Professional Documents
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LECTURE AUF-CON
TREATMENT
WHAT IS TUBERCULOSIS?
1.1 Record the patient’s demographic and contact The following steps are involved in screening for
information in a register of consults. pulmonary TB (PTB) in children <15 years old:
1.2 Ask all patients consulting the health facility, if they 2.1 Ask if the child has TB signs and symptoms. Identify
have the following cardinal signs and symptoms that as presumptive TB if the child has at least one of the
are lasting for ≥2 weeks: three main signs and symptoms suggestive of TB:
a. cough a. coughing/wheezing of two weeks or more,
b. unexplained fever especially if unexplained (e.g. not responding to
c. unexplained weight loss antibiotic or bronchodilator treatment)
d. night sweats. b. unexplained fever of two weeks or more after
1.3 If any of the above signs/symptoms are present for common causes such as malaria or pneumonia have
at least two weeks, identify as a presumptive TB. been excluded
c. unexplained weight loss or failure to thrive not
1.4 For those who do not have any of the cardinal responding to nutrition therapy
signs/symptoms above or experienced it for less than
two weeks, offer chest X-ray screening if one has not 2.2 Ask if the child is a close contact of a known TB
been conducted in the past year. case. If the child is a contact, the presence of fatigue,
reduced playfulness, decreased activity, not eating
well or anorexia that lasted for two weeks or more
CHEST X-RAY POSTEROANTERIOR UPRIGHT VIEW should also be considered and identify them as a
presumptive TB.
● A chest X-ray posteroanterior (PA) upright view
should be requested and previous chest X-rays 2.3 If the child already has a chest X-ray, review the
should be brought for comparison. results. If chest X-ray findings are suggestive of PTB,
identify as presumptive TB.
○ For pregnant women, written consent shall be
taken and an abdominal protective shield shall NOTE: Screening by chest X-ray is not routinely
be used by the X-ray facility recommended for children, except for TB household
● The National TB Prevalence Survey in 2016 showed contacts who are 5 years old and above.
that “screening for TB cases using symptoms alone
2.4 For all PTB identified, ask about previous history of
would have missed one-third to two-thirds of treatment and exposure to TB case to determine risk
bacteriologically-confirmed pulmonary TB cases.” for DR-TB.
○ If resources are limited, you have the option to
2.5 Record the patient. Presumptive TB Master List and
prioritize those with TB risk factors as primary follow the diagnostic algorithm as outlined in the
clients for chest X-ray screening. diagnostic section below.
● Contacts of TB patients
● Those ever treated for TB (i.e. with a history DIAGNOSIS OF TUBERCULOSIS
of previous TB treatment)
● People living with HIV (PLHIV) A. GENEXPERT
● Elderly (> 60 years old)
● Diabetics ● New test that is revolutionizing tuberculosis (TB)
● Smokers control by contributing to the rapid diagnosis of TB
● Health-care workers disease and drug resistance
● Urban and rural poor (indigents) ● In two hours, the test results will be released
● Those with other immune-suppressive ● All processing is fully automated
medical conditions (silicosis, solid organ ● Recommended as the initial diagnostic test
transplant, connective tissue or ○ Can quickly identify MTB
autoimmune disorder, end-stage renal ● GeneXpert MTB/RIF Ultra
disease, chronic corticosteroid use, alcohol ○ Has been developed to overcome the
or substance abuse, chemotherapy or limitations of the old Xpert MTB/RIF G4 assay
other forms of medical treatment for with improved sensitivity in the detection of TB
cancer) and RIF resistance
● If a chest X-ray is not available and these high-risk ● The result will come out after 18 minutes
patients have signs and symptoms lasting less ○ Rapid assay that uses an improved assay
chemistry and cartridge design
XPERT MTB/RIF RESULTS AND INTERPRETATION ○ If the child cannot expectorate (especially <5
years old), nasopharyngeal aspirate or gastric
NOTATION INTERPRETATION
lavage may be performed in facilities where
Mycobacterium tuberculosis detected;
trained staff, supplies and equipment are
rifampicin resistance** not detected
T available.
**indicator of MDR-TB as ○ Label the body of the sputum cup/conical tube,
isoniazid-resistance co-exists with it indicating the patient's complete name and
MTB detected; rifampicin resistance indicating the specimen for Xpert (or SM/TB
RR
detected LAMP).
MTB detected, rifampicin resistance ○ Check the quality of the sputum.
TI
indeterminate ○ For Xpert, testing should be performed on any
N MTB not detected collected spot sputum sample (i.e. a
coughed-out sample) regardless whether it is
I Invalid/no result/error
sputum or saliva.
○ For SM, examine the specimen to see that it is
B. DIRECT SPUTUM SMEAR MICROSCOPY (DSSM)
not just saliva.
● Sputum smear microscopy allows a rapid and ● Mucus from the nose and throat, and saliva
reliable identification of patients with pulmonary from the mouth are not good specimens.
tuberculosis (PTB) where there are more than 5000 ● Repeat the process if necessary.
bacilli/mL of sputum. ○ For SM, instruct to collect a second sample one
● If the sputum has less than 5000 bacilli/mL, smear hour later or an early-morning sputum sample
microscopy is highly unlikely to diagnose PTB. the following day.
● COLLECTION OF SPUTUM ● Follow-up within three days if the patient
○ Prepare a sputum cup or 50 mL conical tube fails to submit a second specimen unless
and accomplish Form 2a (laboratory request the first specimen already tests positive for
and result form) acid-fast bacillus (AFB) in which case the
○ Instruct patient to expectorate one sputum second specimen will not be necessary.
sample on the spot for diagnostic testing with ○ Seal the sputum cum or conical tube and
Xpert (if not available, SM or TB LAMP). transport it to an Xpert site, TB microscopy
● Collect 1ml for Xpert MTB/RIF and TB LAMP laboratory, or TB LAMP site together with the
and 3–5 ml for SM. completed form 2A.
○ Collect specimen in a well-ventilated ○ If the laboratory is in another facility, use the
designated sputum collection area, or outside triple packaging system.
the health facility. ● Place the primary container and individual
● Usually done in the morning plastic bags.
● If possible, ask the client to stay for an hour ○ Place each in a durable, leak-proof, watertight,
for the collection of second sputum sample and properly-sealed container (i.e. biological
○ Confirmatory bottles or plastic jars as secondary containers).
○ Instruct the patient on how to expectorate: ○ Enclosed in a sputum transport box (tertiary
● Clean mouth by thoroughly rinsing with container).
water (do not brush teeth) ○ Transport at cold temperature by placing cold
● Breathe deeply, hold breath for a second or packs inside the tertiary container.
two, and then exhale slowly. Repeat the ○ Accomplish a dispatch list.
entire sequence two more times; ● Submit the specimen within 1 hour (window
● Cough strongly after inhaling deeply for the time)
third time and try to bring up sputum from ○ Specimens for SM can also be smeared
deep within the lungs; and immediately by trained volunteers and then
● Expectorate the sputum in the sputum cup stored appropriately before transport to the TB
or conical tube. microscopy laboratory.
○ Sputum induction for individuals unable to ○ For diagnosis of EPTB, facilities with the
expectorate should be done only in facilities necessary capability can collect body fluid
where the staff is trained, supplies and samples or tissue biopsy samples from the
equipment are available, and infection control suspicious site. Refer it necessary
measures are in place.
TREATMENT OF TUBERCULOSIS
C. TB LAMP
PROCEDURES
● Manual assay that requires less than one hour to
perform and can be read with the naked eye under ● Initiation of treatment Inform the patient that they
ultraviolet light. have TB disease
● Following review of the latest evidence, WHO ● Provide key messages for TB patients and families:
recommends that TB-LAMP can be used as a ○ Basic information about TB disease covering:
replacement for microscopy for the diagnosis of cause, transmission, clinical signs and
pulmonary TB in adults with signs and symptoms of symptoms
TB ○ How TB is diagnosed
● It can also be considered as a follow-on test to ○ How to prevent TB
microscopy in adults with signs and symptoms of ● Duration of treatment: six months for DS-TB, 12
pulmonary TB, especially when further testing of months for severe drug susceptible EPTB, and 9–20
sputum smear-negative specimens is necessary months for DR-TB cases
● The schedule of regular clinical and laboratory
D. CHEST X-RAY follow-up for treatment monitoring
● Potential adverse events during treatment and how
● Posteroanterior upright view should be requested
to address them
● Previous chest x-rays should be brought for
● The relevance of contact investigation and TB
comparison
preventive treatment (TPT)
● Pregnant clients must provide written consent and
● Tracing mechanism in case of treatment
should be given abdominal protective shield shall
interruption (missed dose)
be used by the X-ray facility
● Availability of free-of-charge services for TB
diagnosis and treatment and TPT
TB CATEGORIES — CATEGORY 1
● Discuss with patients their social and financial
TYPE OF TB TESTS needs and offer possible sources of social support
to enable adherence to treatment (e.g. Department
Bacteriologically
(+) Gene Xpert of Social Welfare and Development, Social Security
Confirmed
System, Government Service Insurance System,
Clinically (-) Gene Xpert Employees Compensation Commission, local
Diagnosed (+) X-ray
government units (LGUs), etc.)
STANDARD REGIMENS
4 FIXED-DOSE
COMBINATION (No. of 2 FDC 4 FDC 2 FDC
tablets)
25–37 112 224 112 224
38–54 168 336 168 336
55–70 224 448 224 448
More than 70 280 560 280 560
4–6 months:
Lfx–Bdq(6)-Cfz-Pto-E-Z-Hdh
Regimen 3:
NOTE: Bdq shall always be given
Standard Short All Oral MDR-TB and RR-TB
for 6 months
Regimen eligible to SSOR
(SSOR)
5 months:
Lfx-Cfz-Z-E
Regimen 4: 6 months:
Standard Long All Oral MDR-TB and RR-TB Lfx-Bdq-Lzd-Cfz Request for off-label use at TB
Regimen for FQ eligible to SLOR (no FQ MAC if extending use of Bdq
Susceptible resistance) 12–14 months: beyond 6 months
(SLOR FQ-SI) Lfx-Lzd-Cfz
6 months:
Regimen 5:
MDR-TB and RR-TB Lzd-Bdq-Dlm-Cfz-Cs Request for off-label use of Bdq
Standard Long Oral
eligible to SLOR (with and Dlm combination at TB
Regimen for FQ
FQ resistance) 12–14 months: MAC
Resistance
Lzd-Cfz-Cs
Retreatment MDR-TB
Present the case at TB MAC and
Individualized and RR-TB cases (not Construct to have at least 4–5
follow their advice for the
treatment regimen eligible to SSOR nor likely effective drugs
regimen design
SLOR)
LEGEND
Z: Pyrazinamide | E: Ethambutol | Bdq: Bedaquiline | Dlm: Delamanid | Lfx: Levofloxacin | Cfz: Clofazamine
Lzd: Linezolid | Cs: Cycloserine | Pto: Prothionamide | HdH: High-dose Isoniazid
HUMAN PAPILLOMAVIRUS
HIV/AIDS
(Retrovirus: Human T-cell Lymphotropic Virus 3)
● Most frequently reported STD in the United States
● Affects the anal and genital area ● Human Immunodeficiency Virus (HIV)
○ Flesh-colored or gray growths found in the ○ Causes Acquired Immunodeficiency Syndrome
genital area and anal region in both men and (AIDS)
women ○ Harms your immune system by destroying the
● Start as tiny, soft, moist, pink or red white blood cells that fight infection
swellings, which grow rapidly and may ○ This puts the patient at risk for serious infections
develop stalks and certain cancers
● Rough surfaces give them the appearance ● Acquired Immunodeficiency Syndrome (AIDS)
of small cauliflowers ○ Final stage of infection with HIV
● Often asymptomatic ● Not everyone with HIV develops AIDS
● People who develop genital warts are at higher risk ● MODE OF TRANSMISSION
of developing cancer of the cervix, anus, penis, and ○ Unprotected sex with an infected person
vulva ○ Sharing drug needles
● PREVENTION ○ Contact with the blood of an infected person
○ DOH launched a school-based prevention ○ Patients can give it to their babies during
program (HPV vaccine) pregnancy or childbirth
● Given to girls aged 9–12 ○ NOTE: HIV is not transmitted through air/water,
○ Mayro’n na kaagad target population, saliva, sweat, tears, closed-mouth kissing,
making it beneficial insects/pets, and sharing toilets, foods, or drinks
● Before, HPV vaccines are only given to ● SIGNS AND SYMPTOMS
sexually-active individuals ○ The first signs of HIV infection may be swollen
● TREATMENT glands and flu-like symptoms (fever, muscle
○ Removing warts through chemical applications, aches, and sore throat)
cryotherapy, laser, or electrosurgery ● These may come and go within two to four
weeks
HERPES SIMPLEX VIRUS 2
○ Also includes night sweats, fatigue, chills, and
mouth ulcers
● Most frequently reported STD in the United States
○ Severe symptoms may not appear until months
● Contagious, chronic infection that causes sores
or years later
○ FEMALES
● VULNERABLE POPULATIONS
● The principal sites of primary anogenital
○ Anyone having unprotected sex or sharing
herpes virus infection are the cervix and
needles with infected persons
vulva, with recurrent disease affecting the
○ Babies born to HIV-positive mothers
vulva, perineal skin, legs, and buttocks
● Hindi sila 100% infection
○ MALES
○ People exposed to blood products or tissues of
● Lesions appear on the penis, and in the
infected persons
anus and rectum of those engaging in anal
● DIAGNOSIS
sex
○ Enzyme Linked Immuno-Sorbent Assay (ELISA):
● VULNERABLE POPULATIONS
presumptive test
○ Sexually-active people
○ Western Blot: confirmatory test
○ Newborns infected during birth
○ Blood Test: can tell HIV infection
● SIGNS AND SYMPTOMS
● The health care provider can do the test, or
○ Burning sensation in the genitals
by using a home testing kit
○ Low back pain
● May also be through free testing sites
○ Pain upon urination
● PREVENTIVE MEASURES
○ Flu-like symptoms may accompany the initial
○ Primary
outbreak
● Avoid sexual intercourse or maintain
● TREATMENT
mutually monogamous sexual relationship
○ Currently, there is no cure
with uninfected person
○ Antiviral medications help reduce duration and
● Avoid sharing needles
control S/Sx
○ The presence in a person of other STIs greatly ● Reduction to <1.5% of syphilis among the key
increases the risk of acquiring or transmitting population
HIV
○ It is initially seen among what we call key PROGRAM STRATEGIES
populations which include Males who have Sex
with Males (MSM), Transgender (TG), People ● Continuum of HIV/STI prevention, diagnosis,
Who Inject Drugs (PWID) and Freelance Sex treatment and care services to key populations
Workers (FSW) ● Health promotion and Communication on HIV and
● Philippines STI Prevention and Care Services
○ One of the countries with rapidly increasing ● Enhanced strategic information systems
HIV/AIDS cases ● Strengthened health system platform for broader
○ In Central Luzon, a total of 385 cases have been health outcomes
diagnosed from 1984 to October 2017
○ Our prevalence rate is 2.06% which is above the ROLE OF THE DEPARTMENT OF HEALTH
National Health Target of maintaining a 1% and
below prevalence rate ● Policy dissemination
○ Seventy percent (70%) of the diagnosed cases ● Capacitate health facilities to promote the
are from Baguio City affecting mostly Men continuum of HIV/STI prevention, diagnostic,
having Sex with Men (MSM) treatment and care services to key populations
○ Looking further, the city has an 8% HIV/ AIDS ● Provide information on HIV and STI services
prevalence rate from 1984 to present promotion
○ For the other provinces and cities, the ● Logistics augmentation to health facilities providing
prevalence rate is below 1% in 2017 STI and HIV/AIDS services
● Enhance strategic information campaign
NEW PROGRAM THRUSTS regionwide
● Conduct monitoring and evaluation activities to
● If healthcare workers are supported and protected, identify gaps and propose tangible plans.
they can deliver safe and effective HIV services,
especially to marginalized groups ROLE OF LOCAL GOVERNMENT UNITS
○ Ending discrimination can eventually end AIDs
● VISION ● Implement policies/issuances on STI HIV/AIDS
○ Zero New Infections, Zero Discrimination, Zero ● Conduct mapping of affected key populations
AIDS-related Deaths ● Support establishment of Local AIDS Council
● GOAL ● Ensure adequate supply of logistics needed in
○ By 2020, the country will have maintained a providing quality STI and HIV services
prevalence of less than 66 HIV cases per ● Strengthen advocacy strategies for STI and HIV
100,000 population by preventing the further awareness across key populations
spread of HIV infection and providing treatment ● Advocate for STI and HIV testing especially among
care and support to reduce the impact of the key populations
disease on individuals, families, sectors and ● Network with various agencies and NGOs for wider
communities coverage of STI services and advocacy
● PURPOSE (OUTCOME) ● Capacitate frontline health workers in providing STI
○ To contain and prevent the further spread of HIV/AIDS awareness, skills in counseling and testing
HIV among key populations with four (4) etc.
strategies that enabled strengthened delivery ● Support HIV awareness and counseling activities by
of essential services (prevention, treatment and strategically employing trained peer educators
care interventions)
FUTURE PLANS/STRATEGIES (2018–2022)
OBJECTIVES (NATIONAL TARGETS TO ACHIEVE FROM
2015–2020) Continuum of HIV/STI prevention, diagnostic,
●
treatment and care services to key populations
● Maintain a prevalence rate of less than 1% HIV
○ Includes trainings such as HIV counseling and
prevalence
testing, Reagents and Medicines
● Reduction of HIV incidence among MSM to <50%.
● Expand the platform for publicizing STI services
○ The health services in our trained facilities has ○ On 7 March, the first local transmission of
to be promoted to increase consultations, COVID-19 was confirmed. WHO is working
enrollment to support and care services, closely with the Department of Health in
thereby decreasing the further spread of STIs responding to the COVID-19 outbreak
and HIV ○ As of 2022, the World Health Organization said
● Enhance strategic information for the LGU to that “the end is in sight”
continuously conduct the following: ● DIAGNOSIS
○ Monitor and prevent the spread of STI cases in ○ Viral Tests
their areas, and to conduct mapping of key ● Tells the patient if they have a current
affected population infection
○ Organize, analyze and use their own data to ○ Antibody Tests
intensify and customize strategies ● Might indicate a past infection
● Strengthen health system platform for broader ● Might not show if you have a current
health outcomes infection because it can take 1–3 weeks
● Expansion of STI HIV/AIDS service delivery spots after infection for your body to make
through the following: antibodies
○ Creation of an STI-HIV/AIDS hotline ● Having antibodies to the virus that causes
○ Support establishment and operations of COVID-19 might provide protection from
HIV/AIDS support groups getting infected with the virus again
○ Support to provincial/city mobile testing ○ If it does, we do not know how much
initiatives protection the antibodies might provide
○ Increase collaboration with LGUs and NGOs in or how long this protection might last
the conduct of community HIV screening ● SIGNS AND SYMPTOMS
(community- or facility-based) with emphasis ○ On average it takes 5–6 days from when
on proper counseling and referral to prevent someone is infected with the virus for
loss to care symptoms to show, however it can take up to 14
○ Promotion of the creation of sundown clinics days
○ Establishment of Rapid HIV Diagnostic (rHIVda ○ Most Common
sites) with prioritization per year as per ● Fever, dry cough, and tiredness
guideline of the DOH-Central Office ○ Less Common
● Ensuring continuous supply of logistics to health ● Aches and pains
facilities providing STI and HIV services ● Sore throat
○ A logistics supply management system or ● Diarrhea
mechanism will be placed in these facilities to ● Conjunctivitis
ensure good flow of supply and demand. ● Headache
● Expand tri-media advocacy campaigns on STI ● Loss of taste and/or smell
HIV/AIDS prevention and management (radio ● Rash on skin or discoloration of fingers and
shows, newsprint, social media, videos, awarding of toes
best practices) ○ Serious Symptoms
● Difficulty breathing or shortness of breath
COVID-19 ● Chest pain/pressure
(Novel Coronavirus) ● Loss of speech/movement
● TREATMENT
● An infectious disease caused by a new strain of
○ Vaccinations against COVID-19 are available
coronavirus
○ If you feel sick you should rest, drink plenty of
○ This new virus and disease were unknown
fluid, and eat nutritious food
before the outbreak began in Wuhan, China, in
○ Stay in a separate room from other family
December 2019
members, and use a dedicated bathroom if
● TIMELINE
possible
○ On 30 January 2020, the Philippine Department
○ Clean and disinfect frequently touched
of Health reported the first case of COVID-19 in
surfaces
the country with a 38-year-old female Chinese
○ Everyone should keep a healthy lifestyle at
national
home
● Maintain a healthy diet, sleep, stay active, ● Apply a coin-sized amount on your hands.
and make social contact with loved ones There is no need to use a large amount of
through the phone or internet the product
● Children need extra love and attention from ● Avoid touching your eyes, mouth and nose
adults during difficult times immediately after using an alcohol-based
○ Keep to regular routines and schedules as hand sanitizer, as it can cause irritation
much as possible ● Hand sanitizers recommended to protect
○ It is normal to feel sad, stressed, or confused against COVID-19 are alcohol-based and
during a crisis therefore can be flammable
● Talking to people you trust, such as friends ○ Do not use it before handling fire or
and family, can help cooking
● If you feel overwhelmed, talk to a health ● Under no circumstance, drink or let children
worker or counselor swallow an alcohol-based hand sanitizer
● PREVENTIVE/PRECAUTIONARY MEASURES ○ It can be poisonous
○ Regularly and thoroughly clean your hands with ● Remember that washing your hands with
an alcohol-based hand rub or wash them with soap and water is also effective against
soap and water COVID-19
○ Maintain at least 1 meter (3 feet) distance
between yourself and others LIFESTYLE-RELATED DISEASES
○ Avoid going to crowded places
○ Avoid touching eyes, nose and mouth ● Non-communicable diseases (NCDs) include
○ Make sure you, and the people around you, cardiovascular conditions (hypertension, stroke),
follow good respiratory hygiene diabetes mellitus, lung/chronic respiratory diseases
● This means covering your mouth and nose and a range of cancers which are the top causes of
with your bent elbow or tissue when you deaths globally and locally
cough or sneeze, then dispose of the used ○ 15 million deaths between the age of 30–69
tissue immediately and wash your hands years old
○ Stay home and self-isolate even with minor ○ 85% of premature deaths occur in low- to
symptoms such as cough, headache, mild middle-income countries
fever, until you recover ● 75% of total deaths in the PH are attributed
● Have someone bring you supplies. If you to NCDs
need to leave your house, wear a mask to ● These diseases are considered as lifestyle related
avoid infecting others and are mostly the result of unhealthy habits
○ If you have a fever, cough and difficulty ● Behavioral and modifiable risk factors like smoking,
breathing, seek medical attention, but call by alcohol abuse, consuming too much fat, salt and
telephone in advance if possible and follow the sugar and physical inactivity have sparked an
directions of your local health authority epidemic of these NCDs which pose a public threat
○ Keep up to date on the latest information from and economic burden
trusted sources, such as WHO or your local and
national health authorities VISION
○ Safe Use of Alcohol-based Hand Sanitizers
● A Philippines free from the avoidable burden of
● To protect yourself and others against
NCDs (non-communicable diseases)
COVID-19, clean your hands frequently and
thoroughly
○ Use alcohol-based hand sanitizer or MISSION
wash your hands with soap and water
● Ensure sustainable health promoting environments
● If you use an alcohol-based hand sanitizer,
and accessible, cost-effective, comprehensive,
make sure you use and store it carefully
equitable and quality health care services for the
● Keep alcohol-based hand sanitizers out of
prevention and control of NCDs, and guided by the
children’s reach
principle of “Health in All, Health by All, Health for All”
○ Teach them how to apply the sanitizer
whereas Health in All refers to Health in All Policies,
and monitor its use
Health by All involves the whole-of-government
and the whole-of-society and the Health for All
UNHEALTHY DIET
POLICIES AND LAWS
● Sodium and salt consumption in the PH is high
● AO No. 2011-0003
○ Estimated to be twice as high as the WHO
○ The National Policy on Strengthening the
recommendation
Prevention and Control of Chronic Lifestyle
● Attributable NCDs include stomach cancer,
Related Non-Communicable Diseases
ischemic heart disease, stroke, and diseases d/t
● AO No. 2012-0029
hypertension
○ The Implementing Guidelines on the
○ Proportion of CV deaths attributable to high
Institutionalization of Philippine Package of
sodium is 28%
Essential NCD Interventions (PhilPEN) on the
● Interventions
○ Food-based dietary guidelines
TOBACCO USE
● Major concern
● 40% of men smoke and 12% of school-based
adolescents (13–15 years old) are current smokers
● Attributable NCDs include cancer, ischemic heart
disease, stroke, COPD, pneumoconiosis, etc.
● Smoking prevalence is still greatest among people
with low income