Weight Variation Test of Capsules using Statistical Quality Control

OBJECTIVES:
1. To determine the % weight variation of capsules
2. To apply statistical quality control
3. To demonstrate understanding of the operation, use and care of Single Pan Analytical
Balance

MATERIALS:
- Capsules (20)
- Forceps
- Graphing paper, cross-section
- Pencil
- Rule
- Single Pan Analytical balance
- Soft Tissue Paper
- Watch Glass

PROCEDURE:
I. Weight Variation Test
1. Weigh 20 capsules individually using a single pan analytical balance and record
each weight.
2. Find the average weight.
Formula:
Total weight of capsiles
Ave . weight =
20 capsules
3. Determine the % weight variation of each of the capsules.
Formula:
actual weight per capsule
% weight variation= x 100
average weight of capsules
4. The USP requirements for weight variation are met if each of the % weight
variations is within the limit of 90% to 110%.
II. Statistical Quality Control
1. Fill in the date needed in the table, wherein:-
X =weight of each capsules
X́ =average weight
2. Calculate the standard deviation using the formula:-
2

S=
√ ∑ ( X − X́ )
N−1
± S=( X́ )(
S
)
100
Wherein:-
S= standard deviation
N= Number of capsule
3. Determine the Upper Control Limit (UCL) and Lower Control Limit (LCL) uwing
the formula:-
 UCL= X́ +(± S)
LCL= X́ −(± S )
4. Prepare the Control chart by showing the weight of each capsule for y-axis and
the number of each capsule for x-axis using a cross section graphing paper.
5. Plot the graph and identify the X́ , UCL and LCL.
6. Interpret the results shown in the graph to determine if the batch of sample
capsules is in compliance with the USP or not.

Questions:
1. What is Quality Control
2. What is Quality Assurance?
3. What is Statistical Quality Control?
4. Give the importance of Statistical Quality Control in weight variation test.
5. What are the other tests done for capsules that are official in the USP?

The following are the weight of the 20 Capsules in grams

1. 0.5496
2. 0.5677
3. 0.5582
4. 0.5584
5. 0.5388
6. 0.5741
7. 0.5622
8. 0.5468
9. 0.5478
10. 0.5307
11. 0.5573
12. 0.6155
13. 0.5710
14. 0.5586
15. 0.5189
16. 0.5335
17. 0.5444
18. 0.5893
19. 0.5610
20. 0.5533
EXERCISE NO.1 : Weight Variation Test of Capsules using Statistical Quality Control

NAME:____________________________ YEAR AND SECTION: ____________________