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EPIDEMIOLOGY

Prevalence

Ascites as a result of cirrhosis accounts for 80% of patients who present with ascites in
the US

Ascites occurs within 10 years in > 50% of those diagnosed with cirrhosis

The remaining 20% of often is made by serologic testing in combination with


percutaneous liver biopsy

List of possible causes is long and varied

A number of conditions that typically cause a hepatocellular pattern of injury can also
present as cholestatic variants

Hepatitis B and C can cause cholestatic hepatitis with histologic features that mimic
large duct obtruction

A disease variant has been reported in patients who have undergone solid organ
transplantation

Hepatitis A, alcoholic hepatitis, EBV and CMV may present as cholestatic liver disease

Drug induced cholestasis

Usually reversible after eliminating the offending drug

May take many months to resolve

ascites are secondary to:

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