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    IgG is the most abundant antibody in the human body, making up 80% of antibodies. IgM and IgG can be transferred across the placenta but IgA, IgE, and IgD cannot. IgG exists as a monomer, IgA as a dimer, and IgM, IgE, and IgD as pentamers or monomers. IgG aids in antigen recognition and complement activation while IgA provides localized mucosal protection and IgE mediates allergic reactions.

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    IgG is the most abundant antibody in the human body, making up 80% of antibodies. IgM and IgG can be transferred across the placenta but IgA, IgE, and IgD cannot. IgG exists as a monomer, IgA as a dimer, and IgM, IgE, and IgD as pentamers or monomers. IgG aids in antigen recognition and complement activation while IgA provides localized mucosal protection and IgE mediates allergic reactions.

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    5 views1 page

    Smart Handout 3

    Uploaded by

    OG gang
    IgG is the most abundant antibody in the human body, making up 80% of antibodies. IgM and IgG can be transferred across the placenta but IgA, IgE, and IgD cannot. IgG exists as a monomer, IgA as a dimer, and IgM, IgE, and IgD as pentamers or monomers. IgG aids in antigen recognition and complement activation while IgA provides localized mucosal protection and IgE mediates allergic reactions.

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    of 1

    Characters Ig-M Ig-A Ig-G Ig-E Ig-D

    Total % in body 5-10% 10-15% 80% 0.10% 0.20%


    Placental
    Yes no Yes no no
    transfer
    Structure Pentamer Dimer Monomer Monomer Monomer
    Tears, saliva,
    Other than blood surface of mast
    colostrum milk & Interstitial
    & lymph found B cell surface cells & basophills B-cell surface.
    mucous, sweat & walls.
    mostly in cells
    sebum
    Complement
    Compleme Helps in antigen
    activation i-e Localised
    Function nt allergic reaction recognisation in
    formn of MHC protection
    activation B-cells directly
    complex

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