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NSAIDs:nonsteroidalantiinflammatorydrugs.
*Adjustdoseinpatientswithrenalinsufficiency.
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forthispublication.IllustrationusedwiththepermissionofElsevierInc.Allrights
reserved.
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CytochromeP4503A4(CYP3A4)inhibitorsandinducers*
Strong
inhibitors

Moderate
inhibitors

Stronginducers
Carbamazepine

Moderate
inducers

Atazanavir

Amiodarone

Dexamethasone

Bexarotene

Boceprevir

Aprepitant

Enzalutamide

Bosentan

Ceritinib

Cimetidine

Fosphenytoin

Dabrafenib

Clarithromycin

Ciprofloxacin

Lumacaftor

Efavirenz

Cobicistatand
cobicistat

Conivaptan

Mitotane

Eslicarbazepine

Crizotinib

Pentobarbital

Etravirine

Cyclosporine

Phenobarbital

Modafinil

Darunavir

Delavirdine

Phenytoin

Nafcillin

Idelalisib

Desipramine

Primidone

Indinavir

Diltiazem

Rifabutin

Itraconazole

Dronedarone

Ketoconazole

Erythromycin

Rifampin
(rifampicin)

Lopinavir

Fluconazole

Rifapentine

Nefazodone

Fosaprepitant

St.John'swort

Nelfinavir

Grapefruitjuice

Ombitasvir
paritaprevir

Isavuconazole
(isavuconazonium
sulfate)

containing
coformulations

ritonavir
Ombitasvir
paritaprevir
ritonavirplus
dasabuvir
Posaconazole
Ritonavirand
ritonavir
containing
coformulations

Mifepristone
Netupitant
Nilotinib
Tibolone
Verapamil

Saquinavir
Telaprevir
Telithromycin
Voriconazole

Dataareforsystemicdrugforms.Degreeofinhibitionorinductionmaybealteredbydose,
method,andtimingofadministration.Specificdruginteractionsandmanagementsuggestions
maybedeterminedbyusingLexiInteract,thedruginteractionsprogramincludedwith
UpToDate.RefertoUpToDatetopicsonspecificagentsandindicationsforfurtherdetails.

*TheCYP3A4inhibitorsandinducerslistedinthistablearerelevantfordeterminingpotential
interactionsofdrugsthatareCYP3Asubfamilysubstrates.
LesspotenteffectonCYP3A4reportedinsomereferences.
DatafromLexicompOnline.Copyright19782015Lexicomp,Inc.AllRightsReserved
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