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  • Bab Iv Formulasi Dan Perhitungan 4.1 Formulasi

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    Priliya As Ali
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    The document describes formulations and calculations for a piroxicam suspension. It presents three formulations containing 20 mg of piroxicam per 5 ml, with different combinations of suspending agents, wetting agents, sweeteners, and preservatives. The approved formulation contains 1% Na-CMC as the suspending agent and 20% glycerin as the wetting agent, sweetener, and preservative. The calculations determine the amount of each ingredient needed to produce 61.2 ml of the suspension. It also calculates the dosage amount and percentage of the therapeutic dose delivered by a single dose and daily dose. Finally, it shows the pH calculations and buffer capacity calculations for the citrate buffer system.

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    BAB IV done dong

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    The document describes formulations and calculations for a piroxicam suspension. It presents three formulations containing 20 mg of piroxicam per 5 ml, with different combinations of suspending agents, wetting agents, sweeteners, and preservatives. The approved formulation contains 1% Na-CMC as the suspending agent and 20% glycerin as the wetting agent, sweetener, and preservative. The calculations determine the amount of each ingredient needed to produce 61.2 ml of the suspension. It also calculates the dosage amount and percentage of the therapeutic dose delivered by a single dose and daily dose. Finally, it shows the pH calculations and buffer capacity calculations for the citrate buffer system.

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    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
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    17 views3 pages

    Bab Iv Formulasi Dan Perhitungan 4.1 Formulasi

    Uploaded by

    Priliya As Ali
    The document describes formulations and calculations for a piroxicam suspension. It presents three formulations containing 20 mg of piroxicam per 5 ml, with different combinations of suspending agents, wetting agents, sweeteners, and preservatives. The approved formulation contains 1% Na-CMC as the suspending agent and 20% glycerin as the wetting agent, sweetener, and preservative. The calculations determine the amount of each ingredient needed to produce 61.2 ml of the suspension. It also calculates the dosage amount and percentage of the therapeutic dose delivered by a single dose and daily dose. Finally, it shows the pH calculations and buffer capacity calculations for the citrate buffer system.

    Copyright:

    © All Rights Reserved
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    of 3

    BAB IV

    FORMULASI DAN PERHITUNGAN


    4.1 Formulasi
    a. Utama
    R/ Piroxicam 20 mg/ 5 ml (Zat aktif)
    Propil glikol 10% (Wetting Agent)
    Na- CMC 1% (Suspending Agent)
    Gliserin 20 % (Pemanis dan pengawet)
    Asam sitrat 5,043 mg (Buffer)
    Natrium sitrat 8,8 mg (Buffer)
    Sunset Yellow q.s (Pewarna)
    Aquades Ad 60 ml
    b. Alternatif
    R/ Piroxicam 20 mg/ 5 ml (Zat aktif)
    Propil glikol 10% (Wetting Agent)
    HPMC 1% (Suspending Agent)
    Sorbitol 0,7 % (Pemanis)
    Natrium benzoat 2% (Pengawet)
    Asam sitrat 5,043 mg (Buffer)
    Natrium sitrat 8,8 mg (Buffer)
    Sunset Yellow q.s (Pewarna)
    Aquades Ad 60 ml
    c. Disetujui
    R/ Piroxicam 20 mg/ 5 ml (Zat aktif)
    Na- CMC 1% (Suspending Agent)
    Gliserin 20 % (Wetting agent, pemanis dan
    pengawet)
    Asam sitrat 5,043 mg (Buffer)
    Natrium sitrat 8,8 mg (Buffer)
    Sunset Yellow q.s (Pewarna)
    Aquades Ad 60 ml

    14
    4.2 Perhitungan
    a. Bahan
    Larutan piroxicam 1 botol (60 ml)
    Direncanakan dibuat 60 ml untuk pembuatan larutan encer dilebihkan 2%
    60 +( 2/100 x 60 ml ) = 61,2 ml
    1. Piroxicam 20 mg/5ml = 120 mg/60 ml x 61,2 ml = 0, 2448 gr
    2. Gliserin 30% = 30 gr/100 ml x 61,2 ml = 18, 36 gr
    3. Na- CMC 1% = 1 gr/100 ml x 61,2 ml = 0,612 gr
    4. Asam sitrat = 5,043 mg = 0,00543 gr
    5. Natrium sitrat = 8,8 mg = 0,0088 gr
    Aquades 60 ml – (0,2448 + 18,36 + 0,612 + 0,00543 + 0,0088)gr
    Aquades 60 ml – 19,23
    40, 7 ml
    b. Dosis
    Dosis piroxicam 20 mg setiap 8 jam ( 3 x sehari)
    3 x 20 mg = 60 mg
    Sekali = 20 mg
    % OD = 20 mg/60 mg x 100% = 30% (TOD)
    Sehari 3 x 1 = 3 x 20 mg = 60 mg
    % OD = 60 mg/60 mg x 100% = 100% (TOD)
    c. Dapar
    1) pH piroxicam = 7,5 – 8,5
    pH asam sitrat = 7,0-9,0
    pKa 1 = 3,15
    pKa 2 = 4,77
    pKa 3 = 6,40
    2) pKa = - log ka
    ka = anti log 6,40
    ka = 3,98 x 10-7
    3) pH = - log [Ha+]
    7,5 = - log [Ha+]

    15
    [Ha+] = 3,16 x 10-8
    4) Kapasitas
     = 2,303 x C x Ka . [Ha+] / (Ka + [Ha+])2
    0,01 = 2,303 x C x 3,98 x 10-7 / (3,98 x 10-7 + 3,16 x 10-8)2
    0,01 = 2,303 x C x 7,95 x 10-8
    0,01 = 18, 30 C
    C = 0,00054
    5) pH = pKa + log [g]/[a]
    7,5 = 6,40 + log [g]/[a]
    Log [g]/[a] = 1,1
    [g]/[a] = 12,5
    [g] = 12,5[a]
    6) C = [g] + [a]
    0,00054 = 12,5[a] + [a]
    0,00054 = 13,5[a]
    [a] = 0,00004
    C = [g] + [a]
    0,00054 = [g] + 0,00004
    [g] = 0,0005
    7) Massa asam sitrat
    Bm x Casam X Volume
    210,14 x 0,00004 x 0,06
    5,043 mg
    Massa garam sitrat
    Bm x Cgaram x Volume
    294,10 x 0,0005 x 0,06
    8,8 mg

    16

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