore6ev pnopofoe vcr napcrore( orjte xar or o,vo;[qQrx6xcrqoro<ixl. Bproz6rcv olo xcrtriql.r tou 0o,v<itou %oror yrctpo( tqg r{rcv dror,por fio,Qo,rvo, qOoriv cnd tqv agoond0en vo,rqv xqcrmjoouvorn qof . 7\l"l"olore, rjrav nohi peyril.q yro, vo, uruoBl.q0e(oe peropl6oleuorl xap6rdg. Tqg e(1cv 1ogr1yq0e(6l.a rs oyenxd cpdgpoxa qg napa,8oora,xljglarglxriE, fioQ' 6l.o autti q xarflotuorl rqg Ee n38n

v
t-

r4
)tt

E 4 ,:I

,1,

;.

l3ef,tr.ow6tcv.Aev nrcredape dn, 0a ro xcr<icpegveva lrjoer, p61gl tqv Hp6pc r<rwEulo,pr,or(rDv>. 'Enencr and nol.l.d lqdvn pe ufil"{ ogqqraxrj nkoq, e(ye 6r.oyvroo0e( oqv fl6preq xag6r,ax{ o,ven<iqzene6r6xar 6exaew6a lgdvra. Me q trritpqqaqpdxorv dnolg to Capoten (crvoolol,efg rou lrsrcrreennxorj evlripou rrlE oyysroraoivqg) xcu, aufovdpeveE 66oer.g Erouprlrr,xc6v, xorticpegevc !r{oeI prc notrti evegyql,x{ Eor{ - p61gr toug re},etc(oug dfr, pr{veg, on6re 11 xu:t6.otaoqqg nproo8eurtxd enl6er.vc60qxe Bc0p6 rrou lav_ oe 8rjveueq (6lc rqE n qtll{. 'Otav o 6p )tfBev T. )r,vdrga, 6vcg er6r.xeupdvog sotrlrserxdg rua0oldyoE zrcr,r xag6r.ol.<iyoE oro voooxopefo rou Mdvroeoreg (Kovdxrv*ut) el6rcroe qv neg(mor{ tr;E, oupcpr6vqoe 6tl enp6xeno yr,a plic tol.rj ool3cprj nepfnrorq oupcpoerlrrxr{E g xcrqOr,axrj cvendqxer.og.)e q}lxfc eB8opr{wo evvda erc6v,q fldgeg (r1yr,lep6}"r,g xil.<i xar ro 38 xl.dopo e[c6ftoqg qg xoqEr<iE rqg -6va, pdrqo qE ovrl.qrlxrjg rxc,v6'rqrcrg zcg6rdg- ILXE qg xmeBe( pdl,r,g oro I0-1,5Vo (evc6 11 cpuor,ol,oyrxql,;.pn 50-70Vo), etvcn" yeyovdgnou 6ei1ve 6rr,nol.rj r l.iyo afpc xcr oluydvo tgogoOotorivrcr,voro, lorr,xd qE 6pycvc. <<H zag6r.drqg unol.enoupryorioe po0pd nou pet<i B(cE oe pnoporioe vo, lrsro,t{,rvtl0ei cnd ro xgeBdrl oqv xog6r.r}.axal rotipnal.w>, 0up<fual o 6q Xlvdreo. TIE ng<iteuve,pdl.lora,, ncrgdl"l"ql"c rc qtiqtrrax1"u1g, na(qvel30 mg o,uv6vlupou pe va qoe6Eqv qpdgo, 66o11 onoia o 69 )r,vdrga e(ye Q-10 tger,g tqv nol,rj o,norel.eopotmrloe dl,l.ouEaoOevefg Bqer, rou [.tsnqop],rjornv xcp6r,<i. f)or6oo, cuu,j r; 6<ioqDeBorj0rloeapxetti rr1 lio,ro, )oti(ov, rqE ono(og q xortiorcorl ouvdlloe vc, enl0elvc6vrro,r. To Oepgou<ipr,o rou 1995 q fldqrep ppr,ox6tov oe xgior.pq xartioraoq. Ol nvefplovEqS e(1cvyepioel uyq<i,to f6r,o xol q xoll"r.cxrj 1c6ga. rrlg Avdnvee pe preytil.q Ouoxol.[a xar,6].a 66er,l ro lvav <1T oc6pcrqg xot6ppee. T6re, ro Mdgrlo rou 1995 ouvdpq xo nro exxLqxtwd xcl euruy(.gl"tiOog. <O ylog tqg r'jrav q ottia yro, xo Ocrlpo nou ouvdBq>, l.6er, 6q Xrvdrpa. Avr( hor.ndv ndpeI dvcrqrcrl.(6r,o o va xdqoul,eg totv 30 mg ouvdvlupou e-10 oro xarf"ovlpo er66v trre uyr.er,vrig Orcrgogrjg nou e(1e enroxegnel xaye to <l.dOog> va oyopdoer,dvo cpr,cl.(6r.o zdqoul.sE rov 100mg. 'Flr,or,n II6ptrre rep xatdl.q[e vo,no,(pvet<<xan6. tr<iOog" mg ouv6v(upoue300 10 qpeplo(og - 6ql,G6ri tger.g cpogdE neqr,ootireqo an6 rq o,uvnr39r

'Eva 0r.opdvq06oq qg. privc agydreqc, rov Angil.ro, rl xu:r6"oroori qg e(1e Betrtr,ol0e( 16oo nol.ri pe rr1 Bor{Oe rou ouv6vro c6oT q ooOevligrirc,v oe 06oq vc oqxotOeian6 to e [upou Q-10, xpepdrr, rrlE )cc'rvo, siu,ox,qre(r,o on(tt rou yrou rrlE yrcr ro naolcrlw6 6einvo. <Aev pnoporioop vo, ro nrcrdtl.roupet,l,der rrlE. <H evrfpyerdqE e(1e encrvdl"Oer. nprilr.po ora To n ?t,de1 n66r.a rng ufioxoeorjoe xar ro u1g6 nou e(1e ouoootqeure( orouE avedpov6Eqg e(1e efcrgcrvlo,e(.To ouvevlrlpo Q-10 {rcrv a,nore},eopatlz6>.H xcrt<iorsorj qE ouvdltoe vc pefurrc6vsro,r, xo,rlov Iorjvlo rou (6uou6rouEro xldopc el60qoqg qg xcq6r.<ig xTlEELXI aufqOe(orc20Vo. <Autd pnoqeiva pr1cpo(vegql,6, al.l"ri &av eivo,L 16oo lapqld, en(ne6o,, rar r8ra(tepc oe cx6pq xcu.pfa 6r,ogop<i rrilqE tou 5Vopnopei va e(val nol.f tqE oqpawr,xr{>,}.6ero 6q )r,vdrpa. flcgd}"},q},a un{p[e alr,oorlpeionq peicoorlqg <6r,aggor{g> qE no}.r,v6q6pnoqg zar, rou o(paroE oto cvc6regcr xoil.c6patcrrrlE zopbr,dg.Aur6 e(Xeorgacordl,eopo q petrr(otoqqg l.enouqy(ag qE xo,g6r,dE, rrro o;rorrlv releopctxrj ler,touqyfa rng alE <cw],6crg rou cr(paroE>>, xo,0c6E ?tcrr pe(trlol qg ouooc6gsuorlE xT ulpori orouE lotorlg. Tov Oxtr6pero rou (6r,ou droug, r; )orilcv r{rav cqxetri zo),tfuepa c6ore va prroge( va Byc(vel c,n<jro on(tl ylc, vo, qg. To No6pBqo dglloe vc, nqya,fvet xc,r, x&vet ro qrc6vro nril.r oqv exx),qofu. To Aexdppgr.orc!(6ege yro, vo, EllrLorrlgre( q xrigq qg yr.a ngc6q goqti rov rel.euro,[o evdpr,orl lgrivo. Tov Iavouripr,o naqcrndrqo ?ro,rdna0e zriraypo oto r,o1(o,ol.l,<i q xcg6r,ri qE r{rcv crgxer<i6uvcn{ c6oreva avr6fe r qv endprpcoqenc,vc,tono0dqo1g rou ro1(ou. Kcr. pdl.r,orc q av<iggrrror{ qg ritcv 16oo xo,}rr1, <6ore6e lqeraltirov rr}.dov uaootr{gr.lr1yro, vo, neqnor<iel. Mo}.ovdn r1Xorl[cv cvdntufe x<lnor,anqopl,r{pcno oro 0upeoer,6r{ filE, ro, ono(a 6ev e[1av xup(c oy(,oqlre qv xcg8r,oxria,ven<igxera, <<tc6gc, eival yepd11 lolvr<ivm xcrr.la,qri xcr 6ev 61er, r.ocX0e( oro voooxofovae pe(o yrc ngop),,r{pcra oyeuxd pe rrlv xcq6r,d r4g, o;n6r6re nou tigpoe vcr na,(qver ouvevlripo Q-10n, e[ne r; x6gq qE ro epgou<igr,o r,ou 1997.Ax6pq xcr o{pega q )orllav e[cxol,ouOe( no(gvel 300 mg ouvr6v[upou vcr Q-10 qpeprlo(rrlg. )ro oqpefo curd npdnel va cvcgdeoups drr.Xpqorponor,r{Oqxe lreu6c6vuporrQo%sr.pdvou Jreoord,reu0efq taur6rqto vcl rou nqooc6nou,6pcrtg 6l,a ra ntplzti ororyeio e(val oolotri. r40r

Tr eivcr to ouvdvfupo Q-10; To ouvev[ripo Q-10 efvcrrdva lolupri ovtofiel8olr,tx6 nou e(vo,lenioqg yvcrrotdxo,r trlEubiquinol-l0. To dlouv nepr.ygd,tl.re <<rreooor.trlg pord[ov tq 6qdoq torv pnaprvc6v", 6progoqr.op6vor epneqoyvc6povE uxroorrlg(ouv drl npdzerto,r Gvopgroprirqro yr.c plropivq 6ql.a6{ yr,cr 6va Opentlxd ouorc,rlx6 nou np6nel va ru<ipel or6pc ro vo, ro rpocpo8orr]oe otc xtirtogo, 6tot titott. o oeyovrolidg vc r Tf,o, i'.ertougye(pe p6Irr,oro rpdno. To ouv6v(upo Q-10 Bg(oxercr,oe nol,ri pr,xpdE noodrqteE orrE tgoqdg xa,r r8ro,irepcx oro, Oal.aoor,vri xcl napdyetar crn6 6l"s ro xrittcgc rou oripctog. Idnolveg enronipovrE 61ouv ouvOdoe ro ouv6vlupo Q-10 og npc6tqril.q nou erodr ysro,r os outrrnl.qpr6para br.atgogqgxo,tncDl.efto,r <j].otov xdotrro oe cnd 8r<igopeE rcrnrovlxdg etap(eg. Ilora efvar ta otoryeiu rtou xotc6erxvriouv rq orlpooio tou ouvdvlupou Q-10; flol"l,ri ouvro,Qcrx,mxd or,otrye(a 6e(1vouvdtr,or nepro6tepol oo0eve[g nou dlouv npopl"{pcta p rnv xagbrd rouE rro,Qouor,dlouv 6}.}.er,ppo ouvdvfupou Q-10 oto oc6patoug xar q l.r{t1.rr; oupn}"r;pcopritrrrv ouvdvxor e(vor6uvar6 lupou Q-10 cvolooyoveiq l"enouqyfaqg xcg8r.tig vo neplop(oe rc oupnrc6poro l rnE xogbraxrigv6oou. flgrrxonogror6g pel.6tegrou 6qog Kcgl, O6l"xegg, 6leu0uvtlj rou Ivorttorirou Br,o'r,a'Oorlv rgutriE'Epeuvag oro llc,venrotrlpr.o rou T6fcg oro rrrw HIIA, 66er,lcv 6r,t,ro 757o tr;.l.v ao0evc6vnou ndolouv an6 xogEr.axr{v6oo na,gouor.tltouv ooBagr{ o,ven<igxelaouvdvlupou Q-10 ota xfttcgc qg xcq8r,<iE, o16oq trre en(neba, oe ra rou ouvdvlupou Q-10 oto zrirrcQcxrov uylcfv crdporv. Enurl,6ov, na,qouo(uoe pe oror,le(cr drr, r1 l.{t1.rq ouvdv[upou Q-10 anoOe{J\xe nohi eueqyer,t"xrt orurg(cr tdraprc prcrE opd8ag rll"lxr.opdvrov oo0rvc6v nou dnoolov and oulrgoQrlrrxr{ xcrgOlcx{ uvenriprxer,a. te},sura(a 66xc 1g6vro dlouv Erlpoor,Ta, eure( neprcodtepc un6 nevrlw,c xriglc ripOpo oe yvototri xcl clt6l.oycr t,ctplx<i neqro8rxri oe 6l,o rov x6otrro oyer,wd pe ni 1q{oq rou ouvdv(upou Q-10 os nepmtc6oelgxcp8r.anrigvdoou xo,r l8nirepcr g otqv nsginroon rnE oupgoQntt?n{ zag8r,axr{ avendpxe r.cg. E Extetcp6vq lcrnowlxri6qeuvc d8elle 6ttro707or,av oo0evc6v pe xag8raxd npoBl.rlpcro Beiwr,c604xe q l.{qrn ouvdv[upou Q-10. To pe ouv6v[upo Q-10 Xpqolponorefro,r, en[o'qE, eupdrrlg oqv Ito],[a, dfiou 61er,8oxtpaorei oe xhwm66 6oxr,pdgoe fiol,l.d lcrglx<i xdwqa,, otr.g onofeEouppere ilov 2.500coOeve(g. B0% totv ao0evc6v To nou dnax41 x

fl--

oxov oJ[d xoQ6ro?r{dvsfidQxsro J[oQouo(Goo,v pe]w[rrloqdnelra an6 xrl I{VT 100mg ouvdv[upou Q-10 ncgd],],q].a pe ra q<iqpcxc ruoulj6r; dnclpvav. )e pr.c en6pevq pel.6q ncrgo,xol.ori01orlE, lopliyno4 50 rl mg ouv6v[upou Q-10 qpeglofrrlg yr,c lgovlxri 6r,<ipxer,c evdg privc, p6vq rng { ncqd},},q}"o ps rrl Xoefyqoq d}.}"olvqcqp<ixrrlv, pelrirrloe o4pawlxri ra oupnrc6trroro xap6r,cxr{gc,ven<iqxela,E qv nor.drqE xar qrc ltl{E rrov ao0evc6v. ouv6v[upo Q-10 0eorqe(rolcprippaxo To zcr, npom,ptitor,l8ra(regcr oe nol,l"dgXc6QsE. voooxope(a rou loqcr{}" !ro, ro ouvdv(upo Q-10 lopqye(rar,ot r,wnwl pdoq oroug c,o0eve(E nou ntiolouv anti oupqogqnxr{ xcp6 lcxr{ cv endqxelc. 7\}.}.<rlore, I<inotv g e yr,crpo( Xelorporrorofv to cruvdv(upoQ-10 yr,o ngoBl,r{pctc fiou oxer(owcr, pe xqv xo,pbr,ti,e6ri zal neqroo<fuepo an6 rpuiwc 1q<ivra. Aum{ q orryp{ ro ouvrfv[upo Q-10 anote],ef p(c crnd nE 6ll qoepoxturmg ouo[eg fiou XQqorpronorotiwal neqroodtepo ffiIv Icnolvia. O 6p Xr,vtitQo,, rrou eqyd[etcr, xrrr oE enixougoExoO4ypig mqv Icngr,xr{ )1oh{ rou flavenronlpfou rou Kov6xrlx,ar, r(vc,r, 6vcrg cnd roug Apeqlxavorig yntgofg fiou Xeqoqronolotivol"odvoxal negr,oo6reo ro o'uvdvlupo Q-10. ro ouvdv(upo e-10 oe 6l.oug roug "Xqr;orponor6 co0eve(Epou ftou nfioywv aad outrrgopql,xr{xcp8r,czr{ ovendpzela, otcnt y,uo o'uyxot<i0eo{roug>>, 14 avaqdgel o yr.arp6g.'E1er,1ogqyioer. to ouv6vfupo Q-10 oe 1ll.ui6eEaoOeve[g nou ntiolouv an<j xag0r,axri poq0r{oelnegloo<iregocnd rc 70Vo asr,6 v<iooxc,r,ewqtd 6tr, arn<j d1er, auroriE.)e oqr,opdve afi6 xLE neqr,nt6oer,E 6e oqper,c604xe petrr(ronou E ctn pe rn XoA{floq tou cruvdvlupouQ-10, o (6r,o9 emtp6 &l6e logqyr{04xcv xcr<il,Iq),eg66oer,E 11on"ra ngoidvrc nou lopqyljOqxov e(1crv peropdvq Dgcorlxtir4ra. H 6<ionap6ner va eivar apxen{ npoxelp6vou va ovep<ioerra eni.rreba rou ouv6vlupou e-10 oro c(trra.'Ouav our6 oupBofver,, ororerjerw"to 100Vo rov ao0evr6vpnoqorlvvc oryelqOoriv.

>YNAPIIA>TIKH KAINOYPIA EPEYNA >TON KANIA&{ H nepfntaorl ev6g nou Br1parc66rr1 rc)"md. 6eyped,mrp{eyc XQqoryonoLry1ti To ouvdvlupo Q-10pqioxercloripegooto rtgooxr{vr,o r0n(reoro Egc M<irxl,2ol., xcOqyrpljr,atgr,x{g flovenroro eo XdQn orr{pr,orou Tog6vxo xor 6reu0uvm{ tou Kag8lo},oylxori Kdwgou llfreg Mcwn,ev6gan6ra peyc].rfteQo, nrc yvctorri ]ro,l, r.ctgr,x<i xdwgo yro rrl Oegoreic?ro,r pel,dq rov xaq6raxc6v rn
r42f

].6er, 69 )o]", ,,vo 8legeuvljooupe o fio0{osov. <Efval xolp6g>>, nol.ri ngooe xtt xd u1 Ouvcrtdqro XanonEtou ouvdvlupou Q-1-0 yr,orrl Oeqanefotolv xcrgbrauiv v6orov xal l6lcr(reqo, fflE xoQpaor,op6vor Er.axrjg o,vendqxerc,g, oro peydl.o agr,Opd 6e8op6vrltv nou 61er,r16qouootrlesursf oqv r,orgrxriBrp].r.oyqcrcp(a o;n6 pel,dtegdnrrlgeivar. crurdgtou EpogKcql" @dl.xegE". O 6p )ol. opol.oye( 6tr ro evbr,crgdpov yr,o. o"uvdvlupo rou ro au[rlqrte tfucrv6vcg oo0evr{gtou 6ev dpc}.e pqporo66q, Q-10 ov xor rov e(1e crvdyzq,ttcrrficp' dl.o autri av<iqgore rul.r{qo4. <E(1o dva,vao0ev{ rou onoiou q xcg6r,d enl8ewtrlvdrov br,aqxrfig, pe anotdl,eopc vo, Xesro.orsir1roruo06qoq pqporoEtiq', l,6el o 69 )oL. nagdnep!.raoe x<inorovel6lx6 yrc xqv rorro"Tov Odrrloritou, atrtrd dro,v rov ei6c tdooeqlg privegcqydrepcr, Oev pqparo06q.fIQoE peydl"qpou dxal.qlq, q xcwtio'rooT{ eile pril,er. rou, Jtrouenl8elvov6rov 0ropxr6g ro rel,euta(a 1qdvr,a, e(1e 'Erol oqper,r6oer, Oecpott,xr{Bekr(rrlor1. tou e(ncr: "Aut6 e(vcrr exnlqxnn6! Aev dyrl ficvobel xdn, nogdporo or d].q qv enoyyel.parr,xr{pou orc8r,o6pop[orrlgxo,q6r,o],6yo9". Exe(w1xI oxryprj o ao0evriEpori elrjyrloe 6n 6e lperdoqxe Brlpmobdal6rdtr,, 6newa cn6 qv rel.eurafa exfux,etpqrouolo lcnqeio pou, p(trqoe oe xtinoro qfl,o rou nou 6nc,lgveouv6vlupo Q-10 xar, drol cno'llrcrv g<ioloe vc to 8oxrp<ioerxcn o (6roE>. ro ouv6vlupo Q-10 une60uvo yl' autf fllv svrurToor,ax{pe}w(coon xcnflor,aorlg rnE rou r{ eng6rrrxo yro, pr,c rulo(a Belr(rrloq nou ouvdneo p rrl l"riEqrou;'Oncrlgefuye( o 6p )o1., np6xewcnyKr lno pepovopdvq neg(nt<rloq,yro rqv ono(o 6e yvop(el qv andwlorl. nTo pe negrorctux<i6prrlgcur6 r{rcv rdoo alr,oo4pe(oxo, c6cne dxale (Duor,x<i, OercrgxetdgqoedEoq Eof pou vo vd ovoQon.l0c6. 6lor <rupl3afvouv Ocriporc xal 0u ngdner vo Er.epeuvr{ooups ro ov ouvdv[upo Q-10 efvor,nqtiypam,eueqyetrxd,cqori 6r.e[oydyoupe x.Irwm6.g pel,6tsg nou 0c pog 66oouv sfitornlrovrxri dyxupc cnoteldopcto,. fJot<loo, pnogotlpe r{611 norltrledn cpa(vetal vu opxetd uroo16trrevo, r6orevc al(e r.negawdgo 6r.egerivqoq>. IIor.oEeivcr o rQdrtoEEgrioqEtou ouvdvlupou Q-10; To ouvdvlupo Q-10 e(var,6vo avnofer,8orttxf pt pova6r,xdg rDldqprxgri <<rvrQysrol4d reE fiou 6r,e[o66er oto. epyoortioto,>> xutt6"rcrrv erllv, fiou xatrofwal pu.roldv0gro.F;xeiyfvetar q xcrioq tou oluy6vou, Tlono(a 6(ver orc xrimoqa rqv ev6qyer,o Jtrou e(vcl crnapa(rqtq .43.

yro rrl 6nr{gr1oq qE eo,liS. flgoxer,pdvouvo XQrlorponorrpoouv anorel.eopc,nxti rqv evdgyu,o,, pr,roldv6gr,clgeuilowor ouvdvfupo ro Q-10. )upd 0eclpeirat o <onw0r{gcrE>> [exr.vdxcr, Boq0dq ],er,fiou roupryic rov Frroxov6girrw. @eoprplxri, DflcrrE aqxen'j o.uyx6wgoorl ouvdvlupou e-10, ra xrjr_ rc'ga unoqdgouv c,rr66l"l,enpq eveqyelcrxr6v cnoOep<itcov, anor6l.epe opo vo enqgedlerar, aqvqfl.z<i11 l.er,rougy(cloxtxriw opytivrr;v xal r6ni_ reo rqE xcrq6rdg, nou lpeuilercr. 14 peyaltneq4 noo6qrc o,uvdvlupou Q-10, ngozerydvouvcr eivol oe 06o4 va ncgtiyel ra pey<il.cnoo<i evdq_ yero,E fiou lqeuitowcr, ytc vo, ouvelioel va Xrundeu 'Orav ra xfwagcr rou puoxo,e6[ou nou 61erunoorei 0fuiFn oregofwc,r ro lantx6 ouv6v!upo Q-10, 1 ncpcyrrryr{qg ev6qyeucg br,aqpeircl oe lapr;}.d en&re6a, yeyov6E nou erur,qdpr Frroxov6pr.crxr{ xcpbr,cyyetox{ 6uo},el_ ryl xar. rougyicr.H rpogoOoo(arou puoxcg8[ou pe oupr"ntrqgc6parc ouv6vlupou Q-10 ova(oloyove( ro, evsQrysro,rl,ri oregqpdva xrlrrago,, pe anordl.eolrc va, ncptiyerar, peyahnegq noodrqra evdpyelag, yeyovtig fiou U,srT oelp<irou obqye( os pro llo 6uvcn'i xap8r.<i onofcr6e 1qer.dlercr. 11 va eprydlerorrtioo oxlqpti tpoxer,p6vouvq, xuzl.oqope( ro a[pc. )uvoqf_ (owoE, pnogoripev'noritrre drl ro o,viv[upo e-tO pefurr,c6ver,prrlx*rrl vr,x{ }.ewougy(cr4E xcrgbriE,6ivowcrEoro sveye r,cztl oreqqp"va w6r,_ ro,Qo, <.xcr.ior,po>> 1qer"rilowar y[o,vo,],ewouqyoriv ro nou cnorel,eopau,_ xd. To ouvivlupo Q-10 e(var, en(onE6uvcr6 va o,uppril,er orlv ono(eo_ nrlx.atrrl oepclrcia qg exqul.rorl,2(r4s raw xcrq6nxc6vxurrdpow Frdpns xo,r oryl ouyxgdr4oq nE xctwrlglolqoreq(vqg LDL an6 q Oqpr,oupyia 0q6pBtrworr,E cpruqp[eE. Ikioo ouv6vfupo Q-10 26qer.afripaote; Mfur,unxr106oq yta tt;v xoqbrcxrlv6oo eivar,qg tdEqEtolv 50 dolg 150 mg qpegqo(olg.S)or<ioo,oe negmtc6oergoopaprig xagOlcxrig (ootganalr;Ooriv urprll,6repeg crvendpxelo,g, 6doeq, rrlE1i,o,r mg 300 qpeplo(roE.O 6p )r,v<iteo urroor1e(\et" 6oo nro oopcqr{ e[val r1 6u xcn&.oraoq tou c,o0evo6gxat doo nlo c6rivapq efvar,q xcp6r,d rdoo mo peyril,4 e(vcr q 66oq rou ouvdvluplou e-10 nou o,ns,ne(ro,r. vo, [. Oqr,opdvor. egeuvqrrigouvrororjv 2 mg ouv,v[upoue-10 loqqyq0e yrc xdOe xr.l,6 oolporr.xori BrigouE. I8r,c(reqc oqpcvnxti e(var to yeyovdg drl, ylc vc uadglouv anorel,6opoxcl, Tl 6dor1tou ouvdv[u_ pou Q-10 ngdneI vc cve prile r.orlpawrxri to enfne0a rou ouv6v!u_ pou Q-10 oro a(pc. H noo6tr;ra nou Xger,ri[rro,r yro, vc, enlreul0e[ aw6 norxil,l"er. an6 aoOevrioe co0ev{. )e opr,opdvoug cv0qc6nouE
.44J

efirruyxdvero,r txo,vofiornrrxli cdErlol rtrlv efirx[68ovrou ouvdvlupou Q-10 oro cipc pe rq I{Uq 100 mg, evc6ti}.}.or, lqer<ilovtal 6rio r{ tperg qogE peyal.rfueqq 66oq, npoxerp6vou va enndlouv qv (Or,o ouyx6vtgrooqrou ouv6vtupou Q-10 oro a[pc,,],de o 6re0vorig r. q{pnS xop8loldyoE-eqeuvryr{E fliteq Ativyrr[ev an6 ro T6faE, o ono(og Xe1orlroftort( extetult4vo, ro ouv6vlupo Q-10. O p6voE rp6nog, dnorgtrder,yro vo, Orcrnlorc6ooupe to ouvrivfupo Q-10 eCvo,r o,v o,norel.eopc,rln<i vo,npooElopiooulrerqv o;tanof pevq 66oq eivo,rvo, xul perq{ooupe ra en(ne6drou oro a,(pcr. Ikioo yQriyoQoX,er.tougye( ouv6vlupo Q-10; to )ripcprrlva ps rouE er6rxoriE,Xger.ti(owar.6rio rioE oxt6 eB6opdbeg, ngoxelpdvou vo o1pero0ei xdnolcr Betrrfoloq ora oupnrc6porcrxIE xopbr,oxr{E crvendgxeng.O coOevr{g ngdnel vc },cppdver ouvdv0a lupo Q-10 oe cruvep{Bdoq, r6oreva 6r,cnqgq0ofvrc, euepyerlxri o,norel.dotrrcnc oqv ev8uvripooq qE xcpblrig. Aev np6xencr yrx pro ppclulgdvr,c Oepane(o. Ikioo coqafiE eivcr q XQ{orl tou ouvdvfupou Q-10; Or.ncpevdgyeleE e(va,t oor{pcweg xat ontivteg xc,r, ouvriOa4nepr.og(lowcr oe r1xta,naqoOrxr{vaur[c,. )e pr.opeyd],q pe].dq oqv Ira].ia, 22 or,oug 2.664 o,o9weig cvdqeqcv rinreE nagevdqyer,eE, 6r1l,c0rj ( noooor6 prxgdrego un6 lVo. Aev dler Errnr,orco0erolr.x6qtcr ax6prl no,ror utpql.6g 66oergoe lc6cr av0gr6noug,L(.et 6q @ti},xegg. r{ o flgooo2gr{: Aev nqdner vc lepripe ritt ro ouvdvEupoe-10 6ev o,nor,ehetunoxcrrxioraroraw oupparr.xc6v qagp<ixrrtv,cl,l.tl ouvr{Ootg 1qr1(c, orponore(rar.ncg<il"l,ql.ope tr; oupBarr.xr{ Oegcne rov o,o0evc6v, yla xol.tirepa cnorel"dopcrc. H hirpq rou ouvdvlupou Q-10 e(val6uvard vc enr,rqrftper. pef<rlo4 rq qS 660IS rrrtv ouppctruiv cpcqprixov fiou ol ao0eve6E, al.)d our6 ngdneI vc y(veral ndvr,a un6 XQrforpofiolorjv qv xa0o6r{yrloTl}ror r4v enonrefa rou xcpbr,o].<iyou nou ncrpcxo].ou0e( rov ao0evr{.flo},}.o( <ivOqonorpe buipopoug paOporig oerrlerooxl,{quvoqE, ax6 lr1v ono(cr n<iolouv o1e66v 6}.or.6oor, pgioxowar, orn p6orl ql,rx(cr,pnoqef vc Oelr{oouvva, ndgouv ouvdvlupo-e10 ngol"qnrr.xd'trl01600,6ev nqdner.va fep<ipe titr"q xogEr,ax{ overu<ipxero,e(vo,tp(o ooBagri v6oog aou 6e 0a npdner.vu, o,uto6lo,yr,yvc6ozerar odte xcr vo, auro0ega,nerjeral.Av ndolere crn6)adxota ooBaqlj zcp6r,axr{ v6oo, 0a, nqdner ndwc- vcl oupBou},eure(tedvcryr,crpd yr,c qv xorril,l,ql.r; 0eqcrneunx{ clcoyrj. r45r

r
Or avqou266eE ttov uanantul"andnr To ouvdvlupo Q-10 ncpdyetcr, oqv Icnrrivic, xar orq ouv61er,o aotl.e(xor os nol,l.6gerap(eg, ol onofegro ouoxeud,louvoe U,oaq{6rox(rrrv, xorfoul.c6v nou negldlouv ox6vq rou ouv6vlupou Q-10 ri xctlroul,c6v e(vo,r ouolo,lel.crivqg. Ener,6rlroouvdvlupo Q-10 e(vall,r,noblatrur6, or,w6 va l.cpprivetcu. fqgti ouv6v(upo Q-10 pol( pe xdtt l,lnag6, to yr.o xof,tfuegq cnopgdqqoq an6 rov oQyo,vrop6.Av cnl,c6g xanaxre( xdnorcg pro Ena{ rapn}.6rc ouvdvlupou Q-10, ro peya}.rirego FdQoS aur{g tqg noodtqra,g6e 0' cnogpoqq0ef.'Evcg xclqbr,o}dyog ngote(vu vcxl.crpBdverarpa(i pe l,iyo cpuorr.xoporirugo el,ar.6l,c6o.eor6ri oo, xo,r,voriprcr dgeuvcrdber,ledtl to ouv6vlupo Q-10 pe rn poecpli pcl,axc6v xatpoul.riv eivar. oulvd nro onotel,eoprc,rlxdan6 a,ur<jnou or Bp(oxercu, Eqa{ poag{. )ripgrrrvo pe nqdogareE 6oxr,p6g, prcI -6ql,c8r{ q noo6rqta nou re},lx<i ptc(ver orlv xuxtroElo0eor,pu5qro cpoq(arou a(porog- rou ouvrjvlupou Q-10 nou pg(oxeror oe pcrl.ozrig zdEoul.eElel.cn(vqg pnoge( va efvcr no]"]"dg qoe6E peya].rirepr1 oe pe crutlj nou Bgioxercr,oe lqpdg r,upnlteg r{ zdtpou},eg. oyorl Aurd oqpor'ver oprotrrdveg drr. pogqdg pcrl,cxori!el" ouvdv(upouQ-10 eival nold nr.o 8gaotr.xdg xctt rot"lqer,tiletot va nc,iqvel xdnorog l,r,y6reQrE, neoxrrp6vou vo, enmilel qv (6r,o crilqoq rov enrrd6c0vrou oT:vdvlupou Q-10 oro aiua. MnogeI x<inologenfoqE nqopqOeure( vc ouvdvlupoe-10 oe poqcpi poodpevow 8loxCrltv, onofa dlouv no].ri peyctrrireqrlBr,obr,o0eor.ptira rrlro, o ox6oq trre onl.ti 6r,ox(acn6 lqp6 o,r.rvdvlupo ro Q-10 tc owoia l.apB<ivowcr,p,exo,rdnooq,Ider o 6p Advyxtlev. O (6r.o9 lgqor.ponor,s( ro ouvdv[upo oe poaq{ po,or6pevou }.enrod pcuox6rou, nou 61er, oe Xenorprofior,rl0eI epeuvqtxdg pe].dreg. Ee *oreE 6LLegfieQtnrdoerE efvar Euvatri vo XQqotponorq0ef to ouvdvfupo Q-10; To ouvdv(upo Q-10 e(val zuqirrlg yvrrlord yro,rrlv c,norel.eopattx6nl16. rou oqv neqfnttrlorl r1g ouFcpoQqtluigxcrgEr.azrig cvendqxer.oE. Oordoo, or, pel.Sreg6e(1vouv6tt efuanen(oqg c,norel,eoparm6onl 0egon e[a ti],],ov poqcpc6v xaq6 lcyy ercxc6vnqo B]"q pdrrrrv,6rtco sivo r, g q uqrnM ogqgr,crxri nkoq, q cpgu0pic (o cxcvdvr.orog xog8r,cx6g gugp6g), q oq0riylq xar" q np6nrtrlol rqg pr.rgoer.8orig l3cl,B(6cg. A<iyrrlrrrtv rolupc6v avrlole l6oxrxc6vrou r.Olomirulv, nol,l"<ipeydl.a oe uatglxtl xrivrgo, 6nolg e[val 11 Iarqrx{ X1o}"r{rou flo,venroqpfou rou P6roeoreq, xc0c6g xo,r ro flavenror{pro rrlE Kc},r,q6pvr.c oro )o,v s 46'

ylc Nrldytto, Or,eldyowar, rigeuveg rn Xanoqrou or excpuhrctlxdE vsupol.oyr,xdg v6ooug, oq v6oo fldgxlvoov, oq v6oo X<iwr,vyxrov,orrlv rl,tiyr,a puctgogrzr{ ox}.r1quvoq xo,r orl'l ox}.r{puvo4,ao:r,6 n}'6xag. Maogei to ouvdvfupo Q-10 va poq0r{oet orrlv xatcao},6pqar1 tou xcgxivoul To ouvdv[upo Q-10 rigl,oe vo 8r.egeuvdror yro rrl 8uvordqra <rupl4cxr potrrigrou oq Oegoae tou xc,gx(vouxor rOra(teqo, xopxivou xou [a rou xa,r prdtrroro61ouv avcgepOe(clroo4plefrrxo 9e:,;,xd snore],d;r.c,orof, oForo,.O 6p O6l.tteqg,eqeuvqt4gcn6 ro T6lcrg, o yr,atpdgfiou rreorootdqoe or1 XArjonrou ouv6vlupou Q-10 oalv xcqbrcrx{ crvendgxer,a, naqouo(aoe ororlefa nou xorc,8elxvrjouvdrl or,aoOeve(g nou ndolouv cnd xagx(vo nagouor.rilouv enfoqE6l,l.e Qr1 atoOepdtrrtv o'uvdvlupou Q-10. Ilq6ogoro o 6q O6l"xeqgavdgege 6tr, oe trl,c opri8o 66xa xopxrvona0c6vApeglxovc6v or. 6fr" xordgegav vs vlxrioouv rov xo,gx(vo xur,6.r,rl8uipxe n qg Oegote(og pe o'uv6vlupo Q-10 xal 11[rr{ roug 'Evc ncgardOrlxe o;x6 xfwe 6o4 8exondwe lgdvrr. pey<il"o p6pogtqE yr,c dqeuvaE r1v er(6paoq tou ouv6v(upou Q-10 oe croOeve(g xcgx(pe vo, rrlv ono(o, fexivqoe o 69 O6l.xegg, dlel rrQoypoxofior.rlge( oqv Koneyldyq an6 ro Acvd oyxol.dyo Nour Adxyouw. O 6p Adxyouw 06oer,gOrdcpogrrlv owr,olel0onlxc6v, orc ono(o, IQrlorpofiorsi utpql"6E neqr,l,cp$dvrcrr ouv6vlupo Q-10 xol ra l,rrcgri ol6cr, nagdl,l"ql.a pe to rq o'upBcrtr.xr{ Oegcne(c pe cpd,gpaxcl nou XQrlorl.ronolorjwc,r, "cou xand xcrgzfvou rou pc,orori,rn Xsreoueyr,z{crwrtrreuintorl,rq 1qtrre loOepcrne(a, nl0eqone (o pleaxrwoBol"(eExal rn Xa{oI cpcgp<ixrrlv 6notgto Tamoxifen, dnorgefval 11 ouvr{0qgngcxtlxrl otn Aav(a.

H IEPIIITO>H AYO |YNAIKON AIIO TH AANIA To 1992o Acv6g egeuvrpr{E Nour A<ixyouw dql.oe vo 6oxlp<iq Xq{on o'uvrivlupou Q-10 xar, d}.}"crtv awrolerbonxc6v oe Eel rguiwc 0rio ooOeve(gnou dnoolov ca6 xcpx(vo rou pootori, ql.lxicg tprdwa Erio 6crrg oy06wc evdg eri6v. )ro perclri, o 6q Atlxyouw xor or ouveeydregr,w, otoug ono(ougnegil.apBdvetar, o 6q Kaql" O6l.xepgrou flc,venLo'qp(ourou Tdfag, 6Xouv6qpoorerjoel cgxerdg negmr6oe6 fqeong rou xcpxivou oe yuvcr(xeE lre lrsrooto,rrx6 xogx(vo tou poorori rtou ri],apclvcrupn].qpripara s47s

ouv6vlupou Q-10nopdl,Ill"c pe q oupBam,xr{ pe Oepcne(c ra ovrrlro,Qxwrx<i trroxc. ncprouold,lou l,olndv,&io nepr._ pdq )ag trre, nrc[roerE bqpoolefqxcv o.ro6yxupra nou errrcr1ptovrx<i nepr,o6r_ x6. Biochemicaland Bioplrysical Research communicationsxo,t Molecular Aspects Medicine, 1994xatro 1995. of xo Mla aegfatrooqexalqxuxrigtqeo4g. Tov Iorjhr,o I99Iq K. M. oe wv r1l.r,xfo erc6v 59 uruoBtr{Oqxe XsreouQyr,xri os endpl3oor; rrlv acpo(geyro o4 xcgzivourou pcorori.Tov oxrc6pgrc (6rouroug,croqdoloe rou va, ndqel pdpogonq pel,6q rou 6qogA<ixyouwxcn dglr,oevo l.aprBdver. peqr.vd xaOq psydln noo6trpc ougnl,qprrlprirtov, ono[anegr.],crpBd_ oro vo\,ro,r 2.850 BncrpfvqE mg C,2.500IU (Ar.e0veig Movti6eg) E, Bnopivqg 32,5IU p-xcqotivq 387trnxqoygappdpro r,ou, y y_},wo}.ev g, oel.{v I,2 e. r,_ xoti o[doE(GLA),3,5yQ.ropdyc-3 ].rnoqc6v oldow(r10u6].cr,ou) xor,90 mg ouv6v[upou Q-10.O xcrpxfvoE 6xoveperdoucoq Oev d[or alrd ro o'niOog, al,l"d dvog oyxoEdrove r1v encvepcpriv'o,ri cno crniOog. rou flotrri nprooexrw:rlnapcnol.oriO4oq ps poo.royeogia 66er,le o dyxog cn 6e peydlrrrve. flqdyparr, yra neginoudva1g<5vo cpriv4ze e(ye<<ora_ 6n Oepronorl0e( 1.,5 or,u 6.ag2 ex.>>. Tov Oxrr6Bero 1993o 69 A6xyouvr,xo;L ouvegyrirrE rou or rou anocp<iorocv aul{oouv xrl E6oqouv6v[upou vo e-10 rqg coOevorig 'Evo oe 390mg nprsQqofotg. trlrivo cgy6rseo,,rQoE pleydl,q 6nnl.4lr1 tolv yr,crpc6v, r{tcv 6uvcrr6 evronrorei 6yzogps rrlv oqri. To 0ev va o Aexdpppr,o xcgx(voge(1eefiagavrore[ o cn6 rq pooroyeogfc.Aev un{g1ov ev8eifier,g xtiruorou 6yxou orrlv o,].r,r,voygag(u. xcgxivog O pqr,on6rcv nl,r'jgrl oe riqeol - et$t elacpavrctef! 69 A6xyouvr,nou O 61el avtlperolndoel negrco6reqeg crn6 200 rueqmtc6oer,g xo,px(vou plaoro{xdOe1g6voen( rguivra rudvre rou E{}.rrloe Eev dtr. 1g6vr,o, e(1efova8ei nor,6. cur6x),r1qnl,r{gqripeoq ev6E pr,a 6yxou oto ot'j_ 0og 6r,co'rtioe<rlg 6.,E2 cm. Enr,nl"dov, eile 6er,norri nqlv 1,5 Oev xdnota cv<il"oyq riqeo4tou xopxivou or negmtc6oerg oupBonxr{E 0,vtlx0,Qlnvrxr{ g 0eqcne icg. H e$oqriv'oqevrigOavatqtprigou xcqxfvou.To )entripl3qro tou 1992 pro ooQcworerqdlgrovq yuvcfxc, oo0evriE 6qoEA<5x,youvt, tou uno_ pl{ftxe oe 6m}.ri pcorexropri,Oq},a0rj os XsreouQytxrl txro1nl xut rtov 6tio pc,orr6v, 6.nura c,n6 swonlopd xoqzfvou.O xagxivog efle r{6q enexrcOe( 6rjo ond roug b66exo },epqc66veE Oelr,d oe orq pco;gritrq. yuva(xo6l.cpepr,c H oelgdcnd 66xalqpercOeqanekg.
x48r

Tov Anqfl.r,orcu 1994 or elerdoelg 6Eer,lav6rl o xapzivoE rou paorori eiye xdvtt" petdorooq oro rjlrap. Aumi q el6l,r.[q rirov t6oo oopaqri, c6oreor yr,atgofnpodprloavoro elrig o1d].ro:<H pertiorooq cro rjnap pnoge(vc 0eotqq0ef npoo(pr,oev6gtnmt(prvou 0c,vrirou>>. H 6doq tou ouv6vtupouQ-10 rrourqE loqqyorivruv crulrjOqxe ar<i 90 mg oe 390 mg qirsQqoicrlg. )uv61ros vo, naiqvel q ouvrl0r,opdvrl oupnl,qgorpdtrrrvta onofa dnc4rve ocp<5rou unop].riOr1xe orq pcorexropri, Wal(;re 30 mg rlpegqo(rrlgTamoxifen. Tov Anq[],lo tou 995 va urceqrlloygricpnlic {ncrtog dber.le6:.;ttaxupxtvtxlxt3trou e(1av elcrgo,vlote(evrel.c6g. Enrrl.dov, 6ev umjglcv evbefierg tou xo,px(vouoe dl,l.u oqpe(a tou or6trrar6g qE.

O 6q A6xyouw 0eripqoe une60uvo o,uvdvlupo ro rrlv e-10 yuo, unorou xc,qx,6vou pootori lt,crr e[cp<ivrd rou c,n6to {nap, tou rl1v opol.oyc6wagdtl rdtora neqloro,txd eivol elor,qertx6.ondywo ,rselrrc6oer,E dnou loqqyeirol p6vo oupBatrxrj 0egane(o pe c,wrxopxrvrxd, qiptrroxa. frc to l.dyo aur6 nloterjel drr, <n6 neqr,oodregeE co0evefg 0a npdner.vc loqqyeiro,r ro ouvdv[upo ruagd],],q].ope q oupll3anxlj Oepcne(c.H rlpegrior.a 66oq, unootrlq(er,, 0a wq6nelva xupa(verar om6 90 6olg390 mg yro rtg neproodrrQE rrserrrrr6oe6tclv ao0evr6v. Eqpe6orq: To ouv6vlupo Q-10 efval dva no].ri r,olupd cvrlofel8rorlrcdnou 61eI cvtrxc,pxr.vr,x6g r0l6tqreg, 6ntuog anobellre( oe seycr6yet orqglcxri nelp<ipora zcr, pel.6reE nou dylvo,v o rrsreo,pro,rd(cr;c. Mol,ov<iu,xcrvdvo,g yvolg(el pe BeBar.dqrcrrr e(vc,ro,ur6nou ngo6e qv our6xl.qq ticpeononolou8{nore t(snou zc,qx6vou,o,utdgol ncl,e( nepmrcdoelg 6e(1vouv6tr efval efl,oyrl q 8r.egerivrloq cvrrxu,exrrqE vlxrjg 8gdorlgrou ouvrlvEupou Q-10.

.49.

I
I q"ro' pr nE ovenr,Oriprlteg enrz.fvbrrves er.'rg ncpevdq.lerrq ro xo,r I I f ! ! f I I I I I I I t I f I enrturlc xut 67etboxr.pa,otef exretcrpdvcr oqv Eugrinq - nprcixertaL eva,qurrx6 exlril"Lopc nou xcriefrarhypericum. ouofc cutri 1t,o H curoteie[toqdgtrrczo rllv xoLvri yrcr xatcigirpqoq fe ppcvic,cinou or no.rl.rioerE uJrsQtegodv cg'Oprioe oleoq trre orivoio trrlv rou oe to rol'rioe<ov d)'olvr<ovdl,ialv awrxar'Ol.rntrxr.riv pcir. xa0c6g rou xo,r wrrrotou awrxarcr0iLntrxotjProzac,pe cval,oyfa peyciriteqq cnci ema npogeva. Kci0elqcivo ol fepprcrvo( yr.ctqor. yp<icpouv nepfnou rpfa excrroppriprcr rctpr,xdE ouwcrydg ro hypericum. rrlv dyxqryro, F on tou zpritougzar pcorotrrdvor crnoteidopcta orcr ouotqgc6v xi'vrx6v 6oxr.pdrv. anotel.dopo,ru izoor ndwe peieturvnou rreoylrcTcr e tonoLri0rlxov Lor.cu,regrl ps npooori d6efcv <irrro cpurci aurd cvaxoug(sr cnd qv zatdOl"r,rpq rqv o,vtlpetorn(er xcrr noiidg qopdgto [6r.oanoreieopo,trxci ro 'oxuQd o,vflxa*rlntnttxf" cpcigpcxc, Fe xcr p<iir,ora brlxorE EuotiesorsE ncpevdpyeLsg. ( eE(ur vo,olpsrtrl0e<jtrto qutxd sxpil,r.opa hypericum d1er. rj6q exctropprlpLcr cv0gulnoug Euprrrlnrl Apegr.xrj. oe 0one{oer. rto,r I I I I I I I I I I I I I I I I

l:"'ffi#;,:ffiHr,"ffi:ffi::.fll#ffi'JffiH I

I""I

H @AYMATOYP|H @EPAIIEIA TH> EAIZAMIIEO Eiya xad.9LLpry xaL ro hypericum pou 66ane ntoco rry latl pou flpdxencruyrc 6vc an6 cnrdta nopd8olo, xrserorctlxd nou 6ev pnogei x<inolog vo, rpo,\ryo,ore( pnoge( vc oupl3oriv.To 1-985 6rr, 11El,(cpne0 Ntdwe, pCcl vecrpr{pqtdpcr an6 n1v Kc}.r,cpdpvla xdl"l.qoe atuy6g nol.r,opuel.(rr,6a an6 6vo epB6l,r,o nol.ropuel.G t6og. E(1e pe(ver nogdl.uq yr,cr6vc 1gdvo, zcu,pdl.r,oraqg vo eincrv6tr 6e 0a prcoqorioa neqno,t{oel nor,xta, evc6 raqd},)"ql.o novorioe btogxc6goto l.orpd xor oro n66r,c.Aurd e(1eorg tq ouv6nela va lgerdletar, zaOqpegr,vd l"rltpqrcuofuovtrw. To 1992 ouvsLbqrono oe n].6ov 6"a,4naoye cn6 Bapr,rizcltd0].r,q.rr1, [q xlou rnv 6,^asye ott(lgstor, ax6pr1 xor rqv c,uroxtov(o,.Aurd vu 6xcweqv (6rcrxo,rro ouluyd rqE vo cvrloulrloouv ngcryplcnr,xd. <ilko,v nol.rj Orjoxol,ovo [r{orrl cpuolotroylxtixo,r, },er.rouqyrlvc orrr oe xcOqpeqrvr{l3tioq. Aro0a,vtipouv Bcrqr,d xatd0}"r,r1-rr; xar, pe cp6pr,[e q (6rcr. crur6 no].dr', ],der, T6te, o dvtpag xnErnE d8otoe dvcl BrBl.(oprer(rl.o How to Heal Depression (fkig vc 0eganefosxs rrlv xard0l"nlr4), rou tlruluirgou orTV ru61.q ouyypcqda Xdgol.vr Mrul,oriplcplfuvt, Nrel. Mcrq qE Kal,lcpdpvra.H El"(cpne0 evtunr.oor.doTqne to an6 p{3},io xar anop<ior,or vo, rov errro}rccgrei. yratg6g m{gouvdO orloe dvc, o,vuxc,to0lmnxd cp<igpaxo?4o,r orq ouvdlera 6va dl,l.o, ol"ld cvoyxtloqze vG 6lax6qJer rrl XA{on roug }"6yrrt 8uodgeororv fioQsvsQyerr6v. T6re o 6p Mnl,ofpqr,l.wqg dOcrloe ro Paxil, dvcr 6qpogltr6g cvrlxaro,0l.mtlx<i, nou avr]xel orqv (6r.aolxoy6vro, to Prozac.Me u,ut6,q El,(c6we0 nagamipr Qnoe onpowrx( Betrr(orr1. Ar.o0av6rcv xotrtfuegcr,qro,v nro evepyqtr,xri, xo,r(otlEneproodtepo o,v and ro cprig"fol.r.op6vq> paxo, dprrrgo'uv61lle vo, ro na,(qvel a8ral.eifittog, 6t6tt, 6ntlg opol.6yqoeq (6r,c, va aro0o,v0r6 [cv<i aurdgttg qgr,"6ev {0e}.c yr,(.g or,rypg 6nou pe xottizlulov ozdtpergcruroxtov(o,g'r. 'Enewo q on6 tq(o 1g6vla, 06\oe vcr otapam{oer. }"ritpq rou Paxil. OnoS elqye( 11[6r,a,<].6yrrr rnE sEdqqong nou e(1c uvcrnni[e r.oTonape].Odv oro nsuoffiovc,,6ev ri0e].avc yfvrrtrEoQrnpdwl awrxato0l,r.rnlxd. Anl6g, rlOel"avaprlv na(qvronra qdppcyrc xo,n.S)or<joo, our6 rjrov aqxerd naqo,xw8uveupdvo rqv negiqg rftrrlo{ n1g.'Er,oqo 6q MnLoripcpr,Iw npotelve pra evc,l,l.o,xrrx52x

x{ h1o1.Tq ouplBori}.uoe vo,0oxr,pdoer cguorx<5 6va awlxoro,0l.rrrnx6 nou XQrlotpofiorrircr, euqr6cog feppcvfcr, to hypericum. orq <<)qv cgp{ ripouv mrpu}axctxr1,o},},ridaerra a<qnylaa6ttxaL6 0c ritav va ro 6oxrpd,ororr. Eldl"l.ou, yv6q(e xoL6 x,u^rt"rrcoE, cxv rs natrui o'utrrntcdpato xard0l"u.pqg rr,E rdoe r.g en6lrs ouroxrovr,xdg orerqov, 0c dq1r,!e xan n6]* to Paxil. O 6q Mnl.oripqr$,r rTE dEooe6vo ngdygoppa o,jpgrrlvo, ro onoio orablcxd q 6dor1 ps rou Paxil per,ovdrov, evc6 raw6lgova q Odo'nrou rou hypericum oufcvdrov.' Enewa and pepr,xdg eB6opti6eg, e[1e8tcxdtpa rwrk6g ro Paxil xol ar0avdto,v no)"6x,a)(ntpa and 6:';"e(yec,roOo,v0e(ra tsl.eura(c 1p6vr,c.<Ar.o0tiv0qxa eni8gaon rou qulxof qv eitlul,iotrrcnognr,oygriyoga an6 d,t pou e(ye net o 6p Mnl"otipgilvr.'Hrcv pfo rinr,c petriBooq. Tripa cr,o0<ivopcr, nohi xaLri xor cpuonl,oytx6".Aut6 pnogef va o,xo6yeto,r xolvdrono, al,l"ti titcv 61er, xtiruologrcnoglx6lq6vr,oud).youg xcrd0l,r,{_rr}E,vo, xar ro alo0<ivetal ndl,l "quon)roy tx6" e(vc,roov va,c,ro0<ivetc,r,,undponpcypmr,x<idvc un6polo o,uva(o0qpo. 1o,"! Eivc,r. Asv alo0dvopcrl xo06).ou "lal.opdw1" ofi,6 rc Arigpaxc. Nr,r60crl cnotrritrog uyn{g.Eunv6 xd9e nqori pe to 1ap6ye},oora 1e[1r1 xan ctm6e(ye vo, prou crutrlpe( xor nol.l.d 1q6vm, {we xc,:tt6renw dncpvcr ebc6 ro Paxil. E(var oav vo lavopgr{xc rov nuLr6,rc,},6 eour<ipou>, opol"oyef11 El"(cpne0. Enunl,dov,l El"(cpne0 6ev ncr(pvelnl.6ov cvc\rpr,nd. Me q Bo{Oe el6lxr1g r,a 0epcneiag,6po0evo,xrserro,16..Ax6yq xo,r, vo,loqeriell.iyo. )uve1(er vc, aa(pver,prcrxdtl.rou_ l"a hypericumrper.g cpoqdg qpegqofroE. H El,(opneO dperve ev0ouoraopdvrl pe to hypericum. <E(vcrr exn)qtnm6. @a ro ouvlorofocr oe dl,ouq! Mou d6ooe nfuruoullolri plou>.

H EKIIAHKTIKH EMNEIPIATOY TZOEA Me Bo(9r1oe exe(nou ra d)")"a eiyav anortyet Ed.ptrtaxa O T(del, P<irl"ewl, er,(tv43,yr,crgrig oto endyyel.pa, 6nco1e and xard0l.rqJn 6l.q o1eE6vrrl qo{ rou. eg o,nor6}.eopra, oe Srcv r{rov dqql3oE, rjrav cvayxaopdvog },cppdver, vc r{_ru1o}.oyrx{ unoo"nipr,fq mu e$aoo( 1g6vr,o xar rou dglloe vc na,(qvel a,vrrxara0l, tmw6. To, o,vnxc,ra0l,mtr,xd "crlv xqc,.rodocv x,ar6._ 0l,r,r1-r{ un6 6},eyXo. tou Qor6oo, dngeneva c}.}.<i(er. oulv<i rc
x53x
I

gdQ[ro,x,o, rreox,erp6vou ],dyxerps rov x,d].6rsQo vo 6uvar6 'Exor, rp6no rq v6oo tou. to lelpr6va rou 1996q anorel"eopo,r,wi.ny,artrlv o,wrxo,raOtrmtlxr6v eloo0evr{oer. T[de], eile O e(yexuruxluar,e(o:n6ouvoroOr{pcta cndpo,vnlg O},[tl-rqg, anoefawl,quxrlg x6nol,onE anr6f,elcE xor evdpyell(ag, crtd,0er,ag, cg. Aev dl3gr,oxe rccrp(a eulag(oqo4 oq 6oul,er,<i oE yro,rou tpdg, dnorg errforlE yevw6r,seo xat orqv ngooomr.xrj rou. lror{ H Er,dyvorq'cqgxutdmcor{Erou tirov pe(<ovxor<i0}.r,tpq ouvoOeu6pevq orivOpotrro cn6 enoytxrlgOlorcpa1r1g, 6nou 4 dl"l,eu1rq ql.raxoricpcrxdg nqoxal"e(perapol,dg or4 lqpe(a rou eyxegdl,ou, onoieg dlouv tog c,nordl.eopa Oqproupyio ol t4 pel"oylol.r,xr{g 6r,<i0eoqg. TEde}" O und Bgr,ox6rav qv enonreio, tou Egog N6qpovPdoewol.,sroue(vo,r, cru0evrfa orov rop6aqg xor<i0l,r,tfqg eQsuvyltrlg E0vrx6 Ivorltodro Vulr,r,trig x,or oto Yyefagtov HIIA. O 6p P6oewa],yvrrlg(errlv dqeuvo nou e[1e y[ver, yro, orqv Euqc6nq ro hypericum 0ec6prlcre ourd to xor, drr, Oego,neutlxd 0o va tov B<itcrvo pnogorioe Boq0rioel Tldel.,rou ono(ouq xardOl.r,tpq enl8ewotv6rov Er,cqxc6g. Io,voutipr,o, Tov o Tl6el. dqlr,oevo na(qvelro hypericum Or,ox,[o, 300mg oe ttr;v qopdgm1v tgerg qpldqcl. flog<il,l,ql,odnolpvexo,rro dl,l,a owrxo,ra0l.mrrx<i qrigpoxo, ouv61r,[e 0eqone(aperepqrd qolg q xo,rrqv tpulratqr,xr{ ufiooniQr|q.Tdror"a no}"rin},euqq 0egoneio ^ T,a e(vor, ouvriOnE orlv xotd0l,r,tpq, ctL avtlxaro,Ol,tmt"xd ouvrlOcr;E yto xol.fteqo ouv0uaorux6 onor6l.eopo. Aev logqyoriwol efvcntdoo efxo].o vo Bperxdnotog ro xar<il.],r1[o g<ippcrxo drav nol,Id dl,l"cr cpdgpcxo 61ouvcrnonllervo gdpouvxo rfirOupqtdcrnor6l,eopa, ol.l.<idrav aut<i Bqe0e[, enfDqcori r4 tou ( vc, e[vo,r punope xo0ogr,orr,xrj. Aurd 6ylvexq,r6rav o Tldel, nrjgero hypericum. euegTo yerw6.cnorel,6oparo, ritcrvyeliyoQoxo,rsvruficooraxti.' eno, En cnd pt6l,r,g Edoer,g, T[<isl, erne6n"n qruxr?tf 6r,d0eor1 6rio o rou xo't rqv rou. <<M6ocr Or,doe Belrr,c60qxe exovdxxnos evdqyerd ornpdp(aS 6doeB6opd0cov, aroOriv0qxe pey<i},q Eracpog<i. To { onordl,eoptc r{tav nohl yQ{yoeo>,6q},c6ver,Ep Pdoewol,.H o en(6qoor1 rou hypericum{rov 16oo olr"oorlpe(oxr1, <6oreo TLdeI ouvdlloeva ro nc[qvr]td,ro 0g P6oevta], ouvdoqoe ro ?roros ril"l,oug ooOevefg, orougonoioug6cpege enwuyrj d,Jtrorci'dopcto. O 6q P<ioewc,l. oxonefer va eqeuv{oer. neqa,r,rdprrl a,w<j gurrx6 expil.r.opc 6ql.c6ver ro xcr, pe evOouolcropdvoEm1
r54r

6uvm6qt<1rou vo, XQl1orprofiorq0e ouptl,qgopcrr,xri Oeqc_ i otg xe(a xo't oe nol.l"otig ril.l.ouE aoOeve(gnou 6ev awanoxpivo_ war, nl.ripro4oxa. uwtxara0l.lntlxd, cprigpaxa nou l,cpBdvouv. ..flprdxewo,r, dva no1,6xctL6 gdqpo,xo>, unooqg(e r, o 69 yra Pdoewol,. H neqfutorrl rou T[6e]. ro enlBe par,c6var. xan6._ H 0l,lp{ rou rirav enfprovqxar 6ev pnopodoe vo, o,\,rrLrcro xtme( pe rc ouvr{OqawlxorcOLtmtx1. eordoo, 6va cputtx6grippaxo oe ouv0uaopd pe ro yv<rlorri avrlxoto0l,tmr"x6 xcr<igeqe va petrrr,c6oer, xandoto,on rou T(del,. <Aur6 e(vo,r,L6ro,(teoa r4v rvrurloJoto,?r,<i>r, o 6q pdoevra].. ],6er flgdner. va avacpdqoupe Xelorpofiou{0qxe tf eu6c6vupo, 6tr, ngoxer,pdvou vo, r[eoorcreu0ei 11 tcut<itr;ro, rou coOevorjq, trt01600, nrglxri 6e6opdvce(vor,cxqrl3ri. ra, Tl axglptfg e(vcr to hypericum; H ol.onl,qgrrlpdvq ovopooio, tou e[v'r hypericum perforatum xal nq6rt&rcr yr,c dva ouvrlOr,opdvo oygro}.or1},ou60 dwovc x(rqrvcl dvOrl pe pe plxgti 1.r,cdqc oriypato orr,g<ixpegroug. ,Orov ro tg(tper xd,norog, to gut6 onel,euOeprc6vel x6xxwq lgroorr.nr{ ouofa nou negldlel pia qv ouofc uneqrxfvq,q onofo dler avcyvrrtgr,ore( goQpoxo],oylx<i oE evegyf Xnprloi dvcooq. H ealotqpovlxri pagtugia O r c,vtrxo,ro, g r,drqre rou hypericum, fi ou gr;ol pono I eita I 9luwrw, r,6 E 1 oq 0egcrnefa qE rlnwg dog p6rpr,ag xct<i0l,lt|_rqg, enr,Bepor,or0ei 61er cr6 nol.udprOpeE, xal.ti oleOr,copdveg pel,6reg, onofeg odyxErrvav or ro B6tcvo pe ouOdrepcxcr, a0povrj 6r,oxio (placebo), xcOrirg xor l.rr di'.}"o avtr,xara0l,r,nrr,x<i. peyal,ritego pdqog qg 6geuvag dlel To I nqayparonor,qOeiotq fegpov(a xal otrlv Auotg6c, predvcr na,pa_ 1oxedcopa rou Bortivou ro ono(o efv'r yvcrrotd LI 160.Enr.otrlporog

vrx6gpel,6reg 66er,lcv ro 60 p,e80% tcr;vc,t6polv 6* nou rlno.olav or.6 xu:c60],"r,tl.rq o4pefarov Be],rfotorl rrl Bori0er,cl hypericum pe rou ,cO'r noooor<i xo aurri e(vo,r naprdplolo autd nou avap6vero,r, pe c,n<i TrlXa{on rrov ouvrjOolv ouvgetlxriv o,vrrxcrc,0}.mrlrcc6v. pr,cnp<iXe ogorrfyeppcvlxri6qeuvc orqv ono(c ouppere(1cv 3.250 xaro0l,mrl_ xo( ao0eveig xc0c6g or.yratqoi rouE, gTvoav6.qeqe xo,r ro Bel.r(arorl { anc},}"ayriond ra oupnr<ipcru tqE xa:r60lr.irnE {otepc an6 u1 h{qq rou hypericum rdooegrg B6opd6eg. ylc e 'OrcoE 6e61vouv nol,l,dgpel,6teg, 6ev undgler, opcpr,Bol,[c ro dtr r55r

hypericum efvcr cnote].eoptanx6. Mr,o,pe].6q nou 6ylve oe 105 titopc pe xarri0ll,tirr1crnd egeuvrltdgtou flcventotqp(ou tou )dtrtoptrouQYx 66er.le6tr,to hypericum ritcv 250Voxepwo6tego anotel.eoplattx6 ot a6(llr1pe to placebo. To 67Vo tul.v aoOevriv lou dnatgvov 900 mg hypericum qpegqoiorEoqpe(rooav oqpcrvtrxri Befur(ooqpdocroe tdoto cvdqege pelt(trlol pre ro evc6 28Votcrlvao0evc6v ep8opd0eg, oepr,g xo,t o,vrlplacebo. To qutr.x6 avttzctaOtrtnttx6 petrt(ore q 6r"ri0eoq p6po ?4ot tfuxoooro perrinroe cnotel.eopcttxd ro <ruvor,o0qpcnr,x6 pa"r,r,x,6. outrrntc6pato,<1no4s(val ot Er,ctcgaldg rinvou, ol xeqo,trctry(eg, ra xoqOr.oloylxri ngol3l.r{po,ro q eldw}.qoq. xcrt prdQoE tgttiwo ewda nap6por,a prel.dq,otqv ono[o d],crBcv Mr.cr ouplntripatc 6ev epcp<ivtle d8efie 6r,tro 707otrrrvao0evc6v o,oOeve(g, 1ntncr and 6vc pr{va. Ta oupntcilpctcr nou o,vtlpetorn(xcrtd0trr,tpqg evegyqtlxdtlros, I xdl<rroq, 11 orqxov xal.tftegc {tav: 116}"},eltl.'t1 pe}"6efdvrl,qoq xd,r or 6tctcpcrl6g tou rinvou. Mr,a rfl.l.q yegptavr,xr{ nou 6naolav an6 xatti0].r,!rqefdtaoe 6ylve oe 135 aoOeve[g rrl rrou oe q logrlyqoq 900 mg hypericum qpegqo(tog oriyxgr.oqpe tq 1oq{yr1o475 mg rpr"rreopivqg, ev6g 6qpoqtl,or.igtqlzuxl.lxoti o,vtl?aata0l.t-oe t(yetcr i6ta Oetlxd anotel.dopo,tcr nr,wo6. To cputlx6exlril"r,opcr peprndg,pdtrrta, neqlntr6oetg axdprl xat' 257o xcl.ritepc- oe o1dor1 pe ro ouv0etr,z6 cpdqpo%ottot ritcrv nol.ri negtoo6tepo ooqal,6g, l.ry6teqeE xor, qnr,dtQtEoverrt0fpqteg evdgyeteg. 6qpr,ouqyc6waE e!(oou xu\6 f ox6p4 xol ?\},Iq dqeuvc 6Eerle 6tr,to hypericum e(vcru and to ouv0ettx6 gdppaxo pcrnqottl.fvq ou;v cvtlpetc6nlzalfreqo r,t,cr on rnE xar<i0l"r,ti-rqg or1 Beltfatoq rtrlv vorlttxc6v l.eltoupytr6v, pcto. e 6nolE enr,p Bc r6v ertrr,on6 q l,extpo eyxecpcl.oyqcrgri efiionE vo, ovol4ougfoer crrt6 ro orivbqopo To hypericum ;rnogef Oeqone(a e(vot q poxoOeqone[c. 6r,ctopo.l{g. H ouvr{OqE enoyt"xrtg To hypericum dpoS xutcrnoLep<irqv xctd0llVn, o,ipgttvo, ?{ot ptt ro 6pc Ziyzcpgrvt Krionse rou flcrvenrotqp[ou tqg Bt6vvqg orrlv rqv Auotp(a, ?4o,r Mneyx6vo Mapt(vel xc0qyr{tptc qg Vulr,atqr,x{g g prcrxr{ K}.w r, xig ulS B6wq E, orq f eg pcrv[cr.Xo gqy{ Or1xuv flav enmrq 900 mg hypericum qpegqoftrlgxol {tav t6oo cnote}.eopcttxd, r6ote (cg. svcl,l.oxtlxd qg cpoxoOepone f)ot6oo, to OegoneuttOecrlprlOqxe xd B6tcvo r{tcv cx6pq nto cnote}.eoptotlx6 6tov q loqr{yqoti tou [o. ouvobeudtovcn6 qoxoOepane (a nou crno8erxvrjouv cnotel,eoplcrtlt6nqtatou rIV Ta r,cnglxtiororle hypericum orq Oepcne(a qE xotd0l,ttlqg ngoxrintouv xct cnd n1 owxartllrli o[r,o]dyqo4 torv crnotel.eop<itrrlv e[xoot tqtc6v xtrlvlxc6v x56x

psl.erc6vCIn.E orrofEo,upr!,rsrsfxov ouvol.rxd I.757 ao}evt(g, ta ono(o, 04pooreiiqxo,v oro dyxqwo lcrg ntd neg lo6lxd .Bn M edicalI oumal ro tish 1996.ot egeuvqr6g fzfl.pne Q"papripe!tou rlavenr,orqp(ou rou Boqefou T6laE oro @opt fou6g0 xor, K).doug Aiwe rou flcvenlor4;_riourou Movdlou eldraoov l,rs ro, (6r.a auo.n4gd enr,orqpovlzd ngd.rurro, ro hypericum ^rLcrLr'C]- cpcrgpaxeur,rxd dl"l,a owrxaro0l,rmrna6.,rupoxerpuivou vo o'uyxq(vouvrxrrolrl!;ovmdr,ry o,note],e opartxotry,6".coug..Eror xo:c_ trnEavoro elr']go"utrrndpcopc: B&cvo hypericum eivcr ef(oou onoTo rcl,eoparrx6 pretc oupBo:cntd" c'rtxcna0)*mtx6. Me dhl.a l,6ylcr, ro hypericum 51er, (6r,c6uvcrt6rqta avaxorig'onE onlv xor,vrjzmd0l,r,_ qv qrnW ro orJ\'cyoyeocporjpeva awlxata0l.rmtx6..Autd, 6prog, nou eivo,r ri'crireqo o4pcwr.xd eivo,l6", ro hypericum,c,wiOero, ro goepoxsu_ lre rtx6. cnntnurol0)*mm6,6ev nagouor.<iler cvenriprpeg ev6pyer,eg. Ol 6rjo yrctErof dr|-ro[cvqv largr,xrj Br.l3].r,oyqacpic va pqouv yr.a rriOe afi'dnroq pe]"6rq oye:,xd.pe ro hypericum. Af(er, vo orlper,olOef 6tt,6nuog [6lor cvdcpeqav, e(1cv negr.opr(oel avclrjtrlo{ touE ol ov qv oe cyyl.lx6g pel"6reE, 0o eilav Bge r(nora. Or neqroofteqeg pel,6_ 6e r. reg {rav orn ysQprovmrlykfioouzar c,utcjepn66l!e roug neploo6te_ poug Apegr,xo,vorig, Bgetavorig xcr. <i).l.ougayyldcpatvougyr,orgorig xan xan6.ouvdnera xo,r rouE oooeve(E rouE vo, evqpeqolooriv yro,ro, eupripcru outriv rrov pel,err6v. )rq feppcvia ro hypericum c,norel.e eyxexgr.pldvq (c I Oeqcne yr,c qv rinr,odorypdrgr.oxorti0l,l!_q, "co6yyog xo,rro oresE. Me noro tgriao evegye(to hypericum; @eopqrr,xtiro hypericum, pnoge( vo enlOpd oe nol.l.d ouonjpcrra tou eyxecptil.outuur6lgova, p6oot 8r,cqoqeflxc6v ouoro,rlxr6v. 1qpr.xc6v q orrypri xcvdvog 0e yvop(e r,nc6gaxqlBr6gsvepyeito 0epc_ "Aunl neun"x6 Bdrcvo orrlv o,wrprsrr6nr.oq xar<i0l,ltpqEo, r,o yrargdg tqg l.6e Tldqr Kor tou Apeqr,xovr,xoti Ivotr,rorirouVulr,xrjg yye iag, plol,ov<ir' 1 dpreuvcEe(p er,dr I'ro gutlx 6 exytJfu"opa r.6gaotl x6zryca d1e na 96por.c pe oumj nou 6xouv oqlopdvo an6 to xcrOleporpdvcr c,vtr,zo,tc,0Ltxctx6 gdqplcxa. Aql,xd or,enlorjpoveg nioteuuv dtr ro Bdtcvo 69o pe rov 60r,o tp6no fiou svrQyoriv or a,vo,orol,efg MAo, dnog e(val to Nardil. To q,wrxo,ra0l"mrrxd outrig '1g xcrqyoqiaE anoxl.e(ouv to 6vlupo povoo,prwoo[er6rio4, onoio, xarcotgdcper 6rio oqpaww.i.g yr1p,tu,6.g q ouoieg rou eyxecp<il.ou 8qpr.ougyoriv nou oioOqpc euefiog, rrl oseoro_ vfvq zcr rrf voesr',vqQfvn. f)or6oo, vda ano6erxr,tx6. motyeia Oei_ 6norgor cvcoto]"e ig MAo, ext6g Xvouv<in to hypericum 6e l,er.rougyef x57x

11,r XoQnyrfro,r lrol"rlutfrql,dE ov os 66oer,g, nep(nou 100 gogdEuq_rql"&eqeg cr6 rr,gouvr.otc6psvsg rrl Oeqane(oqg xcnd0l,ul_rqg. yl,o Kor.voripro dpeuva EeiXvel6tr, to hypericum, oulv nqcypcrr,rdrqto,, avaxoucp(er cnd qv xardOi'upq eveqyc6vrcg <<o,vo,orol,dog enovcngdotrrlrrlE qg TnEoeqotovivqg>>, 6ncog crxglBc6E l"elroupye[ xcr,r Prozac. ro VqS f)<n<ioo,<ino4 avcrqdger, 6q Kor, nogo,pdvelooacpdg ruorEE o or yrlgtx(.gevc6oelg cxpr.Bc6g tou Bor<ivouogeil,eror q awrxota0)*mtxr1 rou 0gdoq. H 1qpr,x{ dvoloq nou 0ecrrge firo nr,Ocvrie(vcnq unrerfror x[vq, q x6xnwq lqrrlorrxlj ouofo rou cpurori,nou c,note],e(xc,;tJ[ro[onor,qpdvq tpulorg6to ouo[u. Qotdoo, nqdocpoq dpeuva 66er.[e&r. cumi q Xnprxti dvrrtoq61er, l.r,y6tepo rolupri avtrxorq,0l,mr,wrl6qdoq oe oldoq pe ro nl,rigegguu.xd expil,lopa, uno8erxvrjowcrgdrr,ro orjvOero pe(ypo rrov 1rlprxc6vrou Bortivou, oro ono(o negll,apB<ivowcr xcr, eivor en(oqgoqplcvtlxd yr,crrE suseyerrfiavO<iveg q],oBovoe16{, xdEcpoqpcxeunxdg lOrdqteg rou gurori. Ilora e(var q accgaitqtq 6rfoq; 'Onolg dOellclv or pel,6reg,I ouvrordpevq 6doq yr,c evql,(xouE rrou ntiolouv o:n6 rlnw 6og pdrgro xotri0l,r,rl.rq efvar, 6va 6r,ox[o n plia xtitpoul,o trov 300 mg rou gutlxori ex1ul.(oploroE, rlou 0a npdner,vc negr61er, 0,3Vountptx(v4, tger,EeoQdEqv qp6go. 'Etor,loqqyeitor, qpeqqofrrlgnegfnou 1 mg unegutfvq, nou e[vcrl to xrigr,o evegy6 ouowntx6 tou gumxori exlul.fopcnog. llcr ro ldyo aut6, 0a npdner, vcr elertifer,rc<inoloE npooexrlx<io,vro ruJrofioulpldvo nqo[6v nepr.dler, u1 oorr{ noodr4to trlg ouo(aEuneprx(vq. Ndo 6geuvc rou Eqog E. B<iqpnal oqv Kl,lvlxrj Vulrorgr,xrjg xo,r, Vulo0epcnefcg oro Nrtiqpotcw n1gfeqpav(cg d8er,le<itr. ugq],&eqeE 6doe6 rou Bot<ivouhypericum -1.800 mg rltrreqqo(05, noodrtpcr Or,nl"<ior,oproEwnwrig 66ong- pnope(vc cvoxoucpfoouv and rc oupnrripcro rqg Bopt<igxatri0l,nl-rqg,dto,v o aoOevrjg6ev ndoler, cnd tpu4rxutri ouprrr6pcrc r'] ncpar,o0rjoe6. An6 trlv dgeuva outr{ 6e 0ronr.otr60qxe ofEIoI rolv o,vent0rji.rnrov evegyeuiv l,6yrrlrrrlv utl.rrll.dregcov 06oecov. Ikioo ?(Qdvo 26geuifetol ylo vo evegyrioer,; Mol,ovotr cgxetof dvOQoJlor dlouv no,gar4qrloer qer,wrlavoxoricprplo on o116 o'u;rm<6pmd ro roug agxeni yQliyoQo,pr,6oc 6rio el36opui8eE, oe wxtx6. ra anoreldoporc epgov(owcl oe 1povr,x,<i Ordorqpa cgxetc6v eB6op<i6cw. Mr,a trlel,dq66efe drr,nepr.oo<iregc ro pr,odsuseyrrrand x<i anotel.6oproro,rou hypericum epgav(owcl av<ipeoc,onlv rerdprnl r58r

r
I ! I ! !
I

xaL r4v <iyOorl ep6op<i6uiriVrlE tou. E;lunl.dov,geidreg nou dyrvo,voe nepapardloc dber.lavdrr,q ouoia unegr,nivr; rc awlxoro0l,r.firl?ad xo,r otE anotel"Sotrrato ouoooqeriowo,t orov eyxdgol.o. 'Oncogo,vocpdqouv opr.opdvor, epner,qoyvripovrE, ngdner, avapdvel x<ino'ogtu, anotel.d_ va, oUoo rou cgwr"xorj ez1ul,(oparog dlr,roul.til.otov el36opd6eg. oe

acotel,6oporo; ! trola efvcl tc avtrpevdpeva pdtcvo hypericum To pruope( lrrlv61er ovctrrevdpeva vo ta onoreh6I opcrc oe <il.oug vo pqv efva,r iOrcanorel,eopo'x<i<joo ouwo,_ rj to ta I ouv0erlxdavrlxa'ro,0l.tncrx6". Yovoavoripevc f)or<ioo,'rc arcorel.6! 6e(1vouv ro 80vo auu6v nou nu,fpvouv 6rl ro I oparc trrrv rgeuvc6v nagaqpofv Bel,ricooq mrlv xan1oroo{toug.)e xdnora teor F<fucrvo ! c[rc],<iynonE tpulo],oyrxri rTlE gxut6"or,uorlg o,o0evc6v, pgdOqze rrrrv tfur, I 70vo 6.,og 90vorarv oo0evc6v na(qvouvhypericum$etru,riftfiou Ir'o xav, oe oleoq pe "ro42vo otg 55% rory ao0evc6v 6nolprvo,v nou dva ! cOqovg qdgpcxo (placebo). Mr.apel.dtrl ,rQcyl.roronor,ri0qxe nou oe I 3.250 aoOevefg 6no,r,pvov hypericum nou ro pdvo oto 157o d6er.!e d"' f totv aoO vr6v6ev urur{ e plcv o,nore}.6opo,.ro,. ! f n,ro,, ooqclg ervorro hypericum; T[dvrx oe 6va dqOqo rrouOqpoor,erl_ rou !'Onog cvaqepe'o 6p Mdr,xl" Oq*uo' 6vo, dyxplrolctglx<inegro0rx6, an6 rc peyarrireec dva rrQorsf rou eivor, on<ivleg oyetx1.rinr.eg ol xan Otlpo"c hypericum cvenr.0rjpqtsg I wdgyercg. o'ulvdtegaovocpeq6pevrl H ovenr,0riprlq evdqyero, e(vo,r or I 6nrcgcr16E. al}.eqyieg Or, eivaron<ivrcg.'Ol,sgovrnror !Tcoreeweqrxdg OuFrFeg evdpryercg efagav(owor,yprlyoqa q 6r,azon{ }.r{tpr1g pe qg rou ! Aev eler cvacpeqOei nep(rntrto4 p6vr,trlqg, ovco.rgdrplpqE prq !WOUCrou. )tr,Epel.ereg dlouv yiver,rcrnoooortirorvrlnrcw,avaorpdnou I Fi'cl3ls. tlrr,ucrrv cvenr,0dpqtcov evepyer.c6v xupaivowclond 1 do4r\vo. Aw"\"cu,g, I to noooorcj ovenl0rjprFov rrov evegyelc6v rouEoo0evefg l"cpll3dyro nou I vouvta o'uwi0l ouwoyoyeocporipevc o,wrzara0l,mtrxd, 36va, eivar x,an f goe6E BfuiBeg ngoxal.odwar or nou wtrr,oraopr.opdveg sivor ool3crpdg I zar pq cvcotqetf rpreE. Meqr,x6g qoQdE, pe(roo4qg 66ciqgrou q I hypericum oiorero oc6pc rreoooQlroo-rei geqaneurr,x6 ftol vo, oro I Bftcvo pnope vc elcl,eftper cveltl0ripqteE i tr,E ev6qyer,eg. I OpropdvoL yLcrtqo[ npoerbonoroUv lprjotegrou hypericum roug t cnogeriyouv 6,x0eorl .*lv rouEoxovril,rol,6yarnr0ovr{g cprrrtoctrlvc lepyfcg rj exOrjl.trloqg 6egptcrr.xc6v avtrOqdoerllv. Aurd 61erncrgaq_ I pe avor,X'<ilgrrlpo en0ufos xrrQo,lro,r6lora 6dppo,oro,ono(c, X.QT_ f r59r
f

yrjOqxero pdrcvo pal( pe r4v tpopri roug, al.l.<ior pel,6teEd8erfcv r1rr.,yro, vo r!"rqo,vrorotivtdton tqopl"rjpcto orouE cvOprfnoug, crncrneiro,r Xoe{yqoq 66oqg rqr<lvrc drrlE eB8opriwa gogdg pydn l,tiregqg qg ouvlotr6psvnE 6doqg rcDvo,vtr,xo,rcr0l,mnxr6v. exceH tcpdvq Xa{oT tou hypericum orq feppcv(c 6ev d1er,Oefier oupnrc6para Bga1u1p6vlaEri paxgolg6vr,og tollx6rnxoE ottE ouvr.orripeveE0egane ur,mfE6doer,E. Or ao0eve[g nou no,(qvouvri].].c o,vrlxaraO].rnrrxd.r,j 61ouv Bagrd xard0l,r!-rq, tfulrorr,x<i oupnrc6potcrrLol olur,onxovlxdg tdoetg 0a wp6fier vo, l.cpBdvouv to Bdrcvo hypericum p6vo pe qv xa0o6r{yqorl xo,r rrlv eniBl,etlrl rou ylangod rouE. H zcr<i0l.r,tlrq pnoge( vo, eivur pr.anol"ri ooBopri vdoog xor q 6r,dyvcooq, 6nroExar. q 0egone6a, tr1E, nqdaet vc, y(verc,r, o,n6 el8rxeupdvoyr.crgd.To hypericum 6ev ngdrtru vo, l,cpBdvercr an6 eyxupovofoeE rj yuvaixeg nou Or1l"dlouv. Exioqg,6e 0a np6ner vo logqye (ro,roro no,rEld, tva6g av utdqlel o6r1y(arou yr,ctporl. Aev ngdaer va l.apBdvrxo,ror ouv8uaopd pe ouv0etlx<i o,vtlxo,ra0l.tntw,6", exr6g o,vcurd y(verar lrs rqv en(B],et1.rr1 rou yratgori. IIo reg 6,LI'e ey aLhaxt txdE 0 egcr eie g u a riglouv; E fevrxri, q rinr,c 6<rlE pdrqr,crxcttiOl.r,tpq cvrlptetotn(sxo,r pr nol,l,dg pe0<56oug efvcl r10eponedcyvrootr,xrjg ouU,rTslruloOeqane[cE,6n<rlE pr,qogtig, 11cp<rxo0egofirfo,, al"l,cyr{ tou rjnvou xar, xugirrlE, r1 q er )tqv oyoqri xuxl.oXoeliyrfon rcrlv or-rv0 txriv o.vlnxana0l.t,nrr,xriv. cpogotivneginou oag<iwa ouvOerlxri avrlxata0l,tnr,txd.. H xrigra o,vqou16c rou oler(ero,r ps 6l,s ourd eivol q nl0cvdrqra ooBapc6v ovenr0rlp4r<rlv svseysrr6vxuqiarg oro vsuQrl(,6 o'forqpc, ol,ld xor, oto xog8lcryyer,ax6 orlorqpa.

XPH>IME>>YMBOYAE>IIA O>OY> @EAOYN NA AOKIMA>OYNTO HYPERICUM O 6p N6gpcv P6(ewol,, pu1(argog-egeuvqujg E0vr,x6 oro lvonroriro Vul.xrig Yye(cgxc,L auOevr(o 6r,e0vdg oe enine orov roprda Oo tr1E xard0l,r,r1rqg, ogr,opdveg 6Cver, ouppoul,dg curorignou 06l.ouv oe vc 8oxrpdoouv hypericum. 6p Ptilewol, ngore(ver 1gr{or1 ro O tq tou hypericum, pdvoun6 rqv en(Bl.et1.rq ynrqof, Dr,dtr, avrrper<6q rrroqrIE xcrd0l,r,gqg r,crpr.zr{ xa0o6r{yr1oq pnopefvo, e[vo,t XcrlQfE r60x

n./.is tnwfu8uvq. Qor6oo, o,cpori apxerof yrorpo( xo' d],].ol el0txoi oro lrrrpro t4g uye[cE Oev61ouv cx<ipq opxer6g yvc6oer,g oyeux| pe ro hypericum, o 69 Pdoewo). npoocpdger, peglxdg lqljortrlegy"atEl_ Ouwr{qr.eg ygcppr6g: o Mq 0eogrloe-re6u to hypericum e[vo,r, 6vo playr.xdpdrcvo nou Oeqcnerieqv xard0l,u1rq. r, . Av l,apptivere ouv0strxd. avrrxanal:Atxctxi., pnv ro 8rcxdtpere andropa y'o vo,ro, o,wt?.(o,xo,otrloerc ro hypericum. Mrc, an6to_ pe pq br,cxonrj oq l,r{tpqrolv ouvro,yoyqaqoriplevovo,wrxo,rcx0imtl_ xc6v0a pnogodoe va, enr,cp6ger crgvqtr.xdo,norel.6opla,ra. . flgoxelpdvou vo, crnal.l.ayeire an6 ro, o,v'%o,rcl0l,lnrr,xdcpdp_ pcxo,,6ncoE efvar "coPtozacxor ro paxil, npdnel vo, pre r6oerc oro,6r'xd rq Odoq evc6ncgdl.l,ql.a vc auldvere ors8r,axd q 66o11 tou hypericum. . To hypericum cruomjvsro,r rrlv o,vrrlrsrc6nr,oq yro, tqE rjnlog drog p6rgr,ag xarti0l"l!-rqg,ccpori peycl.riteqo p6pogtr;g dpeuvagyr,oro to hypericum 61eryiver oe ooOeveigpe aurori rou eiOoug xcrclOl,rqv !-q. Qor<loo, un<iglouv dl.o xa,l nepr.oo6regeg ev6e(er.g drL ro B6rovo cut6 pnogei vc, o,vcxougfoelxat cnd ogr.opdveg poqcpdg oopaqfg xcrdOl"r,tprlg <iprrlg rnE trrovloxcrti0trrpng), (tlp xo,r ortdoo 6ev d1el xrQcyproroJrolq0ei exrerapdvrl6qeuvc yl, autdg xrExrcer_ m6oe6 xo,rro, oupneqdo;rotsOeve6voloplorrxd. . @a nqdner,vc l"cpB<ivrrcxo hypericum ylc lpovtxd 8rdotrlpa roul.<i1r.orov epOopdbcov vo 6efre anot6].eotrra. ora_ d[r, yr.a Av pcnioel xdnorcg rn tr{qJq rou o pr,xqdtegotrov tprc6v lpdvo eB8otrrti6rrlv, 0a cpavofv or sueysxtx,g 6e rou r,6r.drqreg. Kdrr, avdl.oyo oupBaivel x,o,rpe to dl,l,a cvuxaraOl.mr,w6. )e dl,eE rlg neqlnrc(rosrE o,fio,rrsftar. ndgoooE ev6Eel,d,llorou lpovr,xori q 6r,aomipcrog, ngoxelpldvouvo, yivouv epcpav{ra anote},dolroro, q g 6gdor;g rcDvo,v'xo,ra0l,mtlxr6v cpcgprixotvyevlx<itepcr, xcxl rou hypericum e16lxdtepa. ' Av rl xotd0l,*pri oaE enlbelvrrrOe av dlere 6ri tdoerg autoxrovfag q, ax6pq, cw rrcQoxnQrioere oopagdgcvenl0rlp4regevdpye evr6 leg l,cppdvete to B6rcvo hypericum, npdnel vc oropctrjoere q l"rjtprl xou xor vo, eJrrxotvovrioere opdocoglre ro yrorQd oog. Ol {nr,eE ovenr,Ori;rrlreg evdgyer,eg ouvr{0ogunoyoqoriv xar elcqav(ovtar, xc0c6gto oc6paocrgelolzelc6vercnprero gdppaxo. Av autd 6e oupBef,0o npdner,vc ouppou]"eu"ce(tt. yrcrqd oag. to
161 r

Euppoul,dETro toug xutuvalan(4 Ilpozer,pdvouvcr s(ore oiyoupor, dtl l.apBdvete otcOeqd qv (0r,4 noo6trlta qg bgaotrnrlg ouo(cg xdOe cpopd,lger,ti[eote 6vo,tunonolqpdvo nqoiSv urlrll1E nor6rqtag.)q feppov(o,ta neqroo6teqo6oxl8tozfcrhypericum -i/to xcx po,op6voxo,r l.tstq peyal.rftepqzuxl.ocpop(o, ono(c ypricpovtar200.000r,crtplr6gouwcydg xri0e privo, oe o16oq pe ouvtcrydEyto ro Prozac- 61ouv to lqtrrlxd ttino nou 30.000 r,ctpr,x6g yvrrlot6g orgLI 160 nor,n<rl],ofwal Fs ro spfioQlx6 6vopo Jarsin. efvol To (6r,onpo[dv norle(rol ot6 HIIA lrs ro epJ[oetxd6vopa Kira, evti 11 ero,q(crrrou xo naqriyer efvor,q Lichtwer Pharma tou Beqolfvou. pnogorlv enioqg vcr evqpepc6vovrotxat crn6 Or xo,rcrvc,l,oltdg r4v rorooel.ibo tou tpupdtqou Xdqol.vt Mnl,oripgr,l"vrYtd,dl,a ta ve6repo oytrwd pe to rtgoi6vxo,Jlou negldlouv ro hypericum xo,t efvar q e[r{g: http: rqv r{peuvc nou y(vetol yr,'out6. H r,otooe}.(64, www.hypericum.com.

f 62.

Ernlqr<rrrq guolr<q Oeporrurtrcq ouoio yro rrl HV{pn

(Cinkgo biloba)

Afiotel,ei 6vu exnlurlmlxri qrigpuno yra tov eyx6cpui[o, ro oaofo paogei va poqOrioer pvrfpq ooE rrou elaoOeve(, tq ov ro l,dpete eyxafgtog.eotdoo, pqv fieetp 6yerepd1Ql vc eivor rl,dov agyri yr,cvo ro 8oxrpdoete.

epcp<ivrorj touE xa0c6gauldveral q rll,r.xfcr ov0qc6nou,or neprood_ rou tepol o,r,o0tivovro,r cvrjpnopor,xor ofi syvoopdvor, no,yr8eupdvor o[o y{eaE, ro ono(o xcv6vag 6ev pnoge(vc otapotrjoel. H otc8raxrj e[o_ o06vqoq rTE tl,v{pqExo,rrcovvoqu,xc6v }"er.roupryr,r6v eivo,r, nou la,rpr,xri yvrooui p rov 69o dvor,a,Oeolgre ouv{0o4 pr,co,n6tr,Eoz}.qgdg [tcr zcr. avc,n<icpeuxreE ouvdnersE ratrlg ql,r.xfaE. rnE Ko,rd ndoo, dporg,aur6 efvcr crl"rjOela,; undqlel "r(nota, xav6va cptigpaxo,xupfu Oegc_ Aev neio,nou vcrpnoqe[vc enr,l3go6dver, nopefa,eloogdvqoryE qv rrlE trvri_ p4gxu0c6g peyal,rivoups;Eivor cl.rj0er,c e(paote avrlprnoga 6tr Oriporo, rou excpul,r,opori r.ov ey?.(sgo,l"r,xc6v xumdgorv, yeyov<iE,[ou pog proqei vo pcg xo,raomjoe nveupa,tt+ri r av(xavougr{ va pog o8qyrjoel orrl l,{On m1g vdoou Atrroldrpep; 'Ioo4 cpoiveralon(Ocvori efiotnpcytrro,rrx<i yeyovdE6n"m,aqu],]"a ro ev6go'uvqO'opdvou 66wpou undglel puaouoia fiou or lb'dqrdE rTrE rrrv xaOr,orodv xcrdl,l'qtrr1 riv awlperc6nlorlqg gO(vouoag yro el6),rlr1g turv voqtlxr6v l,elrouqyr,c6v. Qor<100, pra r6'rot0 ouofc lgrl0lponore[rcl oe x63x

tav q pv{pq go,iverar efco0evei d},},eg va r{ evOefier,E en"xefirc_ vqg anobuv<ipotor;E 6ro,voqrlxc6v rrov l.elroupylc6v xtlvouv trlv

to xot dhrl qv Euqc6ruq rnv 7\ncoAvatoln pe q poag{ gocg41,lctog, rn yvtoord cn6 tr4v cglatorrpc Yr,o, Oepone(aqg gOogtig ono(o efvar, H ornv rQ(In qtrr.xfcr. ouofo aur{ ovopdfetar, trrv voqnxriv l,enoupyr,c6v o1g anotel,6oporc onlv xuxl,ocpog(cr Ia ginkgo biloba xcxL euegyetr,xd t4v xcr0rrofv 6va rou afpotog xo,t or1 ],eltouqy(crtou eyxecpd]'ou To u,x)rrlxr,tx6cpdgpaxo. ginkgo biloba e(vat l8n(tegcr crnotel.eopo:rtzd clno4 efvol rl rlQtov<ioouE, xo,t, orrEvsuQoexcgul.ro'rr,x6g oltE ayyer,cxdg hdyol tou pr,oprdvtl xot Tlrrcrv"rixuxlocpopfcl c(patog orov eyxdcpcr],o gor{ - yeyov6gnou eu0tjvetor, o'uvt{ayye(trw rcrlvdtpocpdgcov r4g ordvrooqg xo06g ?4o,t ri].],c ouUntc6pata yr,aqv e[oo06vqo1 rns Uvrlpqg, 0o4 YtG (og. q}"rtt q g yepowr,xt{g 6tor, )tq legpav(a xau oq fcrl.l.6o to ginkgo ouvroYoYQcrcpe eug66uo]"eltoupy(tr,wou negr,],opp<iyto rIV eyr,tegal,r,xri trlEoE Oegcrne[c paqtupfc yto H vrr trlv dvor,oxct rt'l v6oo Al,to1<ir,peq. enlorqpovr,xr{ t4v anoteleotrrcrmxdulta xot rqv coqdl"er,ritou eivol, extetgg,dvqxcrl ouytl,ovtottxri, t6r,o(regaoe o16oq lrt rrlv neqloplotrldvqOuvotdqtcl rcn anotel.eopottx6rlta, xc0r6g ?to,tpe tr,g ooBaqdg ovenr,Oripqteg gogpril4ov fiou XQrlotpofiol,otjwo,t rrlv torv evdpyer,eg oupBcrtr,xciv Yto xo,t rnE onr6l,er,cr 1,lvnpqE rn v6oo Altolitpreg. xar, To ginkgo xdver,nqaypatr,xd Oaripoto orov eyxdcpal"o epno6(cvoBd}.}.owo,grqv }"eltouQY(oE, rrlE sYxegcr].lxr{g ler, qv enrOefvoot1 ox6pr1ttal avo(onyovriwo,g oqr,opdveg xo,t epqrivr,oqqg rivor,crg [o<og ple nol.rl pr,xg6 x(v6uvo avenr,0{pqtow l.er,tougy(egtou eyxegdl"ou To evepyer,c6v. nto exn)':qwt'x6e(vot 6tt, 6l.ot paoqoripe vo dloupe rq6oBoorl os cur6 to anl.d B6tcrvo,Yto,xo ono(o a6r,tioetotcreQeuvntou ornv trQoorao(o, tr,xd 6e6opl6vo6e(1vouvdtl pnoqe( vcr oupB<il"l,et pd,E'trou oqpowr,xdteqou ogy<ivoutou oc6pat6gpog, xou eyxeg<il.ou afiorel.e( to udwqo rng rrQooonwomydg pog ?totto xdvtgo tou [6r,ou tqg tr1v vo rou nol.rtr,oporipcg, ttcrt, epno6[oer, enr,6e(vooq ],er,tougyiag rou fiou npoxol,e(rcr, on6 trlv ar1[qo4 qg 1],r,x(og.

TO @AYMATOYP|O OAPMAKO TOY APO> TZEPI KOT To ginkgo mapdrrloe rrpt endefuaorl rrlE xatd.oraoqE pou v1gtrtrlr4pag tou O 6q Tgdgl Kot, enttecpcl,r'ig Epeuvqtuxotlflqoypdppatog OagIvotnotjto Vul,xr1g Yye[o,Ettlv oto paxol.oyr,xrjg@egoae(o,g E0vr,rc6 r, HIIA, dlel pel,etr{oe rrl gcQpc,xtutr.xrl Epaotlxdmltc tou ginkgo ota r64r

syxecpol.rxd xdrtogc xar, yvcog(er.to peytil.o dyxo rrrtv rnrorqpovr_ xc6vorolleiolv ond qv Euqr6nq fiou poQruQorjv unooqq(ouv rnv xo,r. c'norel'eopcnmduy6" rou. E(va,l nenelopdvog drr. oupp<il"l.er. orrlv xcOuordgqoq trlg epq<ivr,or1g cnc6l.ercglivripnE xa' d).l.orvvorltrxc6v lxa,vorrjrrrlvnou ogefl,ovrcxrorcr, syxecpal,r,xd enero66ro,> xar "pr,xg<i 6' eival anorel.eotrrc,rlx6cxdpa t,t,o,r tq vdoo Atrtorir,trrep. Xqv yro, nqay;rmlxtiqra, q (6ra xou q pqr6ga, q fr,orll.o Kor, tiqpoe va nogouor,tiler, ngoBl"ripcro pvril.lqE ora eBboprivrorrlE. Tdooeqc Xp6_ vra aqydtegc dyrve q Oldyvoorl 6n 6.nuoyecn6 q vdoo Aiwolirpeg. H Kot nr{ye oro lo,tplx6 xdwqo rou E0vlxo6 lvor,wofrou Vul.x{g YyeicE oro Mdgr.l.cvtyr,o, rrtecrl.rorlxrj OsEraneic 8rdcpoga pe qtippcr_ xa. Auorulc6g,xavivu 6ev ef1e onordl.sopcr xar. 6lr, p{veg apydtepc mjqe e[mjpro xo,rendo'tgeeeoqv olxoydver,dqg. T6te, o yucnqdg yroErIE tigllos vo rqE loqqye( ginkgo biloba oe orcOepdg0doerg trur'v mg qpsQnoirrlg, 240 6lovrcE un6pq rou 6n ro gdgpaxo cur<i lprlorponole(ro,r, oq fegtrrcvia yr,c tq Oepane(otqg v6oou A).royirpeq. 'Onatg l.der,o (6r,og 6q Kor, q pqrdpcr.rou6ev o enav.x:,rloe q lccpvr,zd lcpdvq pvlitlrl tqE, 6l<itl, <inrog e(vol guorx6, 6ev e(var 6uvar6 vcr avo,p6velx<inoroE an6 dva pdrcvo va, o,vo,or{orr rd, vexgd eyxegcl,r,xdxftrcpo. e)orrioo, ouvdBqnrirr.alr,oorlpe[_ oro. H v<ioogAi.ro1dr,trreg ele).i10qxe pe nol,ri Bgcl8riregopu0p6 und 6,r,t0c r{rcv ovapev6pevo.,.Kc,vovl}tri, neq(pevexdnolog vc 0c (votol r4g uyeiaErqg, p6oc,oe 6el pro oqpcvrr,xrienr6e lgovrxd 6ui_ ornpcx6lr, pqvc6v.H xardoto,ori rlg dpoE ncqdperve ota,0eqrlxo,r, 6ev efiLbeLvc60qxe en6peva, tdooega lqdvla, yeyov6g nou ta nroredcodrl e[vo,tngcypcrr,xd olr,ooqpe(orro?ro,r f6r,onroredouv ro lro,ror til.l.ol yratgo( rlg>>, r,o 69 Kor. )e autd oxqlpc6g orlpeio l.de to nroref er ftl pg(oxerct q c[ia rou ginkgo biloba, ro ono(o pnoqef vc rape ppafver oxqv noge(c rqg vdoou, c,vo,x6nrovroE enrBgoErivo_ 11 vroE oqlrovrvaf"rllv enrbeivoloq rqE onc6l,eloE l.rvripnE, rIE xo0c6g xcr trrlv dl,l.ov oupntolp<iralvpro,E cnd rlg nro rqoylxdg v6ooug,yro rrlv ono(a 6ev undgler xcpl(c dl,l,q npcyl.lctzrj 0egcne(a. <Ae 0a d6lva not otrl pqt6pc pou raxg(vr1 (6vc Adgpc?ro ryxsxQrpdvoo,nd rov Ogyavr,opld Tqocpipuov zcr, Oclqpd?{ovyro, q 0eganeia r4g v6oou Al,rolrilpeq) 6r,ft1 or cvenrOfpqreg evdgyerrErrou olet(owar pre aur6 ro qriqploxo eivc,r, xc,rc,orgocpr,xdg xut, enrnlu6nv,c,vtil.oyo, cpdqpcxc 6ev 61ouv cp6qel xcvrjvo,ouorc,otrx6 cnor6l,eopo>>, ouvr_ 1(el o 0p Kor. ,{116tqv ril,l"q, ro ginkgo biloba 6ev d1er,oXeE6v xopl(c avenr.0ripqq evdgyera. o 6p Kor eivq,rneneLoudvoq ro tfur r65x

ginkgo biloba Bori0qoeq pqt6qc rou, rrou or{pegc e(var,oybdvto xo,t Yto,negr,oodteqo1g6vo an6 6,rt oxtc6 etr6v, va fet xcrl"ritepcr {rcrv avopev6pevo yto rnv xu:cdoruorl"qg. Tr eivar to ginkgo biloba; To qdgpoxo fiou aruoxal.e[tat ginkgo biloba ],apB<ivetor,an6 to rou 66wgou ginkgo, evdExcl.l"trlnrctrxotj 66vrpou nou eu0oxlcpril.l"c pre(orc efxpata xl,[pcrc. Ot nrc yvort6g and tlg evegy6gpplxdg ouvri0og e!<ilovto,l and ta' gu]"],cl ouo(egrou cputori,ol yxr,vyxol"fteg, neglextlx6rpag. pe expjl.r.oqxcl petcng6fiowot oe 66x(c 8r,dcpoqqE undqlouv p6vo oro 66vtpo ginkgoxal6ev ouofeg, Aurgor,Opcrorr,xdg unriplouv nou0evd ol,l.otj or1 quoq. IIom estrt4povr,xri otot26eio crto8elxvrjouv tq Egr(oq tou ginkgo biloba; urroonlp(ouv 6tt to ginkgo e(vcnro rtrto Oprpdvor, epner,poyvt6povsE ouo(eg.And q Oexoeda tr,g Oeganeurrxdg oqpawrx6 on6 <ll,eg quor.xdg '50 oTrlv r,ctgr.xri 61ouv 8qpoowute( n<ivtrlccn6cur6 rou Br,Bl.toygcA(c 400 dp0ga yrclro ginkgo,and ta onoic,tc leqoo6te po efvu legpavriv flepr,oodreqegcnd nevr{wa el.eyldpevegx}rwwtgpe}dteE egeuvrpc6v. tou ttE enr,peBorc6vouv Oeganeww(4 r,8rdtrpeg ginkgo biloba oq 0eqoqg o'uyxriwgtrrotlg, pvt{pqE ?{cltrlg obuvcrp6ag ne6aqE e[o,o06vqot1ErrlE pcrtogxdncloq g, rr1gxan6g, r,cg, tou atoOr{ of yxucvn q g unr6l.er,cgev6qye Olr.lrtlE,rng EdIrlS xot tIlE sprBo{E(tou xou6ouv(opotoEota c4rn<i). q )uyxexgr,p6vo,or eetuvyltdErflouv texpqpr.c6oet XQnonrou ginkgo biloba oTqOeganeicrqg dvor,cg?iotrqE v6oou Afurolitpeg. avofontou ginkgo pnoqe( va e(vat tegdotrc, xc0c6E H en(Eqcloq yove( q l.enoupyia tou eyteqdhou xat eplnoE(er qv epcprivr,orl ouprntolptittrrvfiou ogeftrowor, oqv xcxri xuzhocpop(otou o(pctoE. )ripqcrrvcrpt ptc yegpavrxr{ pe}.dq, q aorl tou o(plcnog,6nog ptxQ{oyyefa trrry ao0evc6v,oulriOqxe xuxd 57% pta Oqxe ora rgr.1oer,6r{ nqdogateg YeQpo.vtrrl 6nena o116 l.r{Eq tou ginkgo. Ario <i}.}.eg c6gcr pe)'&eg ri8er,fcv tvrurrtrlotottd"anoreLf.opcto,dnetta o.st6rutmwttl xg f,ritpqqE Xanontou ginkgo. Xripgtrlvo pe Fto pel,6q orqv ono(o dyr,ve co0ean6 99 rll,r,xr,rrlpdvouE yrc ouofcrg lgovtxd brdoqpa rqr6v prlvc6v yr.o611o nep(nou 1q6OlatoQoxdE veig nou dnaolov an<i eyrceqol.r,xdg xstti },e vr,o,, ginkgo Bekr(ore rnv eyxgol.r.xr{ woupyfc ttrlv co0evc6v ro pdoo 6po. )e plcrdl.l,q pel'dtt1orqv ono6adl.opav pdgog200 72Voxur,6" npop]"tiql.r,xiagteg(nou 69 ectN, ot ono[ot e(1cv epqav(oer, croOeveig

r66r

proro plr1pnEyrc rdooQo xrsQirrou XQdvro,ftoQorrlQrl0qxepetrr(crlo4 cno TlVo t<rtvoo0svc6v dneno,ond rqe lg F{veg Xq{o1g tou ginkgo, oe oX6oTp"e 32Vomov ao0evc6vnou dnargvav dvo,placebo. H peyd),r1 r,o Oegcneu'nxry al(a tou ginkgo cpdvqxe crn6tqv dqeuvarow Ag T[og xcrr Kl<ir,vevxar. llol. Nfuor.l"w rou flo,venlotr;piou A(pnoupyx oro MdaolQrxr rrlE Ol"l,cv8fcg. To 1,992,6norg avcgderro,r oro xopugafo largrqg x6 neqrobr,xd BqetavfugThe Lancet, or,ynrgoi ouro( e!6to,oo,v rd, cnotel.6opcrcr ocqdwa el.eylSpevov pel.erc6v nd,v<rl ginkgo xcr. oto xat6l,qlcv oro oupndqaopcrdtl q ouy?rlrQrlrdvl guor.zrlOepaneurrxrl ouo(a 4to,v efioou xctdl.l,ql"r1yr,orrl Oepcne(crrlg sy?rcpol.rxrig avendqxer.ag(qg per,otp6vrlE xuxl,ocpop(og a,ipcrog orov eyx6gal"o, 11 rou ono(o, e(val 6uvcrt6va o8rlyljorr orrlv rivor,o),6nog xal ro ouv0srlx6 cpdgpaxoo-dergocrine, fiou ouwoyoyQcr,ge(rcleuq6o4 otrlv Eupc6rur1 yro rrf 0egone(craum{gqE vdoou. )qv ngaypantx6nlta, or.O}.},av6o( egeuwpdg rpcv t6oo nenelop6vor yro rqv u,norel.eopcrlxdrqrc, rou ginkgo, r6ore roluq(orntt'o,vtitl xo,r, (6lo10c ro dnapvo,v, o,vxdnolc, ol orryp{ riql,[av vo,lrivouv rn FV{pn toug ri va 61ouv <i}"}"c outrrntriplaro, <<ryxscpo,l,r,xr{g cvendgxeng>. Enrr},dov, o,vazoivoroo,v dtl to ginkgo Eev na,pouo(aleoopcrgdE cvenrOripqteg ev6gyer.eg. tunlxq H 6doq nou enrtuyl<ivel 0eqaneurr,xricnotel.6opc,rc,eivc,l 120 mg qtrreq4o(rrrg. ngrirc oqpdOrc pelr(trloqg el'va,r Ta opo,rd 6newa ax6 tooeq6 6rrrg ep6opd6eg. dfr,

MIA NEA @EPAIIEIA fIA TH NO>O AAT>XAIMEP Mra ouvqOropdvq gOogdgotouE4trrxrcup6voug clt(o tr1g8rovorprxr{g e(var 4 puotqpr,c68qE rQopotum( v6oog AlroXrirplep, plo, vdoog xor orqv oaoio rc eyxegol.r.rd xtittaga oraElsxri xctaotpdcpowal. Nda dpeuva 66elle ouvoerrooru+d.anor,eLoporo,, ofpcprovc pe ta onofa to ginkgo pnope( vo orcpamjosr rqv e[6],r,fuqg dvorag nou npodpg letar an<iq vdoo Altoldr,peq, xc0c6gxol ax6 dl"l"e an(eg. Autd 6e oqpo(vel 6tl q cpuor,x{ Oeponeurr.xri ouo(a Oeganefel tqv (6la tqv o.rt[o,nou npoxa].e( fllv xo,xo,orgogrlrcrlv eyxegc].lx<irvxurrdqatv r{ dtr. pnopef vcr cvcorgdtper, BIdBeg orov eyxdcpal,o, nE sl").d cgxerdg pel.dreg66ellclv 6tl oroug co0eve(gnou no,igvouvginkgo oqper,c6vero,r orlprcvxrxr1 )e Betrrirrloq. pr,apeyri].q pe].dn1nou dyrve oq feppcv(a ro 1996, ouyxewpc60qxcv ra anotel.dopoxo, qg 1pr{oqg tou ginkgo an6 222 cro0eve(9. ao0sve(E, xrou ritcrv 6l.or,ql.rxfag rivro Or s67x

yr.cr. rdooed r,eGrou xe6v Lcr rrc\ocrfilofiqnxt Bil'aktJon ao0evc6v newa an6 tpetg pnves Xq{oqg tou ginkgo, oe

32Vorrlovao0svdv nou 6targvo,v dvo placebo. H peydl"rl xar olfa rou ginkgo cpd.vqxe and tqv dgeuvatorv Aq Tlog IIol. N(nor,Ivr tou flcrvenlotqp(ou Afpnougyz o'to Mtio,r,atqloro o,vacpdeerot xopucpa(o .'Io L992,6nc09 ot ytatpo[ o,uto(eldtcoo,vxo r4g Bgetav(ogTheLancef, oopdwc el,eyl6pev<rlvpeletc6v ndvot oto ginkgo xol cpuolx( 0epaneutr,xrl oro oupndpaopa dtr, rl o-uyxexerlrdvr1 avernE ef(oou xardl,l.ql"q yro rq Oegone(cr syxscpol,txrlg t'1 (qg per,opdvqg tou xuxl"ocpoqfog a(potog otov eyx6cpal.o, xau r 6uvar6 vc obqyrlo'e ornv d,vora), Sncog to ouv0etLx6 eug6tlg otqv Eupriruq o-dergocrine, fiou ouvroyoyQocpeitar, (a autr{g qg vdoou. )tqv ngcryprnw"6uy,u, O}.}.ov6o( ol tou ytc xnv crnote},eoplottxdmltc r{tav t6oo rreneloptlvor (6lor,Ocr dno,qvo,v,uv xdnotu to dtr 6ore r,olugiomlxo,v xor or riprplov va ldvouv rn prv{p1toug r{ vc dlouv d}.}.4 oupntc6prcc,ven<igxercg".Erml,6ov, c,vczo(vrooov ott to H ev6gyeteg. runlxf 6ev ncrgouoia[e ooBagdgavenr,Oriprlteg ennuyldver Oepaneutrxdanoteldopato, e(vo,l120 mg qpeopatd 6xewa un6 "(,riootTc ngc6ta or1pd6la pel,tftoorlge(vcu, dll el36opd6eg.

fIA TH NO:O AAT>XAIMEP NEA @EPAIIEIA

ult(a qg 8nvoqtr,xr{gq0oqdE orouEr1}.tzlorprdvoug ouvrl0r,opdvq q pluoqqr66qg xar, tpopo,xtlxrl vdooE Altoldrpeg, ptcr v6oog xtittogcr orobt,cxd xatcrotgdcpovtal. Nda onofa tc eyxecpal"lx<i 66erEeouvo,ofio,oxrxdaxoteX(.ouoro. ofuocova ue to onofo, ginkgo pnogei vcr otopar'1ost r1v el6)"r.[qn1g dvotag nou ngodgxaOrig v"at o:n6dl.l.eg o,ttfeg.Autd 6e cn6 tq v6oo Afuro1d,tpLeg, q cpuolzriOeqaneu'nxri ouo(c Oegcnefel qv (6ta qv ver 6tr zuttd,g<r:v{ nou ngoxa,l,e(tqv zctcotqocprj rcov sy?1,tqo,l,r,xc6v pnope( vo, avo,otgtllre trg pltiBeg otov eyxdgal.o, al.l.d crpxetdg r, g 66er[av 6n oroug aoOeve(g nou no,fgvouvginkgo oqperiveoqpawr.xr{pelrfooq. )e pr,cpeyd]"qpe]"dtqnou 6yrveoq feqpcqg lgrloqg tou fta to 1996, ouyxevrgri0qxcv ta anotel,dopro,ro, ginkgo o;n6272 aoOeveig.Ol oo0evs(E,xrourltcv 5l,ol ql.lx[og dvtrt x67s

rolv 55 rc6v,6fiooxov cfid r{nr,o, 6rogp6rplo <ivolcrnpoepldpev4 cnd q v6oo Alroldr,peg q un6 pr,c oer,pd pr,xgc6v eyxego,l.r,xc6v. 6ll fla pr{veg aoOeve }.dppcvav eite 6va placeboe(re pro,qpep{or,cE6orl or ig 240 mg runonotqp6vou exlulfopoxoE ginkgo biloba (EGb 761), 6fo qoedg qv qp6qcr, ngw crn6ta yeripoto ginkgo o1prG Avcrpg[po],a,or ao0eve6g otoug ono(oug1oqqyr1Or1ze rrlocv peyctrfteprl Befurirrrorl.'Ono4 d6er,leq dgeuvo, 4 Belrior4 otlg qE l,enougyfeg Fv{pIE ?{orrnEo'uyx6wpar4g rpclv neg(.nou tgerg poq6g xcrfuriteprl curodg nou 6l"aBavginkgo, ot oX6oI trlecutorig nou nrjpav oe griqpozo ritov nepr.oo6rego placebo.To cguolxdOega:reurlx<i onoretrentwa cnd 6[r. FnvegXq{ctngail 6,"ttrioregc and tgerE pr{veg otrrotrxri or evdpyereg ljrav ontlvrcg xar,ole8dv Xa{ong.Enuntrdov, cvenr0riprpeE nd,wa pl4ooBaqdg,dnrrrg x<inolc aL"l.egylxr{ crw(Epaoq, oropcrlr,xdg 6nrclpcl6g ri xeqcl"a\(o. )qper,60qxe p(a pdvo ruovrj oopcrprjovenl06pryn'1 evdpyero,tivo,eyneqcl.r,xdsfieto60ro, pol.ov6l, n oxdo'nnou crurd pcu,afei. Or.egeuvql#g6youvxcrcrhjfer, e[1epe to ginkgo 6ev riler enr.Be oTo ouprndgcopc6rr,q Xanon rou ginkgo oq 0eganeic qg <ivorag0c pnogorioevc crnocp6qel o4pawr,x<iocpdlnotouE c,o0eve(E xo0c6ge(vcl va oupptil,er orq pefurfcoon nordr4rcrglorjg xcn o-rr1v rqE xcrOu8uvatd 0r6eno'nqE el6l.qg qg v6oou.

>YNAPIIA>TIKA >TOIXEIAAIIO TI> HNA

O 6q Touptiv M. Itil., rivagveugol,6yog-rl-ru1(atqog q Nda Y6gxr1, cn6 paxeul,xc6v0epc0eop e(rcr,ncyxoopirrlgauOewic onlv avdnrufq cpap rou nercbvyro t1v crwper6nrcq v<jocrrv eyxeqdl"ou.O Eq IriI nc(gvel ginkgo yr,o, ngootctefoer tq pvr{pqtou ?ro,r i6lo x<lvelxa,l q yuvofvo, ro xo rou, zo0c6gxor or neqloo6regol an6 roug cpil"ouE ql,r,x(agdvtrl rou rorv elriwcr n6we et6v. Kal aut6 ouppcr(vel6r6n o yntqdg yvop(er nohi xal.d m10eganeunxr{ 8rivapl rou ginkgo orov eyxdgcr}.o. O 69 Itil" lcrgtoyqdcprlosrrl 6gdoq tou exlul,iop,crtogginkgo orrE pe l.ewougyieE eyxegdl.ou,ro 8oxipo,oeoe 300 neg(nouaoOeve(g rou oq;rovrr.x6g Dr,orcrgoldg xat yetnemtd 6tl pnope[ vcr, oxo,proFvlilrlE r1 n1oer. vc enr,pgo8r.iver efdl"r,[nqg anc6],er,oE pvlitrrlg,xnE rrlv xrlE dvor,agxor rrlg v6oou Afurolirpeg nou oler(eror lrs qv nqolargqp6v1 ql.r,x(c.<fI<6E efvcl Euvar6 vo ndpo qv eu0rivqva 6c6ool ginkgo ro pou, av 6ev nrorefo oe r6roro Bc0p6 qv alfa biloba otouE croOeve(g tou 6tor c6otevo, pnopc6vc, ro n<iprcrl eyr6;>> o (6lo9 o 6q Itfl,. xa,r l,6el x68x

O 6p Irfl, yvotq(el 6rtto ginkgo 6yel exx\,:qw,r,xrj cpogpoxew,t"xrl 6goo"ur,x6rqxo, orov eyxdcpal.o, dnotg go(vercr xo,r an6 to, eyxegol"oygag{porcr. )e plc 6oxrpr{ yrcxrov 6}.ey1orcrrvo,note}.eopdrorv rou pordvou oro xvreur,6 veuprx6 orjorlpa, o yr,crq6gp6rgqoeq 6pcrotqqr,drqra xrrrv syxscpcxl,r,xc6v zupd,rrrw prcrgopd8crg uyr,cbv vecrgc6v a,vtq6v, ql*xiag rprliwa 6rio erc6vneg(nou, ccpori 6l,apcv rp(a 6r,ccpoqel,x,doxeu<iopara ginkgo. To 6vo oxefcopa pr rrlv epnopr.xri ovopaofo, Ginkgold rltcv ogxerd bqcorlxd, ritote vo XoQcrxxnprcte( <vorqrr,x6g rvsQyonorrltfg" 4 <6lunvo 6rox6o',lodtlpro pe ro, ouvOerlxd cptiqpcrza nou or.rvrj0otE ouvrcryoyeagorivro,r.. Mia plSl,rg ripc riotepa an6 qv nq6ol,qtfq rou Ginkgold, tc, eyxecpcrl.oygcqrlpcta r,lav 66e 6n 4 8qcroqqrdtqro rtrlv o,-eyxegcl.lxc6vxupd,rrov e(1e ewcOei oe 6l.eg rlg ruegr,o16g eyxeqril.ou oro, ritopc rrou xo dl.cpov. Ouolc,rou ortx6",ro [6r,o ngdypo ouvdprlrcr drav or,dwgeg d],aBcvro cpdqpcxo rcxpfvq, nou efvo,rro ng6ro cp<lgplaxo nou nrjge 6yxqr.or1 otr,gHIIA ylc rI Oegcrnefo dvolag. qg Ti0ercl ro eqc6qpc av to ginkgo 0c gnoqorioeva ano6er,1te( elG oou crnotel,eopatr,z6pe ra ouvOeu,xdgrigpal,t,clorrlv enf8goorl nou 6yet or,aeyxeqal,rxri w(spcr,crrlv atdprrlv nou ndolouv o,n6 6lo,to,go,xau Xdg pvnpns. O 69 Irfl", XQrlorporrorc6wcrg ndl"r rc eyxecpcrl.oyeogr{prcrc, cniyxgr.ve ruqocpil" sy%rqo}.r,xljg ta xrls Epcoqgrdqrag tcuv o,v0gc6norv orouE onofoug loqqye(rcl ginkgo ?{cr,r roJv ov0pc6nolv oroug ono(oug loqqye(ror. ro q<ippcxo taxqivq. Aurr{ tq gog<i Xgqol.pr,ono(qoe ql,rxr,rrl1.r,6voug nuo tiwgeE xcl yuvc,fxeg, r1].r,x(og tlrlwa tm6" erriv negfuou, pe ngopl,r{parc pvrjpqE, orouEono[ouEe[1ey(ver, 6rdyvcrtoq{nrag dalg pdtgr,ag<ivoraE.Tc, eyxecpc},oygoprjplotc66er.lav noqdpor,cr rgoq0, eyxegcl,r,xrjgEpaoTqpldr,qtag(.news an6 rq trr{Un ginkgo f rcxg(vr;E rj agxerc6vril,l.otv ouv0errxr6vcpcgpdxrrlvxard: lrlg dvonE nou e(vor eyxexpr.privcr oqv Eupc6nq. f)ot6oo, ro ginkgo cno0e[1qxe cvc6repoxar obriyqoe oe o].].aydg otov eyx6cpal.o rgerg cpogdE oe negrcodregougao0eveig.H 6gooqglSqro rrllv d,-syxrcpcl.r.rr6v xum<iqov 6yrve p6yrorq, xo,r pdl.r,o.rc ogrop6vegqoQdEr]rcv crqxerd u!.rql.ri,6neno, an6 tperg r6peg,oro 667orcovoo0evc6vruoul,<ippcvo,vl.u,o, 6doq rotv 240 mg Ginkgold. To o,vriororlo noooor6 oroug ao0eveig nou 6ncr,pvov raxgivq o.vrjl.Oe p6Ltg 22Vo. Aurd tcr reoT 0e(1vouv xoOaqd u,g Duvcrt<irnrsE rou ginkgo. flqorlyo{pevo rcor rou 6poE Iti}, 68er,lov 6rt" "la <iropa,nou pgioxovtcv oe xanflorcxoqorlyXuoqgr; nagol"qgriplaroEl.<iyo dvor,og, 61ouv pr1 cpuolol.oyrxd eyxeqo)"oyqaqr1po,rc, onofcr yivowal xo, t69x

(.ntna an6 ruxr,mrtl"r{q.rq cpuorcl"oyrxd taxpivqE. Tcruttllpovo efcga'E"roq v(owar q ouyluoq xo,r ro naqal.rlpqpla. 4 lxcrvdtqro, rou ginkgo vc, xdvel xor nd,h <.quorol.oyltt&>> eyxegcl.oypcqr{pcrc ro ra xaOr,ot<inlOov<jvneq roodteqo c,norel,eopcrrr,xd r orrlv ovaorqo gri t,t,o, qE g0ogdE ogr.opdvrrlvvorltr.xc6vlxa,vonitrrrv xo,r l.ertougyr6v, oe ox6oq Fs ro ryr,sxgr,pdvo ouvOerlxdq<iptrraxo, onoio ncpouord(el ro ogxerdgovenr,OriprpeE evdpyer,eg. Me rorov tqrfao l,ertouqyei to ginkgo; Kcrt'crq1<ig, ginkgo efvcn6va,ruotrri ro r.opp6 cwr,ofedtrxr.x<ixal o,utd oqpcrfver,6tlngooro,rerier xrimopo cn6 q 0ld0n, nou efvar q cr,r(a ra zd0e cp0ogdE rou or6patoE,ornv ono(o, negll,apl3dvowo,l, 6uol,erro, touqylz<i eyxeqcl.lxti xrirrcgc ?{o,r qgcypdva atplopdqo cyyeicr ro, oTov eyx6qc,ho,omlv xcg0r,d ?ro,r olo rixgc. Tcr xriqr,aqcgpaxeun"x6" orolle[o rou ginkgo Oerrlgoriwor, efvcnor.ytruxol(teg qE cp].al36vr1g drl xo,r or l,or,trdveg regnev(ou lto,r r,6irrlg povc8lxdE,p11ttx6.g tou or. ouofeg nou ovoptilowo,r yxwyxol.(reg. To ginkgo 6ev enltq6ner,n1 ouoorrlpuircocrn rtrlv arponero,l,(rrrv Lrso,w<jrov tprdno egno6(er tq 6qpr,oupx,or y(a rolv xoro,ctuesrrrr,xc6v 0g6ppcDv oro c(pa xcr0r6E rrlE aOrlqolpuixor rtrlonE.En(orlE, prr vdc 6qeuvc 8eilver 6rr. r,6r,airepr1 oqpoo(a prope( vcr dlouv ol owr.gl.eyplovc66e6 r8r6qreg rou ginkgo, or ono(eg e(vcrr Euvorri vo, xreoororerlouvrlE cpqqfeE cnti ozdprl peyol.riregq l3ltipn. fal.l.r.xd ner.q<ipcncr dbelfcv du, ro ginkgo pnoge( vo, olrot{c,ro,orloer qv lxcv6qrcx rrrlv eyxegol.r.zc6v xtnr<igrrlv va peraBlBdfouv xc,l va l,cpl3rivouv or{pata on6 rouE vsugo0rcrpr,Baordg xupr,cglorjv o.rrl nou l"er,tougyiatou eyxeqdl.ou. flcpap6ver, tiyvooro o,v ro, dpeoc Oeponeur,rxdcnorel,dopoto cnov eyxrigol"o e(vor rel.rzd q xcl.rftepq ruxtroqogfa tou c(porog. O 6q kfl. oqtr^lelc6ver: ginkgo culdve r,ro l.rsxo,<<To rqg ytruzdlqE orov eyx6qal.o, auf<ivowag pe aurd rov rpcino l3ol,r,op6 qv evdpye tou eyx,gdl,ou. yvap(oupe yro,noro l.6yo oupBcrfver, lo Ae aur6. Mnoqe( va oqefl,ro,rorTlv cu[rlpdvq xux].ocpopfcrou c(parog otov eyx6qal.o, o,l.l.<i aur6 6ev Unoec6 ro rrrrlpe BeBcl&rrpo. vo, Exnlqt.rl"ltEvdegpel,dregoro flc,venlon{plo tou Kewdxr rov HIIA on6ro 6gc Nt6r,Br,w )v6ouwov unoor'4q(ouv aum{rq 0eop[cr. An6ng vexqorf(egfiou r[Qoyporonoiloe orov eyxdgo,],oq].uarrlpdvrrw xa0o].1xc6v povalc6v nou dnaqlcrv crru6 v6oo Afurol<irtrreg, 6p )v6ouwov q o pgf xe drr q cnfa rqE cnr6],er,aE pv{pnExor rnEtivolog pnopei vo prlv qE eivcr pdvo n l3ldpn ralv ryxego,Iynut'w wmdgaw (or,veugona0ol,oyrx6g aLl,or6oer,g), <inorg n[oreuc,vnglv, cr].].<i or p]dl3egnou ouvo8efouv xo,r rTOr

ro spqQdyporo ti rcr <prxQd ryxrcpo},r%d pe rfietodbr,o>>, cnot6}.eopc rqv xroQsUrr6br,orl xuxl.ocpop(ag u(po,rog.Aur6 ro ororyeio rqg tqg rou dqeuvcgeivcncruvapnuoilx6,6r,6t oqpcliver6n,q l3ltipn or4v xuxl.ogoqia tou o(pctog pnoge( va el.ey10ef, ax6pq xc,l <jrc,v6ev efval buvotd 'Erot, q vcr el.ey10e( vdoog Alwcrydrpeg. or. goBeg6gouvdnereg r4g vdoou Afuro1<irpeq yfvetcr vo Gwtl,rsronlororjvlrs rqv c,norgonrlrdtor,trrv<plxqc6veyxegal.r,xriv>, rq Xoa{yno1 oonr.pirrrlg <i},}.crlv xal o,wrlm r:quaweiw pe q petrt(roor1 nuxl.oqog(agrou o,(pcnog, qg xo,r dncrlg xdver, to ginkgo. flgdypcnr,, aur6 emBeBcr6veldtr,q culqp6vtl qotl rou cipo.roE oro, eyxeqal.r,xdxtlrraga e(vcnq xfgla anfo rlou ro ginkgo e(vcr. t6oo enlrulq trr6vo o"rqvawlperc6nro414g voqtlxri g 6uol.er,rou gyicrg. Ilolog rgdrer, vei to raigverl 'Onorcg cwrpetron(er ngopl.r{pcrcl pvrjpqg pnoge( va orpage( oro ginkgo, yro vo, ngooncOriou vo, oro,pranioel q orcbrcxq voqtr,rrl q0oqd nou o8qye( o"rqvonc6l.e pvr{pqgxa,rnfav6v oe pq clvatqdtllrra pq dvor.cr. ovcpovri gnoge(vc eivc,rxcnc,otpogr.xr{, H unoo,qp(el o 6q Itil,. Eldl"l"ou, enrqpc,iveu <itl doo negr,oo6repoler xdnong rdoo neproo6regeg nr.0ov6q"ctg yel vc pr.r6oer pr.c yevr,xr{nc,paxprl tolv voqnxc6vrou r,xcrvotrjxtrrv, e(vor,yvrrlonj prsrov dpo rivola. Kal ra fiou riropo nou ufioxtofv ngoBtrrjporo pvl{prnE ayer,m6. vrrrg(g oq lotr{ roug g 61ouvneg r,oo6re g ar.Ocvdtqre va epcpav(oouv Bagd nqo Bl"ri ge pcra oo opyr5teqc.Auro( nou 61ouvnpoptr{para pMiFnEoto ocprdwo,?{o,r oro, nevjwo xouE?{,o,r r,8roireqoc,utoi nou epgov(ouv rdrora ngop},r{prata ora elr{wa }io,roro epbopr{waroug 61ouvno},},6g nl0cv6uqregvcx, o,vo,(.ag 66xc 1g6vro agydtepu. Kctri nnilouv q vdoo Alwcrltilpeg n'6v,e xrigr.ol,6yo, q tivon nou oler(ero,r Lrsqv ql.lxia ngo6pletal crn6qv cyyer,oxrlv6oo otov eyx6cpal.o, onqv ono(a negr,l.opBdvowor syxrro, cpol.r,x<i enem66uaxar.4 vdoog Alwoldr,peq. Ta rupcfuacrupnrr6pcta eivc,ror 6r.ol.eitl.reoq pvr{trrq,Iouyxuorl xo,ror petoBo}.dg fiQooor,g rnE nva6ny,ag, owofugouvo8efowal an6 no,pd,vorc, or, xarti0l,n].r1, !.'uxtrll,xd ncrgcrlqgr{ptcrcxo,r,fiL0o,v6venr,otgoqrl o,rl vqnlax{ r1}"lz(a,pr,c, xatdotooq nou cncrwe(ntr{pq xar o'uvepi qpow(6a. )ripqolva pe ro 6gc Itil", q oroorl orrypr] yto vo cp1(oer xdnorcE va na(gvel to ginkgo e(val p61.6 ovril.qcpOef nqc6ta orlpd6r.a6r"cra tcqapjE rnE FvriprlE,ra onoia anorel.odv dvber,lq xd,norou fiqopl"n0a lroroEorov eyx6gol,o.'Orov q nogdppooq y(vetol vrrlg[9, pnogoriot vo, npol.qcpOe( vo, enr.l3pobuvOefnegatrdpo enlOefvalorl q xor rrlE l,enoupy(crgtou eyxegdtrou.
371 x

@a pnoporioe ro ginkgo vcr Oe<rrpr10ei quolx{ Oega,neurlxr{ ouo(a xrourrQooro,rerieyevlxri rov eyx6cpal,opretriq pdoq rql.r,x(a; r. )ripqrovc ps ro 6gcrKot, x<ltr r6rolo 0a pnogorioe ngtiyl.rcrtlvcr r,olier, tr,crr yr, aur6 xar o 66loE,4l,r,z[oEnevrjwo, etc6v,no,(pver, ginkgo o4 pdoo to nq6trqpnEyro,rnv afic6l.elarTE trvlil.rqE. <Alo0dv0qxc <irr. (por.tl,6ov e oqv xcrtil,trql,q r1l*x(a yKx, op1(orova ro na(qvo>>, vcr l.del o (6tog. fl6oq coodtqtcr 26qelafripuot e; H a:rorel,eoporrl4li 6doq yr.cl qv obrivaq p\n1prn alet(eror ps rnv nou ql,r.x(c xa0c6gx,o,ryro, dl,l"a rinr,cr oqpd8r,a eyxegcl,r.xc6v 6r,orcga1c6v eivaLouvol.rx6.120 qpegqo(roE, mg os pe 1copr.op6va, rerE6doer,g 6r.oxic rcrw40 mg. QoT 6oo, ofpcprovape prcx vr1o, dgeuva,pr,au!_r4l,oreaq 6do,n e(vo,rneqroo<lrepoo,norel,eotrrctxrjoe cv0gc6nougnou nfiotrouv and ooBoqdreglE poaq{E dvorr xo,r v6oo Akrol<ir,pep.H 6<ioq nou dleL 6oxrpao're(oe rdroreg negmrr6oe6 e(var ouvol.w6 240 mg qpegqoirog. f)or<ioo, 6ev e(var cncgc(r4ro vc, ndger n<inologeEcqX{E urpq}"<1re_ r4v E(var.xol,ljrseo vo,fiexlvr{oerxdnorog Fs Xopnen 060rl,l.dveoLer,6lxo6. l.5req 66crqxar.,agori naqcnlpr{oel oqtrrd8r,c va BelrirrloqE, npolrrlprloa,, o,vlpercrorei, oe pteycrlfreerl6don, unoorqg(el o 6p Iril,. Ikioo 26qovlxri0rriotrlpa lgerriferar Tto vo cpavoriv ta unoteLop,orc; )uv{0olg pelricooq rnE FV{pqErrQoyporofioreirc,r. pdoc oe tdooeprg 6rrlg 6lr ep6opd8eg, pol,ovdt ro ginkgo d1er,dtrreoqen(6gooq orov eyx6qol,o. S)o16oo,o,fpgrrrvo pe ra euqr{po,ro, rcrlv eyzega}.oygagqpritrov oe cv0gc6noug, ginkgo auldver, q 6goor4pr,6qta rrrlv ry?{,e_ ro qal.rxc6v xup<itrrrvoe p(o pdl.r.gc6ga rioreqa an6.q l,rjr1.rq rou. Xripgrllva Lis xdnoteg avacpoq6g, ogr.oprdveg qoQ6Eor,lgrioreE 6rcnlorc6_ vouv xdnora al,)"cryrj pia c6gonegfuou f.nena cnd q l"r{qq rou. f,)or6oo, o,ripqtovope ra eupriporc Fro,E peyti),r1g pel.dqg, ro, rure_ yerwd. onorel,dopctcr tou ginkgo go,iveta,l 6rr ouoorlgedowo,t orov oqyavlopti ps rrlv nrigobo tou 1g6vou zc,r e(vc,rnol,ri pr,eyol,rireeo, os 6lr pr{veE, otiyxqr,oqpe ro ngc6rorqipqvo yr,cr oe neglnrr6oelg dvorcg. <flg6nel vo eival xdnorog urropovsttn6g. peycl.riregeg Ol peto$ol"dE epqcv(owcr, tr,ErreQroodteqeg goQdEperd rouE npc6rouE p{veg 6!r, },6er, 6p Iri},. Elti},}"ou, rc 6e6otrr6vcl0e (1vouvdn, ro ginkgo o Xe{onE", napapdvel eveqy6 orov eyx6qcl,o yr,a peyril,o lqovr,xd 6r,<loqpcr. <'Eloupe rraqcqqrioer o,notdl.eop,o, fiou 6rapxe( p61qr,xcr, ewdo, c6qeE dner,tccn6 pic p6vo 6doq ginkgo>,cvacp6pel.
a 72ll

Ilrioo cocpaL(.Eefuaq flegroroolo,xri ol lqljorsE rou ginkgo dlouv avc96ger nohri rlnr,eg xo,r, avco, gdtl.tpeg crventOriplteg ev6gyer,eg, Snorg oropo,Xrl1,6g or 6latcqcyf.g nut or xeqol.ol"y(eg. Mdvo r,o 0,57o o !no, pey<il,q pel.6q o,rqv onofcr ouppste(1av 8.500 dtopa x(ye r,6towg avl,6ptioelg. Ytpn),6g 6doer,g rou ginkgo e(val 6uvo,rdvcr npoxo,l,6oouvxd,noto cfoOqpo Av ncgarqqn0e( [d],r1, or er8rxoi ouvrororiv va lexwljoer. Ititng. xdnorog pe lapql.6repq Odoqrqg ouo(cg cunjg xar vc ngolop{osr or u!;ql"&egeg6doer,E. O 69 Itfl,6ev 61eroqper.r6oe r,xcp(a ooBapriovenr,Oriprlq evdqye rr oe 300 aoOeve(g oroug onoioug 6yetlogqyrioer.ro ginkgo. To 0e<oge( po aoEa).6e ax6pryxat an6rD J3mapfuDE iltaBmapivD nou npocpi)" aoq6)vtwE. 9m6oo, ot\v LaxeLrrq fi$),"roypaI vdeg nepmrrtoetg nou oyetfiouv to ginkgo n(oa an6 rov ocpOal.p6 orov eyxcpa),o. xat r<llvrrsQtoro,rlxc6v d1er, 6ev e[cxpr,Bot0e( to rqE drpoeQoyfugttut culrive I rrl eo?i ol utpql"6g 6doer,gefval nr0av<jvo cvrevbef_ czol.ouOorjv uwmqxrmq oycoyli rj 61ouv prl

orpoeeoyrxdnqopl,{pata r1 rcropnrd
. ).t crttg <rq neqtm<ircerq owrs<6<or

xurd q drdqxela lrflpng tou ginkgo. Av nagouor.dfere6rurogcl6g pvtip1E,np6nel vo, ouprfre cpdooE ro ylatg6. Ol 6ro,ragcX6g Fv{png eival 6uvar6 O,owc,roe 6yt+ootov eyxdcpo,l,o, nou anc,ne[ rorgr,x4 cryoryf. np6ner,vc OeoprjoeteopdoolEdtl unocpdqere afid oto8r,cxrj ldyo ql,r,x[cg,q onoio, eivar 6uvol6 vo, o,vtl1retotnr_ FvriprnE

per; poriOero, ginkgo. rou

e(vc,l or eyal,huntrng L6oet"g; HIIA 6rjo eivo,tro eyxexglp6vo,grippoxo fiou ouvro,yoypocpori_ Tro r1v avttrretc6nrcqrqE dvom,g,al.l.d aur<i ouvrjOognpotefvo_ a4 6o1cnq l,rioq -p<ivo ocporirq anc6l,eropvnpqE xal 116uol.er,_ ryic rou eyxecptil,ouefvar oe nohri ngolcopqpr6voord6r,o_ l.6yot ooBcqtfv avenrOripqtrov eveqyer,c6v goelr6xrr-ov. un<ig1er, rorv Aev r.ooOrivcporou ginkgo fiou vo, pnogef vo, ro ndper. <irov ro 1ger,<ilerar, neguoodtego- dtcv 6ql,a6ri ap1(oouv tc

r:prfuc nqoBl,{paro pvtipqEri yla fl1v o,rroreonnxnEev8eldpevqg crr6l.eragpvr{pqE oler(ero,r ps trlv q}.r,x(c. nou
x73a

III6E eivar,Euvatri va xcrtal,riper xrirtoroE av to ginkgo eivar crotel,eopanwdl To xatrrirego pdtqo olr,ol.6yrloqg e(vcr q ouvep{g nagcnrlpqoq qg pelrirrro4grnE pv{trqE r{ d}.}.crlv pe }.er,tougyr,6v tq },r{9rg xo0r1pegr,v6v tou ginkgo. <Aur6 eivar xolfrepo cn6 onolo8rjnor rcor r{ 6oxlpr1 nou y(vetcn ora 1c,qrld, xo06g xc,r o,n6ttg perg{oerE rcrlv eyxegcrtroypcq4ptit<rrvr, r,o1uq(ercr,o Eg Tldgr Kot, rou E0vr,xoriIvotr,tor.itou VupxriE Yye(ag tolv HIIA. @dpctc xatcvol,rotr6v florog dnog ginkgo e(vo,r, 6prrlg o xohitegog; Eivar, cl.r{Oer,s 6ev drl dlouv 6l.o ra epnoqlxd oneudopota qv fbr.c wyu. An6 ra tp(a ei6r1 nou Eoxfpaoe o 69 Irft p<ivoto Ginkgold e(1eqv w{s xanrqv ffrorsl.eopcrtr,x6n4tc ev6Eqoelrol4sunxorj oxeudoporoE.Kcr,ro rgfc befypcro, fiou cyop<icrqxcv oe xoroon{porcr rtov H[IA, {ro,v runonor,rlpSva 6r,ot tilor,tvcrnepl6louv 24Voyluxo[(reg q],oBdvqg xan6Vore gn6vro. flaq' 6l.a ctur,6, Ginkgold d8elle peycfufregl Brobr.a0eoqdnpa ro rdr qoelroxoeuu,xrl 0qcotr,zdnrya. To Ginkgold e(vcr tcrur6o4po pe to eug6F,Gb 761,, dvo cunonoqpdvo nqo'idv grnkgo fiou XQrlorl"ronom(rc,u elxexgrpdvo ofi6 rrl yeQpovrtrlEorn feppcrv(c ?rolrr'l fal.l.fa xc,r e(vc,r, r4g xr{ xupdgvqo4 <yro rqv cwrper<6nlo4ttrlv ouprrropr,tirolv cyyer,cxr{g <ivorcg,o-roono(o neqr,},cpB<ivowo,r 6r,clr{t1.re6 r4g or xcl exqul,nrr,xr{E q pv{p1Excru o8uvcpfa ouyndwQoo-ylE, xo0c6E q eppor{ xcr, tcrwcfrrcw xc,r q 6r,cl,e(nouocl }.6yo xoxr{gxux}.ogoq(ag). lorldarqtcr(crlyoErnE xv{prqE Ee aoug 6LLuEnegrrt6oe6 e(val xulu6 va r(eqo4r.o*owitan to ginkgo; tow eqeuvr6v,to ginkgo gcr(vetal dtr, Xripgrrlvo lrc ro, cr,fiors],6opatcr 6norE or4 Belrioloq xar ril.l.ov veugotroylxc6vnqoBl.qp<ircrw, BoT0d Tl nx<i e(vor rc rgoripcrta qg necpcrtr{E, rppo{ nou oqe ftetar oe cryye rgoBhiparcr, q xorriOl.nlrrl rrou oler(ercrr i.rsr4v npoyrlgqpdvq ql.r,voqaxd ouprut<iporaqg oltloqgdvercE. To x(a,xa06g xar,ogroprdva, ginkgo d1er,en(oqg XQrlor,l.rofior,q0e( Oegane(a 6r,riqogcrlvxcqoq 6nyyercxc6v ngoBlqtrxir<rlv, nlOcvdrcncrl.6yol qg cni[qoqE rrlE eoliE rou a,(pcnoErrou nporcal,e(.)rcl xop8r,oyyer,ox<i npoph{pcna aepr.)'cp$rivowcr rl dQrrlQlool4l{puvor1, xr"goo(,q 6rol.e(nouoa 1or},<fuqor, 11 ro, ?ro,r oefoual.r,xr{ovr,xav6qta. To anorel,doproroxqEcri[qoqg tr1gxuxtroqogiog rou a(pcrog pe ro ginkgo pnogei va dlouv ruol,l,dgeueqyetlxdg enr6qrioer,E. feqpo,vo(
.74 f

I TTIE

).i.ttl
Dct,pri

ntronfuou

r 6ev ei6r1
lo-[tIYFOpdva n0.

ougol.dyor, Bgrjzavnpdogora 6tt ro ginkgo anorel"eixal.r10epcne(c yro rrlv clvrplxri o,vrzcrv6rpo,. Oegunefope ro Bdrovo ourd 6reye(H pel tr; qo{ tou a,ipatog pdorrlrrov cgmlgr6v tou n6oug, evtoliovtag pe c,urd rov tq6no al o:uuttxrl l,eltougyia. flgdyparr., or eqeuvqtdg6r,onforcDoo,v ro 78Vanevrlwa avtgc6v nou undgegov Crn6<agtqpnxrl drr otul'rxrl ovlxo,v6trpo," pelrlr6grlxe 6nens, ond l,r'1t1rq mg qpsQn240 oiog exlul"iopcrog ginkgo biloba yr,o1povlx6 Or,<ioqpc ewdc, pqv6v. H qo{ rou aiprcroEo'rr,g agqgisg rou ndoug yevva6. rioreBetrrr.c60qxe pcrcn<i rqer.gpr{veg.Efxool <ivrgegenav<ixtrloav nl ocu"u"xrlrouE }.elroupyia 6.xewct ard 6lr p(v9. Aexo,ewdcrdvrgeg enav<imrlocrv tr1 oturtxrltoug l,elrougyfo drav 6l,opcv ro ginkgo oe ouvbuo,op6pe opr.'Evrtxa op6va gtigpaxo. dvtgeg nag6pewav c,v(xavoroefoual"r,xd. )e pro nporlyorlprevq plel.6q or.egeuvrpdg nclqam{gqoav xdnora pe}.t(or1 6rcrvloprlyorivtcv qpeqrioleE 66oe6 60 mg ginkgo.Kopia 66oq 6ev ngoxdl,eoeavenr0f trrqteg ev6gyer,eg.

nnr0' [ xo
ilQd-

[0'vro,tuls STNE vxO,r uK).

n dtr iroS wx6. li't;.To

t(0Q-

poris
rtQrgcnla To avo(

.75 s