TRNG CAO NG I VIT SI GN

KHOA: DC
B MN: BO CH

BO CO THC HNH

NHU TNG DAU PARAFIN

GVHD: TH HNG HNH
NHM V:

Thng 06/2016

THUC NH MT KM SULFAT 0,5%

YU CU:
Tnh cng thc pha ch 45 ml thuc nh mt km sulfat 0.5% vi lng acid boric l
0,75g
Thnh phn cng thc:
Km sulfat ........................................ 0.5g
Acid boric .........................................

Dung dch Nipagin M 20% ......... 0.25 ml

NaOH 0,5N hoc HCL 0,5N........ va
Nc ct .............................va 100 ml
I. PHN TCH CNG THC:
1. Hot cht chnh: Km sulfat (ZnSO4)
Tnh cht: Km sulfat l cht bt kt tinh trng hoc tinh th trong sut khng
mu, khng mi, d ln hoa khi ngoi khng kh kh. Rt tan trong nc, d tan
trong glycerin, thc t khng tan trong ethanol 96%.
2. T dc:
- Acid boric: t tan trong nc lnh, tan nhiu trong nc nng, lng acid boric trong
cng thc m bo pH dd t 4,5-5,5, tnh khng khun tt
- Dd Nipagin (Methy paraben): kh tan trong nc lnh, tan trong nc nng, tan trong
cn, dng lm cht bo qun.
- Mui n NaCl: tinh th trng, mu trng, tan tt trong nc, dng lm cht ng
trng cho ch phm.
II.

TNH TON:
ng trng ha dung dch bng cng thc LUMIRERE-CHEVROTIER:

X(g) lng cht ng trng ha cn thm vo (g/100 ml dd nhc trng)

tA : h bng im ca dd nhc trng c do bng dng c thch hp.
t 1 %: h bng im ca cht dng ng trng nng 1%
Xc nh lng NaCl ng trng:
t

ca NaCl 1% = -0,58

ca Acid boric 1% = -0,2880C

>> t ca Acid boric 0,75% = -0,288x0,75=-0,2160C

t

ca Km sulfat 1% = -0,0830C

>> t ca Km 0,5% = -0,083x0,5=-0,04150C

tA = (-0,0415)+(-0,216)= -0,2575
x=

0,52| tA|
= (0,52-0,2557)/0,58= 0,45 (g)
| t 1 |

Cng thc pha ch 45 ml thuc nh mt km sulfat 0.5% vi lng acid boric l 0,75g
Km sulfat dc dng..........................................

0.5 x 45/100 = 0.225 g

Acid boric ..............................................................0,75 x 45/100 = 0.3375g

Dung dch Nipagin M 20% ............................0.25 x 45/100 = 0.1125 ml
NaCl ng trng..................................................0,45x45/100=0,2025g
NaOH 0,5N hoc HCL 0,5N..........................................................va
Nc ct ............................... ............................................va 45 ml
III.Quy trnh k thut pha ch:
1. Chun b v x l dng c:
- Ra sch, tit trng dng c trong nc si 30, sy kh...
2. Cn ong nguyn liu
Cn km sulfat, acid boric trn giy.
Dung dch Nipagin M ly bng ng nh git (1 git = 0.05 ml)
3. Phng php bo ch: Phng php ha tan (c gia nhit)
Ly khong 70% lng nc trong cng thc vo cc, un trn bp in cho si tm
(80oC).
Cho acid boric vo , khuy tan hon hon ton.

 Cho Nipagin M vo, khuy tan.

ngui dd hon ton, cho km sulfat vo, khuy tan.
Cho dd vo ng ong, b sung nc ct va th tch.
*Ch :
Acid boric, dd Nipagin M tan tt trong nc nng.
Phi m bo nc ngui hon ton mi cho km sulfat vo.
4. o pH:
dd ra cc, khuy u.
Chm dd ln giy ch th mu. (pH t 4.5 5.5).
5. Lc:
Lc s b 2 ln qua giy lc xp np hnh qut.
Lc v khun qua mn lc milipore cho vo chai thnh phm.
6. ng chai, dn nhn. Nhn c dng ch THUC TRA MT
NHN L THNH PHM
KHOA DC TRNG CAO NG I VIT SI GN
S 12 Hong Minh Gim P.9 Q.PN TP.HCM
THUC NH MT KM SULFAT 0.5%
Chai 10 ml
Cng thc:

Cng dng: St khun mt, cha vim kt mc.

Km sulfat ....... 0.05 g

Cch dng: Theo hng dn ca bc s.

T dc ............ va

Bo qun: Kn, mt, trnh nh sng.

Nc ct .......... va 10 ml
NSX: 26/05/2016

HD: 26/05/2017

SK: TCVN ..XX

2605
THUC TRA MT

SL: