C2132 Úvod do bioinformatiky – seminář

Cvičení 5
Predikce genů

Úkol 1: Jste členy týmu zabývajícího se vlivem radiace na mikroorganismy. Zkoumáte

metagenomické vzorky z bazénu vyhořelého paliva v jaderné elektrárně (spent fuel pool,
https://www.sujb.cz/jaderna-bezpecnost/nakladani-s-vyhorelym-jadernym-palivem/) . Predikujte „geny“
v jedné ze získaných sekvencí DNA. Použijte nástroje Translate
(https://web.expasy.org/translate/) a BLAST (https://blast.ncbi.nlm.nih.gov/Blast.cgi).
1) Odhadněte, jaké proteiny predikované „geny“ pravděpodobně kódují.
2) Z jakého organismu sekvence pravděpodobně pochází?
3) Byla již přítomnost tohoto organismu v bazénu vyhořelého paliva někdy zaznamenána?

Sekvence:
GCAGAAATGCCTTCAGTTTATGCGCGATAACCTGAACGCTGCTGAAGACAATTCTGACCTTAAAAAACTTGAAAAATCTTTCGATATGCTATTC
GATAAGGTTCAGCCGCTTTCATTGGTGGCCAACAACCTTACGTTGATCGTACCGAGCGATTTTTACAAGGAATATATAGAGGATAATTACCTGT
CCCTGCTTTCTGCTGCCCTGAAGAAAAATATTGGAAAAGGAGTGAAATTATGGTATTCTGTGATGGAAAACAGGCCAAAAGGCGAAGAAAAGCC
GGTTACCATGAACATCAAGGGACAAAGCGTTCCTACTCCGAAAACACAGGAAACAATGCCGCAGGGATTCTCTGCCAATATTGTAAACCCATTT
GTGGTTCCTGGAATAAGAAAAGTAAATATAGATTCTAACCTGAAACCTGACTATTCATTCGATAGTTATGTAGAAGGAGAAAGCAATAAATTTG
CAGCAACTGTAGCCAGATCGATTGCAAAAAGACCTGGAGCAACAGCATTTAACCCATTATTCCTATATGGAGGTTATGGAGTTGGAAAAACACA
CCTGGGACAGGCTGTTGGTCTTGAAGTAAAAAATCAGTTCCCTGATAAAGTTGTACTTTATTTATCATCTGAAAAGTTTATCCAGCAATTTATC
TCTGCTGCCAAAGCACACAAACAGACTGAATTTGCGAATTTCTATCAGATGGTAGATGTACTGATTATTGATGATATCCAGTTCTTATCAGGAA
AATCAGCTACGCAGGACAGCTTCTTCCATATTTTTGATCACCTGCATCAGAACGGAAAACAGATTATCCTTACTTCAGATAAGGCGCCTGCAGA
CATTATGGATATCCAAGACAGAATTGTTTCCCGTTTCAAATGGGGACTTTCTGCAGAAATCAAATCGCCGGACCTTTCTACAAGAAGACAGATC
ATTGAAGATAAACTAAGCAGAGACGGAATTGTTCTTCCGGGAGATATGCTGGACTTCCTTGCTGCCGAAGCCAAAACCAATGTAAGAGAACTGA
TTGGAGTAATTAACTCAGTGATCGCTTACTCTACAGTATATAAGAGAGACCTTAGTCTTGAATTGCTGAAAGAAACGATTAACAGAATTGCTGC
CAACCAGAAAAAAGTCATCAATATTCCTTACATCCAGGAAGTGGTTTGTGATTATTTCGGAATTAAAAAAGAGCAGCTGCTTTCAAAAACAAGA
AAAAGAGAGATCGCATTACCAAGACAGCTTGCGATGTATTTCTCAAAAGAATTCACCAATTCCACCTTTACTAAAATAGGTGAAGAAATGGGAG
GAAAAGACCATTCTACAGTAATGTATGCTTGTGATACCATCAAAGACGTATCGAAAATTGATAAAGAAATCAAGAAATACGTAAAAGATCTTAC
TGAAAGAATCAAACAGTAAATAATCACTGAGCTTTAAAATAATTAAAATGAAGAATCGTTGTATTCTTCATTTTTTATTTAGTTTTGTCGTTAA
AAGTCTTTTTTATAAATACTCATATGAAAATATTAATGGTTTGTCTGGGAAATATATGCAGAAGTCCGCTGGCAGAAGGAATTATGAAAACAAA
AGTACCGGACAACTTTGTGGTAGACTCAGCAGGAACCATTTCATTGCACGAAGGAGAACATCCGGATAAAAGAATGAACAGCCTTCGTAGCGGC
GAATATTTTGGGGAAACCAATCAAATGGTCAATTTGGAAGGATTGACCATCACCGATACGGAGTATACTCATCCTTACGTAGACTGGCATTATC
ATGAAAATGCTTATTTCACTTTTCTTCTACAGGGCACCATGACAGAAGGAAACAGAAAAGAAACCTACGGCTGTTCTGCAGGGACATTATTGTA
TCATCATTGGGAAGATCCGCACTATAATCGTAAACCGGATATTTTCACAAGAGGCTTTCACATTGAGCTTTCGCAAAGCTGGTTTGATCGGTTT
GATATTCAGAAAAATAAAGTGGAAGGAAGTTTTAATATCAAAAATCCTGCTTTAAAACTATTGGTTTATCAGATGTTCAAAGAAACCAAAACCA
ATGATATTTCTTTTGATCTAAATATTAATCAGTTATTACTGCATCTTTTCAACCAGTTAACTCATCAGAAGGAAAATACAGAAAGAAAACCTTT
GTGGGTAGGCCGGATCAATGAAATTCTGCATGAAAGCTTTACAGAAAATCTCAGTCTTACAGAACTTTCCAAAACACTGAACATCCATCCTGTT
CATCTCAGCAGGGAATTTCATAAACATTTCCATTGCAATCTGGGGGAATATCTCAGAAAATTAAAGATTAATAAATCAATGGAACTTCTCAATT
CACCTTCTTCTTTAACGGATATTGCTCTGGAATGTGGTTTTTCAGATCAGAGTCACTTTATCCGATGTTTTAAAGAAAATATCGGAATTACTCC
TTTGAAATACAGGAATCTGTTGAAAAATCATTGA

Úkol 2: Zkoumáte různé kmeny Deinococcus radiodurans izolované z různých oblastí.

Predikujte ORF v části genomu této bakterie s využitím nástroje ORF Finder
(https://www.ncbi.nlm.nih.gov/orffinder/) .
1) Jak byla tato bakterie objevena?
2) Jakou přezdívku si vysloužila?
3) Vyzkoušejte predikce ORF s různým nastavením nástroje ORF Finder.
4) Vyberte si tři libovolné predikované proteiny a ověřte pomocí SmartBLAST, zda mají
v databázích homology.
Sekvence:
TCGACCCCCTGCACTACGCGGCGGGCGGGCACCCTGGCGGGGCCATCTACGGCGCGGCGGCTCCGCTGTGGCGCGCTGGGCCGTTTCATCCGCA
GCCCTACCGCCTCGCGCCGGGGCTGTGGCAGGTGGGGACCGGCGTGCATCCCGGCGGCGGCCTGCCCGCGATTTTCGGGGGGGCGCTGATTGTG
GACGGGTTGCTGGCTCTTATACGGCTTTAATCCGATTCCCGAACATCCGGAAAGGCGCCGGATGCCCGTCCATTTGAAACCGTATTACCTCCCT
CTGAACACGAAATACACCGCGCCCATCATGCACAGCGCCGCCCACAGGTAATTCAGCCGCAGCGGCTCGCGCAGGTACAGCACGGCGAAGGGCA
CGAAGACCGCCAGCGAGATGACCTCCTGCAACATCTTGAGTTGCGCGACCGTCAGCACCTGATGCCCGATGCGGTTGGCGGGCACTTGCAGCAG
GTACTCGAAAAAGGCGATGCCCCAGCTCGCCAGCACCGCCAGAAGCAGCGGGCGAGCGGCCATTTTGCCCAGCAGGCCGTACCACGCGAAGGTC
ATGAAGACGTTCGAGAGGGTCAGCAGCAAGGCGGTGCGCAGGACAGGTGACATGCGCGGAGGGTAGCAGTCCCGTGCACAGGTTCGGCGCCGAG
CCCGGGGCGCTGGCGGTCGGGGGGCCGCACCCACGAAAAACCCCCAGCCGCAAACCCCCAGCGGCAGCCGGGGGTCTTGTTCTGCCGGCTGCCG
CTGGGGGTTCGCCCCCCTCTGTGGGGTTACTGCCCGGTGATTGCCTTGAGGGGGTTGACGAGGCCGGAGCCGAAGTCGTTGTCCTTGCCCGCCG
CGCCGAGGTCCTTGGCGGTGGAGGTGAGCAGGTTGAGCAGCTGGGTGTTGGTCAGGGTGGGCTTGGCGGCCCAGACCACGGCGGCGGCGGCGCT
CACGTGGGGGGTCGCCATGCTGGTGCCGTCGAAGAAGTCGTAGTCCGCGCCGGTCACGGCCACGGTGCCGGTGGTCGGCAGCTTGCCCAGCAGC
GCTTGCCCATCGGCCTGGAGAATGCCCACCACAGGCACGCTGTAGGCGTTGGTCAGGCTCGTGCCCAGGGGGCCCGCCGCGTTGTTGTAGATCA
TGACGGCTTTGGCGCCGCTGGCGACCGCGTTGGCGGTCTTTTCCTCGAAAGAGCAGGTGCCGCGCGCGATCAGGGCGATGTTGCCGCTCAGCGC
CGCGTTGCGGGTGGAGGTGCCGCAGAACTCGTTGGCGCCCGCCGTGCCGGTGCCGTCGCCCGCCTTGACGATGGCGCCGCTGAAGGTCGCCTTG
CCGCTCTTGTCCGCCGCGCTCACGTCGGTGAAGGTCACGCCGCCGCCCGAGGCGCTGGCCCTGGTGCCCTGACCGAGCGGAATGCTGCTCAGCA
CGCTCACGCCGGGGCCGACGAGGTCCACCTGGCTGCCGAAGTTCGAGAAGCTGGCCCTGGCCTCCGCGCTGTCGATGGCACCCACGCCCACCAC
GTTGGTGTAGGCGGCGGGGTAGGACACGGCGGCGCCGTCGTTGCCGGTAGCGGCGACCGTCAGCACGCCTTTGTTGTAGACGCTGGTGTAGGCC
CGCTGCTCGGTCTGGCTGGCGCGGCCCCCACCCAGCGACAGGCTGATGACGACCTTGCTCTCGGTGCCGCCCTGCGACTTGAGCTGCGCGGCGC
ACCAGTTGACCCCGTTGATGATGCCGCTCGAAGACCCGGAGCCGTCGTCGCCCAGCACGCGGGCCATGTACAGGTTCACGCCGCTGGCGACGCC
GCCCACACCGTTCGCGTCCATGCCGCTTTGCAGGCCGCTTGCGCCCGTGCCTGCGCCGTACTGGGCGAACACCGTGCCCGCGACGTGGGTGCCG
TGGTGCGACACGTCGTTGAGCTGGTAGGGGTCGTTGCGATTGAGGTCCGCCGTGAAGTTCTTGAAGCCCTTGATTTTCTTCTGGAATTCGGGGT
GGTTGCCGTCGATGCCCGTGTCACCGATGCACACGGCCACGCCCGCCCCGGTGTAGTTGCTGGCGCGAAGCTGCTCGACCTTGAGCGCGTTGTC
GCCCCAGGTGTACTCGCCGCTGGCGGTGTACGGCGGGGTGGTCAGGGCGAGGCTGCTCAGGTTGCCGCCCTTGCTGGCGCCCGCGTCGGTGCTG
CCGCTCTTAAAGCCCTGGGCGCGGCGCACCAGATCAGGCTCCACGTACTCCACCAGCGGGTTTTTCTCCAACTTGCTCAGCGCCTCGGGCGAGA
GCTTGACCGCCGCCGCGCTGATCTCGGTCCACTGGCTGGTCATCACGCCGCCTGCCGCCGTGATGGCCTGCGCCTGCACCGCCGCCTGCTCGCT
CAGGCTCTGGCCCGTCATTCCTTGGGCGCTCAGCGCACCCTGCTTGAAACCGACCAGGTAAGCCCCGGCAATCACTTCGTTGTCCGCGCCGGGC
TGGCTGGTCGCCGGCTGGCCCGCAGTGGGGGCCGGCGTATGAAGCTGCTGACCGCAGGAAGCCAGGGTGAGGGCGAGGGTGGTGGCGAGCAGGG
TGCGGGTGCGCTTCATGGGGCCTCCGGGGAAAAGGGAAAAAGAGTAACGGCCTACCCACGATGGGCAGGCGACGACTTTCTGTCAGGTCCTGAG
AACCGACACCGAATTGAGCTTGGGCGGAATCCTAATGTCCCGCTTATGTTTCACCCACCAGGTTCACTAGACAACTTTTGAACGGGTGCAAAAC
AATGGGTTTTCTCTCTCGGAGAGGCGTTTGGATCGGCCTGGAAAGGTCACAAAGTGAACAATTGGAATGCTGTGCGGTTCCCTGCTGATGACAG
CGGGCCGCTCACGAGTCGATAAAAAGCCCCCAGCTTCTGCGCCGGGGGCCAAATCTTTTATCCATCACCCATCATCTATCAACTGTCACCAGCG
TTCCGTCACCGTCTTGAGCTGCATGAAGTTGCTCAGGTAATCCGGGCCGCCCGCCTTACTGTCCGTGCCGCTCATGTTGTAGCCGCCGAAGGGC
TGCACGCCCACGATGGCGCCGGTGATCTTGCGGTTGAAGTACAGGTTGCCCACTTCAAACTCGGCGCGGGCCTGCTCCAGCCGCTCGCGGGAGT
TGCTGCACACGCCCCCCGTCAGCCCGTACTCGGTGGAGTTGGCGATGTCGAGCGCGTCTTGCCAGTCTTTGGCCCGCAGCACGGCGACCACTGG
CCCGAAGATTTCTTCCTGCGCCAGACGGGAGTTCCGGTCTACGTCGCCCACGATGGTCGGCTGAATGTAGTAGCCCTGCTTGCCGTTCGCTTCG
CCCGTGGCCTCGCCGCCCAGCAGCACTTTGCCTTCGCTGGGGGCCAGTTCCAGATAGCCCTTGATCTTGTTGAAGCTCATCTGGTTCACGACGG
CGGTCACGTTGGCGTTTTCCTCGCCCGTCCCCATCTTGAGGGCTTTAGCCCGTTCCACGAAGCCGTTGACCACTTCGTCGTACACGCTGTCCAC
CACGATCAGGCGGCTCATGGCGCTGCACTTCTGGCCGTTGAAGCCGAACGCGCCCTGCGTGGCGGCGGTAATGGCGTTTTCGATGTCGGCGGTT
TCGTCCACGATCAGGCCGTCTTTGCCGCCGAGTTCCATGATCACGCGCTTGATCCACTTCTGGCCCGGCTGCACTTTGGCCGCCACCTCGTTGA
TGTGCAGGCCCACCGCACGGCTGCCGGTGAAGGTGATGAAGCGGGTTTTGGCGTGCGTGGTCAGGTATTCGCCCACTTCCTTGCCCACGCCGGG
CAGGAATTGCAGCACGCCGGCCGGCAGCCCGGCCTCGCGCAGGATGTCCACCATGAACCCGGCGATCAGGCCCGCATCCTCGGCGGGTTTCACC
ACGACGCAGTTGCCCGCCACGATGGGCGCCGCCGCCATGCCCACGAAAATGGCGCAGGGGAAGTTCCAGGGGCTGATGCTGACGCCCACGCCCA
GCGGAATGCTCATCAGGCCGTTTTCCTCGCCTTCAAACCACGTCGTTTCGCTGCTGCCAAAGCCCGCGTACTTCATGGCGCTGCGGGCGTAGTA
CTCCAGAAAGTCAATCGCTTCGGCCACTTCCACGTCGGCCTCAGCGTAGTTCTTGCCCACTTCGATGCTCATCAGGGCGCAGGCTTCCAGGCGG
CGGCGCTTGAGGATGGCGGCGGCCTTCAGCAGAATGCGGGCGCGGGCGTCCATGTCCCACTTCTTCCAGCTCTCGAAAGCTTTCCAGGCGCCTT
GTAGAGCGTTTTCGGCGTCACCTATGGTCGCTTTGGCGGTGGTGCCCACCACTTCGGAGGTGTCGCAGGGGTTGATGCTCTGAATTTTCCCTTC
GGTGTCCACTTCCTGCCCGTCGATAATCAGCGGGTAGTGCTTGCCAAGGAGTTCTTTCCGAACTTTGGCGAGGGCGGCCTGGTACGCCTGGACG
TTTTCTTCTTTGGTGAAGTCGGTGAAAGGCTGGGGGCGGTAGTCCTGAACTTTAATCATGGTGAGTCTCCTTTAAGAGGCGTGGAGTTCTACGA
AGAGGACGCCGATACGGGATTTGTCTATCGCCAGCAGGCCAACGCCATGTGGTTTGTCGGTGCGGAGCAGGTCGAAGCGGGCAGAGGGACTGAA
GATTTCTAGAAAGGCACAGGCGAGTTCTTTGCGACAGCGTTTGCGAGGATGTCGGTTGATGCCTGTTAGGGCGGAGTAAGCTCGCCGGGCGCCT
ACATCGGCACGGGAGACATAAGAGAGCTCACCATCGGGTGCATGGGCCTTCAGGCTCTCCTGCACGCCTTTTCCACCTCGGCGTGATGCTCCAT
GAGCCCCTGGCTTTGCATCGCGTACCCCCCGGAAGCGGCCCAAGCACGCGCTACAGGCCAAAAGACGGGATTGTTGGCATCCGGTTTGGCCGGG
TAATCATGACCGTAAAGCTTCATGAATTGACTCGATGTCTACAACGATTCAACCCTTCAACATCCCCTGCACCACAAACGCGGCGTTCCTCGGC
GTTTCGGCAATGCGGCGGCTGAAGTACGCATACCAGTCGCGTCCGTAAGGCAAGTACACGCGCACGCGGTAGCCCTCGGCGGCGAGTTGTTTTT
GCAGGTCGCGGCGAATGCCGTAGAGCATCTGGAATTCGAAGGCGTCCTTGCCGATGCCGTGCGCCAGCACAAACCGCTTCACGTCGTCGATGAT
GCGCTCGTCGTGGGTGGCGACGTTGGTGTAGTTGCCCGCCTTGAGGTGCTGAAACACCAGGCGGCGGTAGTTCTGGTCCACGTCGGCCTTGTCG
GGGTAGGCGACGGTAGCCGGTTCGAGGTAAGCGCCCTTCACCATGCGGATGTTGGGCCGCAGGTCGTCCAGCGAGGCGCGGTCGCCCAGCGAGC
GGTACAGGTAGCTTTGCAGCACGGTGCCCACATGCTCGGCGCCGAACTCGCCCACCAGCGTGCGGAACTGCTCCAGCGTCACGTCCACCCGCGT
GTGGTCTTCCATATCTAGGCAGATGAAGCCGCCGTATTCCTTCGCCTTGGCAATGATGCGGCGGGCATTGGTCAGGCCGAGGTCTTCGCCGTTT
TCATCCTTGCCCTGGCCCACGCTGCTCAGCTTGATGCTGACGTAAGGCTTGATGCCGGCAGCGTGCGCGGCCTCGATCAGCTTGATCACGTCGT
CGGCAAACTCGGTGCATTTGGCCGGGCTGTCGATAAATTCGCCGAGCAGGTCAAGGTTCCCGGCGATGCCGTCACGCTCAAGTGCCTGCACGGC
CTGGATAGCGCTTTCAATGCTTTCGCCGGCCACGAACCGTTCGGCGAGATTCCACATCTTCTGACGGGCGAGCTGTTCCACCTGCGGTCGCTCG
GCGACGGTCAGGACGGCTTTGCGGTAAAGCTGGTCAATCATGCGGGGCTCCT

Úkol 3: Zkoumáte různé kmeny Deinococcus radiodurans izolované z různých oblastí.

Analyzujte část genomu této bakterie. Využijte ORF Finder a GeneMark
(http://exon.gatech.edu/GeneMark/).
1) Jak dlouhá (nt) je sekvence?
2) Kolik ORFs predikoval ORF Finder (uveďte, jaké jste použili nastavení)?
3) Kolik genů predikoval GeneMark?
4) Kolik genů je třída 1 a kolik třída 2?
5) Vyberte si pět libovolných predikovaných proteinů a ověřte pomocí BLAST, zda mají
v databázích homology.

Sekvence:
AGCCGGCGCCGGACTTCGGCTTGCAAACACCGGGGGCACACCCAGTCGTCGGGCGCCAGCTTGCGCGCGAGCTGCTCTCGTTTGTTCAGGCGGGAACGGTAGTCGAAAAAGCCCCAGACCGTGACCGCCACCAGTCCCAG
GCCATTGACGAGCACAAATGTCAATTGGCTCGTGACGCGTCCGCCGATGGACAGGGCCAGCCCAAGCAGGCTGGGGCCGCTCGTCAGCGAGAGCAGCAGCAACGCGCCAAAAATGATGATGTGCCAGGGCAAGGTCCATT
CGTCCGGCTGCCAGCGCGCCCAAACGCGCTCCGGGGTGGCCCGCACCCGGTCCCAGCGGCTCATCGGATAACGGCAACGCGGACAATCGCGCCATTCCAGCGCTGCCGGATCGTGCCCCAGGCGTCCCATGCCCGCACTC
TGCGCCGGGGCGACTGACAGTTTTATGCCACTGGCCGCCGGTCAGTCGCTTTGTACAGATTCCGCTTCATTCCAGCACAGTCGGAAAAGCGCCGCCTGTGCTTCCATACCGCAGAATCCGTATTTTTTCCTTCTCGCATC
CGCTCGGATTGAATCCAGTTGTTCTGGATTCAATCGGAATTTGTCTTACTCCGCGTAGATGTTTTCGATGGGGAAGATATGGTCGGCCAGCGCTTCAAGCCCACGCTCGCCGGCGCGTTGCTGGCAGCCTTCGGTGGGCG
TGCACAGCGTCACGTAGCGGGTGCGGCGCGACCCGACGACCACGCGGTACATCTGCGCCTCGCTGCGGCTGCGGGTGTGGTGACACAGGTCGCAGTGCAGGGCGGTGCTGCCCTTGGGGGCAATCGGCGTGAATTCGGCG
AGCTGGTTGCCGTGTACGAGAGCCAGCCGCCCGTCGGCCACCGGGTAAAGCCCCAGGGTGGGCGGGGTGTTCAGCGGACGCTCGCCAAAGATTTCGCGGTACGACTCGGGAAACAGTTCGCGCAGCAGCTCGGCGGCGGT
GTGGGCCTTCTCGCTCATCGGTCAAAGTGTAGGCGGCGCCGAGCTGGGCCATGGGCAACAAGGGTACAAACTCGGCCGTTGCTGAAGCTTCGGTGATGGGGTGGCTCACGGCACGCTTGCAGGGCTGTCTCGCCCGTTTT
TGCTGAAGACGCGGCAGATGGAAGCGAGTCACAGACCCTCGGCGCCTCTTTCTCTAGACTCACGTCATGCGCTCACGCACCGCCAACCGCAGCGGCATCGTCATCCGCCGCCGGGTGACGCCTGCCGGCGACATCATCGT
CACGCTGCTGACCCCCCAGGGCAAGCTCAAGGCCATCGCGCGTGGCGGGGTCAAGGGGCCGCTGTCGAGCAGCCTCAACCTCTTTCACCATGTTGGGGTGCAGGTGTACCAGGGGCCGCACAACGACCTTGCCAGCGTGA
AACAGGCGGTGCTGGAGGGCGCCCTGCCCACCCTGGCCGAGCCTGAGCGCTACGCCTTCGCGCACCTGATGGCCGAATTTGCCGACGCGCTGTTTCAGGAAGGCGAGTTCTCCGAGCAGGCCTTCGACCTCTTCGCCGCC
TCGCTGCGCGGCGTGGCGCACCAGCCCGACCCCGAGTGGGTGGCGCTCGTCATGAGCTACAAGCTGCTCGGACTGGCCGGGGTGATCCCCCAGACCGCTCGCTGCGCCCGTTGCGGCGCGCCCGACCCTGAGCACCCCGA
CCCCCTCGGCGGACAACTGCTGTGCAGCAAGTGCGCGGCCCTCCCGCCCTACCCGCCCGCCGTCCTCGACTTCCTGCGCCACGCCGTGCGGCGCACCGTCCGCGCCAGCTTTGAGCAGCCGGTGCCGAGTGCCGACCGCC
CCGCGCTGTGGAGAGCGCTGGAAAAGTTCGTCACGGTGCAGGTCGGCGGCGTCCACAGCTGGCGGCAACTCGTCCCAAGCGGCGTGCCGGTGCTGAGCTAGAGCATTTGACAAAAGAATGGCCTTGCGCTGTTTGACCCT
CTACCCAGGGGAGAGGGCCTGCCGAAGGCAGAGGTGAGGGGGTCTTTTTCTGTCAAATGCCCTGAGCAGCGGCTACGGCGCACCAACGATGAATGCGCTAGGGAGAGCTGAAAAAGGGCTTGGACTTCTTCACGGCAGCA
CCACTCCCCGCGTTTTCAACTGGCAGACCTCAAATCCCGCGCTGAAACGTCGGCAGGTGGTGTCGGCGGAGAGGTCCGCGCCGTTGTTGTAGCCTCTGCCGCTTCCCATCTGAAGGCTGAGGACAAAGCCCTGTTTCCGC
AGCCAGCCGTCCATTCGCCCGACGCGGCTGAGATAACGCCCGTCCAACCCCGCCGCCGGGCCGCTCACCTTCTGAGGCGTCAGCAACGCACGCGGCGCGGCGGCGTAGAGCTTCGCGGCGTCGGGTTCCTGCCGGGTCAG
CAGCGCCCGGTCACTCGTCCAGAGGGCGAGCAGCGGCCAGCCCCAGCTGAGGAAGGCCAACACAAAGGCCCCCAGCAGCAGTGGGAGCCAGCGGCGGGGCGAGGTCATGGCCTCAGCATGCCGTCATTTCAGGCGGTTGG
CGTCCACAAAACGGATGATTTCGGCCCGCGTGCCGCCCAGCCAGGTCAGGTTGCGCGCCACCGCGCCGATGATGGTGACGTGGTTCAGGCGCGGCAGCACCACGCGCTGCACCGGAATTCGGGCCTTTTGCAGCGCCGCT
TCCATGTTCAGGGCGTTTTGCGGAGCGACCACGGAATCGTTGGCAGCCACGAGCAGCAGATGGGGCGGCGCGTCGGGGCGCACGTGGCGGTCGGGCATGATGTCGTCCGGGTTGCCGTTCTCGGGGAAGGCCACGCGGGT
CTGGTACGCGCGGAAGTCGTAAGAGTACGGCCCGGCGATGCCGATGACGCCGCGAATGCTCGACACCGGCACGTTGACCTCGGCCAGCCAGCGCGCGTTGTCCACCAGTTCCACGGCGTTGAAACCGCCCGCCGAGTGCC
CGCTGACAAACAGGTTGTTCGGGTTGCCGCCGAACTGCCCGGCGTGGTCGCGCAGCCACTTCAGCGCGGCGGCGCCGTCTTGCACGTAGCTGGGGTAGCGGTTTTGCGGCGCAAGGCGGTAATTCATCACCCCGACCACG
TACCCGGCGCGGGCGAGCGACTCGCCGACGAAGGCGTGCCCCGACTTGTCGCCGCCCTGCCACGACCCGCCGTGAATGAAGAGGATGGTGGGTGCGCCCTGGGCGTTTTGCGGGGCGTACACGTCGAGTTTGTTGCGGGT
GTCCGGGCCGTAGCTCTGGTTGAGCACGACCTTCAGGCCCCGCGTGGAATTGGTGGTGTTCACGGCGTTCTGGACCTTCTCGCCGGAGCACGAGCTCAGGACCAGGGTCAGGGCGGCGGCCCCGGCCCCCAGCAGGGCGA
GGCGGCGTAGGGGCAAACGGCGGGCAGTTCGGCGGCTCATGGCGGCCATGCTAGGTCGCCCGCTGCCCGGCAAGGGAGGTGAATCCCACCATGCATCTGGACAGGCGCCGAGTCTAGAGCATTTGACAAAAAGATGGCAC
AGCTTTTTGCGAGCGGACTGGTACAGCTCGTAGAGAGCGAGTGCAAAACACGGAGCAGAACGAAGAATGTAGCGGGTGGCGGTGCTGTTCCGACGCACGCCTAATTCGCAGAACTGCTCTAAAGAAGCGCTCAGGAGCGG
CGGCTCAAATGCTCCAGCCCCCGTCCACCAGCAGTTCCTGTCCGGTGATATACGCCGCCTCGTTCGTCGCCAGAAAGGCAATCGCGGAGGCCACTTCATCCGGCTCACCGAAGCGCCGCGCCGGAATCTTGGCCCGCAGT
TTGTCGGCCTCGGCGGGGTCGGCGTGCAGCTTTTGCAGTCGCTCGGTGGCGGTGTAGCCAGGGGCGACGGTGTTGCAGGTGACGCCATCGGCGGCGACTTCGAGCGCCAGCGTCCGCAGGTGGTTGGTCACGGCGGCCCG
CAGCGCGTTGCTCACGGGGAGGGTCAAGCTGGGCCGCCCGACGGTCAGGCTGGTGATGGCGATGATGCGCCCCCAGCGCCGCTCGCGCATTCCCGGCAGCACGGCGTCCACCAGCCGGGCGGTGCTGAGGAAGGTGGTCT
GAAAGCCCTGCTCCCACGCGGCCTCGGTGACTTCGCTCGGCAGCGAGGGGGGCGGCCCGCCCGCGTTGCTCACCAGAATGTCCACCTGCCCGGCGGCGTCTGCGGCGACCTTCACCCCTTCGGGTGTGCTCACGTCGGCC
ACCACCCACGCCGCGCCAATGTCCTCGGCGGCCCGGCGCAGCGTTTCCTCGCCCCGCGCCGCGAGCGTCACCTCGGCCCCCAGTTCGCGTAGCTGCCGCGCCGCCGCCAGGCCGATGCCTTTGCTGCCGCCCGTCACCAG
GGCGCGTTTGCCGTCCAGCCGAAAGAGAGCACTGTGGGAAGTCATGCGGCAAGTGTAGCGGTCTGGGGTTGAGCCCCTGGGCCGCCCGCCCACGCGCCTTGACACATTCCTCTGCCCCGGCGCCTATGCTGGCAGGGCTA
TGACAGTCATTCTGGGCATCGACATCGGCGGCAGCGGCATCAAGGGGGCGCCCGTGAACACGGAGACGGGCGAACTCGTCGCCGAGCGGCACCGCATTCCCACCCCGGCGGGAGCCAGGCCCGACGACGTGAAAGGCGTG
GTGGCGCAGCTCGTCGAGCATTTCGGGCTGGAAGGGCCGGTGGGCGTGACCTTTCCCGGCATCGTGCAGGGCGGCAGGATTCTCAGCGCGGCCAACGTGGACAGCAGCTGGGTGGACGTGGACGCCGACGAGCTGTTTAC
CCGCACCACTGGGCACGAGGTCTACCTCATCAACGACGCCGACGCCGCCGGGCTCGCCGAGGCCAAGTTCGGGGCGGGCAAGGACGTACCGGGCACGGTGCTCGTGCTGACCTTCGGCACCGGCATCGGCAGCGCCCTGA
TTCGTGACGGAGAGCTCGTGCCCAACACCGAACTCGGGCACCTGTGGCTCAAGGCCAAGCACGCCGAAACCTGGGCCTCCGACCGCGCCCGCGAGCGCGACGACCTGAACTGGAAGCAGTGGGCGGCGCGTGCCAGCCGT
TACCTGCAACACCTCGAACTGCTGTTCTCGCCCGACCTGTTCATCATCGGCGGGGGCGTGAGCCGCAAGGCCGACAAGTGGCTGCCGTATCTCCAACTCACCCGCAGCCGCGTCGTGCCTGCCGCCCTGCAAAACGAAGC
CGGCATCGTCGGCGCCGCCATGCTCGCCGCTTCGGGACCGGTGCGCCGCGAGCAGCCCGCGCCTGCTGGGGAAACACCGAATCAGCCTGCTCGCACGGACGCAAAAAAATCGGACGTGAGCAAGGCCCGGAAAAAATAAG
CGCTGCACTGAGTTGCTCCCTTCCCACTGAACGTCGGAGGGGGCTTTCTTTGCGCTTTTCTGCCGTCAGCCGTCATCATCGGGGCGCTAGCATCGACCCCATGACCTTTTCCGAGGCGACGACTCCCGATGCCCTGACTC
CCGACGCGCATACTCCCCGCCTGCTCACCTGCGACGTGCTCTACACCGGCATGGGCGGGGCGCAGTCGCCGGGGGGCGTGGTCGTGGTGGGGGAGACGGTGGCCGCTGCCGGGCACCCGGACGAGTTGCGCCGCCAGTAC
CCGCACGCCGCTGAGGAGCGGGCCGGCGCCGTCATCGCCCCGCCGCCGGTCAACGCCCACACCCACCTCGACATGAGCGCCTACGAGTTTCAGGCGCTGCCCTACTTCCAGTGGATTCCCGAGGTCGTCATCAGGGGCCG
GCACCTGCGCGGCGTCGCGGCGGCGCAGGCGGGAGCCGACACCCTGACCCGCCTCGGCGCGGGCGGCGTGGGCGACATCGTCTGGGCACCGGAAGTGATGGACGCGCTGCTGGCGCGCGAAGACCTCAGCGGCACCCTCT
ATTTCGAAGTTTTGAATCCCTTTCCCGACAAGGCCGACGAGGTGTTTGCGGCTGCCCGCACTCACCTTGAGCGCTGGCGGCGGCTGGAGCGTCCGGGCCTGCGGCTGGGCCTCTCTCCCCACACGCCTTTTACCGTCAGC
CACCGGCTGATGCGGCTGCTGTCCGACTACGCGGCGGGCGAGGGCCTACCCCTGCAAATTCACGTGGCCGAGCACCCCACCGAACTGGAGATGTTCCGCACCGGCGGCGGGCCCTTGTGGGACAACCGGATGCCGGCGCT
CTACCCGCACACCCTGGCCGAAGTCATCGGGCGCGAGCCGGGGCCCGACCTCACCCCGGTGCGCTACCTCGACGAACTCGGCGTGCTCGCGGCGCGGCCCACCCTCGTTCACATGGTCAACGTGACCCCCGACGACATCG
CGCGGGTGGCGCGTGCCGGGTGCGCGGTGGTGACCTGCCCGCGCAGCAATCATCATCTGGAGTGCGGCACCTTCGACTGGCCGGCCTTCGCTGCCGCCGGAGTCGAAGTTGCCCTGGGCACCGACTCGGTGGCGAGCGGC
GAAACACTGAACGTGCGCGAGGAAGTCACCTTCGCCCGGCAGCTTTACCCCGGCCTCGACCCCCGCGTGCTGGTCCGCGCCGCCGTGAAGGGCGGGCAACGGGTGGTCGGCGGACGGACGCCTTTTCTCCGCCGGGGCGA
GACGTGGCAGGAGGGTTTTCGTTGGGAGTTGAGCCGCGACTTGTGATACACTGTCTCGGTTAGCCCGCTACGCACAGTGACGTGGCAAAAGGAGTCAAAAGATGCAAAAAGACCTGCACCCCAAGGCCGTGCCCTGCAAG
ATCATCTACCAGGGTCAAGTCGTGATGGAAACCATGAGCACCCGCCCCGAAATCCACGTGGACGTGTGGAGCGGCGTGCACCCCTTCTGGACCGGCGAAGAACGCTTCCTCGACACCGAAGGCCGCGTGGACAAGTTCAA
CAAGCGCTTCGGCGACAGCTACCGCCGCGGCAGCAAGAAGTAAACCGCAAGTTTTGCAAGACGCCTCACCCGCACGGTGGGGCGTTTTTTGTTGGGAGCTGCGGAGTTTGCAAAGAGGGGAGGCGAGCCATCTTGGGCCG
CCTCCCCCTCATAGCTTCGTTGTTTACTCTGCCGTCGCCTGCGCGTCCACCCGCGCCAGCTCGGCTTCAATGGCGGCGTCGAGTCGGGCCCGCGCCTCGGCATAGGAAGAAATCACCGTCGCGCCCGCTGCGGGGACGTG
ACCGCCGCCGCCGAGGGCCACGGCGATGTTCTGGGCGCTGACCGGGCCGCGCGAGCGCAGCGAGAACTTGACCCGGTCGCCATAGTCTTTCGCCATCACGGCGAGCTGGGCACCCTCGGCGTTACGTAACATGCTCACGT
AGTTTTCGACCTGTTCCCAGGTAGCACCAGCGCGGGCGAGCATTTCCTCATCCACCCGCGTCTGGACCACCCGGCCACCGTGCAGGAATTCCAGTTTGCCCAGCACCTCGCGCAGCAGCAGGTAGTACGACTGGGGGTTT
TGCCGCATCTGATCGTTGAGCCAGCCGATGCGGGCGCCGTGGGCCCGCAGCCGCGCCGCACACTCGAAGGTCTCGGCGCTCACCGAGTCGAAGGCGAAGTTGCCGGTGTCGGTGTTGAGCCCCAGCATCAGCGGGGTGGC
GACGGCCTCGCTCCAGGGGGCGCCGAGCGCGTCAATCACGTCGGCGACCATCATCGCGGCGGCGGGCTTGCTGGGGTCCACCACGCCGGCGTCCGCGCGGCGCAGGTTGGTGCCGTGGTGATCCACGTTGACCACTGGGC
CGTCAAACTGGGTCAGGTCGGCGCCCGCCACCCGCACGGGGTCGTTGTTGTCCACGTCCAGCACGGCGGCCAGGGCCCCCTGCGGCCAGCTTTCCAGCGGCGCAGTCAGTTCGCCCGGCTGCGGCAAAAAGCTCAGATAG
TGCGGCACGGTCATGGGCGCGAGTACCGTTTTGCCCAGCGTCCGCAGCGCCCGCGAGAGTCCCAGCACACTGCCGAGCGCGTCGCCGTCGGGGTTCTCGTGCGACAGCACCACGATGGGGCCAGGGTGGGCCAGCAGGGC
GTCGGCCACGGCTCCGACGTTCCGCCGGTAATCAGGGGTGGCAGAGTTTTCGGCGGTCATCACTCCCGAGTATAGGTCGGGCGGCTCTTTACGGTCTGCACAGCCGTTGGGGGGATTAAGGGCAAAGCGTCACAATGGCG
CCATGACTGTTTCCCAAGTTTCCACCGGAACCGGCCTCGGCACGCGGCACGTCGCCTTCGACTGGGGCGGCGTTTTTACGGTGGGCACCTTCGATGGCCGCAGCACCCAGAACGTGGCCGAGCGCAGCGGCGTGCCCGTT
GAAAAAGTGCGCGAGAGCTACTTTCGGCACATCCGGCAGCTCGAAGTCGGGGCGTGGACTCTGCCGCAGTTCTGGGAGACGGTGCAGCAGGAAACCGGCATGACGCTGCCCTACGCCGACTTCGAGGCGCTGTACCTCGG
CAGCATCCACGACAACGCGCCGATGTACACCACCCTCGCCGCCCTTCCCCGCAGCGTGCGGGTGGGCCTGCTGAGCAACAATTACCCCGTCGTCAGCGAACACTTGGGCCGTGACCCGCGTTTTGCCCGCTTCGATGCGC
TGGTGTTCTCCAACGAAATCGGCCACAAGAAGCCCGCGCCCGAAGCTTTTGCCGCGCTCGAACAGAAGATGGGACTGCCCGCCGCGCAGGTCGCCTTCGTGGACGACGTGCAGGAGAACATCGACGCGGCGGGTGCCTTC
GGCTTTCATGGCATTCTCTATCACCACGACGCGCACGAGCGGTTCGAGCAGGAGTTGAAGGAGTGGCTCCGGGGCTGAGCGCGGCGGCAGGTTTCGAGGGGCCGCAACTCGCGGTGGCCCTTGCGCGCCACTTGCACGGA
AAAAAGCTTCATTGTGCCCGGCTGGTGAATGTCTGCGACCCATTCCAGCCTGCGCCCGAATGACTGTGCGGTGGCAATGACTCTTCGGTGCCTGGGGCGACGTTGGAATAGTGGAGGAGGGGCGGCTGACTCACCGGACT
CAGGTGGTGTTGTCATACGGTTTCAAATTGAGTCCCGGGCATGTCCGGGCGCAATTTTGCGCGGAGCGCATGAAAAAATACGGTTTTAAGGAGATGGACGGGCATCCGGTGCCTTTCCGGATGTTCGGGAATTGGATTAA
AACCGTCTGAGGGTGCCAGACAGTCCCAGAACCTCCTCTCTGAAGCTCTGTCGAAGCCGCTGACTCCCCACAGCCCGGACTCCTAGGTGGTGTACTTCTCCGGGTGGTGTACTTCGCAGCGTCAGTCGTACACCAGGCCT
AGCGGGCCCCCGTGCCAGGCAAACTGTCCTCACTGAACGAAGGGCGCTGGCCACAGCGAAAGACACCTCCCCACGGTGGGCGAGGCGGCCCTGACTCTCACTCAAGGAGCGACACCATGACCCCCACCCCCAAAACCCCC
GCCGAAATCCTGGAAAAGACCTGGCAGACCGAAGAGCGCTGGCAGGGCATCAAGCGCAACTACACCGCCGAGGACGTCGTCCGCCTGCGCGGCAGCCTGCCCATCGAGTACACCCTCGCCAAGCACGGCGCCAACAAACT
GTGGCAACAGATGAAGGAAATGCCCTTCGTCAACGCGCTCGGCGCCCTGACCGGAAACCAGGCGATGCAGCAGGTCAAGGCCGGCCTCAAGGCCATCTACCTGTCGGGCTGGCAGGTCGCCGGTGACGCCAACAACGCGG
GCCAGATGTACCCCGACCAGAGCCTCTACCCCGCCAGCAGCGTGCCGGACGTCGTCAAGCGCATCAACAACACCCTGCGCCGCGCCGACCAGATTCAGACCAGCGAGGGCAAGAACGACATCGACTACTTCGTGCCGATT
GTCGCCGACGCCGAAGCGGGTTTCGGTGGCCCCCTCAACGCCTTTGAACTCATGAAGGCCATGATCGAAGCGGGCGCCGCCGGCGTGCACTTCGAAGACCAGCTCGCCAGCGAGAAGAAGTGTGGTCACCTCGGCGGCAA
GGTGCTCGTGCCCACCAGCCAGTTCATCCGCACCCTGAACGCGGCCCGTCTCGCCGCCGACGTGAGCGGCGTGCCCACCGTCCTGATTGCCCGCACCGACGCCGACGCCGCCAACCTGCTGACCAGCGACGTCGACGACA
ACGACAAGCCGTTCTGCACCGGTGAGCGCACCCCCGAAGGCTTCTTCTACGTCAAGCCCGGCATCGACCAGGCCATCAGCCGCGCCCTGGCCTACGCTCCTTACGCCGACGTGATCTGGTGCGAAACCAGCGTCCCCAAC
CTGGAAGACGCCAAGAAGTTCGCCGACGCCGTGCACGCCCAGTTCCCCGGCAAGCTGCTCGCCTACAACTGCTCGCCCTCCTTCAACTGGAAGAAGAACCTGGACGACGAAACCATCGCCAAGTTCCAGGTCGAACTCGG
CAAGATGGGCTACAAGTTCCAGTTCATCACCCTGGCCGGCTTCCACGCGCTGAACATGAGCATGTTCGACCTCGCCTACGGCTACGCCCGTAAGCAGATGAGCGCCTTCGTGGAACTTCAGGAGCGTGAATTCGCGGCCC
AGGAACGCGGCTTCACCGCCGTGCGCCACCAGCGCGAAGTCGGCACCGGCTACTTCGACCTCGTCTCGCAGGCGGCGGGCGGCGGCCAGAGCAGCACCACCGCGCTCGCCGGCAGCACCGAAGCCGAGCAGTTCGCGCAC
CACTGAGCTGACCTCAGAAGCTTAACCATGCAAAGGAGCCTCCCGTTCGGGGGGCTTTTTTTCGTGCTGGACACCGGATACCCCTTTCGGATGACGCCGCGCTGCCAGGCCCCCGCTCTCCTGCCGCCATGCCCAGACTC
GCTATATCCAGACTCTGGCCGATGTTGACCGCCGTAGCGCTGCTGTCGCCGCTGGCCACCGCGCAGCAGGGACAGACGCTGAGGGCGGGCGAGCTGACCGTGACCCTGACGCCCACCCAGCCGGACAGCAACGGCTGGTA
CAGGGCGGGCAGACTGGAGCTTCAGGGGACGGACGAGGGGATTCGGGGGGTGGAAACTTCCCGGCTGCGCGGCGCGGTGCTGGGCGAACTCAGCCCGGATGGTCGCTGGCTGAGCGTGCTGGGGACGGGCGGCGGGTATG
TCCAACTGTGGAACGTCGCCACTGCCGAGCGCCAGTTCACTTTCCTGGCGCACGATAAAAAGTCCTATGATGCCCGCCTCGCGGCCTTCTCGCCCGATTCGCGGCGGCTGGTCTTTTATTCCTACCCGAACGAACTGAGC
CTCTGGGACACGGCGACAGGCGTGCGCGTCAAGCTCCTCAGCGACGTGCGAAAGGGAGGCTGGTGGACCGCCGATGCCGACGCCGTGTTCAGCCCGGACGGGAAAACCTTCGTGGTCACGGGCGGCGGGGGCGGGGCGCA
ACTGTTCGACACCCGCACGGGCGACCTGCTCCAGACCTTCGACCGGCCCTGTCAGTCTTTCGGCCCCGGTTCTCCCGGCGGCTTCTGGCGTGGGGCGGTGGGTGCTACCTTCAGCGCCGACGGCAAAAACGTGGCGGTGC
TTTATGCGGGCGGCGCGGCGCGGCTGTACGGCGTAGCCGGGGCGGGGGCGCTGGCAAAAGCGAGCTGGAAACTGGACAACTTCAAACCCTCGCAAATGCGTTTCTGGGCTGGAAAACTGACCCTGAACGGGCGGGAACTG
AGCGGCAAGACTCCGAATGGCCTGAGCTTCACGCTGACCTTCTGAGCCTCCGGCCTCACCCCGGCAAGTTCTCGCCGCAGCGCTTGCAAAACCGCGCGTCGGCGTCGTGCCGGCTCAGGCCGCACTGCGGGCAGGTACGG
CCCCGCCGGGCCTCCTGCGCCTGCTGCAACCCCACCGTGACGATGCCGGTCGGCACGGCGATAATCGCGTAGCCCGAGAGCATGGCGAGCGTGGCGATGAACTTGCCCAGGCCGGTTTTCGGTGAAATGTCGCCGTAGCC
GACGGTGGTCACGGTCACGACCGCCCAGTAGATGCTGGTGGGAATCGAGGTGAAGCCGCTTTCCGGGCCTTCGACCATGTACAGCAGCGTGCCGAACACGATAACCATCGACAGCACCGAGATGAAAAACACGATGATTT
TCTCGCGGCTGGCCTGAAGTGCTTCGCCGATGAGGGCCGCCTGGTCCGAGTAGCGGGCGAGTTTGAACACCCGGAAGACCCGCAGCAGCCGCAGCGCCCGCACCACCAGCAGGTACTGGGTGCCGGGAAACAACAGGCTG
AGGTAAGACGGCAAGATGGTCAGCAGGTCCACCAGGCCGTAGAAACTCAGGGCGTAGCGCAGGGGCCGCCGCGCCCCGAGCAGCCGCAGCAGGTAGTCGGCGGTGAACATCACCGTGAAGACCCACTCGGTCTGCCGCAG
CCGCGCCCGGACCGCGTGCGAAAGCTCGGGCACGCTTTCGAGCGTCACTGCGAGCACCGACGCCACGATCAGGACGATCACGATCTTGTCGTAGGCGCGGGCGGCGGGGGTGCTCAGGCCGAAAATCAGGTTGCCCAGCC
AGCGGCGCCACGGCGGGCGGTGGTCGGGGTGCGGGGGGTCCGGCGGCGGCGAGATCACGGCGGCGAAGATAGCGTCTGGCCTCGCCGCCTTCTGTCGTGCTGTCGGTCAACTGGCCTTTATTCCGGCAGTTCGCCGATGT
TCCAGCCGTCAATCGCGCTGAACCGCAGCGAGAGCGCGGGCAGGTTGATGACCCGGTGGCCCTGGTAGGAGCGCACGTCAATCAGGTAGAGGTGCTCGAAGTACACCGGCTCGTCCGCCGTGAGCTGCTCGGGACTGAAG
ACCGTCCGGGCGGGGTACATGTCGAGCAGGCCTTCCAGAATCTCGGGGTCGCTGTCCGGCGCCGCCTTGAGCAGCCCGCGCATCCGGGCGTTGTAGCCGTCGGGCCCGGCGATGCGGCCCGAGAACATGCTGCCGCCCGA
AATCACGATGACCGGCGGAAACGACACTTCGGGAAAGTCGCGGCTCTCCTCCCAGGCGGGGTCCTGGGTCACGTTGCGGGCGGCCTGGTGGGCCATCTTGGCCTGGTACATCCTCAGGTAGTCGAGTGACATGCCTCTCA
GAGTAATCGGCGCGGGGCGGGCTCAAGCATTGGCTATCGAGACGGGGTGAGGTTGTCGTCTTGCTGGCGGAATGGAGCGGGTGGGTTTTGACGAACAGGACCATGTTATTCAGGGAACTGCTCTAGGCTCGGGACATGAC
TGCCGAACCTGCCGCCACGTCTGCCCCGCTCTCTGGCCCCGTCGCCGTTATCGGCTGTGGCTGGGTGGGCTGGCCGCTCGCCCGCGCCCTGCTCGTCGCTGGAGCGGAGGTGCGCGGCAGCGCGACCACGCCAGAAAAAG
TCGCGGCGCTGCGGGCGGAAGGCGTCGCGGCCACCCGGCTCAGGCTCACGCCGGACACGTCGCCCGAGAGTGACGAGCTGACCGAGCTGCTGCGCGGCGCTCACCGTCTGGTGCTGACGGTGCCCCCAGGCCGGGGACCG
GAACGCGAGCGCTACGCCGAGTATCTGTCGCCCGTGGCCCAGGCCGCCGCGCTGCATGGGGTGAGGCAGCTCATTTTCACTAGTTCTACCGGCGTCTACCCCAACGACCCCCATGTGATGACCGAAAGCGACGCGCTGGC
GACCCCCGATTCGCCTTCGCCGCTGCTGCGGGCTGAGGCGGCGCTCGCCGCTGCTGGCGTGCCCCTCACCGTGCTGCGCTTTGCCGGGCTGTACGGGCCGGGCCGCCCGCCGGGGCGGTTTCTGGCCGGGCGGACGGAAG
TGGGAGAGGGGAGCGCCCCAGTCAACCTCGTGCATCTCGACGACTGTGTGGGTGCGGTGCAGCATATGCTCGGCGGCGATTTCGGCGGGCAGACCTTCAACGTCTGCGCGGCGGCGCACCCGCTCAGGCGCGACTTCTAC
CCGGCAGCGGCGCGGGCGCTGGGACTGGAAGCGCCCTCTTTTGCGCCGCATGAGGGCGGGGGCAAAATCATCGGCAGCGAGGCGTTCCGGGCCGCGACCGGCTACCACTTCCGGCACGACGACCCGCTGAGCGACCTGCA
TACGCTGGGCAACGGGCAAGGCGCCTGAGATGGTCCTTGGCCTGCTCATCCTGCTGCTGCTGAGCCTCAACCTCGGCGGCATCTTCAGCGCGGCGATGCAGTTCGGGCGCCAGGATTTTCTCGCAGGACTCGGCACCCTG
CTGATGGTGGGACTGCTCGACGCGGTGGGCTTCTGGCTGTTGCAGGGGCTGCGCGGGCGGCGCTGAGGACCATTCAGGGCAGAGGTGGCAGAACGCCACAGACGCCCGGCCCCGCACTCTCTACCCTGCCCGGCATGGCC
CACCCTTTTCGCGCCTACTCGCCCGCCGACTTTCACTTTCCGCTGCCCGAGGGCCACCGCTTTCCCTATTACAAGTACGAGGGGGTGAGGGCGCGGCTGACCGGACTGCTGCCGATTCTGCCCACCCCGCAACTGCGCTG
GGCCGACGCAGGGCGAGCGCACGACCCGCTGTGGCTGCGGCGCTGGCGCAGGGGCGAGGTGGACCGGCGCGAGCAGCGCGAGTTCGGCCTGCCCTGGTCGCCGGAAGTGGTCACGCGGGCGCTGCGGGCGGCGGGCGGCA
GTCTGGCCGCGCTCCACGACGCACAGAGCACGGGCTGGGGCGCCAACCTGGCCGGCGGCACCCATCATGCCTTTCATGACCGGGCCGAGGGCTTTTGCCTCGTCAACGACGCGGCGATTCTGACCCGCATCGCGCTCGAC
CGGGGGCTGGCGCGGCGGGTGGCGACCCTCGACCTCGACGTGCACCAGGGCAACGGCACCGCGAGCCTCCTCACGCCGGAAATGGCGGCGGGCACGGCGTTTACCCTCAGCATCCACGGCGAGCGCAACTATCCTTTTCG
CAAGGAACGTAGTTCGCTCGACCTCGGTCTGGGCGACGGGGTGACGGACGCCGAGTATCTGGCGGTGCTGACGGGGCAGGCGCTGCCCGCGCTCGACGCTTACCGGCCCGACCTGCTGCTTTACCTCGCCGGGGCCGACG
TGCTCGCCGGGGACCGCTTCGGGCGCTTTGCCCTGACGCTGAGCGGCGTGAGCGCACGCAACCGGGCGGTGTTTCGCTGGGCGCAGGCCGCCGGGGTGCCCATCGTGACCATGATGGCGGGGGGGTACAACAGCGACCAC
GCGCTGACCGTCGAGGCGCACGCGAGCGTGGTGCTCGACGGTTTAGACGTCCTGGGCTGACCCGTAACCGCTGGGGCTGACAAAGATGTGACCCGCCGCTCAACTCGATTGACTGTGGGTGAAGGCGGCGCCTCATGCCC
GTGCCAGTTCTGACAGGGACAATGTAAAAAGTAAAGCGGTCTGCCACGCTCTGTGCCGGTGCCTGCTCCGATTCTTTCTTCTGGAGGCTTCCTATGTCCCCGACCCCCTCGGCTGCGGCTTTTGCTGCGGCGCCCCTGCC
TGAAAGCCGCCGCGCGGTGCACCGGGGCGAGACGCTCTACTACGCGGGGGACCCCTCGCCGACGCTCTACCGCCTCGAAACGGGGCTCTTGCGGGCGGTGCGGCTCTCTCCGCAGGGCCGTAACCTGACCGTGCGTCACA
TCCAGCCCGGCGACATCTTCGGCGAAGAAGTCCTGCACGGTCAGCCGCGTACCCACCAGCTCGTCGCGCTGACCGACGCGGTGGTCACGCCGCTGCACGTCGAGCAACTCAGCGTGCGCGACCTGTGGGACGTGACGCGC
AGCCTCAGCCTGCAACTCCAGCGGGCGGTGCAGGGCGGCATTCACGTACAGGACGGCGACCTGCGCGAGCGCATCGCCCGCTACCTGCTCAGCCTCGCCGATTCGAGTCTCGGTGGCACCCACCCCGGCGGCCAGCGCTT
CGTGCGCGCCACCCACGAACTCATTGCCGAGGGCACCGGCGCCACCCGCGAAAGCGTGAGCAAACTCATCGGCGAAATGCGCGACGACGGGCTGCTGCTCCCCGCCTACCGCTGCCTGACGCTGACCGACGAGGCCGAGT
TGCGGCGGCTGAGCGGCCTGACCGAGCCGAGCTGAGAGAAGCGGGGAAGACAGGCGCCAGGGCGAAAGCTGCGGCGCCTTTTTCTTGTCATTCCCTCCACTTGGGTAGTTGGCTGGAACTATGCCCGACAGGAGACGCCC
TGCGGCTGTGAGAGCCAGTCCCGCACCTTCCAGACGTGATCGGTCAGCCCGATGGTCATGGCCGGTGTGCGTTGGAGGTACAGCTGACGTCCCTTTGGGACGTCGAGCTTGCTCCGCAGACCCCGTTGAACTCGGCACCA
GTTGTAGATCCCCTGCACCAGATGAGCCAGGCTCACCCGGTGAATCCTCAGCCTCGCGAACGCGAGGCTTTTCCTCGCCAGGTGCGGGTTCATCCGCCGTGCCGTGGCATTCTGACGCTCCACAGCCGAGGTGTTGGGCT
TGTGGTAGCCCAACCGCTGCAACTCCTCGTTCACGCGAACCTGAGTGCCGGCCGCGATCTCGGTGCGCACGTTTACGATGCGCTTCCCGGCATACTCCTTGATGATCCGGACATGGGCTGCGGAACGCGGGATCCGGTAG
GCGGTCTTCGGGAATCGACCACGCGATCCTTGTCTCGCAGGCCGATACGGCCTGCCGAACACTTCAGGGAACAACGTCTGGTACGACAGAAATCCATCGGTGAACAGCACGAGTCCATGCGGATCTGTCAGGCGTGCCCT
GGCGTGCTTGAGGAGCGACTGGGTCAGGGCCGCGGTGCGCTCGCCGATCTCGCCCTGGATCAGGAACTTGCTGCTGGGATCGATGACGGTCGCGTCCCATACCGCCTCTTTCTTGCGCCCGACGAATCCGTAGCGTTCGT
CCGCTTGAATGCTCGTGACCTTCAGGTCACGAGCATTCAGGTCGTGGAGGTGTCGCGCGTGACTTCCGGCAACGCGGACGATCCGCGCGACCGTGGTGCGGTGACACCCGACCAGGTGGCCTGTGGTGACGAAGCTGTTG
CCGTGGGTGACGTGCTCGACGACGGCGTCGACGGTGTCCTGTGAGCAGCGGGCATTCCAGTAGGGCGTGCCTTTGAGTTCACTGAATTCCGCACCGCATGCGGTGCACTTGAGGAGTCGTCGGCGGTGAGGGCCGTATCG
TCTGCGGAGCTTGATGGTGCCGTGTTGCGCGTGATGCTGGGCTGGACAGGCGGGGTTCTGACAGACGAAACGCTCGAGTGGGAGCTCTGTTGACACGTCCGGGGATAGGCCCCGGACGCTCCCATTTCAGTGGTGTCGGG
CATAATTCCAGCCAACTACCTCCACTTGTGCCCACCATGTCTTTTCTGCCCCTGACATCCCGGCTGCCGTACAATCCTCCCCATGCGTATTCGTCTGGACCCCTGGCCTATCGATACTTTTGAGGGGCAACTGACGCTGA
AACCCTTTGCCGGACTGGTCTTCGACGTGGAAACCGACCGCTGGGAGGCGATTCCCACCCTCGGCATCCCGGAGTCCGTGCGCGAGGTGCTGGTGGTGGACGGCAAACCCCGCATGGAGGCGCGGCTGCTGATGGACGAC
GACTCGGGCGAGCTGCACCTCGCGGCGTTTGGGGCGTATGTGGTGGGGGCCGTGAGCCTGTGTCCCCACGGCACGCGGCAGGCCGAGTTGCTCGACGTGCGGGCGCGCCGGGTGCTTGCCTACAGCTCGGACGCGCCGCT
CGAACCTGCCCGCCTCAGCCCACGCAACCCACACACCGGGGTGCTGGACTACGAGCCGTATGCTTTTTCCGGGCGGCAGGTGGAAGGCCCGCGCGCCGCCGTGCAAAAGCTGATGCTGCAAGACGAGCAGAAACTCAGCC
GCCAGCTCGCCTCACCCATCGCGTTGGAGGAAGGCGAAGCCGACGCCCTGCCCGAATCGCTGGTGCTGCAAGACGGCCCGGTGCGCCTCGGCGGGGGCGGCAGCGCGGTGGTGGGCTACGTCAAGACGCTGCACACCGAC
TATCTGGGTGCCGACCGCATCGGCCTGCTGAGCAGCCTGAAATGCGGCGAGCGCACGCCCATCCTGCGCTTCCGGGTGGGGGACCGGGGGGGCACCTTCAGCGAGGCCGAGGGCCGCGAGCAGCGCTTTACCTGGTACGT
GCGGCTGTGCGACGCGCCGTTTTACCAGCACCCGCTCGCCGGCATCATGCGGCTGGAAATGCACGCGCCGGAAGACAGTTCCTTCGTGCCCGCCGCCGTGCAGCAGATTGCCGACCTCTCGGGGGCGCTGCTAAGCAAGC
TGGGCAGCAAGCTTCACAAGGACAGCCGCGCCCCGCAAAACCTGATTCCCACGGCGGCGCTCGAACAGGCGATGAACCGCAGCATGGGCAACCTCGAACTCGTCACCCGGCGCATCCGCACCCACCTGGTGACGCAGGGG
GTGGTGGCGTGACGGGGAATGACGTGCAAGGCGCCGAAAAGGCCGACGCCATCGGCATGGTGCTCGGCACCGAGGACGTGACCCCCACCGTCTTCTGGTTCGCAGTCAGCCACGGCGCGAGCGTGGGCCTCGACGATTTG
GTGGTGGTGGAGACCCGCAAGCCCGACGGCACCCCGGTGCGCTTTTACGGGCTGGTGGACAATGTGCGTAAGCGGCACGAGGGCGTCACCTTCGAGTCGGACGTGGAGGACGTGGTGGCGGGGCTGCTGCCCGCGTCGGT
GAGCTACGCCGCGCGGGTGCTCGTCACGCGGGTGGACCCCGAGAACTTCATCCCCCCGCAGCCGGGCGACCACGTGCGGCACGCGGCGGGCCGCGAACTCGCCATGGCGCTGAGTGCCGACAAGATGGAGGAAGCCGCGT
TTCCCGGTGGCCTGCTGGCCGACGGGCAGCCGCTCCCGCTCAACTTCCGCTTCATCAACGGCGAGTCGGGCGGGCACATCAACATTTCCGGCATTTCGGGCGTGGCGACAAAGACGAGTTACGCACTGTTTTTGCTGCAT
TCCATCTTCCGCAGCGGTGTGATGGACCGCACCGCGCAGGGTAGCGGCGGGCGCCAGAGCGGGACGGCGGGGGGCCGCGCCCTAATTTTCAATGTCAAGGGCGAGGACCTGCTGTTTCTCGACAAACCCAACGCCCGCAT
GGTGGAAAAAGAAGACAAGGTGGTGCGGGCCAAGGGGCTGTCCGCCGACCGTTACGCGCTGCTGGGGCTGCCCGCCGAGCCCTTCCGCGACGTGCAACTGCTCGCGCCGCCGCGTGCCGGGGCCGCTGGGACTGCCATCG
TGCCGCAGACCGACCAACGCAGCGAGGGGGTCACGCCCTTCGTCTTCACCATCCGCGAGTTCTGCGCCCGGCGGATGCTGCCCTACGTGTTTTCCGACGCCTCGGCCAGCCTCAACCTCGGCTTCGTCATCGGCAACATC
GAGGAGAAACTCTTCCGACTCGCGGCGGCGCAGACGGGTAAGGGGACTGGGCTGATCGTCCACGACTGGCAGTTCGAGGACAGCGAGACGCCGCCCGAAAATCTCGACTTTTCCGAACTCGGTGGGGTCAATCTCCAGAC
CTTCGAACAGCTGATTTCCTACCTCGAATACAAGCTGCTCGAGGAGCGCGAGGGCGAGGGCGACCCCAAGTGGGTGCTCAAGCAGTCGCCCGGCACGCTGCGGGCCTTTACCCGGCGGCTGCGCGGGGTGCAGAAGTACC
TCTCGCCCCTGATTCGCGGCGACCTGACCCCCGAGCAGGCCGAGGGGTACCGGCCCGACCCGCTGCGGCGCGGGATTCAGCTCACGGTGGTGGACATCCACGCGCTCTCGGCGCACGCGCAGATGTTCGTGGTGGGCGTG
CTGCTGCGCGAAGTCTTCGAGTACAAGGAGCGGGTGGGGCGGCAAGACACCGTGTTCGTGGTGCTCGACGAGTTGAACAAGTACGCCCCGCGCGAGGGTGATAGCCCCATCAAGGACGTGCTGCTCGACATCGCCGAGCG
TGGCCGCAGCCTGGGCATCATCCTTATCGGCGCGCAGCAGACCGCCAGCGAGGTGGAGCGGCGCATCGTGTCCAACGCCGCCATCCGGGTGGTGGGCCGCCTCGACCTCGCCGAAGCCGAGCGGCCCGAGTACCGCTTTT
TGCCGCAGAGCTTCCGGGGCCGCGCCGGGATTTTGCAGCCCGGCACCATGCTCGTCAGCCAGCCCGACGTGCCCAACCCGGTGCTCGTCAACTACCCTTTCCCCGCCTGGGCCACCCGCCGCGACGAGGTGGACGACCTC
GGGGGCAAGGCGGCGGCGGAGGTGGGGGCGGGGCTGCTGCGCTGAGAGAAGCGGACGATGCTGAGGTTCTGGAGGCGGCAACTTTCGGAGGATGCCTCCAGAACCTTTTGTCGCTACGCTGTCGCCATGACCCGTTCTCG
CCTGCTCACGGTCTGGGCTGCGCTGACCCTCCTGGCGGCACTTTCGCTGTGGGGCGTCACCTTTCTGGATCTGGCCATGGCGGGGCGCACTTGGACGGATGCCGGTCCCTGTCCTTATATGCCCGCCGACTCGGTGCGCT
ACGGCCTGAGCGGATTTCGTTTCTTCTGCGGGCACGAGGCCATTGGCGGCCTGCATCCGAGTTACCCCCTCGTCCTCATCACGCTGGCTCTCAATGCGCTTTTGCTGTGGCTGATGCGGGGCAAAGGCCCACAGGCACGG
CAGATGTTGCGGGTGAACCTCTGGACGCTGCTGCTCACGCTGGGGCTGGGTTGGCCGGTGCTGGCGGTGGGTGAGCGGGTAGAAAACAAATTCCTGGCGGGCGGCGACGTGCTGCGGGCGGAGGCTGGTCCGGCGCTGCT
CCAGGCCGAACGCTGCGAGGTCCGGGAGACAGCAGGGCGCTGCACGCGGCAAAGTCGGCTTTGGTGGCCCAACCCAACGGCGTGGGGCCTCATCGGGCTGGCGCTGACCGGGGCGGCAGGCTGGCGGCGGGGGAAAGATG
AACTTTAACGTCAAAACCCTGCTTTTTATTCTCGCTCCGGTTGTTCTCCTGCCGCTTTTGTTCGTGCTGGCCTATGTCTGGCAGGCGGGGCTGGACCTTCACAGTCCGGCCAATGCCCGTCGGTGGGTCAACGTGTGCGC
CCGCAGCCGGGAAGACCTCTACTGCAAAGCGGCGGCGCGGGTGTTGCGCGGCACGTCTGGCCCCATCGTCTTTTTGCATCCCAACAAGGGTGACCACGAAATAACCGCCGACCTCATTCGCTGGAAAGGCCACCCGCCGA
CCCGCGAAGAAGCGGAAGCGGTGGCCCGTGCCAATCTGTTTGCAGCTCCGCAGTTGCGTGAGGGGTGGGCGGCATCGCTGGACGGACAGCGGCGGCAAGTGAAGCTGAGCTTGCCGGAGAGTCGCCATCTGGGCCAAGTT
GGACAGTTGCGCTTCGGTCTTCCGGCCAAATCAGCGGTGGAGGCGGCGCGGGAGGGGACAGTGTATCTGGTGACGGACCCGGCTCATCAGCGGGACTTTTTTCTGCCCGCTGAGTAGGCTTCTACGACCTCCCGAATCCT
CCGCGCCCCTGCCTGTGCCTCCTTGACCGTCAGCCCGCCGTAGCCCAGCACCAGCGCGTTTTTTGGCGGTCAGTGAAAGTGAAGGTCCGCAATGTCTCCACGTACACCCCGCGCTCGGCGAGTTCCTGCGCGACGGTCTT
CGGCGTCTAACGGCGGCGCGAGGTGTAGGCAAACATGCAGCCCGGCCTCAATGCCCCGCAGTGTGGCAAGGGGCGCGAGCGGGGAAAGTTCCGCCGTCAGAGCCTCCCGCACCTGCGCGTGCCAGCGCCGGGCGCGGCGG
ACATGGCGGTCCACCTCGCCGGAAGTCAGCAGGTGCAGCAGCGCGTGCTGAAGCGCCGGGGCGTGGCCCCCGTCGGTCAGGGCGCGCTCATGGCTCAGGGCGGCCAGCAGCGCCGGGGCCGCCACCACGAAGCCGGTTCT
CAGCGCCGGACTCAGAACCTTGGAAAAGGTGCCGAGGTACACCACCCGCCTCGCCGTGTCCAGGCTGGCGAGCGGAGGGAGTGGCGGCACGTCGTAGCGGAATTCGCCGTCGTAGTCGTCTTCCAGAATCAGCGCGCCCT
GCCGCTCGGCCCAGGCCAGCAGCGCGAGGCGGCGCGGCAGGCTCAGGCGGCTGCCGAGGGGGAACTGGTGGCTGGGAGTGACGTAGACGGCGTGCGCGGGCGGCAGGTTGTCCACCACTGGCCCGTCCTCGTCCACCGGC
AGCGGCACGAGGCGCAGTCCGGCCCCTTCCAGCACGGCGCGGCCCGCGCGGTAACCGGGGTTCTCAAACAGCACCGTCGCTCCCGCCGGCAGCACCGCCCGCGCCAGCAGGCCGAGGCTTTGCAGGGTGCCTGCCGTGAG
CAGCAGCGTATCCGGTGTGGCCGCCAGCCCCCGCGAGCGCCCCACGAAGGCGGACACCGCCGCGCGCAGTTCGGGCAGGCCCGCCGCGTCCGCGTAACCGCCTCCCACCGGCTGCCGCGCCGCGTAGGCCCAAGCGCGTT
TCCAGGCCTGCGCGTTCAGCATCGCCGCCGAGGTGACGCCCGTGCGGAAGTGAAGGCCGGGCCGCTCGTCGCTGTGCATGCCCGGGGAGGGCACACGCGGTGCAAACCACGCGGGCGACGGTGCGGCGGCCTGCGCCGTG
CGCCCCACGCCCCGGCTGACCCGGGTGCCGCGCCCCACCTCGCCTTGCAGCGTGCCGTCGGCGGACAGCAGCGCGTAGGCGGCCTCCACCACGCCCCGCGTCACCCCGAGGTCACGGGCGAGCGTGCGCGTGCCCGGCAG
CAGACTTCCGGGAAGCAACTGCCCGGCCAGCGCCGCTTCGCGCAGTTGAGCGGCGAGTTGCAGGTGGATGGGCGAAGGGCCAGCGCGGTTGAGTGTTACGGCAAAAGGCAGGTCGGGCATGGGTGGCCCCCGCATTCTGT
AAAAAAGTGGAGCTTTTGCCAAGCCGGTTTCCTCGCTACCTTGCCGTCGTGCCGCACAGCACTTCCTGTCCAAATCTTGAACCCCGCCCAGCAAATCCGCTGGCGACAAGGAGAACTACGATGTCTGACCCCCGATATCC
CATCGGCCCCGCGCCCGCCGTCCAGACCCTCACGCACGAGCAGCGGCAGGAGCGGCTGGCCCACCTGGCAGCACTGCCAGAAGAATTTGAGGCGGCGTTTGCGGGCCTCAGCGACGCACAACTGGACACGCCCTACCGCG
AAGGCGGCTGGACCCTGCGCCAGCTCGCGCACCACGTTGCCGACAGTCACCTCAACGCCTATGTCCGCACCAAGCTGGCCCTGACCGAGGACCGCCCGACCGTCAAAACCTACGAGGAAAACCTCTGGGCCGAGCTGCCC
GATACGCGCGCCATCGCGCCGAGCCTCGACCTGTTGCGGGGCCTGCATCGGCGCTGGGTGGCCGTGCTGGAGAGCCTGACCCCTGAGCAGTGGGCGCGCGTCTTCGTTCACCCGGTCAGCGGTCCCAACACGCTCGACAC
CATGCTGGCCTACTACACCTGGCACGGCCAGCACCACACCGCCCACGCCCTGAACCTGAGACAGGAGCGCGGCTGGTGAGCGACTTCTACGACCCCCGCGAGCGCGACCCGAGTGTCAGCCGTCGCCCACAAAATCGCCA
GTCCGACGAGTGGATTCGGGAACTGCTGCTGCGCGGCACGATTGCCCGTGTCGCCACCCTCTGGCAGGGCGAGGACGGCGCGGCCTTTCCCTTCATCACGCCGCTGGCCTACGCTTACCGCCCCGAACAGGGCGACCTCG
TGTACCACACCAACGTCGTGGGGCGGCTGCGGGCCAATGCGGGGCAAGGGCACCCGGCCACACTGGAAGTCTCCGAAATCGGCCAGTTTCTGCCGAGCAACTCGCCGCTCGAACTCAGCGTGCAGTACCGCAGCGTGATG
GTCTTTGGCACGGCGCGGGTGCTGGCGGGCGAGGATGCGCGCGCGGCCCTCACCACCCTCTCCGAGCGGGTGTTCCCTGGTCTGAAAGTGGGGGAGACGACCCGGCCCATTTCCGAGGATGACCTCAAGCGCACCAGCGT
TTATAGCCTGTCCATTGACCGCTGGAGCGGCAAGGAAAACTGGGCCGAGCAGGCGATTCAGGAGGAGGACTGGCCGGCGCTGGGGCCGGAGTGGCTGGGGTAAAGCCTTGCTGTTCCGAGGAGCCAGAGCCAAAAAAGCG
GGCGGAGGATGAGTTCCCCCGCCCGCCTGCTCGCTCCGTCCTCAGAAAATGCGCGGGTTCGGCGCGATGTCCAGCGTGTTGTCGAAGTCCGTTTCGTCGGCCCAGACTTTCATGTTGACCAGCTTGGCGCTGCCGAAGGA
GGTGGTGAACGCCACGTCGGAAGCGTCGCGGCCCTGCGCGATCAGGACACGGCCCGTGCGGGGAATGTTGTGGCGGGCGTCGAAGGTGCGCCACTCGCCGTCGATGAAGGCCTCGAACCAGGCGTGAAAGTCCATCGGGA
CGGGATCGGGCGGATAGTCGATGTCGGGCATGTACCCGCAGACATAGCGCGCCGGAATGTTGAGCGCCCGGCAAAACGCCACGCCCATATGCGCGAAGTCGCGGCACACCGCTCGCCCGCTGCCGAGGGCCTGCGACGCC
GTGGTGGTCGAGTTGGAGCCGTAGCCGTACACGCAGGTGTCGAAGAGGTAGTCGCACACCGCCTGCACCTGCGCCCAGCCGCCCTGGACGTTGCCGAAGCGTTCCCAGGCCTCGGCGCTCACGAGGTCGCTGTCCACGTA
GCGGCTCGGCAGCAGGTACTGAAGTACGTCGTCGGGCAGCTCCTCCACCATCATCTTGCGCAGGCCCGGCAACTGCGGGTCGGGGCGGCGCTCTATCTCGGCAATCAGGTCGTGCCCGATGGTGAACTCGCCCGGCTGCG
CCACCGTGCGCCAGATGAGGTTGCCGTGGGTGTCGGTGTAGGTGTGGATGCCCTCGGCAGCGGCGAGCGGGCGCTGGTCGATGATGCGCTGGCGGGTGCCGGTGGGGGAGAGGCGGTCTTGCGGCTGAACGACAAAAATC
ATGGGCGTGGCGTAGGGCACGTCGAAGGTGAGCGAGAAGCCGGCCCGCACCCTCACGGGCTTTTCAAAAGGGGAATCCTGCCGGGGCGTGTTGGTCATTGTCATGGCACAGTTTGCCGCTTGTGGGGGCCCCGTAGGTGT
GATGCCTATCCCACAGGGACGATTTTGTCTGGGTCGGGTCTGTTTGAGCCGGCTGCCTAACTGTTCATGCAGCCCCGCGCAGGACCTTGTGTCGGGCTAGCCTGCCCTATGCCCAACCGACTCGCGCAGGAAAGCAGCCC
GTACCTTCTCCAGCACCAGGACAACCCGGTGGACTGGTGGCCCTGGTCGCCCGAAGCCTTTGCCGAGGCCCGGCAGCGCGACGTGCCGGTACTGCTTTCGGTGGGCTACTCCACCTGCCACTGGTGCCACGTGATGGCGC
ACGAGTCGTTTGAGAACGAGCGAACGGCGGCCTTCATGAACGCCCACTTCGTGAACATCAAAGTGGACCGCGAGGAAAGGCCCGACGTGGACGCGGTGTACATGGCCGCCACCCAGGCGCTGACCGGGCAAGGCGGCTGG
CCGATGACGGTGTTCCTGACGCCCGACGCCGAGCCGTTCTACGCGGGTACGTATTTTCCGCCGCAGGAAGGCATGGGGATGCCCAGTTTCATGCGGGTGCTGGCGAGCATCGACGACGTGTGGCAAAACCGGCGCGACCA
GGCACTCGGCAACGCGCAGGCCCTCACCGAGCATGTGCGCGGGGCGAGCCAGCCCACGCGGCGTGAGGGCGAGTTGCCCGGGGGCGCACTGGCCCGCGCGGTGGAAAACGCTGCCCGGCTGTACGACGCGCAGTTCGGCG
GCTTTGGCCGGGCACCCAAGTTTCCCGCGCCCAGCACGCTGGATTTCCTGCTGACCCAGCCACAGGGCCGCGAGATGGCGCTGCACACCCTGCGGATGATGGGCGCGGGCGGCATCTACGACCAGCTCGGCGGCGGCTTT
CACCGCTACTCGGTGGACGCGCAGTGGCTCGTTCCCCACTTCGAAAAGATGCTCTACGACAACGCCCAGCTCGTGCGGACGCTGCTGCGGGCCTATCAGCTCACCGGAGAAGACGACTTCGCCCGCCTCGCCCGCGAAAC
GCTGGCTTATCTGGAACGCGAGATGCTCGCGCCGGACGGCGGCTTTTACTCTGCCCAGGACGCCGATACTCCCACCGAACATGGCGGCGTAGAGGGGTTGACCTTCACCTGGACCCCCGATGAAATTCGCGCGGTGCTGG
GTGAGGACGCCGATTTGGCGCTGCGCTCCTTCAACGTGACCGCGCAAGGTAATTTCCGCGACCCGCACCAGCCCGCTTACGGCAGCCGCAACGTGCTGCACACGCCGACGCCGCTGCCAGCCCTGGCGCGCGAACTGGGA
GACGACGCCGCTCAGCGGTTGCAGGCGGCGCGGGCCAAGCTGTTCGCCGCCCGCCAAGTGCGCCCGCAGCCGCACACCGACGACAAGGTGCTGACCTCGTGGAACGGGCTGGTGCTGGCCGCGCTGGCCGACGCCGCGCG
CATTCTGGGCGAAGAAAAATACCTGGACCTCGCCCGCCGCAACGCCGACTTTGTGCACCGTGAGCTGCGCCTGCCAGGTGGCACCCTGCGCCACACATTCAAGGACGGGCGGGCCAGCGTGGAAGGGCTGCTGGAAGACC
ACGCGCTTTACGGGCTGGGGCTGGTCGCGCTGTTCCAGGCGGGCGGCGACCTCGCACACCTGCACTGGGCGCGCGAGCTGTGGAACATAGTGCGGCGCGACTTCTGGGACGAGGGAGCAGGGGTCTTTTACTCCAGCGGC
GGGCACGCCGAGACGCTGCTGACCCGGCAGGCGTCCTTTTTCGACTCGGCCATTCTCAGCGACAACGCCGCCGCCGCGCTGCTCGGCGTATGGATGAACCGCTATTTCGGAGACGCGGAAGCCGAGGCCATCGCCCGGCG
CACCGTCCAGAGCTTCCATGCCGAACTGCTCGCCGCGCCGACGGGTCTGGGCGGGCTGTGGCAGGTGGCGGCGTTCCTGGAGGCGCCGCATACCGAAATCGCTGTCATCGGCACTCCCGCCGAGCGGCAACCGCTGGAAC
GCGAACTGGCGTGGCATTTCCTGCCCTTCACGGCTCTCGCCCCCGCCGACGAGGGCGGCGACCTCCCAGTGCTAGAAGCGCGACCCGGCGGCGGACAGGCGTATGTGTGCGTGAACCACGCCTGCCAGTTGCCGACCCGG
GACCCGGCAGAGCTGGCGCGGCAGGTGGCGGCGCTGTAAGTGGGCAAAAGGAAAGGGCCAGAGCAGTGGCATGTGCTCCGGCCTTTTTTGGATTAGAGGGGTGTTCTGGGACTGATTCGCCAATAGACTTTATGCACCTC
GCTGTCTGCCAGTGTGACCCGCAGCCACCAGAGCATTTGACAAAATAATGCCCTGCATTTTTGACCCTCTACCTTCATGGGAGAGGGCCTCGCGCAGCGAGGGGTGAGGGTGTCTTTTGCTGTCAAATGCTCTAGCCCTG
CGTTCCGGCAAACACGTCCCGCTGGTCTCTGCCCAGTGGTCCTTCTGCCTTCCGCCGCCACGTTATGTGCAGTGTTCAGCACCATCAGAGTTAATGCTTCCGTTTCATTCCCGCTTTGCTAAGGCGCTCAAAATCTCATT
CTCGCCAGAAGAAATGCGCCCTCCGACCTCCACCTGTGCAGAGAACGGGGGGCCGAACACTTCATTCAGCGCGTCAGCTCCTGCACCCCGTCCGGCGCGGCCACGAAGGCCCGCTCGGCCATTCCCAGGAACAACCCGGT
GTCCACCACCCCGAGCGTGCCCTTGATGCGGCGTTCCAGTTCGCGGGCGTCAAACTCGGCGGGCAACTGCGCGTCGAAGATGTAGTTGCCGTTGTCGGTCACGTAGGGCTGCGCGCCGGGCTGCCGCAGACGGCCACCGG
GCAGAAATTCGCGCAGCCGCTCGATGGTGGAGAGAAAGCCGAAGGGCACAATCTCGATGGGCAGCGGTGCCTTCTCGCCCAGCCGGGTCACCAGTTTGGTGTGGTCAGCGATGATAATCAGCCGCTTCGCCTGCACCTCG
GTCATCTTCTCGCGCACCAGGGCGCCGCCCAGCCCCTTGACGAGGTCCAGATTGGGCGCAATCTCGTCAGCGCCGTCAATAGCGATGTCCAGCGGGCGCGGGTCGAGCGGCTCGGTCGGAATGCCGACCTCGCGCGCCAG
TTTTTCGCTCGCCTCGCTGGTGGACACGCCCACGATGCCGCTCAGCTCGCCCGCCGCTAGCTTGCGTCCTAGTTCTTCAATCGCGTATTTGGCGGTGCTGCCGGTGCCCAGGCCGACCCGCTGCCCGCTCTGGACCAGGG
CGACGGAGCGCAAAGCGGCTTCTTTTTTCAGGGCTTCAAGGTCCATCAGGCCTGGCCCTTCTTTTGCAGATCCTTGTCAATCGCGGCAGCAACCGCGTCGGCGTGTCCGTCCACCTGCACCGCCAGCCACGACTTGACGA
GTTTGCCGTCGGGGCCGATCAGGAACGTCTGCCGCTTGACGCCCTCGCTGGTCTTGCCGTACATCGTCTTGGGGCCGTAGCTGCCGATGGCCCGCAAAAATTCGGCATCCGGGTCGCTCAGCAGCGGGAAGGGCAGGCTG
TACTTGTCGGCAAACTGCTGGTGGCTCGCGGCGTCGTCGCGGCTCACGCCCAGGATGACCGCGCCGTGCTGCCGCAGGAGCTGATGGTCGCGGAAATCACAGGCTTCCCTGGTGCAGCCGGGGGTGTCGTCCTTGGGGTA
GACGTACAGCACGACGTATTTGCCGTCGTACTGGCCCAGGCTGTGCAGGTCGCCCGCCGCGTCGGGCAGCGAGAAGTCGGGGAAGGTGTCGCCGGGCTGGAGGCGCGCCACTTCGGGCTGAGTGTCCGGGCTCTGGGAAT
CAGAATCGGTCATGGCTACAGGGTAAACGCTCAGGACTTGGGATACAGCACGGCCTGGGTGCAGCGGAACAGCGCCATCACGTTGCCCTGCTCGTTGCGGACCTCGGCATCCCAGACCTGGGTGGTGCGCCCGGCGTGCA
CGGCGCGGGCTTCACAGGTCACGACGCCCTGGCGCGAGGTGCCCAGGTGATTGCTCTTGAGTTCGATGGTGGTGAACCCGGTCGCCTCGTCGGGCAGCAGCACGCGGGTGCCGTAACCGCAGGTCGTATCTGCGAGCGCC
ACCACCGACGCCGCGTGCAGGTAGCCGTTTGGCGCGAACAGTTCGGGCCGCACCGTCAGCTCGGAGCGCAGCAGCCCGCGCTCAATGTGGGTAAATCGGATGCCGACCATGCCGGGCAAAAAGCCCTCGCCGCGCTCGTT
CAGTTCTTCAAGGGTGGGAAGGGGACGCATGGGGCCACTGTAGAGGGTCGGGCGGCCTCTCGGCTCGCCTCGCTCTACACCTCCCCGGCCTCACGGCCAGAGCTTGCCCATCCACCCCGCCGGGTTGGTGCCTTCGCCGC
GCACCCGGACTTCGAGGTGCAGGTGCGGCCCGGCACTCAGGCCGGTGCTGCCGACCTCGCCCACCTTCTGCCCACGCTTAATCTGCTGCCCCACCTTCGCCGTCACTTTGCTCTGGTGGAAGTACAGGCTGACCACCCCG
GCCCCGTGGTCGATGACGACCAAGCCGCCGCGCACCGGGTAGCGGCCCGCGATGACCACCGTGCCGTCGTTGATGGCGAGCACCGCTGTGCCGCTGCGGGCGGGGTAGTCGGTGCCGTAGTGGTAGGCGACCTTGCCGCC
CGCAACGTAGGTGCGCGGCTGCCCAAAAGAGCTGCTCGTGGCTTTACCGCTCGCGAGCGCGGAGGCGAAGGGCTGCTGCCACTGCTGCGGCGTGCGGCGCTGGTACGCCTGTTCCACGGCAGCGTCCTCGGCTTCGCGCG
CGGGGTCTTGCAGCACTTTGCTGATGCTCGGCGGCAGGTTGAGGTGCTGCACCCGCTGCCCGAGGTCGCCCACCGGAATCTGTCCGCGCACCACGTCGCCGCCCAGCCGCACCTCGTAGATCACCGGGGTGGTCTTGCCG
AGCACCACCCGGCCCGGCACGATGTACTGCCCGCTGCTCCACAGGGGCCGCAGTTCCTCGTTGGGCTGCCGCACGTCCTCGCCGAGTTCACTGGGAAAGCGCACCGTCACGTTCGCCGCCTGCTCGCCGCTCAGCCGCAG
CGCGAAACCGTCGCCCATCTTCAGGGCCTTGGGGGCCGTAATCGTCACGCCGGGCAGCTTGAGCACGTTGGCCGCCGTCGCCACGGTGGGCAGCTTGGTGGGCACGGCAGGGGCTGGTGCGGGGGCCGCCGGAGCCGGGG
TTGCCGGTGTGGGGGCTGCGGGTGCTGGCGTGGCCGGAGTCGCCGCTCCCTCGCCCGGCAATTTGATGACCTGCCCCACCCGCAGTTCAGGGGTGCTCAGGCCGTTGAGCCGCATCAGGGCGTCCACCGTTAGGCCACTG
CCCCGGGCCAGCGAGTAGAGGGTGTCGCCTTTTTTGACGGTGTACGCCCCGGCCACGCCCGAGAGCAGGGCGGCGAGCAGCAAAAAACGGGCCTTCATGTGCCCGAGGATAGGGGCTGTGCGGGTGAGAATCCCGACCCG
GCGGGCTTGACCACGAAGCCGTGCAGCGGCGGCAGCGTCCGAAAGGCCACCCAGTCGCCGGGCTGCGCGGACGGCAGCGGCCCGAAGTCGGCCAGCACCAGCGGCAGCCGCGCCTGCACCACCCACACCCGACGCGACGC
CTGCACGATCTGCCCGCGGCCCGTGACCGCCGAAACGCCCTGCACGGTCAGGCTTTCCCCAGCGTCTCCGGCATCTGGCCCCAGCACCTCAGTTTCGCTCAGGTCGAGCAGGCCATGCACCACCACCCGCGCCGGACCGG
GCCGCGCCGCGTAGGGGCCGCAGCGGTCGAAGAGGTACAGCACCCGCCCCCCACTCAGAAATTCCAGCAGCGGGCTGCCCTCGGTCTGCGGGTAAAGCTCGCCCTCGGCAGCGTAGGCGGCGTAGCGGTGGGCGAACTCG
GCCTCGGAAGTTTCCAGCGTGCGGTCCTGCGTCAAGCGGCGGCGCTCCGGGAGAAGGCGGGGAGGCAAAGAGGCATGAGGGACAGTTTAAGGGCTCGCCGCCCCAGCCCGCGCTTCGAGGTCGTCGAGCGTCGGCAGCTC
GGCACCCAGGGCGAGCAGCGCCGCGTCCGAGCGTTCCAGGGCAAAGGTGCCTTCCACCTCGCGCAGCACGTGGATGGACACCAGGCCGTAGAGCCGTTCCAGCCGCGCCCAAGCCAGGCTGCCGGGGGCTTCGGCGTCAC
GGGCACGGGCGAGCAGCGTGCGGGCGTGATGCTCGTCGCCGTCCACGAAGGCCCGCGCCGCGTCCGCCGGAATCCATGCCAGACGCTCAGGCGGGCCGTCGGCGTTCAGGTCAGCGTCCGCCACGTCACGTCCATCACGA
CCCCCAGCAGCATGGTGATCGCCAGCCACATGTTCGCGTCGAAAAAAGCCACGTTGACCCGGCCCAAATCCTGCGGGTCCACGATGCGGTGCTCGAACAGCAAGATGGCGCCCATGACCAGCGCGGCGAGGTAATACCAG
ACGCTCGCGCCCGCCAGCACACCGACGAGCAGCAGCAGCCCGAACGTCAGAACGTGGCTCACCGCCGCGATGTTGAGCGCCGCCGGAATCCCGAAGCGTGCCGGAATGCTCTTCACGCCGTTCGCCCGGTCGAAGGCGTA
GTCCATCGTGGCGTAGATGGTGTCCAGGCCGATCATCCAGAAAACCACGGTGGCCCACAGCGCCCAGGCGACCGGCGAGAAGTGCCCGGTGACCGCGATCCAGCCGCCCGCCGCCGCCGCCCCGTCGGTCACGCCCAGCC
AGGCGTGGCACAGCCAGGTAAAGCGCTTGGTGTACGGGTAGCCGATCAGAAAGAGCAGCGCCAGCGGCAGCAGCGCCACGCACAGCGGGTTGAGCTGCCACGCGGCGAACAGCAGCACCGCCACGCTCACCGCCACCAGC
CCCCACGCCTGCGCCGGACTGACCTTGCCACTCGGCACTTCGCGGCCCGCCGTGCGGGGGTTGCGGGCGTCAATAGCGCGGTCAATGACGCGGTTGGCCGCCATCGCCGCCGTGCGGGCCGCCGCCATCGCCACCGTGAC
CCAAATCAGGGTGTGCCAGCCAGGCCAGCCGGTGCCGTTCTGGGCCATGCTCGCCAGCAGCATCCCCGCGTAGGCAAAGGGCAGCGCGAACACTGTGTGCTCGAACTTCACGAGTTCCAGATAGGTCTTGACCTGTGTTC
CACTCCGGGCAGCCGCACTCACAACCGCCCAGGATAGCGCGTCGCTGCCCAGATAAAAGAGCAACACACACCGAAAAAGGCGCCCAGAGTTTGACGCTCAGATGAGCAGATTCATCAGGCTGGTTCAGGGCGGAGGCGCG
GCGCTGGGCGCGATAAAAGCCCCCTTTTCTGCTATCCTGTAGGACGCTGAAAGCGGAGGAAAAGCAGTTGCCTCTTTCGCCTAAGCTCGCTGGGGGTGACCCGGTTTCGACAGGGGAACTGAAGGTGATGTTGCGTGTCG
AGGTGCCGTTGGCCTCGTAAACAAACGGCAAAGCCATTTAACTGGCAACCAGAACTACGCTCTCGCTGCTTAAGTGAGATGACGACCGTGCAGCCCGGCCTTTGGCGTCGCGGAAGTCACTAAAAAAGAAGGCTAGCCCA
GGCGATTCTCCATAGCCGACGGCGAAACTTTATGGAGCTACGGCCTGCGAGAACCTGCCCACTGGTGAGCGCCGGCCCGACAATCAAACAGTGGGATACACACGTAGACGCACGCTGGACGGACCTTTGGACGGCGGTTC
GACTCCGCCCACCTCCACCACTTTGGCCCCTGCCCACCCGGCAGGGTTTTTTATATACTCATGCCTGCCTTCTCGTCGGGATGGCGGAATCGGTAGACGCATTCGACTTAAAATCGACCGAGGCAACTCGTGCGGGTTCA
AGTCCCGTTCCCGGCACCAACAAAAAGGCCCCTGCGGCGGCGGGGGCTTTTTCGTCGGTGCTCGCGGTGAGGGCGGAGGTCACTCTTCCCAGCGCAGTGGCTCATGGCGGCGGGTCAGGAAGACGGCGAGCAGCAAGCCG
AGCACGGCGGCATTGAAGCCCAGCCACGAAATGAGGGCAGTCGAGATGTATTCCATTGGGGTCTACGCAGCATAGCTTTAGAATCCCAATAAAGCAATCAGTTTGGCGTCAGTTTCGGTAAGGCGGAACACAAAAAAAGC
GCCTCCACCGGCGAGGCAGAGGCGTAGTAAGCGGGCGGAAGCGTCAGCGGTTGCGCGACAGCTTTTCCAGCACCAGGCGGCTGGTGGCCTTGAGCGTCTCGAACACGCCCGTGCCCTTGGAAGCGACGGCCTCGTAGGTC
GGGTACCGCCTCTGGGGGTCGATGACGGCGCGGATCATGTCGGCGGGCAGGGCATCGGGCAGGTCGCGCTTGTTGATCTGAATCACAATCGGCACGTCGTTGATGTCGATGCCGTGTTCGGCGAGGTTCTCGCGCAGGTT
ACGCATGCTCTCGGCGTTGGCACGCAGGCGGCCCGGTGCCGAGTCGGCTACGAAAATGATGCCGTCTACGCCGCGCAAAATCAGCTTGCGGCTGGCGTTGTAAAAGACCTGTCCCGGCACGGTGTAGAGGTGAAAGCGGG
TCTTGAAGCCCTGCACCGTGCCGAGGTCAAGGGGCAGAAAGTCGAAAAAGAGCGTGCGTTCGTCCTCGGTCGCCAGCGACACCATCTCGCCGCGCAGGTGGCCGGGTACTTTGCCGAACACATGCTTGAGATTGGTGGTT
TTGCCGCACATACCGGGGCCGTAGTACACGATTTTGCAGTTGATCTCACGGGCAGCGAAGTTGATGGTACTCACGTGACCTCCGGGAAAAGAAGCTGGGCGGGGGCCTCAGCGCAGGGGAAAAGCAGGAAGGGAGACAGG
ACCGGGCCGCAGGGCGCTTGGCCGACCAGATGTTCAGCCCAGCAAGAACTCAGCCGAGCAGGTCGTCAAGCAGAGCGGTGGCCCCCTGGCTGAAGTCCGCGCCGAGTTCGGGCTCGGGCAGGTCGCGCACTTCGTCGAGA
ATGGGTTCGAGTTTGCCGATGGTCTTGCGGGCGTACACCTTGACCTTGCCCAGCGCCACGCTGGCATCGAAAATCAGCGTCAGCAGGGCGTCACTGCCCACCGATTCGACGTACAGCGTGCCGTTTTCTCCCTGGTGGGT
CTGCTCCGCGAAGGTGGGCTCGCCTAGCATGTTCGCCAGCGCCGTGGTGGCGGCGGCGTTGCTGGCGACCAGCGTGGCGACCGAGTCCAGCGCGGGGGGGCGAGGCGCCCACAGGGCTTCTTTGTGCGACAGCACGAAGC
CCTTGCGGTCCACCAGCAGGCAGTAGCGCACGCCGGTGGCGCCGAGCAGCTCTTCCAGATGCTGGTCGACCCGGGCGAACGCTTCGCCGTACAGGGCAAGTGAAGGTTCAATCATGTCGCCGCGCAGTATAAGGAGCGCT
CTGGCACAAAGCTCTGACGGCCCCGTTCCGTGCGTGCCGCGCGGCATTCGCGCCCGCTATGCTCCCCACGTGAAGATGCCGGTTCTCCCTGTTCCCGTTCGCTTGCGCCCGCCGCTCTGGGCCCTCGCCACTGCCCTCCT
GACGCTCGGAGCGGCGCAGGCCCGGCCCGTCGCCATCGGGGGGAGCGTGCAGGCGGCCAGCGTGGGCACCCGGCTGCTCGGCGGCGCGGAGATGCTGCCGGTCTGGTCGCTGCCCCGCCTGGGGGTAGAAGTTCGTAACG
ATCCGCAGGACTTGCGCCTGAAATGGGGAGCGCGTGAACTGCGCTACGCGCCGGAGCGGGGCTGGCGCGCGCTGGGATTGAGCCTGAATGGCTCCCTGCCCGCGCCGCAGCTTCAGGGCCAGAGCCTGTACGCGCCGCTC
GCCGCCCTGCGCCTGCTCGGAGTGCCGCTGGAGGCCGATACGCCGGGGCTCCTCGCCTTCAGCGCGCCGCTGCGGGTGCCGGGGGAGACGTTGCCGCCTTCGCCGGACCTGCCGCCAGTCCTGTCATCTCCAACGGCGCC
TTCCCCGGTGGTGCCGACGACCTTCTCAGCCGACGCTGTGACCACCGCGCCGCCTCCGACTCAGACCACGCTGGGGCCGGTGCCAGTGTTCGGGAACCAGTTGCAGACGGTCCGGGTCAACCGCGAGTTGCACCGGCAGG
TGGAAACGCAGCGGGTGGTGCTCGAACTCTCGGCGCCCGTCGTTCACGAGGTGCAGCGCATCACCGATGGGCTGGCGGTGCGGCTGCCGGGGGTGGGCCTCACGCCGGGCGAGCAGGCCTTACCTTCCGGGGACCGGCTC
ACGCTGGAGCAGGACGCCGGGGGCGGCTGGGTGCGGCTGCATACCGGCGAGGGCCGCAGCGAGGTGTTCACCCTGGCGGACCCGCCCCGCATCGTCATCGACACGGTGACGCAGCTCAGCCGCGAGGTGCCGCCGCCGCT
CGACCCGCAGGCGTTGCCCGCCGGGGTGACCTACCGGCAGCTCGGCGGGCTGCACCTGTTGAGTTTCGACCCGGCCCGCTTTCAGGCGCGGGTGGTCTCGGCACCGCGCGGCAGCTTTGCCGAAGTGGCGCAGCTCGTGA
CGCAGACCGGCGGCGTAGCAGGGGTCAACGCGAGTTACTTCGACCTGGCCTCCGCCCTGCCAGTGGACCTCGTGGTCAGCGGGGGATTGATGACCGCCGCCAGCCTGGAAAAACGCGCGACGGTGGGGCTGCTGCCGGGA
GGCGGCCTGATTTTTGGATATCCCCGGCCCCGCTACCGGGTGCGCGGGGCCTTCGGCGAAGTGCAGGCGAACGCGGTGACCAGCCGGGCGCGGCCCGAGTGGCTCACGGCTTTTGTCGGTGATGGGCAAACGTTGGTCGG
CGCGGCGGGGCTGCTCACCCTGCACGTGCAGCTCGGCGCGGGTACGGTGACGCGGGCGGTGTCTGGCCCCCACGTGCCCCCGGCGGGCACCCTCACCCTCACCTTCGACCCCGCCCGGTTCGCGCAGTTGCCCCGGCAGG
CGGGTGAACCGCTGGACGTCGGCCTCGACTGGCGCACGGACGACGCGCCGTGGCCGCAGACCCGCGACGCCCTGAGCGCCGGGCCGCTGCTGGTGCAGGCGGGCCGCCCCGTGACCGACCCACGCCGTGAGGGATTCGAT
ACGGGCGCGTCCATCTGGCGCCCGACCCGGCAGGTGGCGCTGGGCTTGTGGCGGGGCCAGCCCACCATCGCTTATCTGGAGCACGGCACCCCCGAGGCGTTTGCTGCCGCGCTGGTGCAGGCGGGCCTGAGCGACGCCCT
GCGGCTCGACAGCGGCAGCAGCGCCACCGCCTACAGCACGAGCGGCTACGGCGACCTCGGCGGCTACCTCAACACGGTGTGGAGCCGCCCGGTGCCCAACGCCATCGTGTTCGTGCCGAAGGTGACGGGCGCGGCGCGGT
AAACGTCGCGGAGCGTTCTCAGCCGAGCAGTTCGAGCAGGCGCAGGTAAGCCTGAGCGGTCACCTGCACGTCGCCGTAACTGCGGTGCCGACCGCCGGGGGCGAACTCCAGGCCCAGCCGCTCGGCGAGCACGGTGAGGT
TGTGCGTCCGCTCGCGGGGAAAGGCGCGGCGCGAGAGCTGCATGGTGCACAGCTCGCGCTCGGGCGCCCAGCTCAGGCCCAGCCGCTCGGCGCCCGCCCGCATGAAACCGCCGTCGAAGCTGACGTTGTGCGCCACCACC
GCCGAGCCGTCCACGAAGTCGAAAAAGTCGGGCAGCACGTCTTTTATGGCTGGCGCCCGGCGCACCATCTCGTCGCTGATGCCGTGGACCCGCTGGGCCTGCCAGGGAATGCTCAGCAGGCTGCCGTCGGGCCGGGTGGG
GCGCACCAGCGTCTCAAACTTCAGCGTCTCGTCGATCTGTCCGCCCACGATCCGCACCGCGCCGATTTCGACAATGGCCGCGCTCGCCGGAGAAAACCCGGTCGTTTCCAGGTCGAACACCACCACGTCCTGCGGCCAGG
GACCGCCCGCCGTCTGTGCCTTTCCTGCTGTTTTCATTCCACCTGCCGTCACGCCCCGAGGCTAGCGCCTGCGCCGCCCCCGTGCTGTTACCCGGTCGGCAAAGCGGTGGCATCGCCTGCGGAGCGAAACGGAGGGCCAA
GGCGCTCCCGGGCGGCCCCGCGCTACCCTGACCCCAGAATGACTGCTCCGGACCGCCCGCCGCCCCCACCTGCCCGGCCCGAGGAGCAGGTGACGCCTTCCTTGCCTGCCGCACCCAGCCCAGGCTGGCCGGAGGATGGG
GCACTGCCTCCCGTGCAGGCCGCACCGTCCCCGGAAGCTCCCCAGGACACCGGGCCACAAATCACGGCGCTCAGCGGCAACCGCGCCGCCCTGACTCTGCTGGTGGTGCAGAACGTGGTGTCGGCGTTCGCGATGGGCGT
GTGGGTGCCGCTGGGCGCGAACGGACAGGCGGTGCGCTTGGGGCTGGGGCTGCCGCTCGGCACGGCGCTGCTGCTGTCGTTTGCCGTGACGGTGCTGGTGGCGCTGACCGCTTTCAAAGGGGCGATGGCCGCGCTGCGGG
CCGACACCCGCTGGCGCACGCCGCCGTCGTGGGGCACGGCGCTGGCGGCCTTCGTGCTGGCGTTTCTGGCGTCGCGGGCCTTCGTCATCGCCTACGTGATGCTGGTGCCGAGCGCCGCCGACACCGTGCCCGAGTTCCTG
TCGCGCGGGGCGGACGTGGTGCCGCTCGTCCTCGCGGCGGGGCTGCTTATTCCCCTGGCCGAGGAAATCGCCTTTCGCGGCCTGATGATGCGCGGCCAGGAACGCGCCGCCGGGTTCGGGGTGGCAGCGGTGGCGACCAC
TGTGGCCTTTGCGCTGGCGCACGGGGTTCCGGCGAGCATCGCAGGCATCTTGCCGCTCGCTTACGTGCTGGCGCGCCTCACCCAGCACACCGGCAGCCTGTGGGACTCGGTCATCGTTCACGCGCTCAACAACCTGCTCG
CGGTGGTTCTGGGGCTGGTTCTGATCGGCAAAGTCGGCCAGGGCCAGAGCGGTGACCTGCTCGCGGGCGGCGCGTTGCGGCTGCCCGCCGCCCTGCTCGCCCTGCTGTTCGGCGCCGCCGTGCTCACGGTGCTGCATCTG
TGGCTCACGCCCCGGCCCGACCCAGTGGAGCGGCGCGCCCCCGGCCCCTGGGTCAGCGGGTCTTACGTGATCATCGTGCTGTTCGGGCTGGCGCTGGCGCTGCTCTCGCTGCCGGGGGTGCAGAGTCTGTTCGACACGGC
GGAGCGCTTCTTGCGCTGAGGCCATCAGCCGTGGGGGCGCCGTATCCTGGCCGGGCGGCGCCCCCGCGCATTACAGTGCCCGGATGCCCGCTCCCCGTTCCCGCGCCTCTGCTCGCTCGTCCAAACCCCGGAATAAGCCC
CAACCCCAGCCCCAACCCCAGGCCCCTACGTCCGCGCCGCTGCCCGCCGAGGTGCTGACCCGGCCTGAGGCGTTCGGGGCCGCCGTGGTGCGCTCGGGGGCAGGCGTCGGGGAGTACTGGCTGCCGGTGTTGGTCGCGGC
GCTGCTGTCGGGCCTGAGCTACGCGCTGCTGCTGCGGCCCGGGCTCAACCTCGCGGCGCAGGCGGCGCACACGGCGGGACAGGGGGCCAAACTCACGCCGCCGCTGCTGACGCACGTGACCAATGTCTTCGGCAGCGTCT
TTCTGACGGCGCTCACCTTCGGGCTGATGTGGGGGCTGGGTTTACTGGGCAGCCGGCTCGGCACGGCGGCGGGCGAAACGCGGCGCTTGCCCGTCGCGCAGGTCTTCAGCGCCACTTTCACCCTGCCCATGTTGCTGAGC
GTGCTGACGCTGGTGCTGATCGCGCTGACCCCGGCGGCGAGCTGGGCGCTCGACCCGGCGCAGGTCACCGCCGCGCATGGAGCGCCGCTGGCGCTGCAACGGGCGGCTCTGGTGAGCGCTGCGCAGACCCCGGCGGCGCT
GGTGCTGGTGCTGGGCAGCCTGCTCGTGACCGCCGCGCAGTGCGTGCTGGCGGGCCGGGCGCTGCGCGGCGCGGGGGCCGGTGCCGGGGCGTGGCCCGCCGCGCTGCTCCCACTGCTGCCCGCGCTGCTGGTGCAACTTT
TAGGGTTTCTGCCGCTCTTGGTAGCGCGCCTCACAACCGGGGGCTGACCTCGGCGGGCCGGGGCGCTAGCCTGAGGTCCATGACCGACTTCATACCGACCACCGACCTGAGTGACGCCCAGCCACAAGCGCAGGTGGCTG
CGCCGGTCTTGCGCGACTTCGGGGGCCGAACGCGCTTTCAGGGCGCCGCCGTGACCCTGCGAATCAGCGAAAACAACCCGCTGGTGCGCCAGACGCTGCAAACGCCGGGCGCGGGCCGCGTGCTTGTGGTGGACGGCGGC
GGGAGCCTCAACTGCGCGCTGCTGGGCGGCAACCTGGGGGTCTTCGGGGTGGAGAACGGCTGGGAAGGCGTCATCATCCACGGCTGCGTGCGCGACACCGCCGAGCTGCGCGAGCTCGACCTCGGCATCCGGGCGCTGGC
AGCGCATCCCCGGCGCAGCGGCAAACTCGAGGAAGGCGAGCGCGACGTGCCGGTCACCTTCGCGGGCGTGACCATTCGCCCCGGTGACCACGTGGTGGCCGACGAGGACGGCTGGCTGGTCCTCGGCGCGGAGTCGCCGT
GACCGACGGGTCTACCAGCGGCACTGCGCTGAGGGGGCCGGCATGACCCAGGCGAGCAGCTCCGCTGGGACGCCTGCTGTGTTCGTCGTGTCGCCTGCCGAGGCCCAAGCGACCGCACTGGCTGCCGAGCTGCCGGGCAC
CGAGGTGCGCTGGGTGGCCGACGGCGACCAGTTGCTGCGCGAGGCGCACGCCCGGATTCCCCAGGTCGTGCTGCTCTACAGCCAGGTGCCGGGCACGCCGCTGGGTCAGGTGCTGGGCATTCTGCGTCAACGCGCCGAAC
TCGCCTCCACCCACTGGCTGGCGGTGGGGTCAAGTGGGCTGGGCGACCTGCTGGCTGCCGGGGCCGACGCGCTGATTGGGGACACCACGCCCCCTCCGGCCCTCGCTGCCCAGGTCCGCACGCTGCTGGGCCGCGCCGCG
CAGCAAACCCACCTGCAAGAGCGCCTGACCCGCTTACAGGGCCGGCTCGACGGCTGGGAACACGACGAACAGGTGCGCGACCAGTTGGTCCACATGCTGGTGCACGACCTCAAAAACCCCATCGCGGCGGTCATTGGCCT
GCTGCAAATCGTCGAGGACGACGACGGCCTCTCGAACGAGTCGCGTGAGTTGCTGCGGCTGTGCCGGGACGAGTCGCAGCACCTGCTGCACCTCACCGTCAACATGCTCGATGTCCGCAAGATTCAGGCGGGCAAGATGA
ACCTCCGGCGCGAACTGATGTTCAGCCCGATGTTCGAGGAAGTCATCGAACTCGCGCGCGGCGACGTGGGCAGCAGCCTGCGCGAGCGCCGCGTGGGCGTGCAGGTGGCGCGTGACCTGAATCCCGTGAGCGCCGACCCC
GAGATTCTGCGCCGCGTCCTCGCCAACCTGCTCAGCAACGCCCTCAAGCACAGCCTGAGCGGTTCGGCGATCACCGTCAGCGTGCAGGCCGAGCGCGGTGGCGGGGGCGTGCGCCTGAGCGTGCGTGACCACGGCGAGGG
TATTCCCGCCGAGGACATCCCCAACCTTTTCGCCGCCTTTGAGCAAAGCCGCCTGACCCTGCATGGCCGCTTCGACACCGGCATGGGCCTGGCCTTTTGCAAGATGGCCATCGAGCAGCACGATGGGCGCATCTGGGTCG
AGTCGGTGCGCGGCGAGGGCTCCGAATTTTTCATGACGCTGCCCTACGCGCAGGACCCCGAAGACGGGGACGACGACGATTACGCCGAACTGCTGACTTGAGCGTGGACAAGCACACGAACAACGGCCCGCGAACTTGAA
GTCGTGGGCCGTTGTTCGTATGACTCATACGGCTTTAATCCGATTCCCGAACATCCGGAAAGGCGCCGGATGCCCGTCCATCTCCTTATACGGATTCCGATTGAATCTGGTCGTTTCAGATTCAATCCGAGCGGATGCGA
GCAGGAAAAAATACGGATTCCGCGATATGGATGCACAGGCGGCGCTTTCCCGACTGTGCAGGAATTAAGCGGAATCCGTATGACTCAGCGCCGGATGTCCGCGTGAATCCCGAAGTCCTCGGCGATCAGGCGGGCCGTCA
TCTTGGCCGACATCATCACGCTCGGCGTCCCGGCGCCCGGCTGCGCGCCCGCGCCGACGAGGTAGAAGTTGTGCAGGTCCTCGCTGCGGTTGTGCGGGCGGAAAAAAGCGCTCTGGACAAGCCGTGGCTCCGGCCCGAAG
GCGTTGCCGAGGTAGCTGTCGAGCGTGCCCGCGAAGTAGTCGGGCGTGATGAACTCGAAGTGGGTCAGGCGCTCACGCAGCCCCGGAATCAGGCCGCGCCGTTCGATGTCGGCCAGGGCAGCTTCGGCCAGCTTTGGCCC
TTCCACGTCCCAGTCGATGCCGCTGCCGTTGTGGGGCACCGGCACCAGCGTGTAGGCGGCGTGGTGCCCGGCGGGGGCCAGCGCGGGGTCGGTCAGCGTGGGCACATGCAGGTACTGGCTGAAATCCTCGCCGAGCCGCT
TGGTCCCGAAAATCTCGCTCAGCAGCGCCTCGTAGCGCGGCCCCAGCAGGATGTTGTGGTGCTTGAGCGGCAGATCGTCGCCGCCGCGAAAGCCGAAATAGACGACGAGCAGGCTCATGCTTTCGCTGGCGGCCTTCACC
CGCAGGTCCGAATTGACCAGCCGCGCCGAGGGACGCACGCGCTTGAGGTAGGTGTTCGCCCAGTCGCCGTTGCTCGCCACCAGGTCGGCCCGCAGCTCTTCGCCGCTCTCCAGCCGCACACCGCGCGCTGTGCGTTTGCC
GGGTAGATTGCCGTCCACCAGCACCTCGTCTACGCCGGCGCCGTAGCGGATGGCTCCGCCGAGCTCCTCAAATTTCTGCACCAGCCCGCGCACCAGCGCCCCGGTGCCGCCCATCGCGTAGTGGATGCCCCAGGTCTTCT
CGACGAAGTGAATCATCGCGTAGATGGCGGGCACGCTCAGCGGATTGCCGCCGACGAGCAGCGTCTCGAAGGAAAAGACCTGCCGCAGTTTGTCCGACTGGAAGTATTTAGACGTGAACGAAAAGAGGGTGCGCACCGCG
TCGAGCTTCAGCAGGTCGGGCACCACCCGCAGCATCGTCGGCACGTCGCCGAAATGGGTGTAGCCGAGTTCCAGAAAGCCCCGCCGGAAAATCGCCTCGGCGTCGGCGTGAAAGCGCTCATAGCCCGCGAGGTCGCCCGG
CGCGAGTTCGGCAATCTGGCGCCGGGTGCTCTCCGGGTCGCCGTCGTAGTCGAAATACGTGCCGTCATGAAAGACGATGCGGTAGAAGGGCAAAATCGGCACCAGCGTCACGTACCGGCTGGTGTGGGGGCCGCCGCTCA
CGCCCTCCTTGACCCGCTCGCCGCTCAGCACCTCGGGTGGGTAGTCGGGCGCGTCCAGGCCAGCGCGGTCCCGCTCCAGCGCGAACAGTTCCTCGATGAAATGCGGCACCGTCAGCACGGTCGGCCCCATGTCGAACACA
TACCCGTCCGGCGTGCGCTTCTGGTAGGCGCGACCCCCCGGTCCATCGAGCCGTTCCAGAATGGTGGTGTCGAAGCCTAGGCTTTGCAGCCGAATGCCGAGCGCGAGGCCGCCGAAGCCCGCGCCGATGACGAGGGCCGT
CTTGCGGCGGGCATAGGGCGAAGGAGCAGGGCGAGGAAGTGCAGATGTCATGACAGTAAACCTCGGAAGTCGGGAAATCAGAAATCAGGGAAAAAGAACAGGGAACAGGGAAGAGGCCGGAGAACGCTGGGCCTCCCGGA
GGGGTGACAGATCAGCCGTGGACCGCGCCCAGCGAGCGCAGTTCCCACCACGCCTGCGGCAGCATCAGCAGTTTGCGCCGGCCACTCACGTAGGCGCGGCGCCCGAAATTGTCGTAGCCGGCGCGTTCGAGGTCGTCCAG
AATGCCCTCGTAGGCGCGGGCGGCGGTCAGCACCGCCAGCGGGCCGCGTCCGTCGAGCTGCGGAATCCCGGCGCGGCCAGCGGCGTACCACTCGCGCGCCAGCCCGCCGAGGTGCGTCATCAGGGCGCGGTAGGCGGGGC
TGAGCGGTTCGCCCTGGCCCCAGCGCTCCAGCGCGGCGCGTGACAGGCCGTATTCGTCGAGCAGGCTCTGCGGCAGGTAGACCCGTCCGCGCGTCAGGTCCTCGCCCACGTCGCGCAGGATGTTGGTGAGCTGCATCGCC
TGACCGAGTTGCAAGGCGTCGTTCAGCGTCGCCGCGCCGCCCCGGTAGCCGCTGATAGGCGCGACCATGAACCCCACCACCCCGGCCACCCGGCGGCAGTAGAGCAACAGGTCGTCCATGTCGCGGTACTCGTGCCCACG
CAGGTCCATGTTCAGGCCCTCGTGCAGCTCGGCAAAGGCGCTGTGGGGAATGGCGTAGCGCCCCGCCGCCCACGCCAGCGCCGTGCTGATGGGGTCGTCCGCCGGTTGCCCCGCAAACGCCGCGTCAATCCGGCTGCGCC
ACTCACGGAGTTCGCGCTCGCGGTCCCCGTTTCCCGCCTCGTCCACGATGTCGTCCCCGGCGCGGCAGGCGGCGTAGACCGCCCACACGGCGGCCCGCTCGGGTGGCGAAAACAGTTGCGACCCCAGATAAAACGTCTTG
CTGTGCTGCCGCGTCAGGTCCCGGCAGTACCTCACTGCCTGCGCCAGCGGCGGGCGGCGCAGTTCGGTGCAGGGCAGGGCAGGTGAATAGTCCGTCACGGTGAGGGTCCTCGTCGGCAGTCTAAGAGACAAACCGGCCCT
AGACCTCACGCCTGCTTACAGAAAAGGAAAGACAGCACCAGCAAGGCGCGGGCGCGGCGGGCCATCGCCAGCACCAAATTGTGTTGACGTTTCCTTTGGGGTAACGGCGATCAGACGTTTCTTTCACTATGCTGGGGCGT
GAGGATGCCCCCGCCGGGGCACGAAGCTTGGAGGAAGCACATGGAAGAACGCAAGAGTATGGGAAGCGCACTGGTCGACGTGTTCGATGCGGGCGTGGTTCTCGTCAAGTCCGAAATCAATGCGCTGGCCCGTAAGGTCG
GAGAAATCGCCAAGGCCAAGGGCCTCGGGCTGGTGCTGCTGCTCGCCGCGCTCGGGCCGCTGCTGCTGGGGATGATTTTCCTGATTCTGGCGGTGTTCTACGGCCTGATGCGTCTGGGCCTCGCCGCCTGGGCCGCCGCG
CTGATCATCGCCCTCGTCAGCCTCGCCATCACCGGCGCGCTGATCGCGATGGGCCTGCAAAAGCTCAGCGCCGAAGTCGACACCGACATGCCCCGCCGCCCGGTGGACATGAGCGGCCCCGAGTTCCGCGCCGGCCAGGG
CGCCGAGTACCAGAACGCCCCCGGCGTGCCCGCCACCTCGCTGAAGTACCCCGTTCCCGGCGCTGCCGCGGCGACGGCGGTGCCCGCTGCGAGCTACGGCACCACCGGCAGCCGAGTCACTGGGAGCCAGGTCACGGGAA
CCCAGGTCGTCGGCAGTCAGGCTGCCGGCACCGTGTCGGGCAGCGTCCAGCCCTCGGTGGAAGGCGCCGAGCGCGTGCCGGTCTATGAGAGCGACGCCGATGGCCGCGCCACGATGTACGGCGACCGCCTAAACGACAAG
CTCGAAGGCCATGACGACCACGACGACCCCAACCTGCAAAACCCGGTCGTGCTGCACGACGCCCCCGGCATCGCCGTGAGCACCACCCCCACCTTCCGCGAAGACATGCGCCGCGAGGGCCTGAGCGTGAACGACGTGCC
CCCCACCGACCCCGACCAGACCAAGCCCGGCCAGGGAGGTCACTGAGATGGCAGATTCCAAGGACATTCGCACCGAAGCCCAGGGCCCCGTGACCCAGGTGCAGACCATTCAGGCGCAGCCCGCCGTGACCCATGAGCCG
GTGCCTGCTCAGCCGCCCGTCCAGTCCCAGGCGCCCGTCAGCCGCGCCGAGGACCAGAGCCCGGTGATGTCGGGTACGCTGGTGCGCGTGGGGGAAAACACCGACGTGCGCTATCTCAACGAGCAGGAAGAAGCCCGCGA
GCGCCTCAAGGCGAGCGTGGACCGCCTGACCCAGCAGGCCAGCTTGCAGGTCAAGGTCGAAAAAGAGCCGCTGAAGATGCTCGGTGGCGCTTCGGCAGTGGGCGCAGTCATCGGCCTGGTGCTGGGTCGTCAACTGCGGC
GTTCCAAGAAGATCTACGTGGACGCCCACAGCCCGGTCAAGCACCAGCGCGAGTTCGTTAAGGCGCAGCAGCGCGCCCAGAACAACAAGAACAACGTCGGCGGCGCCCTGCTTGCCACGCTGGGCACCATGGCCGTCAAG
ATGCTGACTGACAAGGTGCTGGCGCCCAAGCTCGAAGAAGTCGCCAACAACCTGCTCGACAAGGCCGGGCAGCCGAGCGCGGCCACGCGGGTTGCGGCGCCCTCCAACGCCAACGCGACGGCAGCCGCCAGCAACGCGGG
CCAGATTCCAACGGTCAACCGGGCAAGTACTCCAGTCGCGCCTGCTGCGGCCCCAGCTCAGACTCAGTCGCAGCCCCAGGTAAGTGGCGATCATCCCCACCCCGGCGTACATTACACCGCCAACCCGGTGCACCCCGGCG
TGGTGCCGATTCCGGACAGCGTGGTCGAGGCGAAGGCCCAGGGCACGCCTATCAGCGAAGACCAGAAGGTCAACCCCAACCTGTCCTGAGACTCTTTTCCTGTGGCGGCTCCCTGCGGGGGGCTGCTTTTTTGTGCCGCC
GTTCCTGGGTCGGCTGCGCTTGCGCTTTGCTACCCTGCCTCCATGACCGCCCGCCGCAGCACCCGCCAGCGTGACGTGATCGCCCGCGTGTTGCAGGACGCGCCCGGTCCGCTCGGGGTCACCGAGGTACACGCCTGCGC
ACAGGCCGAGCTGCCTCGGCTGGGCATTGCCACGGTGTACCGCACCCTCAAGCTGCTGACCGAGGAGCGCCGCATTCACCCGGTGCTGCTTGACGGCGAAACTCTTTACGAAACAGTAGGCCGGGGACATCATCACCATT
TCAGCTGCACGCGCTGTGGCCGAGTGTTTACGCTGCATACCTGCCCGGTAACCTTGCCGAGCAGCGCCGTCTATCCCGGCGGGTTCGTGGTCGAGGCGCACGAAGTGACGCTTTATGGGCAGTGTCCGGAGTGCGCGGCG
AGGAAGACCGGGGCCCACTAAGGCGGGAAGTTTTTACTGCGTGGCTTCTGCGAAAGCCTGCGCCACCTGCCCCACCGTCTGGTCAAGGCTGTGATGGTCAAGGACCCATTCCCGCGCCGCCGCGCCGTAACGCCGGGCCT
GTTCCGGGTGGGCCGCAAGCGCCCGCAGCGCCCGGGCGAGCAGCGCGGGCTGGGGAGGCACCAGCAGGCCGGTCTGACCGTCTTGCACCAGTTCGCGCTGGGCGGGAATCGGCGTGGTGACCAGCGGCAACCCGGAAGCG
AGCGCCTCCAGCGTGACGAGCGACTGGTTTTCGGCGAGCGTAGGTTGCAGCAGCACGTCCGCCGCCCGGTAGAGGTCGGGCATGTCCCAGCGCCGGCCCCAGAATTGTACGTTGGGCTGAGTGCGCGCCAGTTGCTGCGC
GAGTCGCCCACCTCCCGAATCCATATCGCCGACGAACACGAAGTCGAGGTCGGAAGCTTGCCGCGCTGCCCAGACCGCCGCCAGTTGATTTTTTTCGGGGGCGAAGCGGCCAGGGACGAGCACGGTAAAGCGGCGAAATC
CCAGCTCGGCGCGCAGCTTTTCGCGCGCGGACTCAGGCAATGGCGAAAAACGGTTAGTGTCCACTCCGTTGGGCACCGCCCGCACGTCCGACACCCGCAGTTCTTGCTGTAAGAAAGCCGCGCCCCACCGCGACACCGTG
AGGCGCTGCTCAGCCTGGGGAAGGAATTTGGCCTTCGTCTGCCGGTAAATTTCGCGGTAAAGGCCCTGGAGCGGCCAGCCGTAGTGATAGTCGAGCTGGTCGTGCAACACCACACTGCGCGGCGCCCTGAGCTGGGGCAG
TAACGTGCGGTAAGTGTCTGGATTCCAGACTTGCAACACCCGCAGGTCGGCGTCCCCAGTCATCTCCGGCAACGTCAGCAGATCGGTCCAACGCTCCACCGTGACGCCCTGCTCGGTGAGTTGCGCCGCCCAGCGGTCGA
GGGCGGGCGCCGCCGAGCAGTACACCGTCGCCCGTTGCCCATGCGCGCGCAACCGGGGCAACACGTCAAGCAGCCACACCTCGCTGCCCGCCACCCGCGGCGCGTCGGTGATGACCGTCAGATTCAGGTCGTGCCCTGCC
TCAGTCATCCACTGGCTCCCCGCGCTGCAACTTCACGCCGCGCACCAGATTCTGGTACATCAGCGCCGAGGTCAGCGGCCCCACGCCGCCCGGCACCGGGGTCTGGGCGCGCACCGGCAGCTCGGGTAGAGCGTCGCCCA
CCATGTCACCGCTTTCCTGCACGTTGATGCCGGCGTCAATGACGACGTGCTCCGGCTGCACCTGCTCGGGCCGCAGCAGCCCTGCCTTGCCTACTGCGACCACCACCGCGTCCTGCGCAGCCAGCACCGCCGCGAGGTCG
CGGGTGTGCTCGTTGCACAGCGTTACCGTCGCGCCCTTATTGTTCAGCATAAACAGCAGCGGGCGGCCCACCGTGCGCCCCGGCCCGATGACCGCCACCCGCAAGCCGCGCAGGTCGTCGCCCAGCGCGTGCCGCAGCAG
AAAGCGCACCGAGCGCGGCGTGGGCGGCAACAGCGCCTCGGGTTCGCGTCCGGCGGCGATCAGGGCGAGGTTGGCCGGGCTCAGCCCCTCGATATCCTTGCGCGCCGCAATGTGCAGCAGCGCGGCGTCGGCGTCCAGCC
CAGCGGCCAGCGGCAGCTCCAGCACGATGCCGTGCACGGCGGGGTCGGCGGACAGCTCGCGCAGGGTCTGTTCCAACGCCTCCTGCGTGGCCGCCGCGCCGAGGTCCACCACCCGGAACGCCACCCCCAGCTTCTTGGCG
CGCTTCGCCTTGCTCTGCACGTAGACCTGCGAGGCCTCGTCGTCAGAGGCCAGCACGCTCACCAGTTGCGGCTCAAAGGGTGGGTCCAGTTGCGCCCAGGCTTTCAGGTCGGCGCGCACGCCGCGCATGACCCGATCGGC
CAGCGGTTTGCCGAGCAGCGCGGCGGTTTCGGAAGCGGCAGGTTCGGAAGAGGTCTGCATCCTGTCCTCAGTGCCGGAAATGCCGCGACCCCGTGAACACCATGCTGATGCCCAGTTCGTTGCAGGCGGCAATCACTTCG
GGGTCACGCTTGGCGCCGCCGGGTTGCAGCACGGCGGTCACGCCCGCGCTCGCTGCCAGCCGCACCACGTCGTCGAAGGGGAAAAAGGCTTCGGAGGCCAGCACCGCGCCCTGAGCTGCTTCACCCGCGTTGGCGATGGC
GCGCTCGGCGGCCCAGATGCGGCTCACGGCCCCGGCACCGAGGCCCACCGTCACGCCGCCTTTGCACAGGGCGACGGCGTTGGACCGCGCCCCTTTCACCACCGCCCAGGCGAAGCGCAGGTCGGCCCATTCCTGCTCGC
TGGGCTGGCGCTCGGTCACCACTTCGGGGCACAGATCGTCCCAGGGGCGGGCGTCGCGCTCCTGCACGGCAAACCCGCCGGTCAGCGGGCGCACGTCCAGCACGCTCACGCCCTGTGGCTGGCCCGCAATCAGCACCCGC
AGGTCGGGCTTTTTGGCGGCGAACCACTCCACCGCGTCGGGGGTCACGTCGGGCGCGATTAGCACTTCAAGGAAGGTGCCTTTCATGCTCTGCGCCGCCCCGAAGTCCACCGGCTGACTCACCGCCACTACGCCCCCGAA
CACACTGAGGGTGTCGGCGTCGCGGGCGCGTTCCCAGGCGGTCTTCACGTCGGCGGCCACCGCCACACCGCAGGGGTTGGCGTGCTTGACGGCCACGCACACGGCGCCCTGCTCCTGCGCCGCCAGCTCCTGACACAAGC
TCCACGCAGCGTCGGCGTCGGCATAGTTGTTGAAGCTCATCGGCTTGCCGGCCACCACCTGCGCGTCAATCACCGGGCCGCGCGCGTTGCCCCAGCGGTAAATGGCGCCGGGCTGGTGGGGGTTTTCGCCGTAACGGACC
TGCGCGGTGCGGGTGAGGTCGAGGCTGAGGTGCTCGGGCAACTGCGTCGGCAGCTCGTCCGATTCGCCTGACAGATACGCCGTAATCGCCGCGTCGTACTCGGAGGTGTGGCGGTAGGCCTTGGCGGCCAGGCGGCGGCG
CTCGGCGGGGGAGACCTCGTCTTGCAGGGCCAGCGCGTAATCGGCGGGGTCCACCAGCACCAGCACGGCGTCGTGGTTCTTGGCCGCCGAGCGAATCATGGCCGGGCCGCCGATGTCGATGTTCTCAATCACTTCGGGGT
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sachty.A060923_120543_domaci_mr