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Name:

Anni
saPuj
i
ant
iLest
ari Dat
e:30Agust
us2021 Gr
oup:
11

HOMEWORK
Whydoy outhinkt
hatoralmucosaf
ormsanimportantprot
ect
ivebar
ri
erbet
weenthe
exter
nalenv
ironmentoftheor
alcav
ityandi
nter
nalenvi
ronment
softhesurr
oundi
ng
ti
ssuesexpl
ain.

Theoralcav i
tyi
sl inedwi t
hstrat
if
iedsquamousepi
thel
ium, whi
chmaybekerati
nized,
part
ial
lykerati
nized, ornonker
ati
nizeddependi
ngonthelocati
on.mucosaf
uncti
ons
asabar r
iertopr otectthedeeperti
ssuesfr
om mechani
calinsult
sandtopr
eventthe
entr
yofpat hogensaswel lastheexogenousharmf
ulsubstancesinor
dert
omai ntai
n
theti
ssueintegrityandhomeost asis.

Whati
sthef
unct
ionofsal
i
vaandment
ionesal
li
tscont
ent

Funct
ionofSal
i
va:
-Keept
hemucousmembr
aneoft
hemout
hmoi
st
-Lebr
icat
est
hef
ooddur
ingmast
icat
ion
-Begi
nst
hedi
gest
ionofst
arches
-Ser
vesasani
ntr
insi
c“mout
hwash”
-Pl
ayssi
gni
fi
cantr
olesi
nthepr
event
ionoft
oot
hdecayandi
ntheabi
l
ityt
otast
e
Cont
entofSal
i
va:
Variet
yofelectrol
ytes,i
ncl
udingsodium,potassi
um,cal
cium,magnesi
um, bi
car
bonat
e,
andphosphat es,i
mmunogl obuli
ns,
pr ot
eins,
enzymes,mucins,
andnit
rogenous
products,
suchasur eaandammoni a. 

Ther
ear
emanyassoci
ateddi
seaser
elat
edt
otheesophagus,
ment
iononeoft
hem t
hat
Name:
Anni
saPuj
i
ant
iLest
ari Dat
e:30Agust
us2021 Gr
oup:
11

i
sfami
li
art
oyou,
andwhyt
hathappenedr
egar
dingt
oabnor
mal
i
tyi
nit
shi
stol
ogi
cal
f
orm.

Achalasi
aisaswall
owingdisordercausedbylossoffuncti
onintheloweresophageal
sphi
ncter(t
hemuscularr
ingatt hej
unctionoftheesophagusandthestomach).
Achalasi
aoccurswhennervesintheesophagusbecomedamaged.Asar esul
t,t
he
esophagusbecomesparalyzedanddilat
edov ert
imeandev ent
uall
ylosestheabil
it
yto
squeezefooddownintothestomach

Expl
ainaboutt
her
enewalofsur
faceepi
thel
i
alofst
omach

Thest omachepithel
ium i sahazar dousenv i
ronmentt hatcur t
ail
sthel i
fespanof
constit
uentcell
s,imposingar equir
ementf orcont i
nuousrenewal ofepi thel
ium.St ems
cell
sinourgutar e,t
hus, essent i
alforepitheli
al r
egenerati
onanddamager epairowi ng
totheirabi
li
tyforsel
f-renewal, hi
ghpr oli
ferationcapacityandpot enti
al f
ormul ti
ple
diff
erenti
ati
on.Gastri
cst em cel l
s,agroupofadul tstem cell
sr esi
dingint hest omach,
playakeyr ol
einmai ntainingthedy namichomeost asi
soft hegastricepi t
helium.Mor e
i
mpor tantl
y,gi
ventheirabi l
it
yofdi r
ectional diff
erenti
ati
on,tissue-
residentst em cell
s
areresponsibl
efortissuehomeost asis,injuryrepair
,andev encancerdev elopment .

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