RESEARCH TOPICS

BME CAPSTONE DESIGN – SEMESTER 2

2022-2023

GENERAL REQUIREMENTS

PROJECTS
No. Project Name Advisor Priority

1 Healthcare Individual Smartcard (HI card) Prof. Tới

2 Hospital delivery robot controlled by a mobile app B.E. Lê Ý

3 Electric Multi-Function Wheelchair Accessories Prof. Tới

4 Blood pressure monitor BPBI0320 B.E. Tiên

5 Cuff-less blood pressure monitor B.E. Tiên

6 Bio impedance B.E. Lê Ý

7 Arm prosthesis conducting experimental tasks B.E. Lê Ý

8 Crushing Tissue Machine Prof. Tới

9 Device to help Alzheimer Disease sufferers to find way home Prof. Tới

10 Dermatoscope Prof. Tới

B.E. Nguyên
11 Holter for ECG
B.E. Việt

Investigate the method to mass produce the Holter for blood pressures and heart rate
12 Prof. Tới
designed by BME

13 EOG portable device Ph.D Lụa

14 Live Cell Incubating System Ph.D Quả

15 Automatic hydrogel filling system for application in the production of microneedle patches. Ph.D Quả

16 Pneumatic pump system for nano particles synthesis using microfluidics device. Ph.D Quả

17 Infusion pump Ph.D Giang

18 Dip Coating Device Ph.D Giang

19 Arm-band EMG Device Ph.D Giang

20

21

22
Project 1: Healthcare Individual Smartcard (HI card)

1. Person(s) in charge:

Name: Prof. Võ Văn Tới

Email: vvtoi@hcmiu.edu.vn

2. Project Description

A healthcare individual smartcard with a unique QR code that are capable of vital information of its user including personal details, past medical history, drug history, etc. When

accidents happen, a mobile application is used to scan the QR code for navigating the nearest ambulance and providing patient information to paramedics and physicians who

make an appropriate decision on emergency medical care. The app constantly updates user medical records and ensures information security to significantly enhance a

connection between patient and hospital.

3. Technical specifications and requirements

- Design a mobile application scanning individual QR cards in order to access the nearest ambulance in case of emergency.

- The app can update all individual information as well as the position of patients after scanning.

Project 2: Hospital delivery robot

1. Person(s) in charge:
Name: B.S. Nguyễn Lê Ý
Email: nly@hcmiu.edu.vn
2. Project Description:

A hospital delivery robot is a machine that can deliver hospital items such as meal trays, sterile equipment, medicines, specimens, and medical records. The robot can have the
ability to move in different directions such as going straight, turning left and turning right. The robot moves to the requested place and stops to deliver the medicine to the patient
automatically. It is also combined with a smartphone for the doctor to monitor, control, or set up specific locations or paths. Moreover, the speaker is used to announce for the
receiver when the robot stops in front of the room or some specific locations and when there is an obstacle.
3. Technical specification and Requirements
- Design a robot can be controlled sustainably via Wi-Fi through the mobile app
- Focus on investigating the way to manage the wheel-controlling motors synchronously while the robot change directions.

Project 3: Electric Multi-Function Wheelchair Accessory

1. Person(s) in charge:
Name: Prof. Võ Văn Tới
Email: vvtoi@hcmiu.edu.vn

2. Project Description:
In the basis circumstances, a wheelchair manually manipulated by hands becomes challenging for those who are suffering paralysis, ALS (Amyotrophic Lateral Sclerosis – the

degeneration of motor neuron), etc… To solve this problem, an accessory such as a gear system or synchronous motor system is attached to the wheelchair and used to control

the wheelchair's motion. The highlighted feature is the accessory operated by biological signals, including EEG, eye or head movements, facial expressions, or gestures, etc…

3. Technical specification and Requirements

- Design a motion-controlling system that can control properly and synchronously the wheelchair movement.
- Design a system to recognize biological signals and convert them to move the wheelchair.

Project 4: Blood Pressure Monitors BPBI0320

1. Person(s) in charge:
Name: B.S. Lê Thị Thủy Tiên
Email: ltttien@hcmiu.edu.vn
2. Project Description:

The Upper Arm Blood Pressure Monitor is for use by medical professionals or at home and is a noninvasive blood pressure measurement system intended to measure the
diastolic and systolic blood pressures and pulse rate of an adult individual by using a non-invasive technique in which an inflatable cuff is wrapped around the upper arm. The
monitor measures systolic, diastolic pressure, and pulse rate on the principle of oscillometric on inflation. The oscillometric method detects volume displacements within the
artery and senses pressure variations within the blood pressure cuff during inflation. The device is easy to use since patients simply sit down, place their hands inside the cuff and
press the start button. This helps eliminate the hesitation of the wrong placement on the upper hand when wearing the typical cuff.

3. Technical specification and Requirements

- Focus on designing the cuff

- Design a blood pressure monitor that can measure the systolic, diastolic pressure and heart rate
Project 5: Cuff-less Continuous Blood Pressure Monitor

1. Person(s) in charge:
Name: B.S. Lê Thị Thủy Tiên
Email: ltttien@hcmiu.edu.vn
2. Project Description:

The common blood pressure monitor uses the monitor measures systolic, diastolic pressure, and pulse rate on the principle of oscillometric on inflation or deflation by wrapping

a cuff around the upper hand. However, with the continuous measurement during 24 hours, the inflation of cuff causes bruises, swelling... Some cuff-less blood pressure

monitors are designed to solve this problem and these devices operated based on PTT (pulse transit time), Pulse contour, tonometry principles.

3. Technical specification and Requirements

- Design cuff-less blood pressure monitor based on the method after researching and selecting the appropriate one.
- Display the systolic, diastolic pressure and heart rate
- Calibrate with the cuff-based blood pressure monitor

Project 6: Bioimpedance analysis device

1. Person(s) in charge:
Name: B.S. Nguyễn Lê Ý
Email: nly@hcmiu.edu.vn
2. Project Description:
Bioelectrical impedance analysis (BIA) is a method for estimating body composition, in particular body fat and muscle mass, where a weak electric current flows through the

body and the voltage is measured in order to calculate impedance (resistance) of the body. Most body water is stored in muscle. Therefore, if a person is more muscular there is a

high chance that the person will also have more body water, which leads to lower impedance. Bioimpedance analysis has found utility in many fields of medical research.

3. Technical specification and Requirements

- Design a Bio impedance analysis device
- Analysis the fat ratio with this device

Project 7: Arm robot for laboratory experiments

1. Person(s) in charge:
Name: B.S. Nguyễn Lê Ý
Email: nly@hcmiu.edu.vn
2. Project Description:

Design a robot with 6-axis for do some experiment in laboratory, the robot can hand the test tube, shake and mix the chemical. The robot should have software for controlling.
3. Technical specification and Requirements

- Robots have 6 axis movement

- Robots can hand, shake test tubes

- Have software to setup the robot

Project 8: Tissue Crushing Machine

1. Person(s) in charge:

Name: Dr. Võ Văn Tới

Email: vvtoi@hcmiu.edu.vn

2. Project Description:

The very first step of the PCR is DNA extraction which required to collect and homogenize each shrimp tissue sample into small pieces by crushing them. A traditional method

that the laboratory technicians have been used is that they use hand to hold a disposable pellet pestle, then crush the shrimp tissue sample which is in an Eppendorf tube. This is

not tedious but time consuming, especially with a huge number of shrimps needed to be tested, the technicians have been spent a lot of time on grinding many shrimp samples

tube by tube.

Nowadays, the technicians use the crushing sticks or pellet pestles by their hand to crush the shrimp tissue one by one and this is time wasting and lack of productivity. In order

to solve this problem, the technicians need a device that would be time saving and the products of sample after crushing also have to be more effective.

The goal of this project is a design and fabrication of a device that not only can replace the technician’s hand but also can grind many shrimp sample tubes at one time with

different speed until they are completely mashed.

 Figure 10.1. Traditional Crushing Method

Figure 10.2. Developed Crushing Machine

3. Tech- nical specification and Require-

ments

- Conduct experiments on tissue, collect data to

create the crushing standard table (Need how
many RPM to make tissue become crushed totally,
how many time for complete a crushing stage?)
- Redesign the stick to make it easier for tissue
crushing when working with machine
- Cross-con- tamination evaluation.

Project 9: Device to help Alzheimer Disease sufferers to find way home

1. Person(s) in charge:

Name: Prof. Võ Văn Tới

Email: vvtoi@hcmiu.edu.vn

2. Project Description:

Because dementia is caused by Alzheimer's disease, older people tend to get lost easily when going out and can't find their way home. So a device that guides the

way back will be essential for people with Alzheimer's disease. The device has a compact and wearable structure that helps the patient be comfortable when going

out.

3. Technical specification and Requirements:

 Using GPS to locate the patient

  Draw the way home from the patient's location

 Has a device that signals when the patient is going wrong or can guide the patient in specific directions (Turn left, turn right, or go straight)

Project 10: Dermatoscope

1. Person(s) in charge:

Name: Prof. Võ Văn Tới

Email: vvtoi@hcmiu.edu.vn
2. Project Description:

Dermatologists and general practitioners utilize dermoscopy, a non-invasive procedure, to evaluate skin lesions, features, and patterns. It allows dermatologists to more re-

liably identify skin lesion types, minimizing the need for costly and intrusive procedures such as biopsies and incisions. This decreases the possibility of scarring and asso-

ciated difficulties for patients. This method uses a dermatoscope to examine skin lesions, such as nevi, BCC (Basal Cell Cancer), SCC (Squamous Cell Carcinoma), and

melanoma.

3. Technical specification and Requirements:

 Compact design or can be mounted on the phone.

 Upgrade the features of device in the diagnosis based on the available thesis of BME department.
Project 11: Holter for ECG

1. Person(s) in charge:

Name: B.S. Phạm Khôi Nguyên & B.S. Trần Ngọc Việt

Email: pknguyen@hcmiu.edu.vn & tnviet@hcmiu.edu.vn

2. Project Description:

Hardware

- Description: Develop hardware for measuring ECG with at least 1-lead

- Criteria:

 Measure ECG at least 1-lead

 Send data to smartphone via Bluetooth

 Lithium pin, chargeable

 3D printing enclosure

 Small, compact design

Software

- Description: develop web-app to analyse ECG data taken from hardware

- Criteria:

 Read data from hardware via Bluetooth

 Plot ECG in realtime as graph

 Save data to the cloud

 Stream data between different users

 Simple analysis: heart rate, heart rate variability, arrhythmia

- (Optional) Predict systolic and diastolic blood pressure and identify sleep stage (at least awake and sleep stages, and better version with more sleep stages)

from ECG signal based on AI. Please contact Ph.D Ngô Thị Lụa for more information.

Project 12: Investigate the method to mass produce the Holter for blood pressures and heart rate

designed by BME-IU

1. Person(s) in charge:

Name: Prof. Võ Văn Tới

Email: vvtoi@hcmiu.edu.vn
 2. Project Description:

The Department of Biomedical Engineering has successfully designed the Holter for blood pressure and ECG. Therefore, it is important to find a way to produce

and market it commercially and competitively.

3. Technical specification and Requirements:

The project researcher needs to know the components of the Holter device and find a way to manufacture those components at the most competitive cost.

Furthermore, researchers need to search and compare mass production and assembly methods in different places to find one of the most effective ways to help

BME-IU products become competitive and easily accessible to users. As a result, the researcher can provide the overall process of importing components,

assembling, and mass production with the best and lowest cost from the beginning to the time the device is launched on the market.

Project 13: EOG portable device

1. Person(s) in charge:

Name: Ph.D Ngô Thị Lụa

Email: ntlua@hcmiu.edu.vn
2. Project Description:

A portable device that can collect EOG signal with high accuracy. We can use the collected EOG signal to analyse and predict sleep stages of subjects (Wake—S1

—S2—S3—S4—REM).

3. Technical specification and Requirements:

- Design a portable EOG device that can be above eye mask (or other shape)

- EOG device can transfer signal to PC wirelessly (Bluetooth/WIFI)

- (Optional) Applying AI to segment sleep stages (Wake—S1—S2—S3—S4—REM)

 Project 14: Live Cell Incubating System

1. Person(s) in charge:
Name: Dr. Nguyễn Thành Quả
Email: vvtoi@hcmiu.edu.vn
2. Project Description:

Incubator System is an intuitive and integrated system, maintains all essential parameters in a physiological state ensures optimal experimental conditions for cell viability on the

microscope for the purpose of ‘happiness for the cells and success for researchers.’ It provides precisely controlled conditions including optimized temperature, humidity, CO ₂,

and optional O₂ levels for a long-term live cell imaging with various Magnetic Imaging Chambers fitted perfectly.

Schematic of chamber Top Chamber

3. Technical specification and Requirements

Transparent material
CO2 tank
- Temp sensors
The device aims to maintain the environment of cells during observation in the microscopy
Feedback control: temperature is 37 ° C , CO2 concentration, humidity.
Humid sensors

Project 15: Automatic hydrogel filling system for application in the production of microneedle

patches

1. Person(s) in charge:
Bottom Chamber
Heating Cap
Name: Dr. Nguyễn Thành Quả Heater

Email: ntqua@hcmiu.edu.vn
2. Project Description:

Goal: design an automatic system for precise liquid filling on a micro-needle

Working principle: The system consists of 2 stepper motors, syringe pump, printing head, and micro-needle mold.

• Stepper motor 1 helps mold plate move back and forth between 2 positions #1, #2.

• Stepper motor 2 helps the pouring head move up and down.

• Syringe Pump: Pump the hydrogel into the pouring head.

• The system is controlled synchronously through the control software

Project 16: Pneumatic pump system for nano particles synthesis using microfluidics device.

1. Person(s) in charge:

Name: Dr. Nguyễn Thành Quả

Email: ntqua@hcmiu.edu.vn
2. Project Description:

Microfluidics, also known as a ‘lab-on-a-chip’, enables the precise control, manipulation and analysis of fluids in the microlitre to picolitre range. Furthermore, it

allows the manipulation of living matter by mixing, separating and handling different components at a microscale.

This project aims to design and fabricate the pneumatic pump to precisely control the fluidic flow into the microfluidic device which is used in nanoparticle synthesis.

3. Technical specification and Requirements:

The project researcher needs to design the pump system such as glass bottle cap, connecters, controller, PCP circuits. The pump has to create the stable flow and the

flow rate of the fluid can be controlled in the range of 10 µl/min- 500 µl/min. The flow rate of the pump should be adjusted and displayed in the LCD. The system includes bottle

reservoir, compression airline, pressure sensors, flow sensors, solenoid valves, feedback control circuits as below figure.
Project 17: Infusion pump

1. Person(s) in charge:

Name: Dr. Trần Lê Giang

Email: tlgiang@hcmiu.edu.vn
2. Project Description:

An infusion pump for biomedical applications could be a good choice for a capstone design project in biomedical engineering. Infusion pumps are used to deliver

fluids, such as medications or nutrients, into a patient's body in a controlled manner. They are commonly used in hospitals and other healthcare settings to deliver intravenous

(IV) therapy, but they can also be used in home healthcare settings.

Designing an infusion pump for biomedical applications would require knowledge and skills in mechanical engineering, electrical engineering, and software

development. The pump would need to be able to deliver fluids accurately and reliably, with the ability to adjust the flow rate and volume based on the patient's needs. It would

also need to be user-friendly and easy to operate, with simple interfaces for healthcare providers and patients.

In addition, the pump would need to be designed with patient safety in mind, incorporating features such as alarms and fail-safes to prevent over-infusion or under-

infusion of fluids. Regulatory requirements would also need to be considered, including compliance with standards such as the International Electrotechnical Commission (IEC)

60601.

Overall, designing an infusion pump for biomedical applications could be a challenging and rewarding capstone design project in biomedical engineering, with the

potential to make a significant impact on patient care.

3. Technical specification and Requirements:

Here is a list of some basic requirements that an infusion pump for biomedical applications should typically meet:

 Accurate and reliable fluid delivery: The pump should be able to deliver fluids at a precise and consistent flow rate, and should be able to adjust the flow rate and

volume based on the patient's needs.

  User-friendly interfaces: The pump should have simple and intuitive interfaces for healthcare providers and patients to operate, with clear displays of information

such as flow rate, volume delivered, and remaining infusion time.

 Alarms and fail-safes: The pump should incorporate alarms and fail-safes to prevent over-infusion or under-infusion of fluids, with alerts for low battery, occlu-

sions, air in the line, and other potential problems.

 Portability: The pump should be lightweight and portable, with a long battery life, to enable use in home healthcare settings and other non-hospital environments.

 Compatibility with a range of fluids and medication: The pump should be able to deliver a variety of fluids and medications, with compatibility with a range of IV

administration sets.

 Durability and reliability: The pump should be designed to withstand the rigors of daily use in a healthcare setting, with robust materials and a high level of reliabil -

ity.

 Compliance with regulatory standards: The pump should comply with regulatory standards such as the International Electrotechnical Commission (IEC) 60601,

which sets requirements for the safety and performance of medical electrical equipment.

These are some of the basic requirements that an infusion pump for biomedical applications should typically meet. Depending on the specific application and use case, additional

features and requirements may be needed.

Project 18: Dip Coating Device

1. Person(s) in charge:

Name: Dr. Trần Lê Giang

Email: tlgiang@hcmiu.edu.vn
2. Project Description:

Dip coating is a common method for coating microneedles with drugs, which can be used for applications such as vaccination or drug delivery. The dip coating

device typically consists of a reservoir for the drug solution and a holder for the microneedles. The microneedles are dipped into the drug solution, and then lifted out to allow

the excess solution to drain off. The process can be repeated several times to build up the desired drug coating thickness on the microneedles.

The design of the dip coating device will depend on the specific application and the size and shape of the microneedles being coated. It is important to ensure that

the drug coating is uniform and that the microneedles are not damaged or clogged during the coating process.
 Overall, designing an infusion pump for biomedical applications could be a challenging and rewarding capstone design project in biomedical engineering, with the

potential to make a significant impact on patient care.

3. Technical specification and Requirements:

Here are some requirements for a good dip coating device for coating drugs on microneedles:

 Precision and accuracy: The device should be able to accurately and precisely control the dip coating process to ensure uniform drug coating thickness on the mi -

croneedles.

 Reproducibility: The device should be able to produce consistent results from batch to batch, ensuring that the drug-coated microneedles have similar properties and

performance.

 Contamination control: The device should be designed to minimize the risk of contamination, such as by incorporating a sterile environment for the drug solution

and the microneedles.

 Speed and efficiency: The device should be able to coat a large number of microneedles quickly and efficiently, with minimal downtime or the need for manual in -

tervention.

 Flexibility: The device should be able to accommodate a range of microneedle sizes and shapes, as well as different types of drug solutions.

 Ease of use: The device should be user-friendly and easy to operate, with intuitive controls and simple interfaces for the operator.

 Cleaning and maintenance: The device should be designed for easy cleaning and maintenance, with components that can be easily disassembled and cleaned, and

with minimal risk of damage to the microneedles during the cleaning process.

These are some of the key requirements for a good dip coating device for coating drugs on microneedles. Other requirements may be specific to the particular application and us -

age situation, and may need to be considered when designing the device.
Project 19: Arm-band EMG Device

1. Person(s) in charge:

Name: Dr. Trần Lê Giang

Email: tlgiang@hcmiu.edu.vn
2. Project Description:

Electromyography (EMG) is a technique for measuring muscle activity, which can be used to control prosthetic limbs. A prosthetic arm that is controlled using

EMG signals from an arm-band EMG device would typically work as follows: the arm-band EMG device is placed on the user's upper arm, and the EMG sensors in the device

detect electrical signals generated by the user's muscles.

In this project, students will design and build a portable EMG device that can be easily worn around the arm. The EMG device is powered by a battery. The device should be

able to record the activities of the muscle in the arm and store or transfer the data to another server.

(a) An Myo armband showing 8 channels of EMG electrode. (b) A subject wearing Myo armband to record EMG activity during playing piano.

Overall, an arm-band EMG device can provide an intuitive and natural way for users to control a prosthetic arm, by using their own muscle activity to generate

control signals. The design of the prosthetic arm and the software algorithms used to translate EMG signals into control signals will depend on the specific application and user

needs.

3. Technical specification and Requirements:

An EMG device that is worn around the arm can be a valuable tool for monitoring muscle activity in various applications, such as sports performance monitoring,

rehabilitation, and physical therapy. Here are some requirements for a wearable EMG device that is worn around the arm:

 Comfort and usability: The device should be designed to be comfortable and non-intrusive, with minimal restrictions on movement and activity.

 Accurate and reliable measurements: The device should be able to accurately and reliably measure muscle activity, with a high signal-to-noise ratio and minimal in-

terference from other sources such as motion artifacts.

 Wireless and portable: The device should be wireless and portable, with a long battery life, to allow for use in a variety of settings, including home or clinical envir-

onments.
 User-friendly interfaces: The device should have simple and intuitive interfaces for users to operate, with clear displays of information such as muscle activity,

range of motion, and other parameters.

 Data storage and analysis: The device should be able to store and analyze data over time, allowing for tracking of changes in muscle activity and other parameters.

 Compatibility with a range of applications: The device should be compatible with a range of applications and software platforms, allowing for integration with other

devices and data analysis tools.

 Durability and reliability: The device should be designed to withstand the rigors of daily use in a healthcare setting, with robust materials and a high level of reliab-

ility.