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    Choledocholithiasis, or gallstones in the common bile duct, is the most common cause of extrahepatic cholestasis, which is a blockage of bile flow outside the liver. It can present with a wide range of symptoms from mild discomfort to life-threatening ascending cholangitis with jaundice and sepsis. Primary sclerosing cholangitis may also cause extrahepatic cholestasis by damaging structures in the extrahepatic biliary tree. Chronic pancreatitis can rarely lead to strictures of the distal common bile duct where it passes through the pancreas. AIDS cholangiopathy is usually caused by cytomegalovirus or cryptosporidium infecting the bile

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    Choledocholithiasis, or gallstones in the common bile duct, is the most common cause of extrahepatic cholestasis, which is a blockage of bile flow outside the liver. It can present with a wide range of symptoms from mild discomfort to life-threatening ascending cholangitis with jaundice and sepsis. Primary sclerosing cholangitis may also cause extrahepatic cholestasis by damaging structures in the extrahepatic biliary tree. Chronic pancreatitis can rarely lead to strictures of the distal common bile duct where it passes through the pancreas. AIDS cholangiopathy is usually caused by cytomegalovirus or cryptosporidium infecting the bile

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    9 views1 page

    Ee 25

    Uploaded by

    GOT7 for 7
    Choledocholithiasis, or gallstones in the common bile duct, is the most common cause of extrahepatic cholestasis, which is a blockage of bile flow outside the liver. It can present with a wide range of symptoms from mild discomfort to life-threatening ascending cholangitis with jaundice and sepsis. Primary sclerosing cholangitis may also cause extrahepatic cholestasis by damaging structures in the extrahepatic biliary tree. Chronic pancreatitis can rarely lead to strictures of the distal common bile duct where it passes through the pancreas. AIDS cholangiopathy is usually caused by cytomegalovirus or cryptosporidium infecting the bile

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    Non-neoplastoic (benign) causes of extrahepatic cholestasis

    Choledocholithiasis

    Most common cause of extrahepatic cholestasis

    Wide range of presentation

    Mild RUQ discomfort with only minimal elevation of liver enzymes

    Ascending cholangitis with jaundice, sepsis and circulatory collapse

    PSC may occur with clinically important structures limited to extrahepatic biliary tree

    Chronic pancreatitis rarely causes strictures of distal common bile duct, where it
    passes through the head of the pancreas

    AIDS cholangiopathy

    Usually due to infection of bile duct epithelium with CMV or cryptosporidia

    Has cholangiographic appearance

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