Cell Cycle Cell Division

Chapter 5:
Cell Growth
and
Division
copyright cmassengale 1
Cell Cycle
Cell Division
✓ All cells are derived from
pre-existing cells
✓ New cells are produced for
growth and to replace damaged or
old cells
✓ Differs in prokaryotes (bacteria)
and eukaryotes (protists, fungi,
plants, & animals)
Keeping Cells Identical
The instructions for

making cell parts
are encoded in the
DNA, so each new
cell must get a
complete set of the
DNA molecules
DNA Replication
✓ DNA must be
copied or Original DNA
strand
replicated
before cell
division Two new,
✓ Each new cell
identical DNA
strands
will then have an
identical copy of
the DNA
Identical Daughter Cells
Two
identical
daughter
cells
Parent Cell
Chromosomes
Prokaryotic Chromosome
✓ The DNA of
prokaryotes
(bacteria) is one,
circular
chromosome
attached to the
inside of the cell
membrane
Eukaryotic Chromosomes
✓ All eukaryotic cells store genetic
information in chromosomes
✓ Most eukaryotes have between 10 and 50
chromosomes in their body cells
✓ Human body cells have 46 chromosomes
or 23 identical pairs
Eukaryotic Chromosomes
✓ Each chromosome is composed of a
single, tightly coiled DNA molecule
✓ Chromosomes can’t be seen when
cells aren’t dividing and are called
chromatin
Compacting DNA into Chromosomes
✓ DNA is
tightly
coiled
around
proteins
called
histones
Chromosomes in Dividing Cells
✓ Duplicated
chromosomes are
called
chromatids & are
held together by
the centromere
Called Sister Chromatids

Karyotype
✓ A picture of the
chromosomes from a
human cell arranged
in pairs by size
✓ First 22 pairs are
called autosomes
✓ Last pair are the
sex chromosomes
✓ XX female or XY
male
Boy or Girl?
The Y Chromosome Decides
Y - Chromosome
X - Chromosome
The Cell
Cycle
Cell Cycle
DNA Copied
Cells prepare for
Cells Division
Mature
Daughter
Cells
Cell Divides into
Identical cells
Five Phases of the Cell Cycle
✓ G1 - primary growth phase
✓ S – synthesis; DNA replicated
✓ G2 - secondary growth phase
collectively the 3 stages above
are called interphase
✓ M - mitosis
✓ C - cytokinesis
Interphase - G1 Stage
✓ 1st growth stage after cell

division
✓ Cells mature by making more
cytoplasm & organelles
✓ Cell carries on its normal
metabolic activities
Interphase – S Stage
✓ Synthesis stage
✓ DNA is copied or replicated
Two
identical
copies
of DNA
Original
DNA
Interphase – G2 Stage
✓ 2nd Growth Stage
✓ Occurs after DNA has been copied
✓ All cell structures needed for
division are made (e.g. centrioles)
✓ Both organelles & proteins are
synthesized
What’s Happening in Interphase?
What the cell looks like
Animal Cell
What’s occurring
Mitosis
Mitosis
✓ Division of the
nucleus
✓ Also called
karyokinesis
✓ Only occurs in
eukaryotes
✓ Has four stages
✓ Doesn’t occur in
some cells such
as brain cells
Four Mitotic Stages
✓ Prophase
✓ Metaphase
✓ Anaphase
✓ Telophase
Early Prophase
✓ Chromatin in nucleus condenses to form
visible chromosomes
✓ Mitotic spindle forms from fibers in
cytoskeleton or centrioles (animal)
Nucleolus Cytoplasm
Nuclear Membrane
Chromosomes
Late Prophase
✓ Nuclear membrane & nucleolus are
broken down
✓ Chromosomes continue condensing &
are clearly visible
✓ Spindle fibers called kinetochores
attach to the centromere of each
chromosome
✓ Spindle finishes forming between the
poles of the cell
Late Prophase
Chromosomes
Nucleus & Nucleolus have disintegrated

Spindle Fiber attached to
Chromosome
Kinetochore Fiber
Chromosome
Review of Prophase
What the cell

looks like
What’s
occurring?
Spindle Fibers
✓ The mitotic spindle form from the
microtubules in plants and centrioles in
animal cells
✓ Polar fibers extend from one pole of the
cell to the opposite pole
✓ Kinetochore fibers extend from the pole to
the centromere of the chromosome to which
they attach
✓ Asters are short fibers radiating from
centrioles
The Spindle
Metaphase
✓ Chromosomes, attached to the
kinetochore fibers, move to the center
of the cell
✓ Chromosomes are now lined up at the
equator Equator of Cell
Pole of
the Cell
Metaphase
Asters at
the poles
Spindle Chromosomes
Fibers lined at the
Equator
Metaphase
Aster
Chromosomes at Equator
Review of Metaphase
What the cell looks

like
What’s
occurring
Anaphase
✓ Occurs rapidly
✓ Sister
chromatids are
pulled apart to
opposite poles
of the cell by
kinetochore
fibers
Anaphase
Sister
Chromatids
being
separated
Anaphase Review
What the
cell looks
like
What’s
occurring
Telophase
✓ Sister chromatids at opposite poles
✓ Spindle disassembles
✓ Nuclear envelope forms around
each set of sister chromatids
✓ Nucleolus reappears
✓ CYTOKINESIS occurs
✓ Chromosomes reappear as
chromatin
Comparison of Anaphase & Telophase
Cytokinesis
✓ Means division of the cytoplasm
✓ Division of cell into two, identical
halves called daughter cells
✓ In plant cells, cell plate forms
at the equator to divide cell
✓ In animal cells, cleavage furrow
forms to split cell
Cytokinesis
Cleavage furrow Cell plate in
in animal cell plant cell
Mitotic Stages
Daughter Cells of Mitosis
✓ Have the same number of
chromosomes as each other and as
the parent cell from which they
were formed
✓ Identical to each other, but smaller
than parent cell
✓ Must grow in size to become mature
cells (G1 of Interphase)
Identical Daughter Cells
What is
the 2n
or
diploid
number?
2
Chromosome number the same, but cells

smaller than parent cell
Review
of
Mitosis
Draw & Learn these Stages
Draw & Learn these Stages
Name the Mitotic Stages:
Name this?
Name this?
Name this?
Name this? Name this?
Name the Mitotic Stages:
Interphase
Telophase Prophase
Metaphase
Anaphase
Eukaryotic Cell Division
✓ Used for growth and repair

✓ Produce two new cells
identical to the original cell
✓ Cells are diploid (2n) Chromosomes during
Metaphase of mitosis
Prophase Metaphase Anaphase Telophase Cytokinesis
Mitosis Animation
Name each stage as you see it occur?
Mitosis Animation
Mitosis in Onion Root Tips
Do you see any stages of mitosis?
Test Yourself
over Mitosis
Mitosis Quiz
Mitosis Quiz
Name the Stages of Mitosis:
2 5.
1.
4.
3.
6. 7.
8. 9.
Name the Stages of Mitosis:
5. Early
1. Early Anaphase 3. Early 4. Metaphase Telophase,
prophase Begin
cytokinesis
2. Interphase
8. Mid-Prophase
6. Late
Prophase 7. Late telophase,
Advanced 9. Late
cytokinesis Anaphase
Identify the Stages
?
? ? ?
? ? ?
(i) (j)
(h)
Identify the Stages
?
Early, Middle, & Late Prophase
? ? ?
Metaphase Anaphase
Late Prophase
? ? ?
Late Anaphase Telophase Telophase &
copyright cmassengale Cytokinesis 60
Locate the Four Mitotic
Stages in Plants
C)
D)
B)
A)
Locate the Four Mitotic
Stages in Plants
C) Anaphase
D) Telophase
B) Metaphase
A) Prophase
Uncontrolled Mitosis
✓ If mitosis is not
controlled, unlimited
cell division occurs
causing cancerous
tumors
✓ Oncogenes are special
proteins that increase
the chance that a Lung Cancer Cells
normal cell develops
into a tumor cell
What’s wrong with cancer cells?
Image Credit and Learn More about the Cell Cycle and Cancer (Kahn Academy) 64
Cell Division in
Prokaryotes
Cell Reproduction
Types of Cell Reproduction
✓ Asexual reproduction involves a single
cell dividing to make 2 new, identical
daughter cells
✓ Mitosis & binary fission are examples
of asexual reproduction
✓ Sexual reproduction involves two cells
(egg & sperm) joining to make a new
cell (zygote) that is NOT identical to
the original cells
✓ Meiosis is an example
Asexual Reproduction by Binary Fission
Sketch the “Visual Vocab” diagram on p. 148
✓ Prokaryotes such as Parent

bacteria divide into 2 cell
identical cells by the
process of binary
fission Chromosome
✓ Single chromosome replicates
makes a copy of
itself Cell splits
✓ Cell wall forms
between the
chromosomes dividing
the cell
2 identical daughter cells
Prokaryotic Cell Undergoing
Binary Fission
(similar to mitosis)
Asexual Reproduction occurs in
Prokaryotes & some Eukaryotes
1) Binary Fission
2) Types of Asexual Reproduction 1 3) Types of Asexual Reproduction 2
Some eukaryotes reproduce asexually through
mitosis:
71
72
Multicellular Life
● Tissues are groups of
cells that work together
to perform a similar
function.
● Organs are groups of
tissues that work
together to perform a
specific function or
related functions.
● Organ Systems are
groups of organs that
carry out similar
functions.
73
74
Specialized Cells Perform Specific
Functions: You began as a single fertilized egg.
75
76
77
78
Adult Stem Cells (Somatic Stem Cells)
-undiﬀerentiated cells found all over the body among specialized cells
Advantages: Disadvantages:
-Can be taken -few in number
from a patient, -difficult to isolate
grown in culture, -sometimes tricky
and put back to grow
into the patient, -may also contain
avoiding more DNA
transplant abnormalities
rejection.
-Avoid ethical
issues.
Adult Stem Cells treated with the right combination of molecules
may give rise to a completely different type of tissue. This is called
transdifferentiation, which remains an active area of research.
79
Embryonic Stem Cells
-most come from donated embryos grown in a clinic.
-an embryo is a fertilized egg
80
Review Games and Quizzes
1) ClassZone.com: Collection of online
a) 5.1 Quiz quizzes:
b) 5.2 Quiz
1) Mitosis Quiz
c) 5.3 Quiz
d) 5.4 Quiz 2) Mitosis Quiz
e) 5.5 Quiz 3) Mitosis Questions
2) Interactive Review 4) Mitosis Lab Quiz
3) Mitosis Animation 5) Mitosis Quiz
4) Binary Fission 6) Mitosis Quiz
5) Mitosis Matching 7) Mitosis Quiz
Chapter 5 Ends Here
81
Chapter 6:
Meiosis
Formation of Gametes
(Eggs & Sperm)
Facts About Meiosis
✓ Preceded by interphase which
includes chromosome replication
✓ Two meiotic divisions --- Meiosis
I and Meiosis II
✓ Called Reduction- division
✓ Original cell is diploid (2n)
✓ Four daughter cells produced that
are monoploid (1n)
Facts About Meiosis
✓ Daughter cells contain half the
number of chromosomes as the
original cell
✓ Produces gametes (eggs & sperm)
✓ Occurs in the testes in males
(Spermatogenesis)
✓ Occurs in the ovaries in females
(Oogenesis)
More Meiosis Facts
✓ Start with 46 double stranded
chromosomes (2n)
✓After 1 division - 23 double
stranded chromosomes (n)
✓After 2nd division - 23 single
stranded chromosomes (n)
✓ Occurs in our germ cells that
produce gametes
Why Do we Need Meiosis?
✓ It is the fundamental basis of
sexual reproduction
✓ Two haploid (1n) gametes are
brought together through
fertilization to form a diploid
(2n) zygote
Fertilization – “Putting it
all together”
2n = 6
1n =3
Replication of Chromosomes
✓ Replication is the
process of
duplicating a Occurs in
chromosome Interphase
✓ Occurs prior to
division
✓ Replicated copies
are called sister
chromatids
✓ Held together at
centromere
A Replicated Chromosome
Gene X
Homologs Sister
(same genes, Chromatids
different alleles) (same genes,
same alleles)
Homologs separate in meiosis I and

therefore different alleles separate.
Meiosis Forms Haploid Gametes
✓ Meiosis must reduce the chromosome number
by half
✓ Fertilization then restores the 2n number
from mom from dad child
too
much!
meiosis reduces
genetic content
The right
number!
Meiosis: Two Part Cell
Division
Sister
chromatids
Homologs separate
separate
Meiosis Meiosis
I II
Diploid
Diploid
Haploid
Meiosis I: Reduction Division
Nucleus Spindle
fibers Nuclear
Early envelope
Prophase I Late Metaphase
(Chromosome Prophase I Anaphase Telophase I
number I I (diploid)
doubled)
Prophase I
Early prophase Late prophase

✓Homologs pair. ✓Chromosomes condense.
✓Crossing over ✓Spindle forms.
occurs. ✓Nuclear envelope
fragments.
Tetrads Form in Prophase I
Homologous chromosomes
Join to form a
(each with sister chromatids)
TETRAD
Called Synapsis
Crossing-Over
✓ Homologous
chromosomes in
a tetrad cross
over each other
✓ Pieces of
chromosomes or
genes are
exchanged
✓ Produces
Genetic
recombination in
the offspring
Homologous Chromosomes
During Crossing-Over
Crossing-Over
Crossing-over multiplies the already huge

number of different gamete types
produced bycopyright
independent
cmassengale
assortment 97
Metaphase I
Homologous pairs
of chromosomes
align along the
equator of the
cell
Anaphase I
Homologs separate and

move to opposite poles.
Sister chromatids remain

attached at their
centromeres.
Telophase I
Nuclear envelopes
reassemble.
Spindle disappears.
Cytokinesis divides cell

into two.

Meiosis II
Only one homolog of each
Gene X
chromosome is present in
the cell.
Sister chromatids carry
identical genetic
information.
Meiosis II produces gametes with

one copy of each chromosome and
thus one copy of each gene.
Meiosis II: Reducing
Chromosome Number
Prophase Metaphase
II II Telophase
Anaphase II 4 Genetically
II Different
haploid cells
Prophase II
Nuclear envelope
fragments.
Spindle forms.

Metaphase II
Chromosomes align
along equator of cell.

Anaphase II
Equator
Pole
Sister chromatids
separate and
move to opposite
poles.

Telophase II
Nuclear envelope
assembles.
Chromosomes
decondense.
Spindle disappears.
Cytokinesis divides
cell into two.
Results of Meiosis
Gametes (egg & sperm)
form
Four haploid cells with

one copy of each
chromosome
One allele of each gene
Different combinations of
alleles for different
genes along the
chromosome
Meiosis Animation

Gametogenesis
Oogenesis
or
Spermatogenesis

Spermatogenesis
✓ Occurs in the
testes
✓ Two divisions
produce 4
spermatids
✓ Spermatids mature
into sperm
✓ Men produce about
250,000,000
sperm per day
Spermatogenesis in the
Testes
Spermatid

Spermatogenesis

Oogenesis
✓ Occurs in the ovaries
✓ Two divisions produce 3 polar bodies
that die and 1 egg
✓ Polar bodies die because of unequal
division of cytoplasm
✓ Immature egg called oocyte
✓ Starting at puberty, one oocyte
matures into an ovum (egg) every 28
days
Oogenesis in the Ovaries

Oogenesis
First polar body
may divide a
(haploid) X
a Polar
bodies
X a die
a X
X
Mitosis Meiosis I Meiosis II
A X (if fertilization
Oogonium occurs) A
(diploid) Primary
X
oocyte
(diploid) A X Ovum (egg) Mature
Secondary A egg
oocyte X
(haploid) Second
polar body
(haploid)
Comparing
Mitosis and
Meiosis

Comparison of Divisions
Mitosis Meiosis
Number of 2
1
divisions
Number of
2 4
daughter cells
Genetically
Yes No
identical?
Chromosome # Same as parent Half of parent
Where Somatic cells Germ cells
When Throughout life At sexual maturity
Role Growth and repair Sexual reproduction


Cell Cycle Cell Division

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Cell Cycle Cell Division

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Chapter 5:

The instructions for

Called Sister Chromatids

✓ 1st growth stage after cell

What the cell looks like

Nucleus & Nucleolus have disintegrated

What the cell

What the cell looks

Chromosome number the same, but cells

Name this? Name this?

✓ Used for growth and repair

Prophase Metaphase Anaphase Telophase Cytokinesis

✓ Prokaryotes such as Parent

2) Types of Asexual Reproduction 1 3) Types of Asexual Reproduction 2

Homologs separate in meiosis I and

from mom from dad child

Early prophase Late prophase

Crossing-over multiplies the already huge

Homologs separate and

Sister chromatids remain

Cytokinesis divides cell

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Meiosis II produces gametes with

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Four haploid cells with

One allele of each gene

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Role Growth and repair Sexual reproduction

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