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)]
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FGHIJ:R54.
1 KLMNO:A KPQJ:1
672
2353(2019)23
076
04 DOI
:10.
761
9/j
cmp.
201
92302

Ef
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swithr
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  ABSTRACT:Obj e cti
ve Toi nv est
igatethee f
fectofa mlodipinev er
susbe nazepr
ilint r
e at
me nt
ofa r
teri
os c
lero s
isinpa ti
e ntswithren alhy pe r
tens
ion.Me thods Oneh undreda nds eventy
fivepa 
ti
entswi t
hr e nalh ypert
ens i
oni nourh o spit
a lwerer and
o mlydivide di nt
ot wog r
oup s.Gro upA(n=
94)r eceiveda mlodipi
nef or5~1 0mgo n cead ay,a ndg ro
u pB(n=81)r eceiv
edbe nazeprilf
o r10~
20mgo ncead a
y.Bl o
odp res
sureanda r
terio
scle
rosisindicat
orsi ncludi
ngbr achial
anklepu l
sewa v

vel
o ci
ty(b aPWV)a nda n kl
ebrac
h i
ali ndex(ABI )we reme a
suredbe fo
rea nda f
ter8mo nthso fan t
i
hypertensivet hera
py .Re sult
s  Theb lo o
dp res
surea f
tertreatme nto fbothg roupss i
gnifi
cantlyde 
creasedc ompa r
edwi thbe for
et r
eatmen t(P<0. 05),whi letherewe ren os i
gnif
icantbetwe e
n g
roup
dif
ferencesi nbl oodpr es
s uresbefor
ea nda ft
ertreat
me nt(P>0.0 5).Af t
ertreat
me nt,b aPWVo fB
groupwa ss ign i
fi
ca nt
lylowe r,ABIwa ss i
g nif
ica
ntlyh i
ghert hant hatbe f
oret r
eatment(P<0.05),
butnos i
g ni
fic a
ntdi ff
erenc e
swe refo undi na bor
ei ndicat
orsbe forea nda fte
rtr
eatmenti nA g r
oup s
(P>0. 05).Conc l
usi
on Be na
zeprilha sb ett
ere f
fe
ctint r
e a
tme nto fart
erios
cler
o s
iscause dbyr enal
hypertensiont hana mlodipine.
KEY WORDS:r e nalhypert
en s
io n;a rt
eri
oscler
osis;p ul
sewa v ev e
locit
y;a nkle
brachialindex

[1]
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© CKDQœª,›v‡•¡9ŽgI«¬­ F½¾¿ÀÁ{|… ,KLQMNOPÃxµ

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2 @ A
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4 ‹ÿop A^(n=9
4) B^(n=8
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5 Êà /
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7 2.
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:wxyoy;HDL
C:Hàx†‡ˆ‰ìŠ;
ÇÓ。 ‘™•RS>œQ‹–—,A^2 1~ LDL
C:‹àx†‡ˆ‰ìŠ。

2]HIJKL_`abc<=>?d ("˜™ 2.
2 ;<9:
š¤ÇN› )5mg/
e,1e /
d,3]HIJKL RSf,2^KLQIJ%?:;,VW‚
_`abc<=>?d 1 0mg/e,1e /
d;B^ ~4€ (P>0.05);RS 8hij,2^K
·78· Ä ` Å Æ + Ç È É           '2
3Ë

LQIJ%?z;RSf|‹,VW}~4€ 4€(P>0.
05)。šÙ 2。
(P<0.
05),ø 2^ÚIJ%?:;,VW‚~
珋±s
[ 2 2\12*+ab/09:(x ) mmHg

SBP DBP
^u n
RSf RSj RSf RSj

A^ 9
4 165.
3±10.
2 128. 7
5± 9. 9
8.2±7.
5 7
8. 8
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PWV
RSf,2^KLÚ baPWV、ABI%?:;, %?‹ŒRSf„ A^,ABI%?HŒRSf„
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05)。šÙ 3。
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PWV、ABI%?„RSf…:,VW
珋±s
[ 3 2\12*+abc34/d56eM9:(x )

ba
PWV/
(cm/
s) ABI
^u n
RSf RSj RSf RSj

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2 16
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7 1.
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08 1.
06±0.
10
B^ 8
1 1593.
9±352.
7 1512.
6±3 4#
41. 0.
97±0.
09 1.
11±0.
14#

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PWV:qrNstuvwx;ABI
:rqoy。„RSf:;,P<0.
05;„ A^:;,#P<0.
05。

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3 f B
x„HIJ-©Ãxg.ZHI†、HIC、z
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óñô¹ºé¾Fµj^ê (KDI
GO)o1 ] 16
95~22
68c
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aPWV3H,
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p|JÇÓ,çíîïð*&ñò'(ïðñ 5YKL]CDA›H†I,Îba
PWVQRH
(NDHP
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NC8o1ëì`Œ>œGH Œ14ŽQKL。B^} 2
2YCDKL@ 9Y
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aPWV] 16
85~24
07c
m/s
,Ñ5
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iQRSj,IJz;RSf{|,VW}~4 ¾Ã、
ÊàQÂîR̖„ A^V6Q78。R
€,õQ‚ôŠ ACEI
(RAASòóñQŸÕ )¸ S hij,A^KL ba
8 PWVÎ;RSfVW
Š CCB*ÇÓEFGHIJz}RËQ|JT ‚~4€,B^KL ba
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U。2^QIJßP:;,VW‚~4€,ö Ë{|,öÌABCDE¹ºév3MNOP}
Ì ACEI@ CCB*ÇÓRSFGHIJ³¼›‚ Ÿ¦ST,ç<=>?‚QRTU,€1Í ACEI
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³¼G。 ˆ9ú8。
ba
PWVWÙév3MNOPÃx,³µl9 ABIorMN„:MN:[JQ:Î,Š;
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] 1400c
m/s
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[1
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1-1
2]
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