xx-yy Collaboration

Governance Meeting

12th September 2023

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Overview of xx-yy FTE collaboration

 Approved FTEs: Total 4 FTEs from 11 May ’23, and currently 3 FTEs from August ’23

 Yy contact:

 xx Contacts:

 FTE Collaboration start date: 11-May-23

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Project Charter - APSL

Project Sponsor
xx
(Head of Medicinal Chemistry)

Project In-charge Project Manager

xx xx

Chemistry Lead Biology Lead CADD lead

xx xx xx

1 Chemistry 1.5 Biology 0.5 CADD FTE

FTE FTEs

3
FTE Team - XX
Name Industry Experience (years) Educational Qualification

xx

xx 12+ PhD

xx 17+ MSc
xx MSc
xx
xx
xx

xx

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Key Contacts and Escalation Matrix

Name Designation E-mail Address Escalation Phone Numbers

Level
xx Associate VP Med Chem and xx 1 +91
Project In-charge
xx Head, Medicinal Chemistry xx 2 +91-
Global Head, Discovery
xx Services xx 3 +91-

xx Chief Executive Officer xx 4 +91

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Project Details

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Target status
Target summary No. of targets

Total no. of targets received for synthesis 50

Total Number of targets completed 33
Ongoing targets 5
No. of targets to be initiated/ RMs awaited/ RM not indented 0
Targets on hold/ cancelled 12

Project start date 18 May’23

Shipment schedule As required to APSL, Hyderabad
Average No. of targets shipped/FTE/month (May’23- Aug’23) May’23-July’23 (1 FTE’s): 5.67 & Aug’23 (1.75 FTE’s): 7.06
Average No. of reactions/FTE/month (May’23- Aug’23) May’23-July’23 (1 FTE’s): 44 & Aug’23 (1.75 FTE’s): 42.94
Average No. of steps per target compounds 5.61
Average No. of reactions per successful steps 1.56

Estimated no. of targets for completion in Sep’23

3-5

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Monthly Productivity Metrics
No. of FTE
Total number of compounds synthesized/shipped
Productivity
18

16
16

14

12

10
10 10
9.41
8

6
5
5
4

2 1.75
2
1 2 1 1

0
May June July Aug

Average No. of steps/FTE for Aug’23: 29.41

Average No. of reactions/FTE for Aug’23: 50.59

Projections for September:

• APSL team to plan delivery of 3-5 compounds
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Key challenges observed & Mitigation Strategies

Key challenges observed Mitigation

Completely removed organic solvent (DMF) and extracted with

SC9 intermediate were not extracting from water
DCM/MeOH
SC9 LHS has poor solubility in organic solvents to couple with SC9 LHS was dissolved in DMF at elevated temperature and even after
corresponding acids bring back to the RT it was remain complete dissolved state

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Key metric for project success

 Productivity: Productivity of  ≥4 compounds/FTE/ month

 Speedy & continuous delivery of priority targets on weekly basis for SAR

 Experimental write-ups: Ongoing with experimental write-ups of the completed targets.

 Weekly updates: In the agreed format and with summary line in all the slides as applicable, with more information on the
failed reactions.

 Communication: Proactive communication on challenges and scheduled holidays

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Thank You

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