nh lut Higuchi v m rng vi m hnh gii phng cht tan t matrix nhiu lp.

Summary
M hnh Higuchi m t s gii phng thuc trong ct matrix khi m nng dc cht cn phn tch
vt qu nng bo ha trong mi trng. M hnh c chng minh nh l mt cng c mnh m
trong lnh vc pht trin v ti u ha cc dng thuc kim sot gii phng hin i.Bi vit nhm cung
cp mt s khi nim, c s ton hc cho m hnh v cc h qu ca n, ng thi phn tch,tho lun i
km v d tnh ton v m hnh Higuchi m rng vi cc lp cht tan khc nhau.Khi cc iu kin gi n
nh c duy tr, m hnh m rng cho thy mt t l gii phng thuc gn nh lin tc so vi m hnh
mt lp truyn thng.

Introduction
Trong 100 nm tr li y cc h thng gii phng thuc c nhng thnh qu vt bc, i t nhng
vin thuc n gin truyn thng cho ti nhng cc h duy tr/kim sot thuc c thit k mt cch
tinh vi.
khc phc nhng nhc im vn c ca dng thuc truyn thng nh nng thuc trong mu tng
mt cch t ngt theo sau l s gim nhanh chng n di nng tc dng, nhng h kim sot
gii phng thuc c pht trin vi mc ch c gng duy tr nng thuc trong mu hay cc m ch
cng lu cng tt,hay ni mt cch khc l t c ng hc gii phng bc 0 tc nng thuc hng
nh theo thi gian.
S pht trin mnh m cc dng thuc k trn i hi s hiu bit v tt c cc yu t nh hng n s
gii phng thuc t cc h khc nhau nhm ti u ha chng.T cc m hnh ton hc cho ng hc
gii phng thuc ngy cng c hon thin. Cc m hnh c th c hiu mt cch n gin nh l mt
n d ton hc trn mt s kha cnh ca thc t , m trong trng ny c xc nh bi ton b cc
hin tng, tnh cht chi phi s gii phng thuc.
Cc mc tiu chnh ca mt m hnh ton hc c th k ra nh sau :
-

Thit k h thng gii phng thuc mi da trn cc biu thc gii phng tng qut.

D on c chnh xc tc gii phng dc cht theo thi gian, t trnh c phi th

nghim qu nhiu.
Ti u ha ng hc gii phng.
Lm sng t c ch vt l ca gii phng thuc bng cch so snh d liu ca cc m hnh ng
hc khc nhau.

Vo nm 1961 Higuchi gii thiu phng trnh ni ting nht thng c dng m t s gii phng
dc cht t ct polymer. Phng trnh ni ting ny cp ti t l gii phng ca mt cht, thng l
thuc t matrix m thng l polymer, ni m nng ca dc cht vt qu nng bo ha khi
khuych tn t matrix i vo mi trng lng xung quanh.

Hnh 1. Lc m t m hnh Higuchi

Trong matrix chng ta c nng trong mi n v l ng nht, A, vt qu nng bo ha ca n ,C s,
. Higuchi kho lo xut mt phn tch da trn cc iu kin gi n nh,khi m s gii phng thuc
c kim sot bi s khuch tn cc cht tan, cho thy tc gii phng ca cht tan t l thun vi cn
bc hai ca thi gian. Cc iu kin gi n nh, v kt qu t phng trnh Higuchi ni ting ngy nay
c coi l ng hc gii phng thuc c in. Vi mc ch cui cng l to ra mt ng hc bc 0,
trong k thut, tc gi phng hng nh ny c th t c bng mt s kiu ct v mng bao. Tuy
vy, chng thng kh t tin v kh trong k thut ch to,do phi lm ch nhiu yu t k thut s lm
gia tng ng k cc sn phm li dn ti tng ri ro cho ngi dng thuc ( s l nguy him khi vin gii
phng ko di li gii phng ng thi ton b lng dc cht mang theo ). Khi vin ct matrix l
mt ng vin thch hp hn do r v d ch to, v s gii phng trn vin ct matrix t c ng
hc bc 0 chng ta cng phn tch m hnh m rng t m hnh Higuchi vi nhiu lp cht tan c nng
khc nhau.

Khi nim v c s ton hc cho m hnh Higuchi

Hnh 2. Gin hnh Higuchi vi s phn chia cc vng

gi nh
Trong m hnh ny thuc dng rn c coi nh gii phng theo tng lp, khi lp ny ht ti lp
kia din ra s ha tan v khuch tn. Nh vy ta c th phn ra cc vng gi nh nh sau ( nh
hnh 1)
Dng cht lng thm vo ha tan thuc, vi tan ca thuc trong khong 0 < x <

(trong

khong ny thuc ha tan hon ton) l C = C s . Theo s chnh lch gradient nng , nng
cht tan s gim cho ti khi t C = 0 ti lin b mt gia hai mi trng, ti c C = 0.
Trong khong th tch

< x < L, lng nc thm vo cha kh nng ha tan hon ton

cht tan, vn cn tn ti cc ht cht rn cha b phn r hon ton. Trong khong ny, dung dch
trng thi qu bo ha. Trong khong th tch x > L, cha c nc thm vo, cha c s ha tan
cht tan. Bng cch ny b mt chung gia vng thuc b phn tn hon ton v vng cha cc
phn t thuc b ha tan mt phn ( mt h d th ) di chuyn vo pha trong matrix theo thi
gian.
Phn tch hnh v, s bin thin nng trn mt n v th tch, dM, cng vi s bin thin dy vng
d th cc phn t thuc cha b ha tan hon ton, dh, c cho bi :

dM = A . dh

Cs
dh(1)
2

Theo nh lut Fick I cho s khuch tn cc cht tan ta li c

M Dm .C s
=
t
h

Hay
(2)

M=

(1)

D m. Cs
.t
h

Vi

Dm l h s khuch tn ca cht tan ang c xt.

Khi chng ta cn bng phng trnh (2) v (3) sau ly tch phn v gii ra h ta thu c

D m. C s
C C s
. t= o
h
h
2
2C C s
h h= t
m .C s

2 Do

2 C oC s
h h= t
2 Dm . C s
2C
2
( oC s). h
=t
4 Dm . C s

D .C .t
h=2 m s
2C o Cs

1
2

(4)

Chng ta ly tch phn phng trnh (1) v thay gi tr ca h theo phng trnh (4) ta thu c :

dM =

( A C2 ) dh
s

M=

( 2 AC s ) h
2

D C t

m s
( 2 AC s ) 2 2 AC
s

M =2 ( 2 AC s ) D m C s t (5)

y chnh l phng trnh Higuchi. thit lp c cc phng trnh trn ta phi chp nhn
mt s iu kin gn ng sau :
- Nng thuc trong mi n v th tch ca matrix phi ln hn ng k so vi nng
thuc bo ha.

Mi trng lng m thuc khuch tn vo c coi nh ti nng thuc khng ng

k.
Cc ht thuc c coi nh l nh hn nhiu so vi khong cch khuch tn
Hng s khuch tn ca cht tan c coi nh hng nh.
Khng c tng tc ng k no gia thuc v matrix.

Nh vy vi cc iu kin trn ta c th s dng phng trnh (5) m c th b qua cc gi tr

li nh, khi vi mt m hnh matrix dng c in ta s thu c tc gii phng t l vi
cn bc hai theo thi gian.
Trong mt s trng hp cn phn tch chnh xc, chng ta s buc phi x l cc s liu khi
m nng cht trong matrix tin ti hoc nh hn Cs. S khuch tn thuc lc ny s c
tip cn mt cch cht ch hn theo nh lut Fick 2

C
2 C
=D 2
t
x

y l mt phng trnh vi phn bc hai do vy s l kh phc tp gii quyt, v trong

phm vi ca bi bo qu trnh s khng cp y (Paul and McSpadden, 1976)
Nhng nh kt qu ca bi bo trn ch ra, khi A>>C s th cc li ca phng trnh (5) l
hu nh khng ng k v khi A tin ti Cs th sai s ch l 11.3%. Nn trong hu ht cc
trng hp chng ta c th s dng kt qu ca Higuchi m khng cn bn tm qu nhiu v
tnh gn ng ca n. Tuy vy trong mt s phn tch nghim ngt hn nh s trnh by
di,khi nng A nh hn Cs mt phng trnh khc s c thay th, nh l mt c gng
gim thiu li (Pauland McSpadden, 1976),s c ni phn sau.

Matrix nhiu lp v cc v d tnh ton

1,Matrix nhiu lp
Trong khi vin ct matrix l kinh t hn so vi cc vin vi mng bao kim sot gii phng
v mt ch to,nhng c mt bt li r rng l s nng thuc gii phng gim nhanh theo
thi gian nh phng trnh (5) d on. Hin c nhiu tng v vic sao cho vn gi
c li th v kinh t v d dng trong ch to ng thi li c th c th to ra s gii
phng thuc n nh theo thi gian. Mt trong nhng cch tip cn vn ny l s dng h
matrix nhiu lp,m ti mi lp c nng thuc khc nhau nh trong hnh (2).Hin nhin
rng cng hng v tm th nng phi cng cao b tr s gim tc gii phng theo
thi gian. lm r hn chung ta cng xt mt tnh ton minh ha cho h matrix hai lp,sau
s cng m rng ra trng hp tng qut vi n lp.

Hnh (3) : Minh ha h matrix hai lp vi nng thuc ban u mi lp l khc nhau

2,V d tnh ton cho h matrix hai lp

Trc ht chng ta cng quay tr li vi m hnh HIguchi c in khi s phn b cht tan l ng
nht,khi s phn b cht tan tun theo 3 phng trnh sau:

d M t D .C s
=
(4 )
dt

d Mt
1
d
= A C s
(5)
dt
2
dt

d Mt
=
dt

( A 12 C ) .C . D
s

2t

Vi Mt : lng cht tan c gii phng qua mt n v din tch b mt trong thi gian t.

d Mt
dt : tc gii phng cht tan.

tin d dng hn trong vic th hin mi tng quan gia lng thuc gii phng theo thi gian,t
chng minh c tnh u vit ca m hnh m rng so vi m hnh c in,chng ta s dng cc i
lng khng th nguyn

t:

D .t
2
l
d(

Khi

(vi

l i lng thi gian khng th nguyn

Mt
)
Cs . l
d

l tc gii phng khng th nguyn

l : b dy ca lp cht ban u theo m hnh)

T (4) v (5) ta c :

D . Cs
1
d
= A C s .

2
dt

1
D .C s . dt= A C s . d
2

1
A C ).
(
2
D .C . t=

Vi

(6)

H l thi gian gii phng hon ton ht cht tan m ti cc iu kin gi nh ca Higuchi

vn cn tn ti.

H=

D .tH
l

D .tH

1 A 1
(7)vi =l
2 Cs 2

T phng trnh Higuchi chng minh

1
M t= 2 t . A C s . C s . D
2

A 1
1
2t .
.D
2
t
.(
A
C
s). D
C
2
Mt
s
2

=
=
Cs. l
C s .l
l

d(

Mt
Cs. l

A 1
.D
(
C 2)
)=
dt
s

2t .l

d=

D . dt
2
l

d(

Mt
)
Cs . l
=
d

A 1
.D
Cs 2

2t .l
D
l2

t . l2
= H (8)
D

2
l

T cc mi tng quan trn ca m hnh c in chng ta m rng vi h matrix hai lp.Trng hp

c minh ha hnh (3) l m hnh matrix gm 2 lp i xng c b dy ln lt l

l 1 v l 2 , mi

na cha hm lng cht tan l A1 v A2 tng ng.

Vi iu kin vt liu polymer ca matrix ca mi lp l ging nhau, cc thng s

C s v

D l

khng i trong sut qu trnh; lng cht tan lp bn ngoi A1 t hn so vi lp bn trong. Ta c th

chia qu trnh gii phng thnh 4 giai on

Hnh 4 : Cc giai on gii phng dc cht t h matrix hai lp vi nng tng ng lp th nht v
lp th hai l A1,A2 cng b dy tng ng l 2l1 v 2l2.

Trong khong thi gian t < t1 tng ng vi

<

l 1 , s ha tan gii phng cht tan ch

xy ra lp ngoi vi A = A1
T (4) v (5) ta c :

1
(A C s )d
D . Cs
2
=

dt

D .C s
d
=
(9)
dt
1
A C s
2

Ly tch phn vi iu kin

= 0 ti t = 0 :

d=
0

D . Cs
dt
1
A 1 C s 0
2

D .C s
2
=
.t
2
1
A 1 C s
2

2=

2. D. C s
.t (10)
1
A 1 C s
2

1
2 .( A 1 Cs )
2
D=
2.C s . t

M 1=

D .t 1
l2

1
2 . A 1 C s . t 1
2

2.C s .t .l 2

l 12 1 A1 1
= 2. .
( 11 ) vi =l 1
l 2 Cs 2

Vi <1 ,tc gii phng khng th nguyn tr thnh:

d Mt=

D .C s
1
A 1 C s .
. dt
2
2t

Mt
=
Cs. l

( )

A1 1 D
.
C s 2 2t

l2

. dt

Mt
C s .l
=
d

( )

A1 1
.D
Cs 2

2t .l 2
D . dt
2
l

. dt
=

A1 1
. D . l4
Cs 2

2t .l 2 . D

1 A1 1
l2
.
2 Cs 2 D . t

2
1 A 1 1 l1
l
l l 1

.
. = .
(12 )
2
2 C s 2 l D. t l 1 l 1

T ta lp c mi quan h gia hai i lng khng th nguyn ln lt ca tc gii

phng v thi gian.Tng t nh vy ta tm mi lin h gia hai i lng ny trong cc k
thi gian khc nhau.

Trong khong thi gian t1 < t < t2 tng ng vi

Phng trnh (9) vi A = A2 , ta c :

D . Cs
d
=
dt
1
A C s
2

Ly tch phn vi iu kin

2l 12=

d Mt=

( )

2= 1+

l 1 ti t = t1

2. D. C s
(tt 1)
1
A 2 C s
2

D. C s
dt=

Mt
=
Cs. l

D . C s . dt

2.C s . D
. ( tt 1 ) +l 12
1
A 2 C s
2

D . dt
l.

2.C s . D
. ( tt 1) + l 12
1
A2 C s
2

l 2 A 1
1
1 12 . 2 (15)
2
Cs 2
l

( )(

l1 <

<

l2 :

d(

d(

Mt
)
CS . l
=
d

) (

2.C s . D
. ( t t 1 )+ l 12
1
A2 C s
2

2. Cs . D. t
2.C s . D . t 1
l2

+ 12
1
1
l
A 2 Cs .l 2
A 2 Cs .l 2
2
2

) (

l2
1 A2 1
. 1 12
2 Cs 2
l

2
D .t D . t 1 l 1
. 2 2 + 2
A2 1
l
l
l

Cs 2

2. C s . D .(tt 1 ) l 1
+ 2
1
l
2
A 2 C s . l
2

2.C s . D
. ( t t 1 )+ l 12
1
A2 C s
2

1
2

2. Cs . D. t
2.C s . D . t 1
l 12

+ 2
1
1
l
2
2
A 2 Cs .l
A 2 Cs .l
2
2

Mt
)
CS . l
=
d

)( )

(16)
2
1
2

( )

1
l
l
. 1
+ 12
21
l
l

l12

( )

. 1

l2

l 12
l2

2. C s . D .(tt 1 ) l 1
+ 2
1
l
2
A 2 C s . l
2

 thi im t > t2 khi ton b lng cht tan cn li c gii phng,v hin nhin,lc ny
tc gii phng s l ng nht v khng ph thuc vo phn b cht tan ban u.iu ny
c tnh tnh ton mt cch c th qua cc kt qu trung gian ca J. Crank (The
Mathematics of Diffusion, Oxford University Press, London, 1956, p. 45.) . Lc ny tc
gii phng c cho bi

Mt
C s .l

( )
d

2 ( 2 n1 ) ( 2 )
(1)n+1
4
=
exp
n=1 2 n1
4

Khi m rng vi 3 lp v n lp tip tc ta c ta c

Trong khong thi gian

t 2 <t <t 3 tng ng vi l 2< <l 3

T phng trnh (9) vi A = A3, ly tch phn 2 v s dng iu kin

2 (l 2 +l 1)2=

2.C s . D
.(tt 2 )
1
A3 C s
2

Vng ny kt thc khi =l 1 +l 2+ l 3=l xy ra ti thi im t 3

l 2 (l 2 +l 1)2=
l
2
( 2+ l 1)
l 2

1
. A3 C s
2

t 3t 2=

2. Cs. D
.(tt 2 )
1
A3 C s
2

l
2
( 2+ l1 )

3' =

l2
1

D . ( t 3 t 2 )
l2

=l 2

ti t = t2.

l
2
( 2+l 1 )
l2
1

3= 2+ 3' =2 +
Vi s bin i tng t, d dng thu c biu thc ca tc gii phng khng th nguyn trong

2 <<3
l
2
( 2+l 1)
l2
1

l
2
.
3 2

Mt
d
C s .l
1
=
d

( )

Nh vy theo cch chng minh hi quy ta c th d dng tnh ton v tm c mi quan h gia thi
gian v tc gii phng thuc bt k giai on no khi m cc iu kin gi n nh vn c duy tr.
M rng cho trng hp n lp :

n= n1+

)(

(l ++l )
A 1
1
1 n1 2 1 . n
2
Cs 2
l

Tc gii phng theo dng khng th nguyn ti thi im t :

d(

Mt
)
C s .l
=
d

(l n1+ +l 1)
l

n1 (l n1 ++l 1 )2
.
.+
2
n n1
l

V d tnh ton
Mt vi tnh ton di y s cho chng ta thy r hn mi tng quan gia cc i lng nh hng th
no ti tc gii phng thuc theo thi gian trong m hnh vi nhng thit k cc lp thuc c nng
khng ng nht. Vi mi cht tan v matrix c th, cc i lng nh D v

C s l c nh nhit

xc nh. Bng vic s dng cc i lng thi gian v tc khng th nguyn c trnh by phn
trc, s gii phng cht tan ch cn ph thuc v 3 thng s:

l1
l

B dy tng ng gia cc lp:

Tng lng cht tan,

S phn b ca cht tan, biu th bng t l

A
C s vi

A=

l 1 . A1 +l 2 . A2
l 1 +l 2

A1
Cs .

Phn tch v bnh lun

(Biu t 4.1 n 4.3) M t nh hng ca tng lng cht tan A/Cs trn
m hnh gii phng thuc trong khi hai i lng kia vn gi nguyn. S so
snh c thc hin vi mt matrix vi cng mt lng cht tan ban u
nhng c phn b ng u- m hnh Higuchi c in, s so snh ny cho
php nhn ra s khc bit ca tc gii phng theo thi gian ca hai m
hnh vi cng mt liu ban u. Gi tr A1/Cs c chn l 2, y l gi tr
thp nht ti u hiu qu chng minh m vn cch xa khi im m ti
phn tch gi nh gp sai s ng k nh cp trc .Ti thi
im khi nng cht tan gim di gi tr Cs chnh l nguyn nhn lm
gim nhanh chng tc gii phng,nh vy cng vi tng lng cht tan
ban u,m hnh hai lp cho mt thi gian gii phng di hn so vi m hnh
ng nht nh biu tnh ton ch ra. Mt iu d nhn thy t phng
trnh 12 hay 16 cng nh biu trn rng ti khi = 1 ,tc gii phng
nhn gi tr l 2 hay chnh l t l l/l1. Trong giai on gii phng
<

1 <

tc gii phng khng th nguyn ang xem xt bin i trong gii

hn t 1 n 2 v cng chnh l ty thuc vo t l l1/l chng ta la chn. S

la chn t l l1/l s ni r hn phn sau. cc biu ny cho thy mt
kiu ng hc quen thuc ca m hnh Higuchi vi tc gii phng dc
cht t l vi cn bc hai vi thi gian. Bn cnh s st gim nhanh chng
tc gii phng theo thi gian ca m hnh c in mt lp ng nht,
ng cong ca m hnh hai lp th hn r 3 k ca s gii phng nh m
t,tc gi phng gim nhanh n khi = 1 , sau chm dn cho ti khi

= 2, , ti thi im khi nng cht tan gim di gi tr Cs chnh l

nguyn nhn lm gim nhanh chng tc gii phng.

Hnh 4.1 : Biu m t s nh hng ca cc yu t ti tc gii phng thuc theo thi gian

Tng cao tng lng cht tan ban u dn n gia tng thi gian phng nh
biu 4.2 v 4.3 ch ra cng nh c chng minh phng trnh 11
, 15 . Trong v d ny chng ta vn gi nguyn t l A1 /Cs, iu c ngha l
1 theo vn khng i, khi chng ta m rng lp thi gian gii phng
ca m hnh s lm cho gi tr vn c ca
thc t ta khng th nhn thy giai on

1 s l qu nh trong so snh,v
1 >

trn th,kt qu l

trong ton b thi gian gii phng di ca m hnh,tc gii phng khng
bin i qu nhiu xung quanh gi tr 2 hoc ni chung l gi tr t l l/l1
,tng cao tng lng cht tan ban u cn lm cho ng thng biu din
giai on phn ng > 2 gn nh l mt ng thng.

Hnh 4.2 : Biu m t s nh hng ca cc yu t ti tc gii phng thuc theo thi gian

Hnh 4.3 : Biu m t s nh hng ca cc yu t ti tc gii phng thuc theo thi gian

Biu 4.4 miu t cho chng ta thy cch m s phn b hm lng thuc
trong cc lp khc nhau thi im ban u s nh hng ti cc giai on
gii phng ra sao. So snh vi th 4.2 trn,cc ng cong 4.2 s c
biu din nh l cc ng nt t trong 4.4 ng nt lin l cc tnh ton

vi gi tr A/Cs = 20, iu ny dn ti lm tng gi tr

1 v gim

so

vi khi A/Cs = 2 hnh 4.2, s nh hng ny to ra bi phn b cht tan ban

u trong 2 lp tr nn ng nht hn,m hnh thi gian gii phng dn
tip cn vi m hnh gii phng c in khi m s phn b cht tan l ng
nht .

Hnh 4.4 : Biu m t s nh hng ca cc yu t ti tc gii phng thuc theo thi gian

Hnh 4.5 : Biu m t s nh hng ca cc yu t ti tc gii phng thuc theo thi gian

Hnh 4.5 xem xt n s nh hng ca vic thay i dy tng i ca 2

lp trong m hnh m chng ta s dng trong hnh 4.2. lc ny ng nt
lin c tnh ton vi l /l = 0.1, so vi 4.2 y 1 v u gim,i
1

cng vi s st gim nhanh chng ca tc gii phng khng th nguyn

m 1 nhn gi tr kh cao l 10,so vi 2 cc trng hp xt trc
khi l1/l = 0.5. iu ny dn ti m hnh gii phng y khng khc bit
lm so vi m hnh Higuchi c in.
Khi m rng m hnh ra nhiu hn hai lp,s gp phi vn m chng ti
gi l vn u mt, l khi ta xt ti mt thi im chuyn tip gia s
gii phng ca lp hai v ba,lc ny xut hin mt bc nhy ca tc
gii phng, bc nhy ny di hay ngn ph thuc vo s la chn ca
chng ta khi chn tham s lin quan ti nng thuc tng,s khc nhau v
nng gia cc lp v hin nhin l c v dy gia cc lp. trong m
hnh hai lp xt trn do bc nhy qu ngn nn n khng c th hin
trn cc biu . hnh 4.6 miu t cc giai on gii phng tng ng vi
cc lp ca m hnh ba lp,i cng vi ng cong biu din s gii phng
ca m hnh Higuchi c in, v tng t nh hnh 4.2 y chng ta vn
gi gi tr A/Cs ch thay i cch phn b lng cht tan.

Hnh 4.1 : Biu m t s nh hng ca cc yu t ti tc gii phng thuc theo thi gian

Nh chng ta thy r,vi s la chn cc tham s nh trn, cng ti thi

im khi thi gian gii phng tin ti 2, tc c s khc bit gia lp hai
v ba.Tuy vy nhn vo cc kt qu chng minh phn trc, bng cch
ti u ha cc tham s ta hon ton c th lm cho bc nhy ny ngn
li,khi giai oan 2 < < 3 tc lc s ch bin thin rt nh
xung quanh 1 hu nh l hng s.

Kt lun
Cc tnh ton ni trn cho thy bin i khng gian phn b trong matrix ban u
mt cch hp l c th lm gim nh i s bin thin ca tc gii phng theo
thi gian, K t khi tc gii phng ca cht tan ph thuc vo khong cch ti b
mt thong ca matrix, th trnh s st gim tc gii phng theo thi gian, ta
cn nng cao nng ca cc lp bn trong nh l mt phng php b tr. S
gia tng nng thuc cc lp li cn vo ph thuc vo hm lng thuc thc t.
Khi x l kho lo cc tham s lin quan, ta c th lm cho th ca tc gii
phng thuc theo thi gian kh bng phng,hay ni theo cch khc s l gn vi
ng hc bc khng. Tuy v mt k thut, phng php matrix nhiu lp l hon
ton kh thi ( k thut co-extrusion ),nhng chng ta phi lm ch kh nhiu iu
kin thc nghim m t phng trnh Higuchi khng b sai s qu nhiu.

Tham kho
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Li cm n
Xin gi li cm n ti Trnh Ngc Dng,ging vin khoa Y- Dc ai hc Quc Gia
H Ni cng Nguyn Trng Quyt,sinh vin khoa Ton ng dng,i hc Bch Khoa
H Ni, gip chng ti hon thin cc tnh ton trong bi vit.