Ascarzin (vet) Powder G¯‹viwRb-†fU cvDWvi

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Piperazine Citrate BP
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Composition: cÖwZ‡ivaK|
Water soluble powder containing Piperazine Citrate USP 1000 Dcv`vb:
mg. GK MÖvg G¯‹viwRb-†fU G Av‡Q cvBcvivwRb mvB‡UªU
BD Gm wc G¯‹viwRb-†fU e¨eüZ cvBcvivwRb 1000 M«vg
Pharmacology:
When exposed to Piperazine, worms suffer from
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hyperpolarization of their muscles which produces a reversible hLb cvBcviwRb KvR K‡i, nvBcvi‡cvjvivB‡Rkb Gi gva¨‡g
paralysis that prevents them from maintaining their position in the K…wgi †cwk‡Z wecixZ a©gx c¨vivjvBwmmm„wó K‡i, hv
host’s gut, and they are voided with the feces †cvk‡Ki MvU‡K g‡ji mv‡_ †ewi‡h Av‡m |
Mode of action: Kvh©KvwiZvt
Piperazine blocks the response of the worm muscle (best studied G¯‹viwRb-†fU cvDWvi K…wgi wbD‡ivgvmKzjvi
in Ascaris) to acetylcholine, presumably by causing UªvÝwgkb cÖwZ‡iv` K‡i| d‡j K…wg c¨vivivBwm‡m
hyperpolarization of nerve endings, resulting in flaccid paralysis AvµvšÍ nq I A‡š¿ †ewkÿb wU‡K _vK‡Z cv‡i bv| GB Aek
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of the worm.
Indication: wb‡`©kbv
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It is used in infestations produced by nematode sensitive to
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piperazine, namely Ascaris, & Trichuris. The high doses are cÖwZ‡ivaKG G¯‹viwRb-†fU cvDWvi Mevw`cïi we‡klZ
required to disinfect in case of polyparasitism makes this product GmKvwim Ges cvK¯’jx I Aš¿bvjxi wewfwbœ †MvjK…wg
the anthelmintic of selection due to its low toxicity. It is safely †hgb óªsMvBjvm, B‡mvd¨v‡Mv‡÷vgvg Gi wecixZ
active against all adult forms as well as against some evolutive e¨envh©|
stages of worms where it is found to be a drug of first choice. gvÎv I cÖ‡qvMwewat
Dosage & Administration: G¯‹viwRb-†fUci ci `yB w`b e¨envi Ki‡Z n‡e|
Cattle, Buffalo: 25-50 gm / 100 kg body weight. evQzi t 5-10 MÖvg cvDWvi cÖwZwU evQzi‡K 2 w`b
Horse: 25-30 gm / 100 kg body weight. LvIqv‡Z n‡e|
Sheep, Goat: 4-8 gm / 10 kg body weight.
Dog, Cat: 1-2.5 gm / 10 kg body weight. ‡Nvov t 25-30 MÖvg cÖwZ 100 †KwR ˆ`wnK IR‡bi Rb¨|
Poultry: 250-mg/kg-body weight or use according to the following ‡fov-QvMj t 4-8 MÖvg cÖwZ 10 †KwR ˆ`wnK IR‡bi Rb¨|
dosage schedule: G¯‹viwRb-†fU
KzKzi I weovj t 0.1-0.25 MÖvg cÖwZ †KwR ˆ`wnK IR‡bi
Dosage Number of Poultry Rb¨|
10 gm powder in 6-8 liter 100 chicken (4-6 weeks) or G¯‹viwRb-†fUcvDWvi †h †Kvb ïK‡bv A_ev Zij Lv‡`¨i
of drinking water or 3.5 kg 50-60 pullet or 20-30 layers mv‡_ †meb‡hvM¨|
feed
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Withdrawal Period: gvÎv ‡cvwë« msL¨v
After using Ascarzin vet poultry meat can not eat 2 days, egg 2 10 M«vg cvDWvi ev”Pv gyiMx (4-6
days. Incase of cattle meat can not eat 1.5 days and Milk can not c«wZ 6-8 wjUvi mßvn) 100wU gyiMx,
eat 1 days. cvwb‡Z A_ev c«wZ cy‡jU 10 mßvn 50-
3.5 ‡KwR Lv`¨ 6wU Ges ‡jqvi 20-30
Contraindication: wU
The drug is contraindicated in poultry & animals with known
hypersensitivity to active ingredients or renal failure. c«Z¨vnvi Kvjt
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Side Effects:
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Piperazine is very safe to use, the only occasional side effects are c‡i D³ Mi“i gvsm 1.5 w`b Ges `ya 1 w`b e¨venvi Kiv hv‡e
emesis and softening of the feces. bv|
Storage: wecixZ wb‡`©kbvt
Stored at below 300C temperature, protected from light & dry
place. Keep all medicines out of reach of children. cvBcvivwRb Gi cÖwZ AwZ gvÎvq cÖwZwµqvkxj A_ev
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Pack size: 10 gm, 50 gm, 100 gm sachet.
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Manufactured by
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†ncvUvBwUm BZ¨vw` mgm¨v †`Lv w`‡Z cv‡i|

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