I{uman Karyotypes

Purpose
Io examine and prepare human karyotype
charts
Figure 1. A human karyotype (left) and karyotype chart (nght).
r. eJ
qH
if,;u)-(d 5
u)
g
otl c
-:?,
b6
HE FE
E.e
9E **"€*s sn"*&F
nf HHffiHtrH liltffii
6E Pe
#
3E
EF EE
oo PE ho
6Y
8€ 5dE
Ei
96
xq eF
o
00)
p€
h q)
68
=E
*'ffiffiffi m*rnniiilnnnfin
YY cH
y^ oo
3e Qc
9o
=tr
8p ,)o#pt'$ HK'f;R ffi n',t nm u*
=x
o.i- or 9
eo!-cu)()
E-ra )X() 9;
o !
gE Hs E;
cn ;-- L l
ffi flT To*4)ffi '*,#rrg'
:"'}ff"r$''!'l;
E!, AgE
u.=0)*(lJ(U_C
o@h!s.?rf
H XY
o P F.E 9gP !
; F 6 o* cd- Special staining techniques revear right and dark regions (bands) on the
8p5g:5HB chromosomes. By matching the bands, rt rs qurte easy to identify specifrc
e F ; s,E F 6
5 o -* 9 g f
! chromosomes and prepare a karyotype chart (Frgure 2).

E .}o
9.€ 6; 8:: f Table 1. Some chromosome aberrations in humans.
c .:lhromosome SYndrome
o
:l hbibphdoY
TcSFEPSH (condition)
Effects on individual
abnormalitY (variable)
c0)OLrq)>o>-
ct,
.t<
o b;55EHEe.
ot o.r !u,o r c f E
XO Turner's . sterile lemale
. underdeveloped female characteristics
(E
o €E6-Pe'; . short stature
;t- . sometimes below normal intelligence

XXY Klinefelter's . sterile male

. abnormal male chacteristics
. abnormally long arms and legs
. below normal intelligence
Trisomy #21 . low mental ability
. short arms and legs
o internal detects
o distinct facial features

Trisomy #18 Edward's . severe abnormalities

. fife expectancy about 10 weeks

Trisomy #13 Patan's . severe defects rncluding small, non{unctionrng eyes

. survive only a few weeks atter birth.

Defective #5 Cri du chat . severe defects, both physical and mental

(part of . sound, when crying, similar to cat's meow
chromosome
missing)

)up|cation 3q Allderdices . multiple effects on organ systems

. short limbs
. usually die within a lew weeks of birth

Duplication 9q Allderdice's . grows to be tall and thin

. very little speech
. requires custodial care _
Prenatal diagnosrs is available {or all these conditions
 iq. r , {'\\ *
'r-- 1il ru

r"'-f

A
f.r
ir. I
c'
.}--i-r
,tt-J-t:f
--,{
-\

l {
r:\
'-,

-t-'
i-

ffWR#Mffii
*hru\\*k.\P
;-!i l
d- _\- ii t'
;G.a
:' :+' i"-,

ffVN
.ifrt''
t- :.
'i-)
,: '-{ c-
--f- r!J j
:-\l

o j
c /-!)
"{b W
*+-7 i\:,
"**t
* ^U
v
f^!- - 1:-- t?- -
_-t*\i .,x :-!.

w^asrq
!

--ai_\
iiff gls{
ti \)\.,ffi
*'f\.
i-X
Je
{-:
i --'
! \r\.*s
n-'
-1, f:
' s 'F- *-l
)-j
e
+
r,,.

tr
€rct"il"-
.aY
{)' # _**
4. -5 \\i lr (
i'>is ..-J
,F.nft
-.)
(-
L\r

-. ..
r \La

r/?i
t\ HnEFb'r?FFt?{F*r'
/l t* ".. "

) r-
tl
" a-t
nl

tf\ . 'r,

)' /t]
":
i\
x:L
;-f
tf;')
\n.
i.
; ---f
$--J-
d
\-. a
^d)
R'
\-; rl- -{-
'.t -.-a
L ,\'-
|\+\ .:' /ir
4s
[! ^
.ll .\ ?
an
z-

r.
-\'t
F\

.i* -)\-)r-
".A

:!---
rr. t: ." ,l

-' )t
; F -4-7

ii.l I
c.
.-i-
ci/
t'
(

l-i
{