Consumer Health & Nutrition

Carnipure®左旋肉碱
龙沙概况
超过120年历史

 1897 龙沙诞生于瑞士阿尔卑斯地区
Closer Than You Think®
…

 2016 收购美国InterHealth

 2017 收购美国Capsugel

Consumer Health & Nutrition

龙沙特殊原料业务 – 消费者健康营养
为核心市场提供解决方案

Consumer
Health & Nutrition

消费者健康营养

Building a unique
solutions powerhouse by
leveraging recent portfolio
extensions
结合最新的产品领域的拓宽，
提供独特的解决方案

Consumer Health & Nutrition

健康营养趋势越来越受到关注
结合龙沙多方技术专业的平台能力，为更多市场提供前沿的解决方案

 A strong spectrum of science-

backed nutritional ingredients
supplemented with integrated
formulated solutions

 Cutting-edge delivery solutions

through Capsugel

Consumer Health & Nutrition

什么是Carnipure® 左旋肉碱？
拥有高质量、安全性以及创新性

Excellent Clinically
30+ years Global QA/QC
L-isomer Safety Profile Researched
超过30年 Standards
安全 临床研究

 龙沙提供两种规格的 Carnipure® 左旋肉碱: Carnipure® crystalline and Carnipure® tartrate.

 印有Carnipure® 质量印章的产品，表明其中使用的左旋肉碱来自于瑞士龙沙
 Carnipure® 品牌可追溯，并且依旧持续进行该产品的科学研究

产品外标签上印有Carnipure® 质量印章，
表示该产品所含有高品质的龙沙左旋肉碱。
Consumer Health & Nutrition
Carnipure® 作用机理
将脂肪酸转运到线粒体通过β氧化生成ATP

Consumer Health & Nutrition

Metabolic Role
代谢中功能
 Fatty acid oxidation 脂肪酸氧化
 L-Carnitine shuttles long-chain fatty acids inside the mitochondria for β-oxidation and
energy generation
 左旋肉碱将长链脂肪酸转运到线粒体中进行β氧化，产生ATP

 Free Coenzyme A-buffer缓冲作用

 L-Carnitine serves as a short term depot for Acyl-CoA (=Energy storage)
 调节线粒体中脂酰CoA和CoA的比例，起缓冲作用

 Detoxification解毒
 L-Carnitine removes short-chain organic acids from inside the mitochondria and
contributes to their excretion
 清除线粒体中短链有机酸，加速排泄

Consumer Health & Nutrition

 Evidence for L-Carnitine in Fat Oxidation
Two Studies：摄取左旋肉碱后，增加碳13标记的二氧化碳的产生

 Wutzke & Lorenz. Metabolism. 53:1002-6, ’04  Muller et al. Metabolism. 51:1389-91, ’02
 3 g/day for 10 days  3 g/day for 10 days
 Significant  13CO2 exhalation after carnitine  Significant  13CO2 exhalation after carnitine

Carnitine

Carnitine

without without

Time (hours) Time (min)

Consumer Health & Nutrition

Buffer for Coenzyme A
辅酶A-缓冲功能

Acyl-CoA脂酰辅酶A Coenzyme A辅酶A缺乏症

• toxic in higher concentratrions • formation of ketone bodies

• 高浓度有毒性 increased (ketosis, ketoacidosis)
• act as tensides and destroy cell • 酮体的生成增加（酮症，酮症酸
membranes 中毒）
• 破坏细胞膜 • mitochondrial energy production
• reduce the activity of a variety of reduced
enzymes • 线粒体减少能源生产
• 降低多种酶的活性 • mitochondrial volume increased
• 线粒体肿胀,可导致结构受损
• cell dies because of acidosis and
energy deficiency
• 因为酸中毒和能量不足导致细胞
死亡

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Buffer function for Coenzyme A
辅酶A-缓冲功能

 Freely reversible reaction in intermediary metabolism

 中间代谢的自由可逆反应
 When Acyl-CoA-esters accumulate in the mitochondria, they can be transferred to L-
Carnitine to build Acyl-L-Carnitine
 当酯酰基辅酶A在线粒体积聚，他们会被转移给左旋肉碱，合成脂酰左旋肉碱
 By export of excess acyl groups from the mitochondria and from the cell, mitochondrial
free CoA is buffered
 作为CoA的缓冲剂，将过多的酰基转移出线粒体和细胞,调节脂酰CoA/CoA的比例
 Acetylcarnitine serves as a temporary energy source
 乙酰基左旋肉碱可被用作临时的能量来源

Acyl-CoA + L-Carnitine ↔ CoA + Acyl-L-Carnitine

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Detoxification
解毒功能
 Detoxification: L-Carnitine removes the acetyl groups (formed during -oxidation) and
short chain acyl groups from inside the mitochondria.
 清除线粒体中的乙酰基（ 氧化过程中形成）和短链脂酰基

 Acids that frequently are transported out of the mitochondria by L-Carnitine are:
 左旋肉碱能把线粒体中以下的有机酸转运出去：
 Valproic acid 丙戊酸
Propionic acid 丙酸
Pivampicillic acid 匹氨西林酸
Benzoates 苯甲酸

Consumer Health & Nutrition

Detoxification
解毒功能
 Body uses this system to excrete toxic acids as L-Carnitine-esters via the urine
 机体利用左旋肉碱的解毒功能将有毒性的有机酸结合为左旋肉碱脂通过尿排出
 detoxification protects mitochondria membranes
 解毒作用帮助保护线粒体细胞膜
 metabolic amounts of L-Carnitine needed
 L-Carnitine–esters are excreted via urine
 通过尿液排出左旋肉碱酯
 Increased losses of L-Carnitine for a long time decrease the plasma and tissue levels of L-Carnitine in
the body
 左旋肉碱长时间的消耗会降低血浆和组织中左旋肉碱的含量

 Lack of free L-Carnitine in the cell:

 细胞缺乏游离左旋肉碱
 During O2-deficiency (e.g. heavy exercise) the production of Acyl-CoA increases, free L-Carnitine
decreases
 缺氧（剧烈运动）产生大量的脂酰辅酶A，游离左旋肉碱含量被降低
 Functional L-Carnitine deficiency!
 有效左旋肉碱缺乏

Consumer Health & Nutrition

体重管理功效：荟萃分析（ A Meta-Analysis）
Pooyandjoo et al., 2016

目的 测试左旋肉碱在体重管理方面的作用
实验设计 9 组随机, 对照试验
样本 N=911
指标 BMI，体重

 实验结果
 摄取左旋肉碱补充剂对减重有明显
效果
平均体重变化: -1.33 kg
95% CI: (-2.09, -0.57)
P值= 0.0006

 补充左旋肉碱可以降低BMI值
平均BMI变化: -0.47 kg/m2
95% CI: (-0.88, -0.05)
p值= 0.03

Consumer Health & Nutrition

 Carnipure® 应用
Carnipure® 是由瑞士龙沙公司生产的特殊规格左旋肉碱

Carnipure® 具有多种功效，可应用于多种不同应用领域
左旋肉碱是将长链脂肪酸传输到线粒体膜的必需物质，帮助分解长链
脂肪酸以及能量生成。

Infant Exercise Weight Energy

Nutrition Recovery Management Metabolism
婴幼儿营养 运动修复 体重控制 能量

Healthy Cardiovascul
Pet Health
Aging ar Health
宠物健康
抗衰老 心血管疾病

Consumer Health & Nutrition

Consumer Health & Nutrition

Carnipure®运动营养的临床研究
Recovery Mode of Action
 Carnipure®运动修复研究概况
Exercise Recovery Study Overview
研究作者 年份 # 样本 Characteristics 性别 年龄组 周期
Parandak K et al 2014 21 Healthy active m 21-23 2 weeks

Ho JY et al 2010 18 Healthy active m/f 40-60 3 weeks

Spiering BA et al 2008 9 Resistance-trained m 19-31 3 weeks

Parthimos T et al 2008 10 Basketball players m 18-19 4 weeks

Spiering BA et al 2007 8 Healthy m 19-25 3 weeks

Kraemer WJ et al 2006 10 Resistance-trained m 21-23 3 weeks

Kraemer WJ et al 2003 10 Healthy, weight- m 21-25 3 weeks

trained
Volek JS et al 2002 10 Recreationally weight- m 21-26 3 weeks
trained
Giamberardino MA et al 1996 5 Untrained m 22-33 3 weeks

Consumer Health & Nutrition

Volek UCONN 研究 2002
随机的，双盲、安慰剂对照、平衡交叉式实验设计
研究组 Group 1: Carnipure = 2克/天
Group 2: 安慰剂
样本 人数=10, 平均年龄23.7
周期 运动前，3周服用补充剂+恢复周期6天
主要终点 嘌呤分解、自由基形成、肌膜断裂以及疼痛感

测试时间 D1, D2 (pre-squat), 0, 15, 180 mins 深蹲训练, D3, D4, D5, D6
结果 • 跟安慰剂组相比，肌肉组织拉伤比例明显降低；
• 相比补充LC测试组，安慰剂组在运动后第一天、第二天和4天后的疼痛感明显；
• 服用LC补充剂组与安慰剂组相比，应激标志物明显降低；
或者
• 安慰剂对照组深蹲运动后表现出明显的应激标志物的增加，而补充LC群体没有；
• 观测应激标志物包括，次黄嘌呤、 黄嘌呤氧化酶、尿素、肌球素、肌酸激酶、FABP脂肪酸结合蛋白

 *P 0.05 相对于运动前的数值；

 #P 0.05 LCLT与安慰剂组对照值；

 与运动前两组数据相比较，15分钟后肌球素含量明显上升；另外，服用LC补充剂组，在30，
120和180分钟后，肌球素含量明显上升；

 服用LC补充剂组与运动前的数据相比，运动恢复中的第3天到第6天肌球素水平都没有表现出
明显差异。

 服用LC补充剂组在恢复周期（第3天到第6天）的血浆肌酸激酶水平与运动前相比没有表现出
明显差别；

 结果显示左旋肉碱可以减少肌肉酸痛症的影响。

Consumer Health & Nutrition

 Older Adults Study, 2010
Randomized, balanced, double-blind, placebo-controlled, cross-over design

Groups Group 1: Carnipure® = 2g/day

Group 2: Placebo

Subjects N= 18, Avg age 48.65 years old

Duration 3 weeks supplementation period prior to the squat protocol + three day
recovery period
Primary Endpoint Reduction of markers of exercise stress and perceived soreness
应激标志物以及疼痛感的降低
Time points • Blood markers – pre-exer, 0, 15, 30, 120 mins, D1, D2, D4 post squat
• Perceived muscle soreness – Baseline, pre, immediately after,
120mins, D1, D2, D4
Results The 2g dose reduced post exercise biochemical markers of purine
metabolism, free radical formation, muscle tissue disruption, and muscle
soreness after physical exertion
2g的计量可以有效减少运动后的嘌呤代谢，自由基的生成、肌肉组织的受
伤以及肌肉疼痛的问题。

Source: Ho 2010_LCLT supplementation favourably affects biochemical markers of recovery in baby boomers
Consumer Health & Nutrition
 Older Adults Study, 2010
Results

 #P <.05 from corresponding pre-exercise value.

 *P <.05 between corresponding L-Carnitine and

placebo values.

Source: Ho 2010_LCLT supplementation favourably affects biochemical markers of recovery in baby boomers
Consumer Health & Nutrition
左旋肉碱补充剂最新研究报告
健康成年群体

• 近期Nutrients发表了龙沙左旋肉碱功效的最新研究

• 左旋肉碱对健康成人运动修复作用

健康年轻人群功效

 有助运动中提高运动成绩以及耐力
 帮助运动后修复
 减少肌肉损伤以及酸痛
 改善血管中的血液流动
 抗衰老的最新用途

Fielding et al., Nutrients 2018

Evans et al., Nutrients 2017

Consumer Health & Nutrition

左旋肉碱补充剂最新研究报告
健康成年群体

• 第二份新研究刊登于 Nutrition & Metabolism，研究表明左旋肉

碱在中老年人中的功效
• 对于老龄化人群，左旋肉碱的摄取可以帮助增加肌肉组织以及
提高肌肉的功效

• 该研究实验遵循随机、双盲安慰剂对照测试

老龄化人群功效

 帮助增加肌肉组织
 有效维持肌肉力量
 增强体力以及抗疲劳

Fielding et al., Nutrients 2018

Evans et al., Nutrients 2017

Consumer Health & Nutrition

Carnipure® Value package

 Customer Service/Support
• Reg Support
• Label Review
• Tech Support
• Plant Audits
 Science
• Studies in Carnipure
• Continuous innovation
 Branding
• Quality Seal
• Co-promotion
• Carnipure website

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Carnipure品牌
Quality Seal

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BodyShaper® L-Carnitine

 Product description:
 water based solution with a high
proportion of L-Carnitine
 Recommended training phase:
 Definition phase
 Product features
 per serving 1000 mg high quality L-
Carnitine
 Only 0,2 g carbohydrates per serving
 fat free
 Recommendation:
 Take 1 serving (10ml) per day. Preferably
before workout.

Consumer Health & Nutrition 25/34

Sangaria miracle energy V
Japan

 To people sending active, busy daily life! I

renew it, and "miracle energy V" where
you can supply with energy deliciously
sells it newly! Moderate acidity and
balance of the sweetness are
exquisiteness, and the taste is right
miracle, too!
 Fructose grape sugar solution sugar, L-
carnitine / acidulant, carbonic acid,
arginine, fragrance, taurine (extract),
caffeine, caramel pigment, glutaminic acid
Na, aspartic acid Na, niacin, leucine,
vitamin B2, vitamin B6, valine, isoleucine
 Nourishment ingredient (per 100 ml)
It is energy 59Kcal, protein 0.1-0.5 g, lipid
0 g, carbohydrates 14.4 g, sodium 22 mg,
arginine 130 mg, taurine 40 mg, carnitine
10 mg (per 100 g)

Consumer Health & Nutrition 26/34

Monster Energy Drink

 Carnipure® tartrate content

 250mg L-Carnitine/serving

 Other active ingredients

 Ginseng, taurine, caffeine

 Product Positioning
 Energy

 Field of Application
 Energy drinks

Consumer Health & Nutrition

品牌大使

Consumer Health & Nutrition

Jeff Volek Ph.D.

 宾夕法尼亚州立大学运动生理学和营养博士
 宾夕法尼亚州立大学运动科学MS
 俄亥俄大学教授
 主要研究：低碳水化合物饮食的生理适应性以及补充剂对健康和运动的影响
 《低碳水化合物生活的艺术与科学》作者之一

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Videos

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Consumer Health & Nutrition 31/34
法规总结
中国

物质 应用 使用剂量 参考法规标准
左旋肉碱 调制乳粉（仅限儿童用乳粉） 50-150 mg/Kg
调制乳粉（儿童用乳粉除外） 300-400 mg/Kg
果蔬汁（肉）饮料（包括发酵型 600-3000 mg/Kg
产品等）
风味饮料 600-3000 mg/Kg GB14880-2012

含乳饮料 600-3000 mg/Kg

固体饮料类 6000-30000 mg/Kg
特殊用途饮料（仅限运动饮料） 100-1000mg/Kg
婴儿配方食品、较大婴儿和幼儿 0.3 mg/100 kJ GB 10765—2010
配方食品 或者 1.3mg/100 kcal GB 10767—2010
运动营养食品 1-2g/天 GB24154-2015

• 功效性宣称针对于成品并不是单个原料；
• 左旋肉碱和左旋肉碱酒石酸在中国可以用于保健品作为宣传原料；
• No special dosage level is requested for health claim products.

Consumer Health & Nutrition

Why Carnipure® L-Carnitine?
Differentiation from Competition

 Market Leader
 Lonza is the largest global manufacturer with largest production capacity in the industry
 30+ years of experience (first sales in 1984 to infant nutrition)
 Supplier to all segments within health & nutrition industry (F&B, supplements, infant nutrition, animal nutrition)

 Service
 Science - Lonza has developed and continues to invest in clinical research with over 45 studies published
 Safety – Lonza’s R&D and regulatory teams have worked to develop a comprehensive tox and safety package
 Regulatory – Lonza has a dedicated regulatory department with expertise in opening up new markets for L-Carnitine
 Regulatory – Lonza’s regulatory department has key contacts at government agencies to support customer inquiries
 Marketing – 30+ years marketing, selling, and educating on the benefits of Carnipure® L-Carnitine

 Backward Integration
 The primary raw material used in the manufacturing process is made in a Lonza Swiss facility
 Lonza is the only L-Carnitine manufacturer using this raw material
 Backward integration allows for control over the supply chain ensuring a quality product with limited risk of impurities
 Proprietary production processes

 Strict quality standards

 Strict specifications on raw material, intermediates and final products
 Closed production process and filling in a clean room
 Global quality organization, regularly audited internally and externally

Consumer Health & Nutrition

本次介绍仅供研究使用，不得用于临床诊断。所有商标均属龙
沙公司或其附属机构或第三方所有者所拥有。本广告所涵盖的
内容均认为是正确信息并符合最新的科学技术理论。但是本广 Consumer Health & Nutrition
告不对所涉及的表述、暗示、精确度以及信息使用后果作任何
保证。某些产品可能不适合于所有市场或所有应用领域。任何
用户必须自愿并自行决定龙沙集团所提供的产品及龙沙集团所
提供的信息与参考资料：(i)适合于既定工艺或用途，(ii)符合环
保、健康以及安全法律法规，(iii)不得侵犯任何第三方知识产 感谢您的聆听！
权。

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