PRAKTIKUM KIMIA

FARMASI ANALISIS
 KELOMPOK 4
AMALIA INDAH RIZKY 201910410311042
MOH. ALWAN FALUTHI KELIANDAN 201910410311043
FITRI ARDININGSY ANTIKA 201910410311044
FIDHDHAH FAKHIRAH RAHMAN 201910410311045
NUR IFTA MUFIDAH 201910410311046
SYAILI RAHMA 201910410311047
HUSNA RUSDIANA 201910410311050
ALFIKA THISSWANDA 201910410311051
TRI LUTFIANA MARETHA 201910410311102
ZADA FARAH SALSABILA 201910410311103
MUHAMMAD DONNY CAHYA 201910410311206
KHARISMA PUTRI ENDI 201910410311207
MEIRIZQA PUTRI AULIA AZIZA 201910410311258
ELZA NUR RAHMAH SALZABILLAH 201910410311259
Konsentrasi
-Larutan Baku Induk I Paracetamol
Konsentrasi = PPM = mg/L
= 99,1 mg/100 ml
= 99,1 mg/0,1 L
= 991 ppm

-Larutan Baku Induk II Paracetamol (menggunakan rumus pengenceran)

V1 . N1 = V2 . N2
1,0 ml . 991 ppm = 25,0 ml . N2
N2 = 39,64 ppm

-Konsentrasi Larutan Baku Kerja 1-5 Paracetamol

Baku Kerja 1
V1 . N1 = V2 . N2
1,0 ml . 39,64 ppm = 10,0 ml . N2
N2 = 3,964 ppm  
 Baku Kerja 2
V1 . N1 = V2 . N2
2,0 ml . 39,64 ppm = 10,0 ml . N2
N2 = 7,928 ppm

Baku Kerja 3
V1 . N1 = V2 . N2
3,0 ml . 39,64 ppm = 10,0 ml . N2
N2 = 11,892 ppm
 
Baku Kerja 4
V1 . N1 = V2 . N2
4,0 ml . 39,64 ppm = 10,0 ml . N2
N2 = 15,856 ppm
 
Baku Kerja 5
V1 . N1 = V2 . N2
5,0 ml . 39,64 ppm = 10,0 ml . N2
N2 = 19,82 ppm
2. Konsentrasi
-Larutan Baku Induk 1 Salisilamid (dik. volume larutan baku induk 1 adalah 100,0 ml)
konsentrasi : ppm = mg/L
100,4 mg/100 ml
100,4 mg/0,1 L
1004 ppm

-Larutan Baku Induk 2 Salisilamid (menggunakan rumus pengenceran)

  V1 . N 1 = V2 . N2
1,0 ml . 1004 ppm = 25,0 ml . N2
1004 = 25,0 . N2
N2 = 40,16 ppm

-Konsentrasi Larutan Baku Kerja 1-5

Baku Kerja 1
V 1 . N1 = V2 . N2
1,0 ml . 40,16 ppm = 10,0 ml . N2
40,16 = 10 . N2
N2 = 4,016 ppm
 Baku Kerja 2
V 1 . N 1 = V 2 . N2
2,0 ml . 40,16 ppm = 10,0 ml . N2
N2 = 8,032 ppm
 
Baku Kerja 3
V 1 . N 1 = V 2 . N2
3,0 ml . 40,16 ppm = 10,0 ml . N2
N2 = 12,048 ppm
 
Baku Kerja 4
V 1 . N 1 = V 2 . N2
4,0 ml . 40,16 ppm = 10,0 ml . N2
N2 = 16,064 ppm
 
Baku Kerja 5
V 1 . N 1 = V 2 . N2
5,0 ml . 40,16 ppm = 10,0 ml . N2
N2 = 20,08 ppm
3. Regresi Baku Kerja

 λParacetamol

Baku kerja 1 3,964 0,389

a : 0,0178
Baku kerja 2 7,928 0,795
b : 0,09767
Baku kerja 3 11,892 1,165
r : 0,9964
Baku kerja 4 15,856 1,651
Baku kerja 5 19,82 1,897

a : 0,0178
b : 0,09767
r : 0,9964
 λSalisilamid
Baku kerja 1 4,016 0,066
Baku kerja 2 8,032 0,134
Baku kerja 3 12,048 0,243
Baku kerja 4 16,064 0,287
Baku kerja 5 20,08 0,353

a : -1,5 x 10-3
b : 0,0181
r : 0,9915
 λPerpotongan (Paracetamol)

Baku kerja 1 3,964 0,071

Baku kerja 2 7,928 0,142
Baku kerja 3 11,892 0,187
Baku kerja 4 15,856 0,275
Baku kerja 5 19,82 0,335

a : 0,0037 (3,7 x 10-3)

b : 0,0167
r : 0,9964
 λPerpotongan (Salisilamid)
Baku kerja 1 4,016 0,038
Baku kerja 2 8,032 0,087
Baku kerja 3 12,048 0,139
Baku kerja 4 16,064 0,178
Baku kerja 5 20,08 0,240

a : -0,0121
b : 0,0123
r : 0,9982
4. Konsentrasi Sampel yang Terukur (Paracetamol dan Salisilamid)

λ Paracetamol
y = bxpct + a1 + bxs + a1
1,264 = 0,0977 xp + 0,0178 + 0,0181 xs + (-0,0015)
1,264 - 0,0178 + 0,0015 = 0,0977 xp + 0,0181 xs
1,2477 = 0,0977 xp + 0,0181 xs

λ Perpotongan
y = bxpct + a1 + bxs + a1
0,283 = 0,0167 xp + 0,0037 + 0,0123 xs + (-0,0121)
0,283 – 0,0037 + 0,0121 = 0,0167 xp + 0,0123 xs
0,2914 = 0,0167 xp + 0,0123 x­s

 1,2477 = 0,0977 xp + 0,0181 xs (x 0,0167)

0,2914 = 0,0167 xp + 0,0123 xs (x 0,0977)

0,0208 = 0,0016 xp + 0,0003 xs

0,0285 = 0,0016 xp + 0,0012 xs
-0,0077=. -0,0009 xs
xs. = -0,0077/-0,0009
xs = 8,56 ppm
1,2477 = 0,0977 xp + 0,0181 xs
1,2477 = 0,0977 xp + (0,0181 . 8,56)
1,2477 = 0,0977 xp + 0,1549
1,2477 – 0,1549 = 0,0977 xp
1,0928 = 0,0977 xp
xp = 11,19 ppm
5. Kadar Sampel (Paracetamol dan Salisilamid)

Kadar Paracetamol
Xp = 11,19 ppm = 11,19mg / 1000ml
= 0,0112 gram / 1000ml
= 0,0011 gram / 100ml
= 0,0011 gram% b/v

Kadar Salisilamid
Xs = 8,56 ppm = 8,56 mg / 1000ml
= 0,0086 gram / 1000ml
= 0,0009 gram / 100 ml
= 0,0009 gram% b/v
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