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Reling Cinek mdel DNA nephicatien-

o alteanative mec han 'sm habeen Sewe for ineckibna


replkcaten cinculas DA o in Some bocterohoges, mitoehondial
Chtome Soe and n bac fenial naioalle
hatn ReiCincle me kann

AnMecendonuclease
hanis
EnKymeproqutex a nick in the shonderpisin a
sotaeu and faee s'r end
DNA syntheais S-fant b oldi bases at 3'ot end heenyme
DNA lymenase h e un ae ke Stnand as a template andisth
which nols out as a fre tail
as is the
C e s he s en
Cepein s' to 3 dinec bn. is snand is also Cale atStnand
he othernegat ve - SBtano evolves whle serving a template
Yente the naes iver nolig Cincle.
The tail betome linean doubl sanded DaA a4his lineaa Cepy
Can be Corventes tnto double stnanded cntuandlecale

-stan
Strae
nick

Chele rnods

Tail (4s)

euo thestzes sho

We snamd
elngodes due Ho noling tinele

F mdel son reling Cinule rupitoton


eta O)deBpleton
he neplto
struchune onmeodunina
an
intetmeate
A - stuctune , mefecee pokonyote DNA) oneitaten fonks Cah
DJA
aChtab DNA rin and when vienen0 m aheve
and
anoun the N i d
fhocred independent he gnee k kter e: (Hte-ta)
neSembles CairnsC63)
Jokn
discovere by on
brinerbiona
DntA pletoon
Swos
dergtanding
that bdinte
4 lea to e tonkirutud
nodue
Could toke place Stan
One sinan distontinuowy
ynthesize distenténuo u
too nearly
otken
stronroduepmeclure
sttohdanhe
Caledeasng
Calte isHon een obsenvein
he E cet 3erene ond
neplicaton has
Te mode o
Other prokoryot. forks(T-shaeeh)
one Moue
fdue
reptcaton, two nepka
hen DNA oeale
tw hanos ephealing
progrexivekpana tion Sttoret
ue d ew Compleme ntany
ConComi-tant SyntheiiA
7Tere s also s4hong
these two old
Opposite dinec ion on
Ougin
MeplitatH. AA
etoinec'ono

9ntheat

Rataton anbun
he 0XS

teskng
ou Af

i Thea Ce) mbde DN


Atee douyhes
ENA A Replecaton
mel etules

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