FORMENTERA, SYBYL SEPTEMBER 27,2020

ACTIVITY NO. 8
SUPPOSITORIES

PREPERATION OF GLYCIRIN SUPPOSITORIES

Objective: At the end of the activity the student should be able to:
1. Fill in the table of formulation
2. Enumerate commercially available suppositories
3. Identify generic and brand name of drugs and its dosage strength and method of administration
4. Identify drug indication or category and other available dosage form of the product

Ingredients Amount Reduced Used

Glycerin (sp. gr = 1.263) 91g 26g Glycerin , a hygroscopic
material, contributes to
the laxative effect of
the suppositories by
drawing water from the
intestine and also from
its irritant action on the
mucous lining.
-Helps maintain the
shape and consistency
of the suppositories
Soduim stearate 9g 2.57g The sodium sterate , is a
solidifyung agent in the
supposidtory and may
also contribute to
laxative action.
Purified water 5ml 1.43ml Solvent

To make 105 g To make 30 g

Computation For reduced Formula:

30g
= 0.2857142857 Factor
105g
Glycerine (Sp.gr. 1.263) = 91g x 0.2857142857 = 26g
Sodium Stearate = 9g x 0.2857142857 = 2.57g
Purified Water = 5ml x 0.2857142857 = 1.43 ml
Instructions: Search 20 drugs that are available as suppository and fill in the table.

GENERIC NAME BRAND NAME DOSAGE METHOD OF IS THERE INDICATION/

STRENGTH ADMINISTRATION OTHER ROA CATEGORY
OF THE
PRODUCT
Eg. Bisacodyl Dulcolax 10mg Rectal Yes Laxative
1.Chlorpromazine Thorazine 100mg Rectal Yes Antiemetic
(Glaxo Smith
kline)
2.Hydrocortisone Anusol – HC 25mg Rectal Yes Pruritus ani
(Salix)
3.Hyrdromorphone Dlaudid 3 mg Rectal Yes Analgesic
(Abbott)
4.Indomethacin Indocin 50mg Rectal YES Anti
inflamatory
5.Mesalamine Canasa (Axcan 500mg Rectal Yes Anti –
Scandipharm) inflamatory
6.OxyMorphone Numorphan 5mg Rectal Yes Analgesic
(Endo)
7.Prochlorperazine Compazzine 2.5,5,25mg Rectal Yes Antiemetic
(SmithKline
Beecham)
8.Promethazine Phergan 12.5,25mg Rectal Yes Antihistamine
HCL (Wyeth)
9. Clindamycin Cleocin 100mg Vaginal Yes Bacterial
suppositories Vaginosis
(pfizer)
10.Miconazole Monistat 7 100mg Vaginal NO Antifungal
Nitrate (Personal
products)
11.Progesterone Endometrin 100mg Vaginal Yes Progesterone
12.Nnoxynol-9 Semicide 100mg Vaginal NO Nonsystemic
vaginal reversable birth
Contraceptive control
Insert
(Whitehall-
Robins)
13.Nonoxynol9 Encare 100mg Vaginal NO Nonsystemic
Contraceptives reversable birth
Inserts control
(Blairex)
14.Paracetamol Pandol 50mg Rectal Yes Pain /
Antipyritic
15.Sodium Voltaren 100 mg Rectal Yes Anti-rhumatic ,
Diclofenac Anti-
inflamatory and
 analgesic
16.Domperidone Motin 10mg Rectal Yes Antienemic
17.Sodium CEO- TWO 10mg Rectal Yes Laxative
Bicarbonate
18.Prochlorperazine Compro 25mg Rectal Yes Antiemetic
19.Promethazine Phenadoz 12.5mg Rectal Yes Antihistamin
HCL
20.Caffeine Migerot 100.2 mg Rectal Yes Headaches/pain
Ergotamine
Tartrate
 SCHEMATIC DIAGRAM IN PREPERATION OF GLYCIRIN SUPPOSITORIES

Procedure:
1. Prepare 30g only.
2. Heat the glycerin in a suitable container to about 120F.
3. Dissolve the sodium stearate with gentle stirring in the heated glycerine then add purified water.
4. Mix and immediately pour the hot mixture in a suitable mold (if made of metal) previously heated and
is used while hot.
5. Cool the suppository completely before removal from the mold.
6. Packed individually with a foil. Label.

1.
Prepare 30g With their reduced amount.
Heat the glycerin (blue liquid) in a suitable container
120F to about 120F .
. + PURIFIED
WATER
2.

Dissolve the sodium stearate (Green Triangle ) with

gentle stirring in the heated glycerine then add
purified water.

3. 4.
Mix and immediately
pour the hot mixture in a
suitable mold (if made of
metal) previously heated
and
is used while hot.

5.

Cool the suppository completely before removal from

the mold.
Packed individually with a foil. Label.