Dry blending

Particle . sieve, . ? !
(aggromeration)


ex.


Non-uniformity of mix
Particle size distribution
Over blending :
Low dose aliguot
. (segreation) Particle size

Density
Wet granulation/ wet massing
(dougby mass) = Over mixing
( scale .)
1 1g 10 <10g
binder
(Moisture organic solvent
sensitive drug)
Wet screening
Screen clogging , binder

drying
Non-uniform drying oven = -
Color migration
Dry granulation
Excess fine
1. 2.capping
( 20% . !)
Binder
Weak granule

Granule

binder
.

Fred hopper
Wrap holding glidant = cab-o-sil, aerosil

Weight variation - .!
-
-
-
+ oil , .
(sticking&picking)

abrasive
tablet
Capping&laminating - Fine powder granule - fine powder + ..
( capping

: ) - . .
- elastic
-
- feed shoe
(Chipping&splitting) -
2
(layer -

tablet splitting)
- lubricant ,
- binder
. -
(tooling)
Friability - lubricant
. -
(mottling)