Liiuy-proteinCE.TPxPCSk9@clhoee_lipidmaeT.

B
2 ROÉ loa.sn CHOI lipid
-

:
NGHie.im + ✗

1) So sainh - LP vé coin too , dti.nl?Theoca-ut.ao,titson.g

di Ching chthoa
}→
@ . an# CM 1-a- nhiñi 1
,
(pre B- LP ) ← VLDL
-

(B -
LP>←LDL →
Cholesterol nhieei 1

(pre p - -
LP
; B - LP ) ← IDL
-
Chiles = TG -
LP (a) → Cheeks nhién 1 .

It -
LP > ←HDL
→ Protein nhieii 1 .

2) Theo dien di .
Theo tyto.mg
(→ am Nhe.CM
-
LDL -
VLDL

- VLDL , IDL - LDL

HDL
HDL
- .

* Wagg
-

3) Theo chief nñng ① chuytnhoa chows

#Ñ
.

§?mf2 ¥ÉHDL←
tbgan.ru?ot

_ÉwÑ€⑦ -
acetic Protein)
}
am Ipz
( TG
ngoai LDL -4 Hanoi: Sinh
Sinh) (TG n.ir .
= Chows)
Sinh )

HDL :
+ cceipcaiapolp .

+ vchngrio.ccholesthua.tt cat no
ngozi
bien vegan .
 Enzyme
I. Phon teh ch naing eiea N
protein -
LPL :# bt-m.at noi.ms ma.ch main , hhoñboi .

Apo UITM, VLDL .

+ Phai giai TO 0 VLDL cell

th / gia.ch/hoa- lipoprotein male
, .

.
-
ABC - Al : + Egan , thie.org then tirhhoin ,
. (slide SLB ghi 8 tries mom
, )
co

+
Vch
ngwee Chokshi no → HDL .

-
t.cat :
+ noirs treen HDL
,
hhoñ bot Apo A1 / HDL
'

+ este hoé cheeks → Cath tiép nh.tn Chides pines ale HDL .

thou boi Apo F /VLDL HDL LDL

y , ,
.

-
UITP :
+ Vctevyñs Atolls
{ TG
: ten , LDL → VLDL

} → t.ae " % LDL

nhdid.ae + Lpl +1L enzyme,
,
} →
"☐
4th
: u DLD → Happy
,
nhdid.at
-
HL : + trigon
+ plgiai TG vñ Phospholipid ① HDL .

PCSK 9 rain / gon,

- :
+ rgai not LDL R -
, trey
+ ngai gan ti-pnh.in LDL .

-
SRBL :
+
trend ?ii TB, gain , no Hit steroid .

+ apo F- /HDL → Chokshi TB Rio HDL .

Apo :

+ Apo Alf : this HDL → hhoÉ LCAT gin ABC Al Itai TB

,
.

+ Apo B- 100 : treen VLDL, LDL → gin voi CDL - R / gan .

Apo B- 48 train CM
goin thee the logan
'
:
+ → .

Apo C- II i train Cm , VLDL → hhoai LPL

+
.

+ Apo F- : Ko oilmen LDL → gÉ AM rñ VLDL Remnant bin then

'
the
gon .
 >
3. the ten + Nice YN ✗N lipid main .
-
XN din.hhio.org lipid mate CB .

Cmg /dl)
✗ Nghim KTC -
Bien brain KQ Ytnghia ✗N .

Cholesterol } Binh that d nguyin phat : Ditrvseii

I
bi.at?bEi
zoo
toan Phair ↳ II that phat aioño : Giant, Susan, soy DD .

phat tang
TJ that phat nguyen gdtnh : Chiles
AT UÑG .
thieiinñy gigs:
, ATA, then her, vicinity of

} 6-top
-70 " in ""

:{
LDL cholesterol ctvay FriedeWald
:

-
Ko dins Ct rains khi + nhiñi CM
too
LDL - e = Chol tp - HN -
e -1-61, +
Twig LP typ 3

( chiyct
129 (msldl) /
+ TG 2.600 mgldl ( 4,5mmol L)
[
-192,5 de Cordova : LDL C - =

-3g ( Chol tp HPL

- -
c) =

-3g . HDKC
non
lmmek)
Caig WE heir ?
1-DEC phat cheeseherb .

HDL -
cholesterol d : rwgi lipid main
} Binh that
↳°
HDL c this: ngyco tin ma.ch
-
'

60 I ATA lguen .

G-G) nteagcan b TAK

Trigbycerid
, go
/ Binh that -

Mein 8- 12h tuioc ✗N

-
Taino THE TRe.io : ATA, ntui.io Giant, Viens Ivy cat
C) 500mg 1dL)

-
Dip DOTTG → Phe loaf .

-
non -
HDL - C = Echols ✗air

↳ = Cholestp -
HDL - C

↳ béph tin ma.ch

4. Trinh ba-y-RWa.sn lipid mad

1- I Taing lipid mate Nguyen phat HE doing lipid CHE lethe &/ Giant lipid maei Nguyen phot
>

→
N
: do sho.at, ai wig
61 Aint ,
Ceri Aki Chiles -113 main dog .

a) TCholes do TLDL c ( IA ) -

a) LTG , d chows
Hagen 85% → ATRI : aiuong T cholesterol TLDL
tÑÑn )
-
→ , - C .

Do 1100 /
.

Gen troi ,thgT→ d-bgen → chain chuyinhoa LDL c -

→ TLDL e -
mad . khugit apo B → QSxctci.io LP→dT6,
dchol

- Khugit apo B gctiñh → Ko coin

Apo Bloo / LDL + HC Bussen -
Korn zweig ( abetalipopwteinemia) :
ear Apo B- 48, Apo,go
-

to
-
UT sterol th.icv.at chuyinhou
a .
LDL c - t b p -
LP mad : d-bbc.ch Khang
T cholesterol
{ gen let
gentry thg Pr PCSK 9 Binh ut cm ( Anderson) thins apo B-48
:
→ :
-
+
that then the LDL
'
:

b) I HDL - C doin
too = T NG béph ma.ch oath .

b) TTG Choler bthg ( I, II ) I LP Lido: khyit Apo A- I ho.a-etpcl-Tho.ae Aport

, + ✗ -
gidtnh .
+
- I

+ binh Tangier : db ABCAI → o_0 HPL

DOT lipoprotein giant ( cm, VLDL) , phoqi Fredricson 1,4
Lido :
+ TTG giadirh
Thier LPL
R Loop
+

lipid main then phat

.

+ Thief Apo CI 1cm , VLDL + hhooi LPL

'
c- This Apo CIII → ut che LPL
T Chiles tpheii , TLDL
.

a) C d HDI Cor not

, #-)
c) ( IB
- -

T Chows
,
T TG
,
→ bei.nhtimma.ch -
Beophi ,
at nhiéu chutes .

nhei.io gigs Dies there lioititu

(IB)
.

4- do : gdi-nhda.ykith.is
- -

T lipid (think HA)

+

b) TTG LDL Cbthg

1cm
thiÉ
Rlogn p LP main :(3) gaicmva VLDL remnant ,
-

+ LDL VLDL
-
:
, ,
→
- A-n n hiii carbohydrate
ten
.

tb gon
- ATA , cté Khs insulin , than men, then hi .

TCM, VLDL Omani

↳ TTG thui-ngtn.ie
-

Thien lipase
{ CETPThdo.is c) d
VLDL HDL
+
gon → → IDL → - C doh dog
&
IN LDL Theta Cin bees phi , at IFMÉ giant carbohydrate
yup
→ VLDL -É HDL LDL ,
-

- Thuot
, yup , ,, ,
,

d d) TKDL - c doin dig

HDL , LDL nhiéu TG .

☒ HDL in
,
Uoing high
(
-

+ LPL
d) THDL -
C doin dog > ttlenzyme) nhi.d.ae
0-+90 HDL / LDL nhid.at !
Do Khuyit CETP ( leg thg ) -
Thuot .

HDL Chiesa nhieei cholesterol este

→ .

→ HDL -
C Coo . ( 7100mg 1dL)

tatvaitro-euect-tprapcskg.cl
5. Nein torn

lipid twa .
Bb : RLOA.no CARBO HYD Rat + ✗N

→ glucose main glucose mate

Phai tick cthoa ndo?
'
co Chi 1) Hormone :

Insulin glucagon
MATU
- -

glucose -
In#i Incretin
/ GIP ( ltblruo.tl
GLP-1

) tbk
-
GH : T glucagon ,
T
glucose main

- Tz , Ty -
Adrenaline noradrenaline
,
: Tphlgiai glycogen , T
glucose mad .

* GLUT 4 (ME ,
as vain, ✗ g) iphythu-o.co insulin 2) Thgian San En Theo nhucaii chuyinhoa
↳ Ksoat Line true ctargmñn Ih Glucose
>

glucose → = the de.ec 1. : maei I ,

insulin main I→ ME keñh GLUT → mo-nhe.in glucose . . .

2. Sau Cin 21-23h : Glucose meat byinsulin main I

3 . Sau air 12h
Cngwi ) : dring aa lactate ,
tan t.io
glucose
.
→

glycerol ,

3) Hthu + Cthoa glucose

glucose de hthuhtoa-noru.it non , Edgy mono .

a) Fructose : -
tan : Fructose ; facearose = Glu + Fmc .

→ eph.me Na

{
.

+
C / hoot : -
Qua kénh raft GLUT £15 0-ph.ee C- insulin vño TMBa.at Hvyétnho GWTL ( tb gon , niet , tbong then)

-
teh gon tht divao tb gon : Fructose"H=* → 1=1,6 P → Pyruvate → Agt phon .

FIP P Triosephosphat isomerase

fmc Pyruvate - dihidroxyacetoe

{glyceraldehyde
Tain the : F 1,6 P→ Fructose
-

>
+ →
Glyceraldehyde 3- D- AÉ Phai
.
-

( ht.tk) , nose pnogpna kinase

>

choke logibo fmct

'
→ En ai sucrose .

b) Glucose TEN glucose , maltose 2x glucose

.ua?nNaqua+brueg+p/SGlT1iruEtSCtLT2:o-ng-lupnga-n-
: : =
Moai GLUTS
-

=
→
Qua Kinh SGLT doing
-

(gantry)
Vas tb Glut
1,3 I Phy E insulin
-

gon qua
→
Gan :
-

Glucose →
GGP
→
Fructose IQP → - . -
→ Pyruvate CHDRIHMP)

⑨ Gan → Glucose → glycogen =

3 enzyme
{ glycogen → glucose : day nheit Gan Cho Mai Glucose

du.cttthe-khoi.phat Sorin + Béph thieiihe.it : a

[ gaicheyin gala galaction TAE n

→
c) Galactose : -
galac ; lactose ghitgalac
: =

-
Gallet qwa.ru?ot--G#5?SGLT1Crug+)hoa.-etaihtheeSGLT2Co-nghi.in gain)
↳ Hi Ttwan = GLUT2 ( gantry) → Gan

Pyruvat
.

* * .:* Galactose Morose GGP

→ → → ÷.
[
-

Cut Galac -
LP) .
galactose -
l -
P wridyltransferase W
Logi di galac + lactose Khoi bike En UDP-glucose
 Geht beth Sinh
-

d) Trinh boy Titu Chian chain -

1) DE Khag- insulin I Khiém Khuyit insulin

doañ ✗ Cochet being sina.ua -
la- to / to dart wing aia thee the insulin voi insulin
>

- ① tba-opt.uyphi-d.ae d- é bñtni →
T insulin mad → neiiqua-kiulm-giainphi-da.itBB → d insulin
⑦TH -
②
-

D- e- Khang insulin ① tbnao :-, qua tbnao =

glee GLUT 1 GLUT3
,

+ G- RL T glucose mad ,ATD → → insulin ,

T nhc.in glucose Rio nai

2) Hdiei.nl?iKthEtr.imie-nvEitbctaot.uy
↳
} giup-pbi.lt
I nhieii YN roti ATA
typ 2
vs DTD =/ .

Tien Chuen choir doari-DT-D.co 2*5^4 diñi

'
-
San .

④ Glucose Maui dot 7*1-2^026mgldl ( 7mmol K) ( it nhñt 8h nhip dot )

2) Cholesterol maei 7 100 mg 1dL

,
TGS 50mg 1dL
37 crealininnie.ie 7
30mg 124h
42 ④ Glucose main 2h saw nghie.im phat dung nap glucose 7,11mmol 1L 1200mg 1dL)
☒ ③ Glucose mate bait Ki 7,11mmol 1L 1200 ring 1dL ) +
Trlohuñg tsang Cain nhiñe , wing

nhiñi tieie nhiñi ,

gciys.it cain)
, or bien cluing ceip Cela T d-g-
huyét .

④ Hb Alc 7,6 ,
5% ( 48mmol / more )

1,2 , 4 → 2 lain 2 BP =/ nhau

'
3 → Chi cain I lain in those tkheeén .
 Lift Kt Rtchoa DTA voi -
Rot loan chuyin heat ciea ATA
a) T glucose mate thgian ngai
bi ein Chiang ciea ATA
+
BN tieii nhitu ,
uoñg nhieei Chiong ncgciy
Khat )

+ BN rot logntigiac, horine ( tap Kio Hrmañnao )

}
acid bees (Gon) + TTG ma-uthgttn.ec ( T VLDL
trigon too main )

I
+ " ↳he mad & PH mad → tktmau wa.nme.ipz.in
dÉ CoA
acetyl
?
'

d + BN GAI n Harte ( tphgiai glycogen protein dtta-nt.ae

, glucose)
ketone acid ketone
b) T glucose mate dai

+ AYC thuy linh the

>
( T sorbitol que con d-g- polyol ,
TROS )

1- I % HbAlc
,
& doing maes , Talbuminnctieii ( t.io AGE )

{ |
+ ttha-m-thanhma.ch dthi.l.ie
T tap Kéttiñi coin say their map
T thou hoñ myelin béph IN ngogi bien ATA
-

-
Bien cluing ciea ATA

① Bien cluing céptsñh : Hon ME

Glucose main Aton main pH main cetonctieir glucose nctieii

Hori mé do nhiém T T T T TT

}
402 ME celon mate (taps)
+ insulin
mini acid

[
← Tailed lactic ← T catecholamine Horine do tcp-lu.it TT
chuytnhoa T cortisol
tha-mtha-iimanltyp.IS
Horine doting acid T T T
lactic main

}
Atri ATA : thin mi do hg It
-
.

+Thuot hg glucose imam glucose main

+ Chieh insulin Nleieii
-
Bien cluing ciea ATA

a) Bien cheering ma.ch main loin

DM Kinh
T ✗0 Vita
,
T heyét Khoi → ton +hop
{ AM Mai nai
AM ngogivi

b) Bien Chiong ma.ch Marinho

+
Voto m.ae : I th.il.io dry TTT
, .

+
team : tiéu protein, say their tién then
+ Rl Tuññ Hoon Vi mash da : bin chain ATA dogs Chi .

,
. .

+ XO vuiama.cn toein than

c) Binh big than Kirk : meet CGIat

d) Béph ty bañ chain ATA .

=
Bien aui-noma.ae Maui Med + ton '
1716 Then Gogi Bien
4) Trinh tray WE -

Phbiet DTA typ 1,2

cat Logi ATA

typ 1 : 1 a t.ve mien hiei.nl?iKth-e GADA

'

* +
: ✗ ICA , IAA ,
d

lphi.ie insulin) + 1b v0 cén : di tryin mark + t.imieii.cat

Glucose dot

* Type 2
(I phi.ee insulin)
→
: Atari Arian : -
Noel 114 Tien Chi ATA
{ Nghiem pigs
tbAr
( Glucose bait ki
-

demi insulin
{
-
Mod 112 Deir Chi -36 they → e
→
e nhiénnceton

1- GADA C- ) + ICA (t ) + C- peptid 70,6 mmg 1mL .

ATD thai the Loi ATA Kiwi PHAE irons Kleiman6 THAI
+
-

50% Dearth
typ-2-CID-oah-noteie.im
nary as D- TA
+
"" BE
Pteap Duno nap Glucose 13 Lasts / Gio #1

GIE # 2
5) Weir chief ten - Dinh !g glucose mañdoi
'
.

vñ 5nGeia cat ✗N
-
Dinh 1g glucose
'
main bat Ki
lien quan D- ☒
-

Nghiem phat glucose uoñg carbohydrates = < 70 : co-rlo.am

Dinh lining micro albumin ?
glucose .

d) ✗ N chain

doan-l.io?nhATDGia-TR.iBTnHDUio-noCo-nonwE ,
Tierno SE 5n6Hiñ CEUEE Boi

Glucose Mio Tien 0,5mmol 124h . -

Koduñgdeithdoi -
ntneng hier
bath then ATA -

-
T acid ascorbic

Tsalicybt
} tiéu
one

Glucose mat dot 4,4 -5mmol 1L ✗ N Sau 10 16h -

nhin 37 the ✗Nxdiahkhi
180 -
90mg 1dL ) dot . im I lain .

Glucose 7,11mmol /Chidi Reiman

ma-unga-ienhie-nmmmol.tl daiihie.ee ATA ✗dish
(200mg 1dL) nhiñi, uoingnhieei, tiéunhieei,
sateen gas .

Glucose maiesauan 2h ( 6,7mmol / L 711mmol / Ll >200mg 1dL)

tachi doin DTD

Nghiem phat dung nap 27,8mmol / L 1.Glucose dot ( ( 6,1) - Whip dot to -16h 7,8--11 : RL dungn.gs
2 Glucose gie 1 ( CIO) Iduñgthuoo 33 ngciy
Glucose mad d-gtuong . -
.
Glucose

( OGFT) 3. Glucose giE2 -

I duñg vs BN caftan .
311 : ATA
( (z ,
,
or < g ,g ng CE > 1 KQukvueftnouE.no
thai phy ) ↳ ATA Thai ki

.h!g Ah?
HbgA1c_ 0-afdygBNmaei-th-o.int
Ain
'
4.6% , ring
WE -
du: % -

+ doing mai
68 - 126mg 1dL -
chi mmollmol
.
protein +
thai .
+ his nip bitb
( sp amadori : pptlchuénvay :saÉ -
dri .
mgldl :
+
co-albuminonctie.ee
glucose + albumin -
- fructosamiu) Ki? EAG -28,7 ✗ HbA1c -4Gt
>
5,7 -6,6% : the
Latin
'
co

ATA
G) cat Tierno SE DE Bien -
Dinh hipng Creation main

Lucien Rand XN Tint Hirono Ls Befits

Ahh luging glucose ncliéu
A⑦
-

- Dinh buying creatinine nine tiéei

- Dinh lining % Hb Alc .

② ✗N pbie.t-DT-Dtyp-1hayd-kithu-a.tmie-indi.ch
Ktloano Chien Bi.in 5h6 Hia
-

Team
than

Dinh 1g insulin 10 - 30µV /ml %} Binhthat •

Bit Chi ✗A de BN besphi
dot 30
chieadzcdoan DID
f. Bus phiz pb
.
-

de typ they 2

0,8 - 3,1 ng 1mL DwÉ KTC :

typ 1

Ainhlg peptic
'

0,26 -
1,03 mmol / L Trénktc :
trip 2 → insulin ngogisinh

✗ N tin cat t.inthe Cxhoi type 1) ICA

>

{
:
-

GADA
IA -2
IAA
2h -18A

③ XN theo doi , dtribenh

Khodro Team Chien Bien than g- noria Ueoino aiiai.nu

D-
in.hhi.org 1,5 -
2,4 mmol / L T : vain Cori glucose nhiéii . D-
giaksoat nato? glucose Suyddoj , bqinh Prd ,
Fructosamin mad mais 2-3 than treat . ATA Thai Ki .

( = Glu + prhuyit
+ g)
D-in.h.gs Microalbumin Lñtiso 130mg 124h 30-300 tin albumin vilgcldo-onbie-nchgthe.in ATA Nin SD ncliéei
-
VACR : :

netiñi 3300 : time albumin ctgi gidognsorn . +24h

the >
nhiñn CTPHEUACR)
+
Ngai
7) Trinh bay-pha-nloa.it Cochet bein
h
f ① Rl dung nap glucose
Cela tinh thing T glucose mate f- noocii -
Nghiem phef glucose gi #2:38 -11 mmol 1L ( 140 -
199mg 1dL)
Att .

② Rl glucose dot
-
ta b dung nap glucose dot
⑨ 8,6 -
6,9 mmol K CH ki )
( 100 -
125 mgldl)

① 6,1 - 7mmol 1L ( Biot )

( 111 -
126 mg1dL)

③ Bénh f- gñy RLT glucose main .

-
Tires d-1- d- :

+ Q thou tkhuéi ATA

'
+ G- thro > bthgt :

+ IGT
+
IFG
+
%Hb A 1C : 5,7 -
6,4 %)
8) Trinh bay-cao-nhom-bes.in § -

Bein h ut glycogen
chuyénhoa carbohydrate bairn sink
-

Begin UT
doing mucoolysaccaride .

-
Khiñn Khuyét cthoa Fructose

-
Khiein Khuyit clhia Galactose .

Nguyen nha-nga-g.DE Khang IRS -1 bi UI chi bok

-

-
.

insulin a) PKC hogthooi : UE chef phosphoryl hou-eieath.ee the insulin

-

b) Tcytohingñgiiñm : do TROS nix bat .

TDAG
/ 2
Tp oxh ( but not cuing
?
TROS - us o

ngt D- TB )
-
9) Trinh bag co chtjploqi -
Ag ✗ N glucose :

Aia hg glucose main 555mg 1dL ( E 3mmol / ) ing lost , Itn:

L D- TA

f 50mg 1dL ( f 2,8mmol 14 :

tree em

-
T glucagon i T epinephrine , NE ; b GH , tcortisol .

3 logi :
+
d. glucose main Khidr

+
a glucose man-pcifdba-odo.is Sau heh at )
+ to
glucose mat do Carl wing .

HUCK → G b .
 BU :
Hii ctuiñoctwyén two
AD Mein Dien 1 BN Mai d) Theo WHO : 2 D-iñi Kien

HCCH ? Bbñpc ← I ) BN d- a- A chdooñ ATA

a-
It ) Birthed 214 Hui Chi Sau :

+ Glucose main > 130

mg 1dL .
( NP San 2h)

+ BMI 723 , lo > 0,9 Inam) or 0,7 1mi )

+ Huyit of > 130190

+ TG 3 150 ,
HDL C £50
-

2) 171W NHYCC? I 17106 314 Tait:

+ Glucose mate Sau 2h ( NP) 378 mmol It

+ EO > 0,9 10,7 (0-719)

+ TGI 150mg 1dL va-ho.at HDL C

-
-250mg 1dL

+ Creatinine niece > 30 mmg 1mL or albumin nie.at ?

Theo NHLBI ( un ) voi AHA ( Mt ) : tot thief 315 :

1) Glucose mai doi 3100mg 1dL

[ Dieng thu-oih.ae glucose mat

2) HA 3130185
[ Duty thuoi ha HA

3) TG Maui 3150
[ Doing thuo-ih.ee TG mat .

4) HDL -
c L 40mg 1dL (F)
[ HDL
[ -

Duty Thuot tang

C 50
mg 1dL (f)
HDL - c mas .

5) Eo 3 102 ( os ) ; 88 (f)
[ BMI 7 30 kg 1m?
?⃝
2) Trbaj Rloqn Hot sink ,
1) RI Hoa- Sin H

HE Quoi RL B.int ?
- d glucose →
T acid bees →
TTG →
{ Tsinhtb ME

/
15+17-11Aoi
'
THING SO phidaitbmo doing Kinh insulin

tbmo-t.gg-mono.it?eyT-eotoHoa-sinH@HCCH
→ gas. viñn →

Tb ME bi .
Rloqn Ching .

-
Tb gam + co Khani insulin tnioctbmomo .

① R loop mo ME

-
Nhs ME Tkrch think → I drimau cho mo met →
Hoqitri gñyviñn
,

-
Kalia : + T FFA , PAI -1 leptin ARF, TNF-2 IL
, , ,
- 6 → T Khani insulin ( FFA , leptin ,TNEx , Il
-
6)
T tap huyétkhoi ( PAI 1 , FFA I -

② BE Khañg insulin
THA ( ARF Chi RAA ) , FFA , leptin )
.

Tviern ma.ch ( TNF-2 tr adiponectin ) ,

insulin T → Romain T
→
FFA TN FAIL 6 T
,
. .

2) He
? quoi bginh left thdoithso HS -
Rl ① Hate .

{
1) Bees bring + bees phittarn ,
É
gon + mash
+ lo > 102cm 188cm Cos / f)

+ FFFA → Mitty do vegan → TTG

840gonb.my
-

.
-
hog

2)
many
RL

{
→ Leptin T lipid mate : a) TTG do TTG MEME → TTG gan → oho VLDL d-énmo
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