halasseWia

GiXAup o Hexedi He ClassiLicaliou

CMaya cderdzed hy Ae Thahsseuc Maior

T H a a s s en u a M t o u e d i a
1) Redutto rthesis ot Hb a)-TMalasseuia MiuOSU
2 Produces HypocszowuG wcDb Aue
dueto
Aue
Defective Hb -prodiucDiöu REC
SCC1Taasseia. Moios
asseia Mafort>
Homo3y8aus l a t &
Hewolusis, nerte d ow
TMeMecfwe Erguo paleass 9 4 T n a l a s s e i c geue
CF)
BotM PaJteMts
AJso called ovs Coaleys-Auauia >mascked
Keduced
s chal
Meditestita ueau-Awemia a Auuteais o}
Hewolyais
Discovered Cooley 1925 IMefTawe Exytoo poïcao
Expansiou «}
9AMeuias
M e d u l l a a y - A M e u d a

Pathogevleais Cows
Sieue Deletiou foiut LPPyesaos) ExTxawedullazy-He niopojesJS
MutatioM Boby H Hepato apleuDWegal-
Bakai iroM steleae
teduces S) H e w u o s i d e x o J s de Ho
Jewe o all 3 RBC s
MpalHL xou btoakdouul
Mea

uOTMal, Hb A,A8F ivec)plee

Depositap d o n
lodetaJe
A,A,&F B f aTMaasemia e
+
>Hear)
Apha. Tuabeseuia HEM HF TMalasseuia uteiate
Cbroic Hewoliouei a

&-ETMdeszeua 4) Caused> Defiieut ad F cMalu sJuileat=

Oertay ptoWs
IMtestcuwoteuF ilMe)
a exaggexaoM a-Auenije
Pex stautaundtce
 4) hstouic Jfvet dyaluuodou
5 OsteoPotOfs Managemeut

)Mald uepaouegalu
cMsoic-Aveuua
3 Muo, Tualassena
wild foxl sf luess
RtpeateaBiood ttausAusio
IoM Chelatipu TMeap
SpleuETAo
9 D l )Falio AcidurrleMeItHatRoM
Bone
lasutouwTransplautatioM

Hesoo5Hgasika dhe A 6 ) SuAposctie MauageuueMl

Boliuce
VeTyLnwld aueua
3) uilUdTawwdie TransubioM
a) Repeated Blood
4-Abdouinal Pa dt J e s t 1o t o lla/dL
T o waitaiu Hb at
evouy -3 weckS
f sigu & auptoms n9a UsuallL 10- 15wlka aTeTaMsused
o

Wased Puoked RBC

AAge ot zwouths
4) PalloI skM DDER Nocge TsavsusioM+ Meuw RBCs
bea
TuMdice nawelouget Ife->paw)-> cau also
3 Hepadospleun Wegaly
4) RTI a iOW Ghelatio TMeap
4XDeslesskOXa Me C DeNeca L)
5) elogeueul ol Lmpl Nodes SC IMJusiou, dose o 15 o Soml kalday
6 GhEoWI Failuco
ovot peuod o 8-12.Mz
evere coudit o ionouuLoM puwp
1) Facãa ltpperauee meuglotd n Usually-aveM atr wigut(5-6gti wr)
AMoe Xg VitC oowmatday enhauce. stoW eXcsteli'oul
Poo4 Tstelion
M A

b
4)-Adovuünaldisteuhio Drleriprone
*5o
(oaLIo-cMelahingtget
5) Jequwao Fevet L0oalkaldag iM atiied dc
 SpleueTloi
LudicatoM.wleu Ghild uesd rea
Blood Txalsusio
Hpsus pledis
9DFolicAcid Supplemeutafon
STee vegelabled
Gtus FstuitsOange

Beavs
Gotea
RiGe
E Bovle wasocow btavsplavTao
f Deletioe Tleau 6ells ate Teplacedt
norwal Teal cells
C6) appodie Mavagewe
4 Vaccita o HepaThis Bto be gie
opreveut-> taus Juio/ steldred iuz
aEuaieualauppoT fateilt aila
3) No GaTE
New Approcles
1 a) Gtene THerapy
Wartiovu oNormal Gtene ss dole
done
SeM Gells to GOsGett avldlery
Greue maulipulatiov
EXess oAlpMab-cMan Ves b
Ning Gauula chauM
oJsnonlain-ood
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Date
Page

Malass uua
Ns9 DagUOSA
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S l t - Re duse d celulag cOupoueuf
Cesaeuhiat ta eliver
puko O Gels )_
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at bo'dy, RequWC OMlem.
ac tequCO

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