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‡ JUѭӧXDOFRKROFXQJFҩSNFDO

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 9LWDPLQWDQWURQJQѭӟFÿһFÿLӇPVLQKKyDYjOkP
,ĈҤ,&ѬѪ1*9ӄ1+8&Ҫ8',1+'ѬӤ1*9¬
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‡ &KӃÿӝăQXӕQJKjQJQJj\ ‡ &iFD[LWEpRWKLӃW\ӃXQKѭD[LW
OLQROHLFYjOLQROHQLFFѫWKӇQJѭӡL
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QJRҥLELrQEHULEHULNK{
‡ Carbohydrate = 45% ÿ͗n 65% NK{QJWәQJKӧSÿѭӧFSKҧLÿѭDYjR
pyruvat và alpha-

OѭӧQJFDOR WӯWKӭFăQFҫQWKLӃWÿӇWәQJKӧS cetoglutarat +ӝLFKӭQJ:HUQLFNH.RUVDNRIIJһSWURQJQJKLӋQUѭӧXPmQ

SURVWDJODQGLQYjFiFHLFRVDQRLG
‡ Ch̽t béo  30% WәQJOѭӧQJ dehydrogenase WtQKFyELӇXKLӋQPҩWÿLӅXKzDOLӋWFѫPҳWO~OүQYjUӕLORҥQ
‡ Protein = 0,8 g / kg WKӇWUӑQJPӛL
FDOR QJj\ 5LERIODYLQ 7LӅQFKҩWFӫDFRHQ]\PH 7KLӃXKөWJk\YLrPOѭӥLFiFYӃWQӭWFӫDNKyHPLӋQJP{L
‡ FKRFiFFKҩWEpRNK{QJEmR ‡ DFLGDPLQNK{QJWәQJKӧSÿѭӧF % FMN và FAD YLrPGDYjORpWJLiFPҥF
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‡ FKRFKҩWEpRNK{QJEmRKzD ăQOjhistidin, isoleucin, leucin, lysin,
ÿѫQ methionin, phenylalanin, threonin, 1LDFLQ% &ҫQWKLӃWÿӇWәQJKӧS +ӝLFKӭQJSHOODJUDWLrXFKҧ\VDV~WWUtWXӋYjYLrPGD6ӵ
tryptophan và valin. FRHQ]\PHNAD+, WKLӃXKөWFyWKӇOjNӃWTXҧFӫDWKXӕFFKӕQJODRLVRQLD]LG
‡ FKRFiFD[LWEpREmRKzD
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PJQJj\ FiFHQ]\P 
GHK\GURJHQDVH
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FDUER[\ODVHYtGө
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JySSKҫQTXDQWUӑQJWURQJ
7KLӃXFyWKӇGRGQJNKiQJVLQKOkXGjLăQ
7+$%
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&R$67+$%Yj FKROHVWHURO ‡ Propionyl –CoA FKӃVӵKҩSWKөELRWLQ
‡ &R$Oj FRFHQ]\PH TXDQ WUӑQJ QKҩW WURQJ &+FiF FKҩW carboxylase
‡ 7KDPJLDÿLӅXKzDFKXWUuQK7%
‡ &R$KRҥW ÿӝQJ WURQJ 7%WURQJ PiXP{ Yj FiF Fѫ TXDQ FHOOF\FOHWiFGөQJOrQSURWHLQ
‡ &zQ JӑL Oj&R$6+ KRһF 6+&R$ WURQJQKkQELRWLQ\ODWH

'U'XRQJ7KL+RQJ'LHS ϳ ƌ͘ƵŽŶŐdŚŝ,ŽŶŐŝĞƉ ϴ
 9LWDPLQ%FREDODPLQ
9LWDPLQWDQWURQJQѭӟFÿһFÿLӇPVLQKKyDYjOkP
VjQJNKLWKLӃXKөW &ҩX WҥR KyD KӑFSKӭF WҥS
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UHGXFWDVHWKjQK PRQRSKRVSKDWH trung tâm + 1 nucleotide
WHWUDK\GURIRODWH7+)FKҩW G703GүQÿӃQVӵWtFKWөEҩWWKѭӡQJG803YjR$'1 ‡ +Ӌ WKӕQJ YzQJJLӕQJ SRUSK\ULQ
‡ &y FREDQ &RӣJLӳDo
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FKҩWWURQJFRQÿѭӡQJFKX\ӇQ TXDQWҥRPiXJk\UDWKLӃXPiXQJX\rQKӗQJFҫXNKәQJ ‡ &RFy OLrQ NӃW SKӕL WUt
KyDPӝWFDUERQ OӗPHJDOREODVWLF ‡ 1XFOHRWLGHEDVH1Oj 
GLPHWK\OEHQ]LPLGD]RO
3KөQӳPDQJWKDLFҫQQKLӅXIRODWHKѫQVӵWKLӃXKөWGүQ
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ÿDQJSKiWWULӇQ
‡ 9LW %Fy QKLӅX GҥQJ
‡ &ѫFKӃKRҥWÿӝQJ ‡ 5 &1o F\DQRFREDODPLQ
9LWDPLQ& 6ӵWKLӃXKөWFyWKӇGүQÿӃQEӋQKFzLGӉEҫPWtPPӓL
‡ /jFKҩWNKӱ ‡ 5 2+o K\GUR[RFREDODPLQ
‡ 'ӑQGҽSFiFJӕFWӵGR FѫPӅPYjVѭQJOӧL[XҩWKX\ӃWYjWKLӃXPiX ‡ 5 ¶ GHR[\DGHQRV\O o ¶
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9LWDPLQ%FREDODPLQ
9LWDPLQWDQWURQJOLSLG
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‡ IsomeraseHQ]\PHÿӗQJ SKkQ
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leucine aminomutase) UKRGRSVLQFyNKҧQăQJKҩSWKөiQK
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&iFFRQÿѭӡQJFKX\ӇQKyDFKtQKFӫDFDUERK\GUDWH
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 Ĉͫng hóa ch̽t béo
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&+WKtFKQJKL
NKLQR

Con ÿ˱ͥng thoái hóa chung cu͙i cùng cͯa ṱt c̫ các ch̭t:

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QJKLNKLÿyL ÿyLOkXQJj\

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QJXӗQFXQJFҩS
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nh́ng không ÿͿ oxaloacetate.
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*

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± WKѭӡQJFKӏXNLӇPVRiWFӫDKRUPRQTXiWUuQKELӋWKRiP{KD\
WKtFKQJKLYӟLWKD\ÿәLGjLKҥQFӫDP{LWUѭӡQJ
9'ÿLӅXKzDFRQÿѭӡQJFKX\ӇQKyDWUS
ƌ͘ӇҿŶŐdŚŝ,ŽŶŐŝĞƉ ϳϳ ƌ͘ӇҿŶŐdŚŝ,ŽŶŐŝĞƉ ϳϴ

6LQKWәQJKӧSHQ]\PHFѫ FKӃÿKEKJHQH

‡ &ҧPӭQJ
‡ .uPKmP
‡ .KӣLÿҫXSKLrQPm
± y͗u tͩ ÿ͏c hi͟u
± ch̽t kìm hãm
± ch̽t ho̹t hoá

ƌ͘ӇҿŶŐdŚŝ,ŽŶŐŝĞƉ ϳϵ ƌ͘ӇҿŶŐdŚŝ,ŽŶŐŝĞƉ ϴϬ
 6LQKWәQJKӧSHQ]\PHFѫ FKӃÿKEKJHQH 6LQKWәQJKӧSHQ]\PHFѫ FKӃÿKEKJHQH

Ch̽t kìm hãm Ch̽t ho̹t hoá

± *ҳQYjRÿo̹n tác ÿͱng RSHUDWRUJҫQÿRҥQNKӣLÿӝQJ ± *ҳQWҥLYӏWUtJҫQÿRҥQNKӣLÿӝQJ
± 3KkQWӱWtQKLӋXch̽t tác dͽngJҳQYjRFKҩWNuPKmPÆWKD\ ± &ҫQWKLӃWÿӇKӛWUӧ$51SRO\PHUDVHJҳQYjRÿRҥQNKӣLÿӝQJ
ÿәLFҩXKuQKÆ ÿLӅXKRjVӵJҳQFӫDFKҩWNuPKmPOrQ$'1 ± 3KkQWӱWtQKLӋX
‡ OjPWăQJVӵSKLrQPmOjch̽t c̻m ΁ng ‡ OjPJLҧPSKLrQPmOjch̽t kìm hãm
‡ OjPJLҧPVӵSKLrQPmOjch̽t ÿͫng kìm hãm ‡ OjPWăQJSKLrQPmOj ch̽t ÿͫng ho̹t hoá KD\FҧPӭQJ
7ӃEjRQKkQWKұWYӏWUtJҳQFӫDFKҩWNuPKmPYjFKҩWKRҥW
KRiFyWKӇӣ[DÿRҥQNKӣLÿӝQJ

ƌ͘ӇҿŶŐdŚŝ,ŽŶŐŝĞƉ ϴϭ ƌ͘ӇҿŶŐdŚŝ,ŽŶŐŝĞƉ ϴϮ

ĈLӅXKzDEKJHQHӣSURNDU\RWH ĈLӅXKzDEKJHQHӣSURNDU\RWH

¾ 3URNDU\RWHWKѭӡQJÿiSӭQJWKtFKQJKLYӟLVӵWKD\ÿәLP{LWUѭӡQJTXDÿLӅXKzD ‡ &ѫ FKӃÿKFKӫ\ӃXWK{QJTXDFiFRSHURQ

‡ &ҩXWU~FJHQH
SKLrQPm ± PromoterYQJNKӣLÿҫX
¾ 0RQRG-DNREYj/ZRIIÿѭDUDNKiLQLӋPYӅRSHURQÿӇJWKVӵÿKEKJHQH ± OperatorYӏWUtYұQKjQKOjQѫLSURWHLQÿKFy
WKӇEiPYjRNtFKWKtFKNuPKmPEKJHQHFҩX
¾ 7URQJWE WU~F
± Gene c̽u trúcPmKyDSURWHLQ
± (Q]\PHFѫ FҩXFRQVWUXFWLYHÿѭӧF67+ÿӅXÿһQ ‡ &ҩXWU~FRSHURQQKLӅXJHQHOTXYӟLQKDX
± (Q]\PHFҧPӭQJLQGXFLEOHFKӍÿѭӧF67+NKL[KFKҩWFҫQELӃQÿәL ‡ *HQHÿLӅXKzD
± *HQHFѫ FҩXÿѭӧFSKLrQPmOLrQWөFFiF63FyPһWWKѭӡQJ[X\rQWURQJWEJHQHVӱ
± ÿKVӵSKLrQPmFiFJHQHFҩXWU~F
± ҦKFKӭFQăQJRSHURQ
GөQJJOXFRVH ± .K{QJSKҧLWKjQKSKҫQFӫDRSHURQ
± *HQHÿLӅXKzDUHJXODWRUKRҥWÿӝQJW\WKHRÿLӅXNLӋQFөWKӇJHQHVӱGөQJODFWRVH ± &ySURPRWHUULrQJ
± 0mKyDFKRSURWHLQÿKzD

ƌ͘ӇҿŶŐdŚŝ,ŽŶŐŝĞƉ ϴϯ ƌ͘ӇҿŶŐdŚŝ,ŽŶŐŝĞƉ ϴϰ
 ĈLӅXKzDEKJHQHӣSURNDU\RWH
2SHURQÿѫQYӏSKLrQPm
‡ +RҥWÿӝQJFӫDRSHURQWURQJFѫ FKӃÿ/h ‡ +RҥWÿӝQJFӫDRSHURQWURQJFѫ FKӃÿ/h
âm d́˿ng
± *HQHÿKĺV[UDSURWHLQNuPKmP ‡ *HQHÿKĺV[UDSURWHLQKRҥWKyD ± ӢYLNKXҭQFiFJHQFyFKӭFQăQJOLrQTXDQYӟLQKDX[ӃSJҫQ
‡ &yWUѭӡQJKӧS
± &yWUѭӡQJKӧS QKDXSKLrQPmYjRFQJPӝW$51PSRO\FLVWURQ
‡ Protein kìm hãm ӣWUҥQJWKiLKÿEiPYjR ‡ Protein ho̹t hóa ӣWUҥQJWKiLKÿEiPYjR

operator ĺJHQHFҩXWU~FÿyQJĺJHQH operator 51$SRO\PHUDVHEiPYjR ± &өPJHQQj\YjFiFÿRҥQÿLӅXKRjÆoperon

SURPRWHUĺJHQHFҩXWU~FPӣĺJHQHFҩX
FҩXWU~FPӣNKLFyprotein ÿ͏c hi͟u EiP
WU~FÿyQJNKLFyprotein ÿ͏c hi͟u EiPYjR
YjRSURWHLQNuPKmPĺWiFKQyNKӓL
SURWHLQKRҥWKyDĺWiFKQyNKӓLRSHUDWRU
RSHUDWRU
‡ Protein ho̹t hóa ͷ tr̹ng thái không h/ÿ:
‡ Protein kìm hãm ͷ tr̹ng thái không h/ÿ
NK{QJEiPYjRRSHUDWRUĺJHQHFҩXWU~F
NK{QJEiPYjRRSHUDWRUĺJHQHFҩXWU~F
ÿyQJĺ JHQHFҩXWU~FPӣNKLFySURWHLQÿһF
Pӣĺ JHQHFҩXWU~FÿyQJNKLFySURWHLQ
KLӋXEiPYjRSURWHLQKRҥWKyDĺKRҥWKyD
ÿһFKLӋXEiPYjRSURWHLQNuPKmPĺKRҥW
Qy
KyDQy

ƌ͘ӇҿŶŐdŚŝ,ŽŶŐŝĞƉ ϴϱ ƌ͘ӇҿŶŐdŚŝ,ŽŶŐŝĞƉ ϴϲ

Caáu truùc moät mRNA ôû Prokaryote Caáu truùc moät mRNA ôû Eukaryote

Vò trí gaén Rb Vò trí gaén Rb Vò trí gaén Rb

Maõ khôûi ñaàu Maõ khôûi ñaàu Maõ khôûi ñaàu Vuøng khoâng maõ hoùa
AUG AUG AUG Maõ keát thuùc UAA

¶ ¶
* 333 A-A-A- -
3’ 3’
AUG
¶&$3
Vò trí gaén Rb Vuøng khoâng maõ hoùa
Vuøng khoâng maõ hoùa UAA UAA UAA
maõ keát thuùc maõ keát thuùc maõ keát thuùc

P1 P2 P3

ƌ͘ӇҿŶŐdŚŝ,ŽŶŐŝĞƉ ϴϳ ƌ͘ӇҿŶŐdŚŝ,ŽŶŐŝĞƉ ϴϴ
 &ҧPӭQJWәQJKӧSHQ]\P

‡ 7KѭӡQJJһSÿӕLYӟLFiFHQ]\PÿLӅXKRjTXiWUuQKGӏKRi
7'2SHURQODFWRVHlacӣE. coli
± FKӭDFiFJHQPmKRi
‡ ȕJDODFWRVLGDVHlacZ
‡ JDODFWRVLGSHUPHDVHlacY
‡ WKLRJDODFWRVLGWUDQVDFW\ODVHlacAELӃQÿәLJDODFWRVLGÿӝFKҥLÿӇORҥL
UDNKӓLWӃEjR
± FKӏXVӵNLӇPVRiWFӫDFҧFѫFKӃÿLӅXKRjkPYjGѭѫQJ

ƌ͘ӇҿŶŐdŚŝ,ŽŶŐŝĞƉ ϴϵ ƌ͘ӇҿŶŐdŚŝ,ŽŶŐŝĞƉ ϵϬ

0{ KuQK ÿLӅX KzD FKX\ӇQ KyD TXDÿKEK JHQH ĈLӅXKzDNLӇPWUDÿӗQJKyD± 7USRSHURQ

‡ ĈӗQJKyDDQDEROLVPOj

TXiWUuQKWәQJKӧSFiFFKҩW
FҫQWKLӃWFKRWE
‡ 9'WәQJKӧSDD
‡ 7әQJKӧSWU\SWRSKDQWӯ
FKRULVPDWHTXDSKҧQӭQJ
GRHQ]\PH[W
‡ JHQHPmKyDFKR
HQ]\PHQҵPWUrQRSHURQ
‡ 1ҵPӣSKtDWUѭӟFFzQFy
JHQHNKӣLÿӝQJJHQHÿLӅX
KzD

ƌ͘ӇҿŶŐdŚŝ,ŽŶŐŝĞƉ ϵϭ ƌ͘ӇҿŶŐdŚŝ,ŽŶŐŝĞƉ ϵϮ
 ĈLӅXKzDEKJHQHӣSURNDU\RWH
‡ Trp operonӣ(FROLFyJHQHFҩXWU~F
± TrpE, trpD, trpC, trpB, trpA
± 0mKyDFKRHQ]\PHWKDPJLD67+WU\SWRSKDQWӯ
FKRULVPDWH
± TrpR OjJHQHNuPKmPWUSRSHURQĺPmKyDFKRSURWHLQ
Repressor (R)
± 5HSUHVVRUFyYӏWUt
‡ *ҳQ'1$WҥLRSHUDWRU
‡ *ҳQWU\SWRSKDQ
‡ ĺNKLJҳQYӟLWU\SWRSKDQĺ 5WKD\ÿәLFҩXKuQKĺEiPYjR
RSHUDWRUĺQJăQFҧQ51$SRO\PHUDVHEiPYjRSURPRWRUĺ
NK{QJSKLrQPmÿFWUSRSHURQ
± .KLQӗQJÿӝ7USFDRNK{QJFҫQ67+WUSQӳD
± .KLQӗQJÿӝ7USQӝLEjRWKҩSĺWUSWiFKNKӓL5HSUHVVRUĺ
EҩWKRҥW5ĺ7USRSHURQÿѭӧFSKLrQPm

ƌ͘ӇҿŶŐdŚŝ,ŽŶŐŝĞƉ ϵϯ ƌ͘ӇҿŶŐdŚŝ,ŽŶŐŝĞƉ ϵϰ

ĈLӅXKzDNLӇPWUDGӏKyD± /DFRSHURQ /DFRSHURQӣ(FROL

‡ Lac operonӣE. Coli Fy JHQH

FҩX WU~F
‡ 'ӏ KyD FDWDEROLVPTXi WUuQK WKRiL KyD FiF FKҩW KӳX ± LacZ EJDODFWRVLGDVHSKkQ FҳW
Fѫ Wӯ 7ĂWKjQK FiF SKkQ Wӱ QKӓ Yj QăQJ OѭӧQJ ODFWRVHĺJDOJOX KRһF WKjQK
DOORODFWRVHlacY SHUPHDVHYF
± 9'WKӫ\ SKkQ ODFWRVHӣE. coli FKӫ ÿӝQJ ODFWRVHYjR WElacA
WKLRJDODFWRVLGH WUDQVDFHW\ODVH
‡ 7K{QJ WKѭӡQJ E. coli Vӱ GөQJ JOXFRVHNKL WKLӃX ± 1KLӋP YөYFYj &+ODFWRVH
JOXFRVHFy ODFWRVHĺWE 67K HQ]\PHSKkQ Kӫ\ ± LacIJHQHÿKODFRSHURQ  Khi không có lactose5EiPYjRRSHUDWRUĺNuPKmP67+
HQ]\PHV
‡ &y SURPRWHUULrQJ
ODFWRVH ‡ 0m KyD FKR SURWHLQNuP KmP
 Khi có nhi͙u lactoseODFWRVHĺDOORODFWRVHFKҩWFҧPӭQJ
 $OORODFWRVHEiPYjR55WiFKNKӓL'1$ĺ51$± SRO\PHUDVHEiP
5HSUHVVRU YjRSURPRWHUSKLrQPm/DFRSHURQ
‡ 5Fy Yӏ WUt
± ONYӟL DOORODFWRVH
± ONYӟL '1$RSHUDWRU
ƌ͘ӇҿŶŐdŚŝ,ŽŶŐŝĞƉ ϵϱ ƌ͘ӇҿŶŐdŚŝ,ŽŶŐŝĞƉ ϵϲ
 ƌ͘ӇҿŶŐdŚŝ,ŽŶŐŝĞƉ ϵϳ ƌ͘ӇҿŶŐdŚŝ,ŽŶŐŝĞƉ ϵϴ

.KL>JOX@Yj>ODF@ÿӅXFDR/DFRSHURQSKLrQPmӣ
PӭFWUXQJEuQK
™ .KL>JOX@Yj>ODF@ĹĹĹ ӭF
/DFRSHURQFzQÿKEӣL&$3
™ .KL>JOX@Ļ Yj>ODF@Ĺĺ&$3EiP
YjR\WӕÿKFLVWUrQRSHURQĺ ‡ /DFRSHURQFzQÿѭӧFÿKEӣLSURWHLQKKyDGӏ
51$SROEiPFKһWYjRSURPRWHU
ĺWăQJSKLrQPm/DFRSHURQ KyDCAPӣ(&ROL
™ CAP FDWDEROLWHDFWLYDWRUSURWHLQ

FKӃadenylate cyclase ± .KLFy*OXFRVHĺ&+ODFWRVHEӏNuPKmPGR

ĺNK{QJ67+cAMP &$3WiFKUDNKӓL'1$
ĺ&$3NK{QJEiPYjR
± .KLNK{QJFy*OXFRVHF$03QӝLEjRFDR
\ӃXWӕÿKFLVYjQJWUrQ
ODFRSHURQĺ.K{QJJL~S ± .KLNK{QJFy*OX&$3JҳQYӟLF$03VDXÿy
51$SROEiPFKһWYjR EiPYjRYӏWUt'1$JҫQSURPRWHU/DFRSHURQ
SURPRWHUÿѭӧFĺFKӍ
SKLrQPmӣPӭF7% ± 3KӭFKӧSCAP-cAMP-DNA OjPEӅQYӳQJ51$±
SRO\PHUDVHWUrQSURPRWRUFӫD/DFRSHURQĺ
WăQJSKLrQPm/DFRSHURQ

ƌ͘ӇҿŶŐdŚŝ,ŽŶŐŝĞƉ ϵϵ ƌ͘ӇҿŶŐdŚŝ,ŽŶŐŝĞƉ ϭϬϬ

 &ҧPӭQJWәQJKӧSHQ]\P ңŵӈŶŐƚҼŶŐŚӄƉĞŶnjLJŵ͗
ĈLӅXKRjkP ŝҲƵŚŽăąŵ
‡ 3URWHLQNuPKmPlac /DFJHQlacI PmKRi ‡ KƉůĂĐ ĜӇӄĐĐңŵӈŶŐŬŚŝŵƀŝƚƌӇӁŶŐĐſůĂĐƚŽƐĞ;ŬŚƀŶŐĐſŐůƵĐŽƐĞͿ͘
‡ lacI QҵPWUѭӟFÿRҥQNKӣLÿӝQJFӫDRSlacFyÿRҥQNKӣLÿӝQJULrQJ3,ÿӝF
OұS ‡ >ĂĐƚŽƐĞǀăŽƚұďăŽ͘ĐŽůŝ ;ŶŚӁƉĞƌŵĞĂƐĞͿÆ ĂůůŽůĂĐƚŽƐĞ;ŶŚӁɴͲ
‡ /DFJҳQYjRÿRҥQWiFÿӝQJFKtQK2FQJO~FYӟLPӝWWURQJÿRҥQWiF ŐĂůĂĐƚŽƐŝĚĂƐĞͿ͘
ÿӝQJSKө22QҵPWURQJFiFJHQlacZ YjlacI
‡ ůůŽůĂĐƚŽƐĞůăĐŚҤƚĐңŵӈŶŐ;ƚşŶŚŝҵƵͿŐҩŶǀăŽ>ĂĐÆďŝұŶĜҼŝĐҤƵŚŞŶŚ
ÆĐŚҤƚŬŞŵŚĆŵƚĄĐŚŬŚҹŝĜŽҢŶƚĄĐĜҾŶŐÆĐĄĐŐĞŶĐӆĂŽƉĞƌŽŶůĂĐ ďŝҳƵ
ŚŝҵŶ͘

ƌ͘ӇҿŶŐdŚŝ,ŽŶŐŝĞƉ ϭϬϭ ƌ͘ӇҿŶŐdŚŝ,ŽŶŐŝĞƉ ϭϬϮ

ңŵӈŶŐƚҼŶŐŚӄƉĞŶnjLJŵ͗ ңŵӈŶŐƚҼŶŐŚӄƉĞŶnjLJŵ͗
ŝҲƵŚŽăąŵ ŝҲƵŚŽăĚӇҿŶŐ
‡ DҾƚƐҺɴͲŐĂůĂĐƚŽƐŝĚĐſĐҤƵƚƌƷĐƚӇҿŶŐƚӌĂůůŽůĂĐƚŽƐĞ͕ŶŚӇŶŐ ‡ 'ůƵĐŽƐĞǀăŽĜӇӁŶŐƉŚąŶƚƌӌĐƚŝұƉÆǀŝŬŚƵҦŶӇƵƚŝġŶƐӊĚӅŶŐ͘
ŬŚƀŶŐůăĐҿĐŚҤƚĐӆĂɴͲŐĂůĂĐƚŽƐŝĚĂƐĞ͕ĐƹŶŐůăĐŚҤƚĐңŵӈŶŐĜҺŝ ‡ ſŐůƵĐŽƐĞÆĐҿĐŚұŬŞŵŚĆŵ ĐŚҤƚĚҷŚŽĄ ÆŚҢŶĐŚұďŝҳƵŚŝҵŶ
ǀӀŝŽƉĞƌŽŶůĂĐ͘ ĐĄĐŐĞŶĚҷŚŽĄůĂĐƚŽƐĞ͕ĂƌĂďŝŶŽƐĞ͕ĐĄĐĜӇӁŶŐŬŚĄĐ͘
‡ dƌŽŶŐƐҺĜſ͕ŝƐŽƉƌŽƉLJůƚŚŝŽŐĂůĂƚŽƐŝĚ;/Wd'ͿĜӇӄĐĚƶŶŐŶŚŝҲƵ
ƚƌŽŶŐƚŚӌĐŶŐŚŝҵŵ͘

ƌ͘ӇҿŶŐdŚŝ,ŽŶŐŝĞƉ ϭϬϯ ƌ͘ӇҿŶŐdŚŝ,ŽŶŐŝĞƉ ϭϬϰ

 ңŵӈŶŐƚҼŶŐŚӄƉĞŶnjLJŵ͗ ңŵӈŶŐƚҼŶŐŚӄƉĞŶnjLJŵ͗
ŝҲƵŚŽăĚӇҿŶŐ ŝҲƵŚŽăĚӇҿŶŐ
‡ zұƵƚҺƚŚĂŵŐŝĂ ‡ <ŚƀŶŐĐſŐůƵĐŽƐĞ͗ZWͲĐDWŐҩŶǀăŽǀҷƚƌşŐҥŶĜŽҢŶŬŚӂŝĜҾŶŐ
± ĐDW͗ĐŚҤƚĜһŶŐŚŽҢƚŚŽĄ ůĂĐ Æ ŬşĐŚƚŚşĐŚƉŚŝġŶŵĆ͘
± ƉƌŽƚĞŝŶƚŚӅƚŚҳĐDW ;ZWͿ͗ƉƌŽƚĞŝŶŚŽҢƚŚŽĄ͕ĐžŶŐҸŝůăƉƌŽƚĞŝŶŚŽҢƚ ‡ ſŐůƵĐŽƐĞÆ ӈĐĐŚұĂĚĞŶLJůĐLJĐůĂƐĞÆ ӈĐĐŚұƚҼŶŐŚӄƉĐDW͖
ŚŽĄŐĞŶĐŚҤƚĚҷŚŽĄ͕WͿ͘ ƚĉŶŐƚŚŽĄƚĐDWŬŚҹŝƚұďăŽÆ ŶһŶŐĜҾĐDWŐŝңŵÆ ZW
‡ ZWŐҩŶǀăŽEŵҢŶŚŶŚҤƚŬŚŝŶһŶŐĜҾĐDWĐĂŽ͘ ŐҩŶŬĠŵǀӀŝEÆŽƉůĂĐŐŝңŵďŝҳƵŚŝҵŶ͘

ƌ͘ӇҿŶŐdŚŝ,ŽŶŐŝĞƉ ϭϬϱ ƌ͘ӇҿŶŐdŚŝ,ŽŶŐŝĞƉ ϭϬϲ

ңŵӈŶŐƚҼŶŐŚӄƉĞŶnjLJŵ͗
ңŵӈŶŐƚҼŶŐŚӄƉĞŶnjLJŵ
WŚҺŝŚӄƉĜŝҲƵŚŽăąŵǀăĚӇҿŶŐ
‡ <ŚŝĐŚҤƚŬŞŵŚĆŵ>ĂĐŶŐĉŶĐңŶƉŚŝġŶŵĆÆ ZWͲĐDWŬŚƀŶŐ ‡ ZWǀăĐDWĐžŶƚŚĂŵŐŝĂĜŝҲƵŚŽăƉŚҺŝŚӄƉӂŶŚŝҲƵŽƉĞƌŽŶ
ĐſƚĄĐĚӅŶŐ͖ ŬŚĄĐ͘
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ĜҾŶŐŬŚƀŶŐŚŞŶŚƚŚăŶŚĜӇӄĐƉŚӈĐŚӄƉŵӂÆ Ěƶ>ĂĐƚĄĐŚŬŚҹŝ ƌĞŐƵůŽŶ͘
ŽƉůĂĐ ĐƹŶŐŬŚƀŶŐĐſƚĄĐĚӅŶŐƚƌġŶƉŚŝġŶŵĆ͘
Î^ӌĐңŵӈŶŐĐӆĂŽƉůĂĐ ĐҥŶǀӉĂůĂĐƚŽƐĞǀӉĂŶһŶŐĜҾŐůƵĐŽƐĞ
ƚŚҤƉ͘

ƌ͘ӇҿŶŐdŚŝ,ŽŶŐŝĞƉ ϭϬϳ ƌ͘ӇҿŶŐdŚŝ,ŽŶŐŝĞƉ ϭϬϴ

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ƌ͘ӇҿŶŐdŚŝ,ŽŶŐŝĞƉ ϭϬϵ ƌ͘ӇҿŶŐdŚŝ,ŽŶŐŝĞƉ ϭϭϬ

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