INTRODUCTION

TO BIOCHEMISTRY
Jose Philip G. Maglalang, RPh

J.P Maglalang, RPh

 PHARMACEUTICAL BIOCHEMISTRY

WHERE ARE WE NOW?

MODULE 1:
INTRODUCTION TO BIOCHEMISTRY
1. Review of Organic chemistry
2. Basic aspects of biochemistry and its relevance to
pharmacy
3. Biochemical systems and organelles of the living cell
(Review)
4. pH, buffers, and acid-base balance (Review)

J.P Maglalang, RPh

PHARMACEUTICAL BIOCHEMISTRY

ESSENTIAL OUTCOME
Demonstrate understanding of the different
biochemical systems and clinical importance of
biomolecules in the body.

J.P Maglalang, RPh

PHARMACEUTICAL BIOCHEMISTRY

Learning Objective/s
• Appreciate the scope of biochemistry and its central
role in the life sciences, and that biochemistry and
medicine are intimately related disciplines.

J.P Maglalang, RPh

 PHARMACEUTICAL BIOCHEMISTRY

INTRODUCTION

BIOCHEMISTRY

• The science concerned with studying

the various molecules that occur in
living cells and organisms, the
individual chemical reactions and their
enzyme catalysts, and the expression
and regulation of each metabolic
process.

J.P Maglalang, RPh

 PHARMACEUTICAL BIOCHEMISTRY

IMPORTANCE OF BIOCHEMISTRY
LANGUAGE OF BIOLOGY BASIC TO THE
UNDERSTANDING OF THE DIFFERENT
PHENOMENA BOTH IN THE BIOLOGICAL AND
MEDICAL SCIENCES

IT HAS A PROFOUND IMPACT ON OUR

UNDERSTANDING OF MEDICINE, HEALTH,
NUTRITION, AND THE ENVIRONMENT

DESCRIBES AND EXPLAINS LIFE PROCESSES IN

THE LANGUAGE OF CHEMISTRY

IT LEADS US TO A FUNDAMENTAL
UNDERSTANDING OF LIFE

J.P Maglalang, RPh

 PHARMACEUTICAL BIOCHEMISTRY

AREAS OF BIOCHEMISTRY

METABOLISM

• Totality of chemical reactions that

occur in living matter
• Study of the conversion of biological
molecules, especially small molecules,
from one to another.

J.P Maglalang, RPh

 PHARMACEUTICAL BIOCHEMISTRY

AREAS OF BIOCHEMISTRY

STRUCTURAL BIOCHEMISTRY

• Deals with the components of living

matter and the relationship of
biological function to chemical
structure
• Study of how molecules in living cells
work chemically

J.P Maglalang, RPh

 PHARMACEUTICAL BIOCHEMISTRY

AREAS OF BIOCHEMISTRY

MOLECULAR GENETICS

• Concerned with the expression of

genetic information and the way in
which this information contributes to
the regulation of cellular functions

J.P Maglalang, RPh

 PHARMACEUTICAL BIOCHEMISTRY

BIOCHEMISTRY AND MEDICINE

INTIMATELY RELATED TWO-WAY STREET

J.P Maglalang, RPh

 PHARMACEUTICAL BIOCHEMISTRY

BIOCHEMISTRY AND PHARMACY

REVEALS THE DRUG’S METABOLISM,
EFFECTIVENESS, AND INTERACTION OF A
DRUG WITH THE HUMAN BODY

J.P Maglalang, RPh

 PHARMACEUTICAL BIOCHEMISTRY

BIOCHEMISTRY AND PHARMACY

EDUCATES PATIENTS ON ADRS AND DANGERS
OF THE DRUG
• Recommended maximum daily dose for
healthy adults is 4 grams.
• More than 150 mg/kg or 12 g of
acetaminophen
• BIOCHEMICAL TEST
• Liver function test
• Aspartate aminotransferase (AST)
• Alanine aminotransferase (ALT)
• Arterial blood gas
• Acetaminophen level in the blood
• ANTIDOTE: N - ACETYLCYSTEINE

J.P Maglalang, RPh

 PHARMACEUTICAL BIOCHEMISTRY

BIOCHEMISTRY AND PHARMACY

IMPROVE THE PERFORMANCE OF MEDICINE

IN THE FUTURE

ENZYMES TO SYNTHESIZE DRUGS

J.P Maglalang, RPh

 PHARMACEUTICAL BIOCHEMISTRY

BIOCHEMISTRY AND PHARMACY

IMPROVE THE PERFORMANCE OF MEDICINE

IN THE FUTURE

GENE THERAPY

J.P Maglalang, RPh

 PHARMACEUTICAL BIOCHEMISTRY

BIOCHEMISTRY AND PHARMACY

IMPROVE THE PERFORMANCE OF MEDICINE

IN THE FUTURE

IMMUNOTHERAPY

J.P Maglalang, RPh

 PHARMACEUTICAL BIOCHEMISTRY

BIOCHEMISTRY AND PHARMACY

IMPROVE THE PERFORMANCE OF MEDICINE

IN THE FUTURE

PHARMACOGENETICS

African Americans and

Eskimos and Asians
Caucasians

J.P Maglalang, RPh

 PHARMACEUTICAL BIOCHEMISTRY

REFERENCES

• Campbell, M. K., Farrell, S. O., & McDougal, O. M.

(2018). Biochemistry.

• Murray, R. K. (2003). Harper's illustrated

biochemistry. New York: McGraw-Hill.

J.P Maglalang, RPh