I

ntr
a-ut
eri
net
her
api
esi
ncows
I
ntr
a-ut
eri
ne t
her
api
es means i
nser
ti
ng oft
her
api
es i
nsi
de t
he cows i
nfl
amed ut
erus
t
hroughopenedcer
vix.I
ncows,
thi
sut
erusandi
tscer
vixbei
ngopenedonl
ydur
ingest
rus
phase and af
terpar
tur
it
ion.Thi
sty
pe oft
reat
mentcan be cal
l
ed(
topi
cal
)local
i
zed
t
reat
mentt
odi
sti
ngui
shi
tfr
om sy
stemi
ctr
eat
ment
.Int
roduct
iont
het
her
api
esi
nsi
det
he
ut
erusi
sthr
oughspeci
alcat
het
ert
hroughwhi
cht
het
her
api
espushedi
ntout
erus.

Ty
pesoft
her
api
es
1-Ant
ibi
oti
cs:t
hebestant
ibi
oti
cusedasi
ntr
aut
eri
ne,
isoxy
tet
racy
cli
ne.Thi
sant
ibi
oti
c
has br
oad spect
rum act
ivi
ty agai
nst Gr
am posi
ti
ve and Gr
am negat
ive
mi
croor
gani
sms,
andA.
Pyogenesbact
eri
awhi
chi
sresponsi
blef
ormor
ethan90%of
bov
ineendomet
ri
ti
sinf
ect
ioni
sver
ysuscept
ibl
etooxy
tet
racy
cli
ne.Theav
ail
abl
e
phar
macol
ogi
calpr
epar
ati
onsofoxy
tet
eracy
cli
ne i
sbot
tl
edsol
uti
onwi
th10%,20%,
and30% concent
rat
ion.Thepr
efer
abl
econcent
rat
ionchoi
cei
s10%,i
naccountof
t
hatoxy
tet
racy
cli
nehasi
rr
it
ati
ngpr
oper
tyt
hatmayhav
edet
ri
ment
alef
fectont
he
ut
eri
neendomet
ri
um i
nthehi
gherconcent
rat
ion(
20%,30%)
.Theant
ibi
oti
cpr
ovi
ded
t
otheut
erusmustbemi
xedwi
thanappr
opr
iat
eamountofnor
malsal
i
ne t
oensur
e
adequat
edi
str
ibut
ionoft
heant
ibi
oti
cthr
ought
heut
eri
net
issue.
t
hedoseofant
ibi
oti
cgi
vent
out
erusi
s2-
4gr
ams(20-
40mlofant
ibi
oti
csol
uti
on)
mi
xedwi
th30-10mlofnor
malsal
i
ne,
andt
hewhol
esol
uti
onshoul
dnotexceed50
ml
sol
uti
on.
Anot
herant
ibi
oti
cscoul kepeni
dbeusedl
i cil
l
inandt
hisant
ibi
oti
cisef
fect
ivei
nlong
-
standi
ngcasesi chA.py
nwhi ogeneshasbecomedomi
nant
.Theavai
l
abl
e
phar
macol
ogi
calpr
epar
ati
oni
sbot
tl
edoi
l
ysol
uti
oncont
aini
ngpeni
cil
l
inaspr
ocai
ne
benzy
lpenci
l
li
nmi
xedwi
thst
rept
omy
cinandt
heusualdoseoft
hisoi
l
ysol
uti
on
cont
aini
ngpenci
l
li
nis15-20ml
(3000000-
5000000i
.u)wi
thorwi
thoutnor
mal
sal
i
ne.
Recent
lyi
thasbeenusedanewant
ibi
oti
cwhi
chhaspr
ovenef
fect
ivei
nit
suseasan
ant
ibi
oti
ctot
reatut
eri
ne i
nfect
ions and speci
fi
cal
l
yendomet
ri
ti
sin cows,t
his
ant
ibi
oti edcef
ccal
l it
iof
ur.Thi
sant
ibi
oti
ccanbeusedl
ocal
l
yorsy
stemi
cal
l
yandhas
wel
ldi
str
ibut
ioni
ntheut
eri
net
issueandt
her
ecommendeddosei
s1gr
am.
Not
e:Al
lint
raut
eri
neant
ibact
eri
alhav
ebeennegat
iveef
fect
sonnor
mall
eukocy
te
 f
unct
ionandt
hei
rpl
acementr
isksi
atr
ogeni
ccont
ami
nat
ionandf
urt
heri
njur
ytot
he
ut
erus.
2-Di
sinf
ect
ant
s:t
hebestdi
sinf
ect
antt
hatusedt
otr
eatendomet
ri
ti
sandpost
par
tum
met
ri
ti
sin cowsi
sLugol
s(I
odi
nesol
uti
on)wi
th 2% or1% concent
rat
ion.I
tis
pr
efer
abl
etouse1% concent
rat
ionoft
hissol
uti
on.Lugol
ssol
uti
onhasi
rr
it
ant
pr
oper
tyt
her
efor
eiti
ncr
easesbl
ood f
low,ut
eri
net
one,def
ensemechani
sm i
n
addi
ti
on t
o make r
egener
ati
on oft
he i
nfl
amed endomet
ri
um bysl
oughi
ng t
he
necr
oti
car
easi
nthei
nfl
amedendomet
ri
um.
t
heseconddi
sinf
ect
antt
hatusedcommonl
yint
reat
ingt
hepost
par
tum ut
eri
ne
di
sor
der
sbyut
eri
nedouchi
ngi
spot
assi
um per
manganat
ewhi
chi
sver
yst
rong
oxi
dizi
ngagent
,andhasdi
sinf
ect
ingpr
oper
tyandv
eryusef
ulagenti
nev
acuat
ingt
he
i
nfl
amedut
erusf
rom abnor
malut
eri
nef
lui
ds(
uter
inedouchi
ng)i
ncaseofsept
ic
(
toxi
cpuer
per
al)met
ri
ti
s.Thi
sty
peofmet
ri
ti
sneedst
hesy
stemi
ctr
eat
mentof
ant
ibi
oti
csl
i
kepeni
cil
l
inandcef
it
ufor
.Thedependentconcent
rat
ionofpot
assi
um
per
manganat
easut
eri
nedouchi
ngagenti
s0.
005.