PUROC, LIZA M.

1. Antipsychotic drugs

a. Typical Drugs

DRUG NAME MECHANISM OF INDICATIONS CONTRAINDICAT ADVERSE NURSING

ACTION IONS EFFECTS RESPONSIBILITY/
PRECAUTIONS
 Generic Competitively Haloperidol is Narrow-angle Extrapyramidal  Assess behavior,
name blocks postsynaptic indicated for a glaucoma, CNS symptoms (EPS) appearance,
Haloperidol dopamine number of depression, coma, appear to be dose emotional status,
receptors, conditions including myelosuppression, related and response to
 Brand interrupts nerve for the treatment of Parkinson’s typically occur in environment,
name impulse schizophrenia, for disease, severe first few days of speech pattern,
Haldol movement, the manifestations cardiac/hepatic therapy. thought content
increases turnover of psychotic disease. Marked  Monitor B/P, heart
 Classificati of dopamine in disorders, for the drowsiness/lethar rate. Supervise
on brain. control of tics and Cautions: Renal/ gy, excessive suicidal-risk pt
Antipsycholytic vocal utterances of hepatic salivation, fixed closely during early
Therapeutic Tourette’s Disorder impairment, stare may be mild therapy (as
 Dosage/ Effect: Produces in children and cardiovascular to severe in depression lessens,
Route/freque tranquilizing effect. adults, for treatment disease, history of intensity. energy level
ncy Strong of severe behavior seizures, prolonged Less frequently improves,
Injection, Oil extrapyramidal, problems in children QT syndrome, noted are severe increasing suicide
(Decanoate antiemetic effects; of combative, medications that akathisia (motor potential).
[Haldol weak explosive prolong QT restlessness),  Monitor for rigidity,
Decanoate]): anticholinergic, hyperexcitability interval, acute dystonias: tremor, mask-like
50 mg/ml, 100 sedative effects. (which cannot be hypothyroidism, torticollis (neck facial expression,
mg/ml. accounted for by thyrotoxicosis, muscle spasm), fine tongue
Injection, immediate electrolyte opisthotonos movement.
Solution provocation). imbalance (e.g., (rigidity of back  Assess for
(Lactate Haloperidol is also hypokalemia, muscles), therapeutic
[Haldol]): 5 indicated in the hypomagnesemia), oculogyric crisis response (interest
mg/ml. Oral short-term EEG abnormalities, (rolling back of in surroundings,
Concentrate: 2 treatment of elderly, pts at risk eyes). improvement in
mg/ml. hyperactive children for pneumonia, Tardive dyskinesia selfcare, increased
 PUROC, LIZA M.

Tablets who show excessive decreased GI (tongue ability to

(Haldol): 0.5 motor activity with motility, urinary protrusion, concentrate,
mg, 1 mg, 2 accompanying retention, BPH, puffing of cheeks, relaxed facial
mg, 5 mg, 10 conduct disorders visual chewing/puckerin expression).
mg, 20 mg. consisting of some disturbances, g of the mouth)  Monitor EKG and QT
or all of the myasthenia gravis may occur during interval.
following symptoms: long-term therapy
impulsivity, difficulty or after drug
sustaining attention, discontinuance
aggressivity, mood and may be
liability, and poor irreversible.
frustration Elderly female pts
tolerance. have greater risk
Haloperidol should of developing this
be reserved for reaction.
these two groups of
children only after
failure to respond to
psychotherapy or
medications other
than antipsychotics

DRUG NAME MECHANISM OF INDICATIONS CONTRAINDICAT ADVERSE NURSING

ACTION IONS EFFECTS RESPONSIBILITY/
PRECAUTIONS
 Generic Loxapine is a For the management Asthma, COPD, May produce  Assess all pts for
name dopamine of the previous history of hypotension (3% signs/symptoms of
Loxapine antagonist, and manifestations of bronchospasm of pts), bronchospasm after
also a serotonin 5- psychotic disorders following loxapine orthostatic administration.
HT2 blocker. The such as treatment, acute hypotension,  Monitor respiratory
 Brand exact mode of schizophrenia respiratory syncope. If status every 15 min
name action of Loxapine distress, any vasopressor for 1 hr. If
Loxitane  has not been The efficacy of medications therapy required, bronchospasm
established, LOXITANE in treating restrictive use only suspected, initiate
 PUROC, LIZA M.

however changes schizophrenia was airway disease. norepinephrine, rapid response

 Classificati in the level of established in phenylephrine  Assess need for
on excitability of clinical studies which Cautions: (epinephrine may intubation,
Antipsycholytic subcortical enrolled newly Cardiovascular, worsen mechanical
inhibitory areas hospitalized and cerebrovascular hypotension due ventilation.
 Dosage/ have been chronically disease, history of to beta-  Monitor B/P, pulse
Route/freque observed in several hospitalized acutely seizure or stimulation with for hypotension,
ncy animal species in ill schizophrenic conditions lowering drug-induced arrhythmia.
Powder for Oral association with patients as subjects. seizure threshold, partial  Assess pt’s
Inhalation: 10-mg such elderly pts with alphablockade). behavior,
singleuse inhaler manifestations of dementia-related May increase appearance,
Oral inhalation tranquilization as psychosis seizure activity emotional status,
OD calming effects and related to response to
suppression of decreased seizure environment,
aggressive threshold. Elderly speech pattern,
behavior. pts with thought content
dementia-related  Immediately report
psychosis are at any difficulty
increased risk for breathing,
CVA, TIA, sudden wheezing, chest
death. May cause tightness, cough,
neuroleptic muscle rigidity,
malignant fever, palpitation,
syndrome (NMS) sweating, altered
manifested by mentation.
malignant  Do not breast-feed.
hyperthermia,  Avoid pregnancy.
muscle rigidity,  Avoid tasks that
altered mental require alertness,
status, motor skills until
arrhythmia, labile response to drug is
B/P, diaphoresis, established.
rhabdomyolysis,  Change position
renal failure. slowly to avoid
 PUROC, LIZA M.

Potential for orthostatic

increased hypotension.
anticholinergic
effects including
exacerbation of
glaucoma or
urinary retention.

DRUG NAME MECHANISM OF INDICATIONS CONTRAINDICAT ADVERSE NURSING

ACTION IONS EFFECTS RESPONSIBILITY/
PRECAUTIONS
 Generic Depresses areas of To treat Contraindications Prolonged QT  Be aware that high
name the brain that schizophrenia in : Angle-closure interval may doses and large
Thioridazine control activity and patients glaucoma, blood produce torsade dosage changes in
aggression, unresponsive to dyscrasias, severe de pointes, a form patient with a
 Brand including the other antipsychotic cardiac/ hepatic of ventricular seizure disorder
name cerebral cortex, drugs impairment, tachycardia, may lower seizure
Mellaril  hypothalamus, and concurrent use of sudden death. threshold
limbic system by drugs that prolong Generally well  Frequently monitor
 Classificati blocking QT interval, severe tolerated with blood pressure and
on postsynaptic CNS depression; only mild, assess for chest
Antipsychotic dopamine 2 pts known to have transient side pain in patients with
receptors. Drug genetic defect effects. heart disease
 Dosage/ may relieve anxiety leading to reduced Occasional:  Administer drug
Route/freque by indiretctly levels of activity of Drowsiness during with food, milk, or
ncy reducing arousal CYP2D6. early therapy, dry full of glass of water
Tablets: 10 and increasing mouth, blurred to minimize GI
mg, 25 mg, 50 filtration of internal Cautions: vision, lethargy, distress
mg, 100 mg stimuli to the brain Seizures, constipation,  Instruct patient to
Initially, 25– stem reticular decreased GI diarrhea, nasal notify prescriber
100 mg 3 activating system motility, urinary congestion, immediately if she
times daily; retention, benign peripheral edema, develops unusual
dosage prostatic urinary retention. symptoms
 PUROC, LIZA M.

increased hypertrophy, visual Rare: Ocular

gradually. PO problems, changes, altered
Parkinson’s skin pigmentation
disease, renal (in those taking
impairment, pts at high doses for
risk for pneumonia prolonged
periods),
photosensitivity,
darkening of
urine.

DRUG NAME MECHANISM OF INDICATIONS CONTRAINDICAT ADVERSE NURSING

ACTION IONS EFFECTS RESPONSIBILITY/
PRECAUTIONS
 Generic Occupies dopamine MOBAN is indicated Hypersensitivity to dizziness, feeling  Assess patients fr
name receptor sites in for the management molindone, its unsteady, or signs and
Molindone the reticular of schizophrenia. componenets or having trouble symptoms of
activating and The efficacy of other antipsychotic keeping your neurologic
limbic systems in MOBAN in drugs including balance malignant
 Brand the CNS by schizophrenia was haloperidol, dry mouth syndrome
name blocking dopamine established in loxapine, blurred vision  Instruct the patient
Moban activity in these clinical studies which phenothiazines and increased saliva to follow treatment
areas, molindone enrolled newly thioxanthenes nausea regimen and to
 Classificati reduces the hospitalized and constipation notify prescriber
on symptoms of chronically difficulty urinating before discontinuing
Antipsychotic psychosis, helping hospitalized, acutely blank facial drug because
the patient to think ill, schizophrenic expression gradual dosage
and behave more shuffling walk reduction may be
 Dosage/ patients as subjects.
Route/freque coherently unusual, slowed, needed
ncy or uncontrollable
50-75 mg movements of
50-75 mg/day any part of the
 PUROC, LIZA M.

PO body
restlessness
excitement or
increased activity
depression
inappropriate
happiness
breast
enlargement
breast milk
production
menstrual period
changes (missed
periods or heavy
bleeding)
changes in sex
drive

DRUG NAME MECHANISM OF INDICATIONS CONTRAINDICAT ADVERSE NURSING

ACTION IONS EFFECTS RESPONSIBILITY/
PRECAUTIONS
 Generic Increases To treat psychotic Contraindications: Most common  Administer
name dopiamine turnover disorders, such as Blood dyscrasias, extrapyramidal medication with
Thiothixene by blocking acute psychosis, circulatory reaction is food or milk if
postsynaptic psychotic depression collapse, CNS akathisia, needed to minimize
dopamine and schizophrenia depression, coma. characterized by GI distress
 Brand receptors in the Cautions: Seizures, motor  Don’t give drug
name mesolimbic system. cardiovascular restlessness, within 1 hour of an
Navane Eventually, disease, pts at risk anxiety. Akinesia, antacid
dopamine for pneumonia, marked by  Urge patients to
 PUROC, LIZA M.

 Classificati neurotransmission cerebrovascular rigidity, tremor, avoid smoking to

on decreases, disease, narrow- increased begin a smoking
Antipsychotic resulting in angle glaucoma, salivation, mask- cessation program
antipsychotic renal/hepatic like facial while taking
 Dosage/Ro effects impairment, expression, thiothexene
ute / myasthenia gravis, reduced voluntary  Encourage patient
Frequency Parkinson’s movements, to avoid extreme
Mild to disease, seizure occurs less temperature
Moderate disorder, pts with frequently. changes during dug
Psychosis PO: underlying QT Dystonias, therapy
ADULTS, prolongation, including  Monitor B/P for
ELDERLY, decreased GI torticollis (neck hypotension.
CHILDREN 12 motility, paralytic muscle spasm),  Assess for
YRS AND ileus, urinary opisthotonos peripheral edema.
OLDER: 2 mg 3 retention, BPH, (rigidity of back Monitor daily
times daily up visual problems. muscles), pattern of bowel
to 20–30 oculogyric crisis activity, stool
mg/day. (rolling back of consistency.
eyes), occur  Prevent
Severe rarely. Tardive constipation.
Psychosis PO: dyskinesia,  Observe for
ADULTS, characterized by extrapyramidal
ELDERLY, tongue symptoms (EPS),
CHILDREN 12 protrusion, tardive dyskinesia;
YRS AND puffing of cheeks,  monitor for
OLDER: chewing/puckerin potentially fatal,
Initially, 5 mg g of mouth, rare neuroleptic
twice daily. occurs rarely but malignant
May increase may be syndrome.
gradually up to irreversible.  Assess for
60 mg/day. Elderly female pts therapeutic
Rapid have greater risk response (interest
Tranquilization of developing this in surroundings,
of Agitated Pt reaction. Grand improvement in
 PUROC, LIZA M.

PO: ADULTS, mal seizures may self-care, increased

ELDERLY: 5–10 occur in epileptic ability to
mg q30– pts. Neuroleptic concentrate,
60min. malignant relaxed facial
Average total syndrome occurs expres
dose: 15–30 rarely
mg

DRUG NAME MECHANISM OF INDICATIONS CONTRAINDICAT ADVERSE NURSING

ACTION IONS EFFECTS RESPONSIBILITY/
PRECAUTIONS
 Generic May block To control psychotic Contraindications: EPS appear dose  Use cautiously in
name postsynaptic disorder Myelosuppression, related patients with a
Fluphenazine dopamine receptor coma, severe CNS (particularly high history of glaucoma
sites in the CNS. depression, dosage), divided or renal impairment
 Brand This action may receiving large into 3 categories:  Monitor
name depress arear of doses of hypnotics, akathisia (inability temperature, a
Prolixin the brain that hepatic disease, to sit still, tapping significant,
 PUROC, LIZA M.

control activity and subcortical brain of feet, urge to unexplained rise

 Classificati aggression, damage. move around), can indicate
on including the Cautions: Elderly, parkinsonian intolerance and a
Antipsychotic cerebral cortex, seizures, symptoms need to discontinue
hypothalamus and Parkinson’s (hypersalivation, the drug. Notify
 Dosage/ limbic system disease, severe mask-like facial prescriber
Route/freque cardiac disease, expression, immediately if this
ncy renal impairment, shuffling gait, occurs
Psychosis PO: pts at risk for tremors), acute  Watch signs for
ADULTS: 2.5– pneumonia, those dystonias hepatic failure, such
10 mg/day in at risk for (torticollis [neck as jaundice
divided doses hypotension, muscle spasm],  Advise patient not
q6–8h. decreased GI opisthotonos to mix oral solution
Maintenance: motility, urinary [rigidity of back with beverages that
1–5 mg/day. retention, BPH, muscles], contain caffeine,
Maximum: 40 narrow-angle oculogyric crisis tannins, or pectins
mg/day. glaucoma, [rolling back of  Caution patient
ELDERLY: myasthenia gravis, eyes]). Dystonic about possible
Initially, 1–2.5 visual problems. reaction may dizziness or light
mg/day. Titrate produce headedness
gradually. IM diaphoresis,
(Hydrochloride) pallor. Tardive
: ADULTS, dyskinesia
ELDERLY: 1.25 (tongue
mg as single protrusion,
dose. May need puffing of cheeks,
2.5– 10 chewing/puckerin
mg/day in g of the mouth)
divided doses occurs rarely but
q6–8h. may be
(Decanoate): irreversible.
Initially, 12.5– Abrupt withdrawal
25 mg q2– after longterm
4wks. May therapy may
 PUROC, LIZA M.

increase in precipitate
12.5-mg dizziness,
increments. gastritis, nausea,
Maximum vomiting,
dose: 100 mg.c tremors. Blood
dyscrasias,
particularly
agranulocytosis,
mild leukopenia,
may occur. May
lower seizure
threshold.

DRUG NAME MECHANISM OF INDICATIONS CONTRAINDICAT ADVERSE NURSING

ACTION IONS EFFECTS RESPONSIBILITY/
PRECAUTIONS
 Generic Mesoridazine, as Used in the Do not take an allergic  Monitor serum
name with other treatment of mesoridazine if you reaction (difficulty potassium level
Mesoridazine phenothiazines, schizophrenia, have any of the breathing; closing before and during
acts indirectly on organic brain following conditions of your throat; therapy and
 Brand reticular formation, disorders, or a history of swelling of your administer
name whereby neuronal alcoholism and these conditions: lips, tongue, or potassium
Serentil activity into psychoneuroses. heart disease; an face; or hives); supplement as
reticular formation irregular heartbeat uncontrollable prescribed
 Classificati is reduced without or a history of movements of the  Monitor patient for
on affecting its irregular mouth, tongue, neuroleptic
Antipsychotic intrinsic ability to heartbeats; a cheeks, jaw, malignant
activate the history of arms, or legs; syndrome
 PUROC, LIZA M.

 Dosage cerebral cortex. In prolonged QT fever;  Assess patient for

 Route/freq addition, the intervals; a family muscle rigidity; signs of blood
uency phenothiazines history of muscle spasms of dyscrasias,
Intramuscula exhibit at least part congenital long QT the face or neck; including cellulitis,
r of their activities syndrome; sweating; fever and
Resistant through depression hypokalemia (low irregular pulse; pharyngitis
schizophrenia, of hypothalamic levels of potassium fast or irregular  Advise patient to
Severe centers. in your blood); heartbeats. change position
schizophrenia Neurochemically, slow heartbeats severe slowly to minimize
Adult: Initially, the phenothiazines that require restlessness or orthostatic
25 mg. Repeat are thought to treatment; or other tremor; hypotension
after 30-60 exert their effects heartbeat severe
min if by a central disturbances. drowsiness;
necessary; up adrenergic blocking These conditions blurred vision;
to 200 mg daily action. may increase the dizziness or
has been given risk of irregular fainting; or a
Oral heartbeats, heart rash.
Resistant attack, and death
schizophrenia, while taking
Severe mesoridazine.
schizophrenia
Adult: Initially,
25-50 mg tid.
May adjust
dose to 100-
400 mg
according to
response.
 PUROC, LIZA M.

DRUG NAME MECHANISM OF INDICATIONS CONTRAINDICAT ADVERSE NURSING

ACTION IONS EFFECTS RESPONSIBILITY/
PRECAUTIONS
 Generic Inhibits dopamine For the management A known Drowsiness,  Use trifluoperazine
name D2 receptors in the of schizophrenia. hypersensitivity to dizziness, skin cautiously in
Stelazine brain. It has weak Stelazine phenothiazines, reactions, rash, dr patients with
anticholinergic and (trifluoperazine HCl) comatose or y glaucoma because
 Brand sedative effects but is effective for the greatly depressed mouth, insomnia,  of drugs
name strong short-term states due to amenorrhea, fatig anticholinergic
Trifluoperazin extrapyrmidal and treatment of central nervous ue, muscular wea effect
e antiemetic effects. generalized non- system kness, anorexia, l  Advise patient to
It controls severely psychotic anxiety. depressants and, in actation, blurred take drug with food
 Classificati disturbed, agitated However, Stelazine cases of existing vision and neurom  Instruct the patient
on or violent behavior (trifluoperazine) is blood uscular (extrapyra to notify prescriber
Antianxiety, but may also be not the first drug to dyscrasias, bone midal) reactions. immediately if she
Antipsychotic used for be used marrow depression experiences
nonpsychotic in therapy for most and pre-existing difficulty swallowing
 Dosage anxiety patients with non- liver damage. or speaking
 Route/freq psychotic anxiety
uency because certain risks
Oral: Usual associated with its
starting dosage use are not shared
is 2 mg to 5 by common
mg b.i.d. alternative
(Small or treatments
emaciated (i.e., benzodiazepine
patients should s).
 PUROC, LIZA M.

always be
started on the
lower dosage.)

DRUG NAME MECHANISM OF INDICATIONS CONTRAINDICAT ADVERSE NURSING

ACTION IONS EFFECTS RESPONSIBILITY/
PRECAUTIONS
 Generic Depresses areas of Perphenazine Tardive  Shouldn’t be used
name the brain that (perphenazine) is dyskinesia, a to treat dementia
Trilafon  control activity and indicated for use in Perphenazine movement related psychosis in
aggression, the treatment (perphenazine) disorder, Severe the elderly
 Brand including cerebral of schizophrenia and products are muscle stiffness  Use catiously in
name cortex, for the control of contraindicated in Fever patients with
Perphenazine hypothalamus and severe nausea and comatose or Unusual tiredness depression or
limbic system by vomiting in adults. greatly obtunded p or weakness hepatic, pulmonary
 Classificati an unknown atients and in Fast heartbeat or renal dysfunction
on mechanism patients receiving Difficult or fast and in elderly
Antiemetic, Also prevents large doses breathing patients
antipsychotic nausea and of central nervous Increased  Monitor
vomiting by system depressant sweating temperature
 Dosage inhibiting or s (barbiturates, Loss of bladder frequently and
 Route/freq blocking dopamine alcohol, narcotics, control notify prescriber if it
uency receptors in analgesics, Seizures  rises
4 to 8 mg t.i.d. medullary or antihistamines); Decreased thirst  Monitor blood
initially; reduce chemoreceptor in the presence of Confusion pressure of patient
as soon as trigger zone and existing blood Eye pain  who takes large
possible to peripherally by dyscrasias, bone Fast heartbeat or doses especially if
minimum blocking vagus marrow depression irregular pulse surgery is indicated,
effective nerve in the GI , or liver damage; Rash or hives because of the
dosage. tract and in patients who High or low blood increased risk of
 PUROC, LIZA M.

have shown pressure hypotension

hypersensitivity to Tight throat
perphenazine Vision loss
(perphenazine) Swelling in your
tablets, their eyes, face,
components, or mouth, lips,
related compounds. tongue, throat,
arms, hands, feet,
ankles or lower
legs
Itching
Unusually pale
skin
Unusual tiredness
or weakness

DRUG NAME MECHANISM OF INDICATIONS CONTRAINDICAT ADVERSE NURSING

ACTION IONS EFFECTS RESPONSIBILITY/
PRECAUTIONS
 Generic Depresses brain For the treatment Do not use in Uncontrolled  Don’t open or crush
name areas that control of schizophrenia. patients with muscle ER capsules
Thorazine activity and known movements in  Chlorpromazine
aggression, hypersensitivity to your face, shouldn’t be used to
including the phenothiazines. stiffness in your treat dementia-
 Brand cerebral cortex, Do not use in neck, tightness in related psychosis in
name hypothalamus and comatose states or your throat, the elderly because
Chlorpromazin limbic system by in the presence of trouble breathing of an increased risk
e an unknown large amounts of or swallowing, of death
mechanism central nervous lightheadedness,  Protect concentrate
 Classificati system confusion, from light
on depressants agitation,  Use cautiously in
Antiemetic, (alcohol, feeling jittery, patients with
antipsychotic, barbiturates, trouble sleeping, cardiovascular,
 PUROC, LIZA M.

tranquilizer narcotics, etc.). weakness, breast hepatic, or renal

swelling disease because of
 Dosage or discharge, increased risk of
 Route/freq convulsions developing
uency (seizure), hypotension, heart
I.M.: 25 mg (1 yellowing of the failure and
mL). If skin or eyes arrythmias
necessary, give (jaundice),
additional 25 to fever, chills,
50 mg injection mouth sores, skin
in 1 hour. sores, sore throat,
Increase cough,
subsequent very stiff (rigid)
I.M. doses muscles, high
gradually over fever,
several days— sweating,
up to 400 mg confusion,
q4 to 6h in fast or uneven
exceptionally heartbeats, and
severe cases— tremors
until patient is
controlled. 
 PUROC, LIZA M.

b. Typical Drugs:

DRUG NAME MECHANISM OF INDICATIONS CONTRAINDICAT ADVERSE NURSING

ACTION IONS EFFECTS RESPONSIBILITY/
PRECAUTIONS
 Generic
Blocks
Contraindications: Seizures occur Monitor B/P for
name Concurrent use of other occasionally . hypertension/hypotension.
Clozapine drugs that may suppress Overdose produces Assess pulse for tachycardia

dopami
bone marrow function, CNS depression (common side effect).
 Brand history of clozapine- (sedation, delirium, Monitor CBC for blood
name induced agranulocytosis coma), respiratory dyscrasias.


ne
Clozaril

Classificati
or severe
granulocytopenia,
myeloproliferative
depression,
hypersalivation. Blood
dyscrasias, particularly
Supervise suicidal-risk pt
closely during early therapy
(as depression lessens,
on
receptor
Antipsychotic
disorders, paralytic
ileus, uncontrolled
seizures, severe CNS
agranulocytosis, mild
leukopenia, may
occur.
energy level improves,
increasing suicide potential).
Assess for therapeutic


uency
s in the
Dosage
Route/freq
depression, coma.
Cautions: History of
seizures, cardiovascular
response (interest in
surroundings, improvement
in self-care, increased ability

Tablets brain,
disease, myocarditis; to concentrate, relaxed facial
respiratory, hepatic, expression).

depress
renal impairment; Do not abruptly discontinue

– 25,
alcohol withdrawal; long-term drug therapy.
high risk of suicide; Drowsiness generally

100mg; es the
paralytic ileus; subsides during continued
myasthenia gravis; pts therapy.
at risk for aspiration Avoid tasks that require

orally RAS;
pneumonia; urinary alertness, motor skills until
retention; narrow-C response to drug is
underlined – top established.

disinteg antichol
prescribed drug 272 Avoid alcohol, caffeine.
clozapine angle Report fever, sore throat,
glaucoma; prostatic flu-like symptoms.
 PUROC, LIZA M.

rating inergic,
hypertrophy;
xerostomia; visual
disturbances;

tablets antihist
constipation; history of
bowel obstruction;
diabetes mellitus.

– 12.5, aminic, Pregnancy Categor

25, and
50, 100 alpha-
mg adrener
Tablets gic
– 25, blockin
100mg; g
orally activity
disinteg may
rating contrib
 PUROC, LIZA M.

tablets ute to
– 12.5, some of
25, its
50, 100 therape
mg utic
(and
PO: ADULTS:
Initially, 12.5 mg
once or twice a

adverse
day. May increase
by 25–50 mg/ day
over 2 wks until
dosage of 300–450
mg/day is
achieved. May
)
further increase by
50–100 mg/day no
more than once or
actions.
twice a week.
Range: 200–600
mg/day.
Clozapi
Maximum: 900
mg/day. ne
produce
ELDERLY: Initially,
25 mg/day. May
increase by 25 mg/
 PUROC, LIZA M.

s
day.
Maximum: 450
mg/day

fewer
extrapy
ramidal
effects
than
other
antipsy
chotics.
Blocks
dopami
ne
PUROC, LIZA M.

receptor
s in the
brain,
depress
es the
RAS;
antichol
inergic,
antihist
aminic,
and
alpha-
PUROC, LIZA M.

adrener
gic
blockin
g
activity
may
contrib
ute to
some of
its
therape
utic
PUROC, LIZA M.

(and
adverse
)
actions.
Clozapi
ne
produce
s
fewer
extrapy
ramidal
effects
 PUROC, LIZA M.

than
other
antipsy
chotics.
Interferes with binding
of dopamine at
dopamine receptor
sites; binds primarily at
nondopamine receptor
sites.
Therapeutic Effect:
Diminishes
schizophrenic behavior

DRUG NAME MECHANISM OF INDICATIONS CONTRAINDICAT ADVERSE NURSING

ACTION IONS EFFECTS RESPONSIBILITY/
PRECAUTIONS
 Generic
name

 Brand
name

 Classificati
 PUROC, LIZA M.

on

 Dosage
 Route/freq
uency


risperidone

DRUG NAME MECHANISM OF INDICATIONS CONTRAINDICAT ADVERSE NURSING

ACTION IONS EFFECTS RESPONSIBILITY/
PRECAUTIONS
 Generic
name

 Brand
name

 Classificati
on

 Dosage
 PUROC, LIZA M.

 Route/freq
uency


olanzapine

DRUG NAME MECHANISM OF INDICATIONS CONTRAINDICAT ADVERSE NURSING

ACTION IONS EFFECTS RESPONSIBILITY/
PRECAUTIONS
 Generic
name

 Brand
name

 Classificati
on

 Dosage
 Route/freq
 PUROC, LIZA M.

uency


quetiapine

DRUG NAME MECHANISM OF INDICATIONS CONTRAINDICAT ADVERSE NURSING

ACTION IONS EFFECTS RESPONSIBILITY/
PRECAUTIONS
 Generic
name

 Brand
name

 Classificati
on

 Dosage
 Route/freq
uency

 PUROC, LIZA M.

ziprasidone

DRUG NAME MECHANISM OF INDICATIONS CONTRAINDICAT ADVERSE NURSING

ACTION IONS EFFECTS RESPONSIBILITY/
PRECAUTIONS
 Generic
name

 Brand
name

 Classificati
on

 Dosage
 Route/freq
uency

 PUROC, LIZA M.

aripiprazole

DRUG NAME MECHANISM OF INDICATIONS CONTRAINDICAT ADVERSE NURSING

ACTION IONS EFFECTS RESPONSIBILITY/
PRECAUTIONS
 Generic
name

 Brand
name

 Classificati
on

 Dosage
 Route/freq
uency

 PUROC, LIZA M.

asenapine

DRUG NAME MECHANISM OF INDICATIONS CONTRAINDICAT ADVERSE NURSING

ACTION IONS EFFECTS RESPONSIBILITY/
PRECAUTIONS
 Generic
name

 Brand
name

 Classificati
on

 Dosage
 Route/freq
uency

 PUROC, LIZA M.

DRUG NAME MECHANISM OF INDICATIONS CONTRAINDICAT ADVERSE NURSING

ACTION IONS EFFECTS RESPONSIBILITY/
PRECAUTIONS
 Generic
name

 Brand
name

 Classificati
on

 Dosage
 Route/freq
uency

 PUROC, LIZA M.

DRUG NAME MECHANISM OF INDICATIONS CONTRAINDICAT ADVERSE NURSING

ACTION IONS EFFECTS RESPONSIBILITY/
PRECAUTIONS
 Generic
name

 Brand
name

 Classificati
on

 Dosage
 Route/freq
uency

 PUROC, LIZA M.

DRUG NAME MECHANISM OF INDICATIONS CONTRAINDICAT ADVERSE NURSING

ACTION IONS EFFECTS RESPONSIBILITY/
PRECAUTIONS
 Generic
name

 Brand
name

 Classificati
on

 Dosage
 Route/freq
uency


Assignment:  Drug Study on the following

1. Antipsychotic drugs
PUROC, LIZA M.

a. Typical
b. Atypical
c. New generation antipsychotics
d.
2. Anti-depressant drugs
a. Tricyclic antidepressants (TCA)
b. Selective serotonin reuptake inhibitors (SSRI)
c. Monoamine oxidase inhibitors (MAOI)
3. Anti-anxiety drugs (anxiolytics)

Format FOR THE DRUG STUDY: