Department of Education

Region VII, Central Visayas

City Schools Division
City of Naga
Tuyan National High School
Tabtuy, Tuyan, City of Naga Cebu

Name:_____________________________________________ Grade 10 Section: ____________________ Rate: _____________

Activity No. 4.5 Date:_____________
Chromie Change
Objectives:
 Illustrate the kinds of chromosomal mutations
 Differentiate the kinds of chromosomal mutations

Materials:
Modeling clay of varied color
1/8 illustration board
Procedure:
A. Translocation
1. Using modeling clay make models of two (2) chromosomes. One
should have a different color and size from the other.
2. Break one part of each of the chromosomes. Exchange the parts
and attach them to each of the other chromosomes.
3. Fill in the second column (translocation) of the table.

B. Deletion
1. Make a model of a chromatid (one of the duplicated copies of a
chromosome)
2. When done, remove a portion of it (close to either end of the
chromosome or within the long arm or short arm). If you choose to
remove a part within the arms, be sure to join back the bottom
part.
3. Fill in the third column ( deletion) of the table.
C. Inversion
1. Make a colored chromatid. 2. Break a portion (with 2 colors) of it.

2. Reinsert it to the chromatid in a reverse manner. 4. Fill in the fourth column (inversion)
of the table.
 Chromosomal Mutations
Translocation Deletion Inversion
1. How many
chromosomes are
involved?
2. How did you
change the orginal
structure of the
chromosomes?
3. Which
condition/s do you
think results/s to
change/s of
chromosome
materials?
Note: Indicate using
the words loss, gain,
either loss or gain of
genetic materials

Questions:
1. How are the three chromosomal aberrations different from each other? How are they
similar?
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2. Do you think the normal genetic content of the chromosome is affected?
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3. Which condition results to gain of chromosome material? Loss of chromosome
material?
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4. What are some possible effects of these chromosomal mutations?
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