MHSB

EPITHELIAL TISSUES W4 T2
DRA. CHONA ARAGA September 5, 2017

Lecture, Audio, Book – box, Keypoints – Broken box SURFACE/ MEMBRANE EPITHELIUM
I. INTRODUCTION TO EPITHELIAL TISSUE
- continuous sheet of closely adherent cells covering A. Simple epithelium- a type of epithelium lined by
body surface single layer of cells. Can be furthermore subdivided
- Forms boundary layer that controls movement of according to the shape of the cells
substances between external and internal environment
or between internal compartments a.1. Simple squamous epithelium- lined with single
- May be specialized for absorption, secretion or ion layer of flattened or squamous cells
transport - for easier diffusion of substances that will be
- Lower most cells rest on continuous, thin supporting passing the epithelium
layer called basal lamina Examples: mesothelium, endothelium of small
- Composed of closely aggregated polyhedral cells with strong blood vessels, parietal layer of the Bowman’s
adhesion to one another and attached to thin layer of extracellular capsule, pulmonary alveoli
matrix
- Basal lamina
- Attached to underlying connective tissue via
anchoring fibrils (type VII collagen)
- Acts as selective filter
- Acts as scaffolding when regenerating cells
- Only in EM
- Composed of type IV collagen, laminin and enactin a.2. Simple cuboidal epithelium- lined by a single
o Laminin- glycoproteins that self- assemble as a layer of cuboidal cells
lacelike network below basal pole of cells
- for secretion and absorption
o Enactin/ nidogen, perlecan- holds laminin and
type IV glycogen together Examples: thyroid follicles, germinal epithelium of
- Reticular lamina- reticular fibers associated with ovaries, distal convoluted tubules of the kindey
the basal lamina

CHARACTERISTIC OF EPITHELIAL TISSUES

a. cells are closely adherent with each other
b. cells are arranged in layers or sheets
c. avascular- no space for blood vessel, receive
nourishment only via diffusion
d. the cells rest on the basal lamina
e. they are continuously renewed and replaced
a.3. Simple columnar epithelium- lined by single
f. metaplastic- when subject to prolonger irritation, it
layer of columnar cells
may transform to a different type that is better
- functions for absorption
suited to resist irritant
Examples: cells lining the GIT, gall bladder

Principal functions of epithelial tissues: a.4. Simple columnar ciliated epithelium- lined by
 Covering, lining and protecting surface (eg. Epidermis) single layer of columnar cells provided with cilia
 Absorption (eg. Intestinal lining) Examples: uterus, fallopian tube
 Secretion (eg. Parenchymal cells of glands

II. CLASSIFICATION OF EPITHELIAL TISSUES

 Surface or Membrane epithelium- form surface
coverings and lining membranes
 Glandular epithelium- epithelium of glands

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MHSB W4T2 EPITHELIAL TISSUES
B. Pseudostratified epithelium- a type of epithelium
lined by single layer of columnar cells, but the
nucleus is located at different levels, thus giving an
impression of layering or stratification
b.1. Pseudostratified ciliated epithelium- a type of
epithelial cells provided with cilia
Example: cells lining upper respiratory tract,
trachea, bronchi
b.2. Pseudostratified non- ciliated epithelium- the
cells do not have cilia
Example: seminal vesicles, ejaculatory ducts,
epididymis
C. Stratified epithelium- a type of epithelium lined by
several layers of cells. Depending on the shape of
the upper right layers of the cell.
c.1. Stratified squamous epithelium- type of
epithelium lined by several layers of cells and the
uppermost layer is formed of flattened or
squamous cells. Depending whether the uppermost
layer of flattened cells is formed of living or dead
cells, this type can be subdivided into further
subtypes.
c.1.1 stratified squamous non keratinized
epithelium- a type of epithelium lined by several
layers of cells and the uppermost layer of
flattened cells is formed of living cells.
Examples: esophagus, vagina, oral mucosa
c.1.2. stratified squamous keratinized
epithelium- a type of epithelium lined by several
layers of cells and the uppermost layer of
flattened cells is formed of dead cells
- membrane specialization: keratin
Examples: epidermis of the skin, hard palate,
gingivae
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W4T2
c.2. Stratified cuboidal epithelium- a type of
epithelium lined by several layers of cells, and the
upper most layer is formed of cuboidal cells
- absorptive- secretory function
Example: pars nervosa of male urethra, ducts of
sweat glands and sebaceous glands
c.3. Stratified columnar epithelium- type of
epithelium lined by several layers of cells and the
uppermost layer of cells is formed of columnar cells
Example: penile urethra, ducts of salivary glands,
ducts of mammary glands
D. Transitional epithelium/urothelium- type of
epithelium lined by several layers of cells. The
number of cells layers may vary as well as shape of
cells depending on the functional state of the
organ, whether they are relaxed or empty, full or
distended.
Examples: ureter, urinary bladder, renal calyces
GLANDULAR EPITHELIUM
I. According to number of cells that make up the
gland
a. Unicellular-made up of a single cell
- Common in simple cuboidal, simple columnar and
pseudostratified epithelia
Example: goblet cell
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b. Multicellular- many cells make up a gland a. Exocrine- pour their secretions through
Example: salivary glands, sebaceous glands duct system
- Retain their connection with surface epithelium
II. According to type of secretion b. Endocrine- directly pour their secretion in
a. Purely serous- thin, watery secretion the blood
Example: parotid glands, von Ebner’s gland - Lose connection to original epithelium
b. Purely mucous- thick viscid secretion
Example: goblet cells V. According to structure of multicellular exocrine
c. Muco-serous (mixed) glands
Example: submandibular glands a. Tubular
(predominantly serous), sublingual glands i. Simple tubular- intestinal crypts of
(predominantly mucus) Lieberkhun
d. Cytogenic ii. Simple coiled tubular- eccrine sweat
Example: testis and ovary glands of the skin
iii. Simple branched tubular- fundic glands
of the stomach
iv. Compound tubular- liver, testis

b. Alveolar/ acinar/ saccular

i. Simple alveolar- sebaceous glands
ii. Simple branched alveolar- sebaceous
glands
iii. Compound alveolar- mammary gland

Serous Mucous c. Tubulo-acinar/ mixed/ racemose

i. Compound tubulo-acinar- salivary
glands
III. According to mode of secretion
a. Merocrine- secretory products exit the glands
by exocytosis without loss of cytoplasm or III. CELL COHESION
membrane - Dependent on cell adhesion molecules like cadherin
Example: eccrine sweat glands, pancreatic - Cells are attached by local specializations called
acinus junctional complexes
b. Apocrine- secretory products exit the cell with
some cytoplasm and membrane, hence, with FORMS OF JUNCTIONAL COMPLEXES
partial destruction of cells
Example: mammary glands, apocrine sweat
glands of the axillary areas and groin areas
c. Holocrine- exocytosis of the secretory product
is followed by lysis of the cell, hence, total
destruction
Example: skin’s sebaceous gland

IV. According to presence or absence of ducts

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1. Zonula occludens stresses without becoming

- Most apical part of the cell separated from the basal lamina
- Tight junction, occluding junction o basal lamina- extracellular layer found
- Belt- like specialization that encircles columnar cells beneath all epithelia
below the free surface of the epithelium  lamina lucida- a transparent layer
- Constitute selective permeable barrier between adjacent the epithelium and is
apical and basolateral plasma membrane which composed of large proteogy=lycan
prevent substances from crossing the epithelium and collagen type IV
- Occluding- protein at sites of apparent fusion of  lamina densa- meshwork of fine
opposing membranes filaments of collagen type VII
- Form a seal between adjacent cells looping around collagen type I
- Claudin and occluding- responsible for seal between
membrane
IV. SPECIALIZATIONS OF THE APICAL CELL SURFACE
A. Microvilli
2. Zonula adherens
- array of projections that are functions for absorption
- Intermediate junction, fascia adherens
- also functions to increase absorptive surface
- Encircles apical portion below the occludens - brush border- kidney
- Cross- links are made possible by myosin, α-actinin - striated border- GIT, small intestine
and vinculin - sterocilia- epididymis
- Stabilizes epithelium by connecting the terminal - glycocalyx- covers intestinal microvilli which aids for digestion
webs of adjoining cells of certain molecules
- Cell- to-cell adherence
- Sites of string cell adhesion
- Immediately below zonula occludens
- Cadherin- mediates cell adhesion by interacting with Ca 2+
- Catenin- binds cadherin to actin filaments

3. Macula adherens
- Desmosome
- Small, round specialization on the sides of adjoining B. Cilia
cells - Functions to facilitate movement of substances
- Trans-membrane linkers bind membranes and - Long projecting structures containing internal array of
microtubules
dense plaques together - Primary cilium- non-motile but enriched with receptors and
- Cell to cell attachment signal transduction complexes for light, odor, motion and flow of
- Contribute to the stability of the epithelial by fluid.
linking the cytoskeleton of adjoining cells - Motile cilia- abundant in apical domains of many cuboidal and
- Plakoglobin and desmoplakin- anchoring proteins that columnar cells
bind intermediate filaments to cytoplasmic side of cell - Axoneme- nine doublets form an array around two central
membrane microtubules (9+2 assembly)
- Kinesin and dynein- for transport of molecular components into
and out of the organs
4. Nexus
- Gap junction/ communicating junction
- Cell to cell communication
- Connexons- circular patch on each side of the
membrane
- permits passage of ions and small molecules from
cell to cell
- present in electrically active tissue
- Found not only in epithelium but also in smooth
and striated muscles REFERENCES
- Channels for communication between adjacent cells Dr. Chona Araga’s lecture
o Hemidesmosomes- anchor basal cells to Junquiera’s Basic Histology Text and Atlas
the basal lamina Di Fiore’s Atlas of Histology with Functional Correlations
 found only in stratified epithelium
to withstand blows and shearing

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